KR100356239B1 - 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 - Google Patents

3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 Download PDF

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Publication number
KR100356239B1
KR100356239B1 KR1019940032794A KR19940032794A KR100356239B1 KR 100356239 B1 KR100356239 B1 KR 100356239B1 KR 1019940032794 A KR1019940032794 A KR 1019940032794A KR 19940032794 A KR19940032794 A KR 19940032794A KR 100356239 B1 KR100356239 B1 KR 100356239B1
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South Korea
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acid
compound
alkyl
crystalline
compounds
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Expired - Fee Related
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KR1019940032794A
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English (en)
Korean (ko)
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KR950017957A (ko
Inventor
스코트알란프랭크
더글라스에드워드프라더
제프리알란와드
존아놀드워너
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일라이 릴리 앤드 캄파니
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Publication of KR950017957A publication Critical patent/KR950017957A/ko
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Publication of KR100356239B1 publication Critical patent/KR100356239B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019940032794A 1993-12-08 1994-12-05 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체 Expired - Fee Related KR100356239B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/164,074 1993-12-08
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates
US08/164074 1993-12-08

Publications (2)

Publication Number Publication Date
KR950017957A KR950017957A (ko) 1995-07-22
KR100356239B1 true KR100356239B1 (ko) 2002-12-26

Family

ID=22592858

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940032794A Expired - Fee Related KR100356239B1 (ko) 1993-12-08 1994-12-05 3,4,4-삼치환-피페리디닐-n-알킬카르복실레이트의제법및중간체

Country Status (30)

Country Link
US (1) US5434171A (enExample)
EP (3) EP1607387A3 (enExample)
JP (2) JP3834075B2 (enExample)
KR (1) KR100356239B1 (enExample)
CN (2) CN1057294C (enExample)
AT (1) ATE200279T1 (enExample)
AU (1) AU681198B2 (enExample)
BR (1) BR9404842A (enExample)
CA (1) CA2137221C (enExample)
CO (1) CO4290427A1 (enExample)
CZ (1) CZ290559B6 (enExample)
DE (1) DE69427017T2 (enExample)
DK (1) DK0657428T3 (enExample)
ES (1) ES2155844T3 (enExample)
FI (2) FI106455B (enExample)
GR (1) GR3036136T3 (enExample)
HU (1) HUT71489A (enExample)
IL (1) IL111843A (enExample)
MY (1) MY121543A (enExample)
NO (1) NO302884B1 (enExample)
NZ (1) NZ270039A (enExample)
PE (1) PE41495A1 (enExample)
PL (1) PL181734B1 (enExample)
PT (1) PT657428E (enExample)
RU (1) RU2145958C1 (enExample)
SI (1) SI0657428T1 (enExample)
TW (1) TW290540B (enExample)
UA (1) UA52577C2 (enExample)
YU (2) YU82304A (enExample)
ZA (1) ZA949584B (enExample)

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HN1999000149A (es) 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
WO2002098422A1 (en) * 2001-06-05 2002-12-12 University Of Chicago Use of methylnaltrexone to treat immune suppression
US20030068829A1 (en) * 2001-06-25 2003-04-10 Symyx Technologies, Inc. High throughput crystallographic screening of materials
US7056500B2 (en) 2001-10-18 2006-06-06 Nektar Therapeutics Al, Corporation Polymer conjugates of opioid antagonists
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
US7381721B2 (en) * 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
JP2006522817A (ja) * 2003-04-08 2006-10-05 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用
PL2368554T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
FR2861304B1 (fr) * 2003-10-23 2008-07-18 Univ Grenoble 1 Modulateurs des canaux cftr
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CN100579373C (zh) * 2004-06-04 2010-01-13 阿得罗公司 包含鸦片样物质拮抗剂的组合物
US7700626B2 (en) 2004-06-04 2010-04-20 Adolor Corporation Compositions containing opioid antagonists
US8039456B2 (en) 2004-08-12 2011-10-18 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using ipamorelin
AU2005272598B2 (en) * 2004-08-12 2011-11-17 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
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US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
MX2007010833A (es) * 2005-03-07 2009-02-17 Univ Chicago Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales.
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP1906952A4 (en) * 2005-07-01 2010-04-14 Jenrin Discovery MAO-B-HEMMER FOR THE TREATMENT OF ADIPOSITAS
US7914776B2 (en) * 2005-10-07 2011-03-29 Adolor Corporation Solid dispersions of opioid antagonists
US20070092576A1 (en) * 2005-10-20 2007-04-26 Adolor Corporation Compositions containing opioid antagonists
US7538110B2 (en) 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
CN100383121C (zh) * 2006-03-07 2008-04-23 天津泰普药品科技发展有限公司 阿韦苄酯化合物及其制备方法和以该化合物制备阿韦莫哌的工艺
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Also Published As

Publication number Publication date
JPH07215937A (ja) 1995-08-15
TW290540B (enExample) 1996-11-11
GR3036136T3 (en) 2001-09-28
EP1607387A2 (en) 2005-12-21
DE69427017D1 (de) 2001-05-10
EP0657428B1 (en) 2001-04-04
FI945703A0 (fi) 1994-12-02
RU2145958C1 (ru) 2000-02-27
FI20000353L (fi) 2000-02-17
ATE200279T1 (de) 2001-04-15
IL111843A0 (en) 1995-03-15
SI0657428T1 (en) 2001-08-31
US5434171A (en) 1995-07-18
FI945703L (fi) 1995-06-09
AU7917094A (en) 1995-06-15
KR950017957A (ko) 1995-07-22
RU94042903A (ru) 1996-10-27
DE69427017T2 (de) 2001-09-06
CN1121387C (zh) 2003-09-17
YU70294A (sh) 1997-07-31
JP3834075B2 (ja) 2006-10-18
YU49312B (sh) 2005-06-10
CZ290559B6 (cs) 2002-08-14
EP0657428A1 (en) 1995-06-14
NO302884B1 (no) 1998-05-04
FI106455B (fi) 2001-02-15
CA2137221A1 (en) 1995-06-09
CN1223257A (zh) 1999-07-21
EP1607387A3 (en) 2007-01-03
NO944644L (no) 1995-06-09
UA52577C2 (uk) 2003-01-15
CO4290427A1 (es) 1996-04-17
NZ270039A (en) 1996-08-27
ES2155844T3 (es) 2001-06-01
YU82304A (sh) 2006-03-03
CA2137221C (en) 2011-02-22
CZ299294A3 (en) 1995-10-18
AU681198B2 (en) 1997-08-21
NO944644D0 (no) 1994-12-02
PL181734B1 (pl) 2001-09-28
EP0984004A3 (en) 2003-10-15
HK1013826A1 (en) 1999-09-10
PT657428E (pt) 2001-07-31
CN1111239A (zh) 1995-11-08
HUT71489A (en) 1995-11-28
BR9404842A (pt) 1995-08-08
DK0657428T3 (da) 2001-05-07
IL111843A (en) 2000-02-29
CN1057294C (zh) 2000-10-11
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
EP0984004A2 (en) 2000-03-08
PL306068A1 (en) 1995-06-12
JP2006070042A (ja) 2006-03-16
PE41495A1 (es) 1995-11-28
MY121543A (en) 2006-02-28
ZA949584B (en) 1996-06-03

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