YU82304A - Kristalni 3,4,4-trisupstituisani-piperidinil-n-alkilkarboksilati, intermedijeri i postupak za dobijanje - Google Patents

Kristalni 3,4,4-trisupstituisani-piperidinil-n-alkilkarboksilati, intermedijeri i postupak za dobijanje

Info

Publication number
YU82304A
YU82304A YU82304A YU82304A YU82304A YU 82304 A YU82304 A YU 82304A YU 82304 A YU82304 A YU 82304A YU 82304 A YU82304 A YU 82304A YU 82304 A YU82304 A YU 82304A
Authority
YU
Yugoslavia
Prior art keywords
procedure
obtaining
crystalline
alkylcarboxylates
intermediaries
Prior art date
Application number
YU82304A
Other languages
English (en)
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU82304A publication Critical patent/YU82304A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Kristalna jedinjenja formule 2 u kojo je R C1-C6 alkil; Z je odabrano iz grupe koja se sastoji od hidrohlorida, hidrobromida, sukcinata, i (+)-dibenzoiltartarata. Takodje je opisan postupak za njihovo dobijanje.[Crystalline compounds having formula 2 wherein R C1-C6 alkyl; Z is chosen from the group composed of hydrochlorides, hydro bromide, succinates, and (+)-dibenzoyltartarate. Procedure for obtaining thereof is described, as well.
YU82304A 1993-12-08 1994-12-02 Kristalni 3,4,4-trisupstituisani-piperidinil-n-alkilkarboksilati, intermedijeri i postupak za dobijanje YU82304A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (1)

Publication Number Publication Date
YU82304A true YU82304A (sh) 2006-03-03

Family

ID=22592858

Family Applications (2)

Application Number Title Priority Date Filing Date
YU82304A YU82304A (sh) 1993-12-08 1994-12-02 Kristalni 3,4,4-trisupstituisani-piperidinil-n-alkilkarboksilati, intermedijeri i postupak za dobijanje
YU70294A YU49312B (sh) 1993-12-08 1994-12-02 Kristalni hidratni derivati 3,4,4-trisupstituisanih - peperidinil-n-alkilkarboksilata, njihovi intermedijari i postupak za dobijanje

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU70294A YU49312B (sh) 1993-12-08 1994-12-02 Kristalni hidratni derivati 3,4,4-trisupstituisanih - peperidinil-n-alkilkarboksilata, njihovi intermedijari i postupak za dobijanje

Country Status (31)

Country Link
US (1) US5434171A (sh)
EP (3) EP1607387A3 (sh)
JP (2) JP3834075B2 (sh)
KR (1) KR100356239B1 (sh)
CN (2) CN1057294C (sh)
AT (1) ATE200279T1 (sh)
AU (1) AU681198B2 (sh)
BR (1) BR9404842A (sh)
CA (1) CA2137221C (sh)
CO (1) CO4290427A1 (sh)
CZ (1) CZ290559B6 (sh)
DE (1) DE69427017T2 (sh)
DK (1) DK0657428T3 (sh)
ES (1) ES2155844T3 (sh)
FI (2) FI106455B (sh)
GR (1) GR3036136T3 (sh)
HK (1) HK1013826A1 (sh)
HU (1) HUT71489A (sh)
IL (1) IL111843A (sh)
MY (1) MY121543A (sh)
NO (1) NO302884B1 (sh)
NZ (1) NZ270039A (sh)
PE (1) PE41495A1 (sh)
PL (1) PL181734B1 (sh)
PT (1) PT657428E (sh)
RU (1) RU2145958C1 (sh)
SI (1) SI0657428T1 (sh)
TW (1) TW290540B (sh)
UA (1) UA52577C2 (sh)
YU (2) YU82304A (sh)
ZA (1) ZA949584B (sh)

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GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
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US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
ES2714198T3 (es) * 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
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US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists
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Also Published As

Publication number Publication date
IL111843A (en) 2000-02-29
CA2137221A1 (en) 1995-06-09
NO944644D0 (no) 1994-12-02
CO4290427A1 (es) 1996-04-17
AU681198B2 (en) 1997-08-21
BR9404842A (pt) 1995-08-08
CN1111239A (zh) 1995-11-08
FI20000353A (fi) 2000-02-17
NZ270039A (en) 1996-08-27
RU94042903A (ru) 1996-10-27
PE41495A1 (es) 1995-11-28
EP0984004A2 (en) 2000-03-08
DE69427017T2 (de) 2001-09-06
ZA949584B (en) 1996-06-03
SI0657428T1 (en) 2001-08-31
ES2155844T3 (es) 2001-06-01
EP0657428B1 (en) 2001-04-04
EP0657428A1 (en) 1995-06-14
JP3834075B2 (ja) 2006-10-18
EP0984004A3 (en) 2003-10-15
HUT71489A (en) 1995-11-28
JPH07215937A (ja) 1995-08-15
CA2137221C (en) 2011-02-22
NO944644L (no) 1995-06-09
DK0657428T3 (da) 2001-05-07
KR100356239B1 (ko) 2002-12-26
CZ299294A3 (en) 1995-10-18
AU7917094A (en) 1995-06-15
FI945703A (fi) 1995-06-09
FI945703A0 (fi) 1994-12-02
EP1607387A2 (en) 2005-12-21
CN1121387C (zh) 2003-09-17
ATE200279T1 (de) 2001-04-15
JP2006070042A (ja) 2006-03-16
MY121543A (en) 2006-02-28
FI106455B (fi) 2001-02-15
EP1607387A3 (en) 2007-01-03
HK1013826A1 (en) 1999-09-10
TW290540B (sh) 1996-11-11
US5434171A (en) 1995-07-18
UA52577C2 (uk) 2003-01-15
KR950017957A (ko) 1995-07-22
RU2145958C1 (ru) 2000-02-27
CN1057294C (zh) 2000-10-11
FI106860B (fi) 2001-04-30
HU9403466D0 (en) 1995-02-28
CZ290559B6 (cs) 2002-08-14
NO302884B1 (no) 1998-05-04
PL181734B1 (pl) 2001-09-28
GR3036136T3 (en) 2001-09-28
PL306068A1 (en) 1995-06-12
YU70294A (sh) 1997-07-31
PT657428E (pt) 2001-07-31
YU49312B (sh) 2005-06-10
IL111843A0 (en) 1995-03-15
DE69427017D1 (de) 2001-05-10
CN1223257A (zh) 1999-07-21

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