NO301117B1 - Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser - Google Patents

Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser Download PDF

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Publication number
NO301117B1
NO301117B1 NO940676A NO940676A NO301117B1 NO 301117 B1 NO301117 B1 NO 301117B1 NO 940676 A NO940676 A NO 940676A NO 940676 A NO940676 A NO 940676A NO 301117 B1 NO301117 B1 NO 301117B1
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NO
Norway
Prior art keywords
branched
alkyl
cyclic
hydrogen
formula
Prior art date
Application number
NO940676A
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English (en)
Norwegian (no)
Other versions
NO940676D0 (no
NO940676L (enExample
Inventor
Frank Watjen
Bjarne Hugo Dahl
Joergen Drejer
Leif Helth Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO940676D0 publication Critical patent/NO940676D0/no
Publication of NO940676L publication Critical patent/NO940676L/no
Publication of NO301117B1 publication Critical patent/NO301117B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO940676A 1991-08-28 1994-02-25 Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser NO301117B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05
PCT/EP1992/001999 WO1993005043A1 (en) 1991-08-28 1992-08-27 Novel isatinoxime derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
NO940676D0 NO940676D0 (no) 1994-02-25
NO940676L NO940676L (enExample) 1994-04-27
NO301117B1 true NO301117B1 (no) 1997-09-15

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940676A NO301117B1 (no) 1991-08-28 1994-02-25 Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser

Country Status (18)

Country Link
EP (1) EP0529636B1 (enExample)
JP (1) JP3170584B2 (enExample)
KR (1) KR100277481B1 (enExample)
AT (1) ATE181552T1 (enExample)
AU (1) AU655672B2 (enExample)
CA (1) CA2076948C (enExample)
CZ (1) CZ282759B6 (enExample)
DE (1) DE69229461T2 (enExample)
DK (1) DK0529636T3 (enExample)
FI (1) FI107156B (enExample)
GE (1) GEP20002329B (enExample)
HU (2) HUT70753A (enExample)
MX (1) MX9204914A (enExample)
NO (1) NO301117B1 (enExample)
PL (1) PL170920B1 (enExample)
RU (1) RU2114827C1 (enExample)
SK (1) SK280578B6 (enExample)
WO (1) WO1993005043A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502483A (ja) 1992-10-13 1996-03-19 ワーナー−ランバート・コンパニー 新規なキノキサリンジオン誘導体、それらの製造および使用
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
FI954965L (fi) * 1993-05-13 1995-11-10 Neurosearch As AMPA-antagonisteja ja hoitomenetelmä, jossa niitä käytetään
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
EP0781285B1 (en) * 1994-09-14 2000-01-12 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use as glutamate antagonists
CA2199613C (en) * 1994-09-14 2000-02-29 Peter Moldt Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) * 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
DE60041399D1 (de) 1999-05-19 2009-03-05 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
EP1736468A3 (en) 2000-01-24 2007-01-03 NeuroSearch A/S Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
WO2004039372A1 (en) 2002-10-29 2004-05-13 Sungkyunkwan University Medicament component of berberine for the use of prevention and treatment of psycological dependence on and analgesic tolerance to morphine
EP1957486A4 (en) 2005-11-23 2009-11-11 Painceptor Pharma Corp COMPOSITIONS AND METHODS FOR MODULATION OF IONIC CHANNELS
WO2014095675A1 (en) 2012-12-19 2014-06-26 Bayer Cropscience Ag Difluoromethyl-nicotinic-indanyl carboxamides as fungicides
US9815768B2 (en) * 2014-02-28 2017-11-14 Sumitomo Chemical Company, Limited Method for producing 2-(halogenomethyl)-3-methylnitrobenzene
HUE055651T2 (hu) 2016-03-17 2021-12-28 Fmc Corp Eljárás S-enantiomer konvertálására racém formájává
CN112266368B (zh) * 2017-11-15 2024-03-19 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
WO1993005043A1 (en) 1993-03-18
AU655672B2 (en) 1995-01-05
FI107156B (fi) 2001-06-15
EP0529636A1 (en) 1993-03-03
FI940889A7 (fi) 1994-02-25
CZ39594A3 (en) 1994-11-16
NO940676D0 (no) 1994-02-25
SK23894A3 (en) 1994-12-07
MX9204914A (es) 1993-07-01
GEP20002329B (en) 2000-12-25
HU9400595D0 (en) 1994-05-30
DE69229461T2 (de) 1999-10-21
SK280578B6 (sk) 2000-04-10
JPH06510056A (ja) 1994-11-10
NO940676L (enExample) 1994-04-27
DK0529636T3 (da) 1999-12-13
RU2114827C1 (ru) 1998-07-10
CA2076948C (en) 2002-04-16
HUT70753A (en) 1995-10-30
FI940889A0 (fi) 1994-02-25
DE69229461D1 (de) 1999-07-29
HU211632A9 (en) 1995-12-28
AU2482092A (en) 1993-04-05
ATE181552T1 (de) 1999-07-15
JP3170584B2 (ja) 2001-05-28
PL170920B1 (pl) 1997-02-28
CA2076948A1 (en) 1993-03-01
EP0529636B1 (en) 1999-06-23
CZ282759B6 (cs) 1997-09-17
KR100277481B1 (ko) 2001-02-01

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