US6936694B1
(en)
|
1982-05-06 |
2005-08-30 |
Intermune, Inc. |
Manufacture and expression of large structural genes
|
ATE135370T1
(de)
*
|
1988-12-22 |
1996-03-15 |
Kirin Amgen Inc |
Chemisch modifizierte granulocytenkolonie erregender faktor
|
US20020177688A1
(en)
*
|
1988-12-22 |
2002-11-28 |
Kirin-Amgen, Inc., |
Chemically-modified G-CSF
|
US5906816A
(en)
*
|
1995-03-16 |
1999-05-25 |
University Of Florida |
Method for treatment of autoimmune diseases
|
US6372206B1
(en)
*
|
1989-03-02 |
2002-04-16 |
University Of Florida |
Orally-administered interferon-TAU compositions and methods
|
US5372808A
(en)
†
|
1990-10-17 |
1994-12-13 |
Amgen Inc. |
Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
|
US5676942A
(en)
*
|
1992-02-10 |
1997-10-14 |
Interferon Sciences, Inc. |
Composition containing human alpha interferon species proteins and method for use thereof
|
US5503828A
(en)
*
|
1992-02-10 |
1996-04-02 |
Interferon Sciences, Inc. |
Alpha interferon composition and method for its production from human peripheral blood leukocytes
|
US6001589A
(en)
*
|
1993-06-11 |
1999-12-14 |
Pbl Biomedical Laboratories, Inc. |
Method of identifying proteins modified by disease states related thereto
|
US5789551A
(en)
*
|
1993-06-11 |
1998-08-04 |
Pestka Biomedical Laboratories, Inc. |
Human leukocyte interferon Hu-IFN-α001
|
WO1995015177A2
(en)
*
|
1993-12-02 |
1995-06-08 |
President And Fellows Of Harvard College |
Improved efficacy of alpha-helical cytokines
|
IL112583A0
(en)
*
|
1994-02-08 |
1995-05-26 |
Amgen Inc |
Oral delivery of chemically modified proteins
|
US20030053982A1
(en)
*
|
1994-09-26 |
2003-03-20 |
Kinstler Olaf B. |
N-terminally chemically modified protein compositions and methods
|
US5824784A
(en)
*
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
IL116730A0
(en)
*
|
1995-01-13 |
1996-05-14 |
Amgen Inc |
Chemically modified interferon
|
CA2203377A1
(en)
*
|
1995-08-30 |
1997-03-06 |
Akira Matsumori |
Method for testing myocarditis or cardiomyopathy
|
US5908621A
(en)
*
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
ATE262920T1
(de)
|
1995-11-02 |
2004-04-15 |
Schering Corp |
Kontinuierliche, niedrigdosierte zytokine- infusionstherapie
|
US5739313A
(en)
*
|
1995-11-13 |
1998-04-14 |
Regents Of The University Of Minnesota |
Radionuclide labeling of vitamin B12 and coenzymes thereof
|
US20030026779A1
(en)
*
|
1999-10-15 |
2003-02-06 |
Liming Yu |
Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
|
US5980884A
(en)
*
|
1996-02-05 |
1999-11-09 |
Amgen, Inc. |
Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
|
AUPN976596A0
(en)
*
|
1996-05-09 |
1996-05-30 |
Pharma Pacific Pty Ltd |
Stimulation of host defence mechanisms
|
US5831062A
(en)
*
|
1996-05-09 |
1998-11-03 |
Amgen Inc. |
Use of the human interferon consensus gene for gene therapy
|
ATE316792T1
(de)
*
|
1996-05-09 |
2006-02-15 |
Pharma Pacific Pty Ltd |
Stimulierung wirtseigener abwehrmechanismen gegen krebs
|
US20030190307A1
(en)
*
|
1996-12-24 |
2003-10-09 |
Biogen, Inc. |
Stable liquid interferon formulations
|
US6013253A
(en)
*
|
1997-08-15 |
2000-01-11 |
Amgen, Inc. |
Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist
|
US6017876A
(en)
|
1997-08-15 |
2000-01-25 |
Amgen Inc. |
Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity
|
US6541033B1
(en)
|
1998-06-30 |
2003-04-01 |
Amgen Inc. |
Thermosensitive biodegradable hydrogels for sustained delivery of leptin
|
US6432398B1
(en)
*
|
1998-09-29 |
2002-08-13 |
W. Robert Fleischmann |
Methods of treating diseased cells
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
US6451346B1
(en)
*
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
US6245740B1
(en)
|
1998-12-23 |
2001-06-12 |
Amgen Inc. |
Polyol:oil suspensions for the sustained release of proteins
|
RU2140285C1
(ru)
|
1999-01-25 |
1999-10-27 |
Гапонюк Петр Яковлевич |
Противовирусное средство - капли в нос "гриппферон"
|
WO2000044785A1
(en)
*
|
1999-01-29 |
2000-08-03 |
F. Hoffmann-La Roche Ag |
Gcsf conjugates
|
US6806363B1
(en)
|
1999-04-16 |
2004-10-19 |
Mayo Foundation For Medical Education & Research |
Cobalamin conjugates useful as antitumor agents
|
US8106098B2
(en)
*
|
1999-08-09 |
2012-01-31 |
The General Hospital Corporation |
Protein conjugates with a water-soluble biocompatible, biodegradable polymer
|
US7591995B2
(en)
*
|
1999-10-15 |
2009-09-22 |
Mayo Foundation For Medical Education And Research |
Cobalamin conjugates useful as imaging and therapeutic agents
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
CA2410579C
(en)
|
2000-05-26 |
2010-04-20 |
Jean-Pierre Sommadossi |
Methods and compositions for treating flaviviruses and pestiviruses
|
US7105154B2
(en)
*
|
2000-07-19 |
2006-09-12 |
Pepgen Corporation |
Method of treatment using interferon-tau
|
EP1334114A2
(en)
|
2000-10-25 |
2003-08-13 |
Mayo Foundation For Medical Education And Research |
Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
|
US6878364B2
(en)
*
|
2000-12-01 |
2005-04-12 |
Cornell Research Foundation, Inc. |
Animal model for flaviviridae infection
|
US20050079579A1
(en)
*
|
2001-02-28 |
2005-04-14 |
Guangwen Wei |
Uses of spatial configuration to modulate protein function
|
US20060035327A1
(en)
*
|
2001-02-28 |
2006-02-16 |
Guangwen Wei |
Recombinant super-compound interferon and uses thereof
|
US8551469B2
(en)
*
|
2001-02-28 |
2013-10-08 |
Superlab Far East Limited |
Treatment of tumors and viral diseases with recombinant interferon alpha
|
CN1245215C
(zh)
*
|
2001-02-28 |
2006-03-15 |
四川省生物工程研究中心 |
重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
|
US20030104996A1
(en)
*
|
2001-08-30 |
2003-06-05 |
Tiansheng Li |
L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
|
JP2005508332A
(ja)
*
|
2001-09-28 |
2005-03-31 |
メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ |
薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与
|
US7138376B2
(en)
*
|
2001-09-28 |
2006-11-21 |
Idenix Pharmaceuticals, Inc. |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
|
KR20040037191A
(ko)
*
|
2001-09-28 |
2004-05-04 |
인터뮨, 인크. |
치료 실패 환자에서 c형 간염 바이러스 감염의 치료 방법
|
PL369129A1
(en)
*
|
2001-09-28 |
2005-04-18 |
Intermune, Inc. |
Method for treating hepatitis c virus infection in treatment failure patients
|
BR0213103A
(pt)
*
|
2001-10-05 |
2004-09-21 |
Intermune Inc |
Método para tratamento de infecção pelo vìrus da hepatite com um perfil de liberação de interferon multifásico
|
US20050095224A1
(en)
*
|
2001-12-07 |
2005-05-05 |
Ramachandran Radhakrishnan |
Compositions and method for treating hepatitis virus infection
|
JP2006501137A
(ja)
*
|
2002-01-16 |
2006-01-12 |
ペプジェン コーポレイション |
インターフェロン−τの経口投与
|
US20040063912A1
(en)
*
|
2002-03-15 |
2004-04-01 |
The Brigham And Women's Hospital, Inc. |
Central airway administration for systemic delivery of therapeutics
|
US20030191056A1
(en)
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
CN100348607C
(zh)
|
2002-06-28 |
2007-11-14 |
埃迪尼克斯(开曼)有限公司 |
用于治疗黄病毒科病毒感染的2’和3’-核苷前药
|
JP2005533824A
(ja)
|
2002-06-28 |
2005-11-10 |
イデニクス(ケイマン)リミテツド |
フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
CN101172993A
(zh)
|
2002-06-28 |
2008-05-07 |
埃迪尼克斯(开曼)有限公司 |
用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
|
GB0215293D0
(en)
*
|
2002-07-03 |
2002-08-14 |
Rega Foundation |
Viral inhibitors
|
MXPA05005192A
(es)
|
2002-11-15 |
2005-09-08 |
Idenix Cayman Ltd |
Nucleosidos ramificados en la posicion 2' y mutacion de flaviviridae.
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
PL377287A1
(pl)
|
2002-12-12 |
2006-01-23 |
Idenix (Cayman) Limited |
Sposób wytwarzania 2'-rozgałęzionych nukleozydów
|
US20070077225A1
(en)
*
|
2003-02-28 |
2007-04-05 |
Blatt Lawrence M |
Continuous delivery methods for treating hepatitis virus infection
|
EP1599171A2
(en)
*
|
2003-02-28 |
2005-11-30 |
Intermune, Inc. |
Combination therapy for treating alphavirus infection and liver fibrosis
|
BRPI0419345B8
(pt)
|
2003-05-30 |
2021-05-25 |
Gilead Pharmasset Llc |
uso do (2r)-2-desoxi-2-flúor-2-c-metil nucleosídeo e de uma composição farmacêutica que o compreende
|
WO2005009418A2
(en)
*
|
2003-07-25 |
2005-02-03 |
Idenix (Cayman) Limited |
Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
|
ES2528218T3
(es)
*
|
2003-08-28 |
2015-02-05 |
Superlab Far East Limited |
Usos de interferones con estructura espacial modificada
|
US7585647B2
(en)
*
|
2003-08-28 |
2009-09-08 |
Guangwen Wei |
Nucleic acid encoding recombinant interferon
|
KR20060130009A
(ko)
|
2003-08-28 |
2006-12-18 |
휴이양테크 (유에스에이), 인크. |
변경된 공간 구조를 갖는 인터페론의 용도
|
TW201245229A
(en)
|
2003-10-14 |
2012-11-16 |
Hoffmann La Roche |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication
|
ES2381890T3
(es)
*
|
2003-12-22 |
2012-06-01 |
K.U.Leuven Research & Development |
Compuesto de imidazo[4,5-c]piridina y métodos de tratamiento antiviral
|
AU2004313245B2
(en)
|
2003-12-30 |
2011-04-14 |
Durect Corporation |
Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH
|
US7754718B2
(en)
|
2004-05-05 |
2010-07-13 |
Yale University |
Antiviral helioxanthin analogs
|
AU2005245918A1
(en)
|
2004-05-19 |
2005-12-01 |
F. Hoffmann-La Roche Ag |
Interferon-alpha polypeptides and conjugates
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
RU2433124C2
(ru)
|
2004-09-14 |
2011-11-10 |
Фармассет, Инк. |
Способ получения 2'-фтор-2'-алкилзамещенных или других замещенных рибофуранозилпиримидинов и пуринов и их производных
|
EP1679065A1
(en)
*
|
2005-01-07 |
2006-07-12 |
OctoPlus Sciences B.V. |
Controlled release compositions for interferon based on PEGT/PBT block copolymers
|
JP5209462B2
(ja)
*
|
2005-03-09 |
2013-06-12 |
ウェイ グアンウェン |
コンセンサスインターフェロンの使用方法
|
JP4516863B2
(ja)
*
|
2005-03-11 |
2010-08-04 |
株式会社ケンウッド |
音声合成装置、音声合成方法及びプログラム
|
CN101501068A
(zh)
|
2005-05-18 |
2009-08-05 |
马克西根公司 |
改进的α-干扰素多肽
|
EP2305697A3
(en)
|
2005-07-25 |
2011-07-27 |
Intermune, Inc. |
Macrocyclic inhibitors of Hepatitis C virus replication
|
NZ568135A
(en)
|
2005-10-11 |
2011-06-30 |
Array Biopharma Inc |
Macrocyclic compounds and methods for inhibiting hepatitis C viral replication
|
CA2634749C
(en)
|
2005-12-23 |
2014-08-19 |
Idenix Pharmaceuticals, Inc. |
Process for preparing a synthetic intermediate for preparation of branched nucleosides
|
CA2648077A1
(en)
*
|
2006-03-31 |
2007-11-08 |
Schering Corporation |
Parenteral low dose type 1 interferons for bladder cancer
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
CN101525381B
(zh)
*
|
2008-03-04 |
2012-04-18 |
北京百川飞虹生物科技有限公司 |
一种重组复合干扰素及其表达载体的构建和表达
|
TW200946541A
(en)
*
|
2008-03-27 |
2009-11-16 |
Idenix Pharmaceuticals Inc |
Solid forms of an anti-HIV phosphoindole compound
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
SG172361A1
(en)
*
|
2008-12-23 |
2011-07-28 |
Pharmasset Inc |
Nucleoside analogs
|
EP2376515A1
(en)
|
2008-12-23 |
2011-10-19 |
Pharmasset, Inc. |
Synthesis of purine nucleosides
|
AR074897A1
(es)
|
2008-12-23 |
2011-02-23 |
Pharmasset Inc |
Fosforamidatos de nucleosidos
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
TWI576352B
(zh)
|
2009-05-20 |
2017-04-01 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
JP5908397B2
(ja)
*
|
2009-06-09 |
2016-04-26 |
デフィルス、インコーポレイテッドDefyrus, Inc. |
病原体感染を予防又は治療するためのインターフェロン投与
|
WO2011014882A1
(en)
|
2009-07-31 |
2011-02-03 |
Medtronic, Inc. |
CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF INTERFERON-α TO HEPATITIS C INFECTED PATIENTS
|
CN102101886A
(zh)
|
2009-12-18 |
2011-06-22 |
四川辉阳生命工程股份有限公司 |
构象改变的重组干扰素晶体、其三维结构及应用
|
PT3290428T
(pt)
|
2010-03-31 |
2021-12-27 |
Gilead Pharmasset Llc |
Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
|
US8563530B2
(en)
|
2010-03-31 |
2013-10-22 |
Gilead Pharmassel LLC |
Purine nucleoside phosphoramidate
|
CN102711871A
(zh)
|
2010-06-16 |
2012-10-03 |
麦德托尼克公司 |
用于稳定药物递送装置中的药物的阻尼系统
|
CA2813038C
(en)
|
2010-09-28 |
2021-12-28 |
Amylin Pharmaceuticals, Llc |
Highly soluble leptins
|
PT3042910T
(pt)
|
2010-11-30 |
2019-04-16 |
Gilead Pharmasset Llc |
2'-espiro-nucleósidos para utilização na terapia da hepatite c
|
BRPI1107312B1
(pt)
*
|
2011-11-25 |
2021-09-08 |
Universidade Federal De Santa Catarina |
Composto de acil-hidrazona
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
US8809354B2
(en)
|
2011-12-31 |
2014-08-19 |
Sheikh Riazuddin |
3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections
|
TWI718086B
(zh)
*
|
2013-01-07 |
2021-02-11 |
英屬維爾京群島商遠東超級實驗室有限公司 |
通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物
|
AU2014311827B2
(en)
|
2013-08-27 |
2017-09-14 |
Gilead Sciences, Inc. |
Combination formulation of two antiviral compounds
|