KR100356239B1 - 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 - Google Patents

3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 Download PDF

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Publication number
KR100356239B1
KR100356239B1 KR1019940032794A KR19940032794A KR100356239B1 KR 100356239 B1 KR100356239 B1 KR 100356239B1 KR 1019940032794 A KR1019940032794 A KR 1019940032794A KR 19940032794 A KR19940032794 A KR 19940032794A KR 100356239 B1 KR100356239 B1 KR 100356239B1
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South Korea
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acid
compound
alkyl
crystalline
compounds
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019940032794A
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English (en)
Korean (ko)
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KR950017957A (ko
Inventor
스코트알란프랭크
더글라스에드워드프라더
제프리알란와드
존아놀드워너
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일라이 릴리 앤드 캄파니
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Publication of KR950017957A publication Critical patent/KR950017957A/ko
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Publication of KR100356239B1 publication Critical patent/KR100356239B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019940032794A 1993-12-08 1994-12-05 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 Expired - Fee Related KR100356239B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/164,074 1993-12-08
US08/164074 1993-12-08
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (2)

Publication Number Publication Date
KR950017957A KR950017957A (ko) 1995-07-22
KR100356239B1 true KR100356239B1 (ko) 2002-12-26

Family

ID=22592858

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940032794A Expired - Fee Related KR100356239B1 (ko) 1993-12-08 1994-12-05 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체

Country Status (30)

Country Link
US (1) US5434171A (enExample)
EP (3) EP0984004A3 (enExample)
JP (2) JP3834075B2 (enExample)
KR (1) KR100356239B1 (enExample)
CN (2) CN1057294C (enExample)
AT (1) ATE200279T1 (enExample)
AU (1) AU681198B2 (enExample)
BR (1) BR9404842A (enExample)
CA (1) CA2137221C (enExample)
CO (1) CO4290427A1 (enExample)
CZ (1) CZ290559B6 (enExample)
DE (1) DE69427017T2 (enExample)
DK (1) DK0657428T3 (enExample)
ES (1) ES2155844T3 (enExample)
FI (2) FI106455B (enExample)
GR (1) GR3036136T3 (enExample)
HU (1) HUT71489A (enExample)
IL (1) IL111843A (enExample)
MY (1) MY121543A (enExample)
NO (1) NO302884B1 (enExample)
NZ (1) NZ270039A (enExample)
PE (1) PE41495A1 (enExample)
PL (1) PL181734B1 (enExample)
PT (1) PT657428E (enExample)
RU (1) RU2145958C1 (enExample)
SI (1) SI0657428T1 (enExample)
TW (1) TW290540B (enExample)
UA (1) UA52577C2 (enExample)
YU (2) YU49312B (enExample)
ZA (1) ZA949584B (enExample)

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GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
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US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
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EP1617846A1 (en) * 2003-04-08 2006-01-25 Progenics Pharmaceuticals, Inc. The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome
BRPI0409133B8 (pt) 2003-04-08 2021-05-25 Progenics Pharm Inc preparações farmacêuticas estavéis compreendendo metilnaltrexona
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
FR2861304B1 (fr) * 2003-10-23 2008-07-18 Univ Grenoble 1 Modulateurs des canaux cftr
US20050148630A1 (en) * 2003-12-02 2005-07-07 Carpenter Randall L. Methods of preventing and treating non-opioid induced gastrointestinal dysfunction
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US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
BRPI0608818A2 (pt) * 2005-03-07 2010-01-26 Univ Chicago uso de antagonista opióides para atenuação de proliferação e migração de células endoteliais
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
CN101262867A (zh) * 2005-07-01 2008-09-10 叶林发现公司 用于治疗肥胖的mao-b抑制剂
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Also Published As

Publication number Publication date
NZ270039A (en) 1996-08-27
YU82304A (sh) 2006-03-03
CA2137221A1 (en) 1995-06-09
YU70294A (sh) 1997-07-31
MY121543A (en) 2006-02-28
TW290540B (enExample) 1996-11-11
CZ299294A3 (en) 1995-10-18
CN1121387C (zh) 2003-09-17
AU681198B2 (en) 1997-08-21
ES2155844T3 (es) 2001-06-01
RU2145958C1 (ru) 2000-02-27
YU49312B (sh) 2005-06-10
BR9404842A (pt) 1995-08-08
JPH07215937A (ja) 1995-08-15
UA52577C2 (uk) 2003-01-15
CN1223257A (zh) 1999-07-21
CN1057294C (zh) 2000-10-11
PT657428E (pt) 2001-07-31
NO944644D0 (no) 1994-12-02
HK1013826A1 (en) 1999-09-10
FI106455B (fi) 2001-02-15
ATE200279T1 (de) 2001-04-15
DK0657428T3 (da) 2001-05-07
PL306068A1 (en) 1995-06-12
NO302884B1 (no) 1998-05-04
ZA949584B (en) 1996-06-03
EP0657428A1 (en) 1995-06-14
CO4290427A1 (es) 1996-04-17
EP0984004A2 (en) 2000-03-08
DE69427017D1 (de) 2001-05-10
GR3036136T3 (en) 2001-09-28
FI20000353L (fi) 2000-02-17
IL111843A0 (en) 1995-03-15
FI945703A0 (fi) 1994-12-02
RU94042903A (ru) 1996-10-27
JP2006070042A (ja) 2006-03-16
IL111843A (en) 2000-02-29
EP0984004A3 (en) 2003-10-15
NO944644L (no) 1995-06-09
CZ290559B6 (cs) 2002-08-14
EP1607387A3 (en) 2007-01-03
DE69427017T2 (de) 2001-09-06
KR950017957A (ko) 1995-07-22
HUT71489A (en) 1995-11-28
JP3834075B2 (ja) 2006-10-18
CN1111239A (zh) 1995-11-08
EP1607387A2 (en) 2005-12-21
PE41495A1 (es) 1995-11-28
SI0657428T1 (en) 2001-08-31
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
EP0657428B1 (en) 2001-04-04
AU7917094A (en) 1995-06-15
CA2137221C (en) 2011-02-22
US5434171A (en) 1995-07-18
FI945703L (fi) 1995-06-09
PL181734B1 (pl) 2001-09-28

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