KR100277481B1 - 이사틴옥심 유도체 및 그를 이용한 치료방법 - Google Patents

이사틴옥심 유도체 및 그를 이용한 치료방법 Download PDF

Info

Publication number
KR100277481B1
KR100277481B1 KR1019940700676A KR19940700676A KR100277481B1 KR 100277481 B1 KR100277481 B1 KR 100277481B1 KR 1019940700676 A KR1019940700676 A KR 1019940700676A KR 19940700676 A KR19940700676 A KR 19940700676A KR 100277481 B1 KR100277481 B1 KR 100277481B1
Authority
KR
South Korea
Prior art keywords
compound
hydrogen
branched
cyclic
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940700676A
Other languages
English (en)
Korean (ko)
Inventor
프랭크 와트젠
베르너 위고 댈
조르겐 드레저
레이프 헬쓰 젠슨
Original Assignee
페더 벨링
뉴로서치 에이/에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 페더 벨링, 뉴로서치 에이/에스 filed Critical 페더 벨링
Application granted granted Critical
Publication of KR100277481B1 publication Critical patent/KR100277481B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019940700676A 1991-08-28 1992-08-27 이사틴옥심 유도체 및 그를 이용한 치료방법 Expired - Fee Related KR100277481B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US751,165 1991-08-28
US83185192A 1992-02-05 1992-02-05
US831,851 1992-02-05
PCT/EP1992/001999 WO1993005043A1 (en) 1991-08-28 1992-08-27 Novel isatinoxime derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
KR100277481B1 true KR100277481B1 (ko) 2001-02-01

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940700676A Expired - Fee Related KR100277481B1 (ko) 1991-08-28 1992-08-27 이사틴옥심 유도체 및 그를 이용한 치료방법

Country Status (18)

Country Link
EP (1) EP0529636B1 (enExample)
JP (1) JP3170584B2 (enExample)
KR (1) KR100277481B1 (enExample)
AT (1) ATE181552T1 (enExample)
AU (1) AU655672B2 (enExample)
CA (1) CA2076948C (enExample)
CZ (1) CZ282759B6 (enExample)
DE (1) DE69229461T2 (enExample)
DK (1) DK0529636T3 (enExample)
FI (1) FI107156B (enExample)
GE (1) GEP20002329B (enExample)
HU (2) HUT70753A (enExample)
MX (1) MX9204914A (enExample)
NO (1) NO301117B1 (enExample)
PL (1) PL170920B1 (enExample)
RU (1) RU2114827C1 (enExample)
SK (1) SK280578B6 (enExample)
WO (1) WO1993005043A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502483A (ja) 1992-10-13 1996-03-19 ワーナー−ランバート・コンパニー 新規なキノキサリンジオン誘導体、それらの製造および使用
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
FI954965L (fi) * 1993-05-13 1995-11-10 Neurosearch As AMPA-antagonisteja ja hoitomenetelmä, jossa niitä käytetään
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
EP0781285B1 (en) * 1994-09-14 2000-01-12 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use as glutamate antagonists
CA2199613C (en) * 1994-09-14 2000-02-29 Peter Moldt Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) * 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
DE60041399D1 (de) 1999-05-19 2009-03-05 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
EP1736468A3 (en) 2000-01-24 2007-01-03 NeuroSearch A/S Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
EP1957486A4 (en) 2005-11-23 2009-11-11 Painceptor Pharma Corp COMPOSITIONS AND METHODS FOR MODULATION OF IONIC CHANNELS
WO2014095675A1 (en) 2012-12-19 2014-06-26 Bayer Cropscience Ag Difluoromethyl-nicotinic-indanyl carboxamides as fungicides
US9815768B2 (en) * 2014-02-28 2017-11-14 Sumitomo Chemical Company, Limited Method for producing 2-(halogenomethyl)-3-methylnitrobenzene
HUE055651T2 (hu) 2016-03-17 2021-12-28 Fmc Corp Eljárás S-enantiomer konvertálására racém formájává
CN112266368B (zh) * 2017-11-15 2024-03-19 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250422B2 (en) 2002-10-29 2007-07-31 Sungkyunkwan University Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine

Also Published As

Publication number Publication date
WO1993005043A1 (en) 1993-03-18
AU655672B2 (en) 1995-01-05
FI107156B (fi) 2001-06-15
EP0529636A1 (en) 1993-03-03
FI940889A7 (fi) 1994-02-25
CZ39594A3 (en) 1994-11-16
NO940676D0 (no) 1994-02-25
SK23894A3 (en) 1994-12-07
NO301117B1 (no) 1997-09-15
MX9204914A (es) 1993-07-01
GEP20002329B (en) 2000-12-25
HU9400595D0 (en) 1994-05-30
DE69229461T2 (de) 1999-10-21
SK280578B6 (sk) 2000-04-10
JPH06510056A (ja) 1994-11-10
NO940676L (enExample) 1994-04-27
DK0529636T3 (da) 1999-12-13
RU2114827C1 (ru) 1998-07-10
CA2076948C (en) 2002-04-16
HUT70753A (en) 1995-10-30
FI940889A0 (fi) 1994-02-25
DE69229461D1 (de) 1999-07-29
HU211632A9 (en) 1995-12-28
AU2482092A (en) 1993-04-05
ATE181552T1 (de) 1999-07-15
JP3170584B2 (ja) 2001-05-28
PL170920B1 (pl) 1997-02-28
CA2076948A1 (en) 1993-03-01
EP0529636B1 (en) 1999-06-23
CZ282759B6 (cs) 1997-09-17

Similar Documents

Publication Publication Date Title
KR100277481B1 (ko) 이사틴옥심 유도체 및 그를 이용한 치료방법
JP2756742B2 (ja) Ｎ−アシル−２，３−ベンゾジアゼピン誘導体、その製造法、それを含有する医薬組成物、およびその製造法
JPH11503445A (ja) ｃＧＭＰ−ＰＤＥ阻害剤としてのインドール誘導体
EP0503349B1 (en) Hydrazone derivatives, their preparation and use
RU2190612C2 (ru) Новые производные индол-2,3-дион-3-оксима
KR20050119186A (ko) 인돌론-아세트아미드 유도체, 이의 제조 방법 및 이의 용도
DE69013750T2 (de) Antagonisten von excitatorischen Aminosäuren.
JPH08510221A (ja) Ａｍｐａ拮抗薬およびそれを用いての治療方法
DE69830450T2 (de) Neue Atropisomere von 2,3-Disubstituierten-(5,6)-heteroarylkondensierten-pyrimidin-4-onen
JP3010558B2 (ja) 新規の１，７‐融合１ｈ‐インドール‐２‐カルボン酸‐ｎ‐（１，４‐ベンゾジアゼピン‐３‐イル）‐アミド、その製法及びこれを含有するコレシストキニン拮抗作用薬剤
NO172437B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidindionforbindelser
US4088647A (en) Pyrazino (1,2,3-ab)-β-carboline derivatives and salts thereof and method of preparing same
DE3587556T2 (de) 2-Substituierte Aminomethyl-1,4-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
EP0222703A1 (de) Hexahydro-[1]-benzo-(pyrano und thiopyrano)-[4,3-c]pyridine
US5436250A (en) Isatineoxime derivatives, their preparation and use
US5242918A (en) Isatinoxime derivatives, their preparation and use
KR920000763B1 (ko) 신규 벤조디아제핀의 제조 방법
JP2001512731A (ja) ＡＭＰＡ／Ｋａｉｎａｔｅ受容体阻害剤としての１，３−ジオキソロ／４，５−Ｈ／２，３／ベンゾジアゼピン誘導体
US6075033A (en) Anthranilic acid diamides derivatives, their preparation and pharmaceutical use as anti-gastrin agents
US5114944A (en) 2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid derivatives exhibiting therapeutic effects
FI102276B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 5-N,N-dialkyylisulfa moyyli-1H-6,7,8,9-tetrahydro£g|indoli-2,3-dioni-3-oksiimien valmistami seksi
US5223527A (en) Isatineoxime derivatives and their use
EP0115920A2 (en) Pyrazino(2',3'-3,4)pyrido(1,2-a) indole derivatives
EP0118566A1 (en) INDENO[1,2-b]PYRROLE DERIVATIVES
KR20010092424A (ko) 신규 형태의 축합 피리다지논 화합물

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20031011

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20031011

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000