KR100275976B1 - 인돌로피롤로카르바졸 유도체 - Google Patents

인돌로피롤로카르바졸 유도체 Download PDF

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Publication number
KR100275976B1
KR100275976B1 KR1019920022729A KR920022729A KR100275976B1 KR 100275976 B1 KR100275976 B1 KR 100275976B1 KR 1019920022729 A KR1019920022729 A KR 1019920022729A KR 920022729 A KR920022729 A KR 920022729A KR 100275976 B1 KR100275976 B1 KR 100275976B1
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KR
South Korea
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group
groups
compound
formula
lower alkyl
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Expired - Fee Related
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KR1019920022729A
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English (en)
Korean (ko)
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KR930010039A (ko
Inventor
가쓰히사 고지리
히사오 곤도
히로하루 아라까와
미쓰루 오오꾸보
히로유끼 스다
Original Assignee
나가사까 겐지로
반유 세이야꾸 가부시키가이샤
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Publication of KR930010039A publication Critical patent/KR930010039A/ko
Application granted granted Critical
Publication of KR100275976B1 publication Critical patent/KR100275976B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
KR1019920022729A 1991-11-29 1992-11-28 인돌로피롤로카르바졸 유도체 Expired - Fee Related KR100275976B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP91-341916 1991-11-29
JP6926992 1992-02-18
JP92-69269 1992-02-18
JP91-257306 1992-09-01
JP25730692 1992-09-01

Publications (2)

Publication Number Publication Date
KR930010039A KR930010039A (ko) 1993-06-21
KR100275976B1 true KR100275976B1 (ko) 2001-02-01

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920022729A Expired - Fee Related KR100275976B1 (ko) 1991-11-29 1992-11-28 인돌로피롤로카르바졸 유도체

Country Status (27)

Country Link
EP (1) EP0545195B1 (cg-RX-API-DMAC10.html)
JP (1) JP2629542B2 (cg-RX-API-DMAC10.html)
KR (1) KR100275976B1 (cg-RX-API-DMAC10.html)
AT (1) ATE130617T1 (cg-RX-API-DMAC10.html)
AU (1) AU650376B2 (cg-RX-API-DMAC10.html)
BG (1) BG61036B1 (cg-RX-API-DMAC10.html)
CA (1) CA2083534C (cg-RX-API-DMAC10.html)
CZ (1) CZ287304B6 (cg-RX-API-DMAC10.html)
DE (1) DE69206242T2 (cg-RX-API-DMAC10.html)
DK (1) DK0545195T3 (cg-RX-API-DMAC10.html)
DZ (1) DZ1634A1 (cg-RX-API-DMAC10.html)
ES (1) ES2079774T3 (cg-RX-API-DMAC10.html)
FI (1) FI106864B (cg-RX-API-DMAC10.html)
GR (1) GR3018527T3 (cg-RX-API-DMAC10.html)
HU (3) HU9203754D0 (cg-RX-API-DMAC10.html)
IL (1) IL103844A (cg-RX-API-DMAC10.html)
MX (1) MX9206847A (cg-RX-API-DMAC10.html)
MY (1) MY114655A (cg-RX-API-DMAC10.html)
NO (1) NO178929C (cg-RX-API-DMAC10.html)
NZ (1) NZ245203A (cg-RX-API-DMAC10.html)
PL (1) PL171468B1 (cg-RX-API-DMAC10.html)
RO (1) RO113469B1 (cg-RX-API-DMAC10.html)
RU (1) RU2117671C1 (cg-RX-API-DMAC10.html)
SA (1) SA93130351B1 (cg-RX-API-DMAC10.html)
TW (1) TW224469B (cg-RX-API-DMAC10.html)
WO (1) WO1993011145A1 (cg-RX-API-DMAC10.html)
YU (1) YU48963B (cg-RX-API-DMAC10.html)

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ES2230433T3 (es) * 1994-05-09 2005-05-01 Banyu Pharmaceutical Co., Ltd. Procedimientos para la preparacion de derivados de indolopirrolocarbazol.
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1995034663A1 (en) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
AU6836696A (en) * 1995-09-05 1997-03-27 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
BR9711306A (pt) * 1996-08-22 1999-08-17 Bristol Myers Squibb Co Amino a-Úcar citotÄxico e derivados de a-Úcar correlatos de indolopirrolocarbazÄis
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2004083228A1 (ja) 1999-09-10 2004-09-30 Katsuhisa Kojiri インドロピロロカルバゾール誘導体及び抗腫瘍剤
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6790836B2 (en) 2000-02-24 2004-09-14 Banyu Pharmaceutical Co., Ltd. Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
IL157909A0 (en) 2001-03-22 2004-03-28 Bristol Myers Squibb Co Indolopyrrolocarbazole derivatives and pharmaceutical compositions containing the same
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
AU2002335472B8 (en) * 2002-03-26 2007-12-20 Banyu Pharmaceutical Co., Ltd. Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
EP1541582A1 (en) * 2002-08-23 2005-06-15 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
AU2003248103A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd Indolopyrrolocarbazole derivative and antitumor agent
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
RU2255089C1 (ru) * 2003-12-26 2005-06-27 Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN103965204B (zh) 2008-11-19 2016-09-07 赛福伦公司 吲唑并[5,4-a]吡咯并[3,4-c]咔唑化合物的新形式

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
WO1992018507A1 (en) * 1991-04-11 1992-10-29 Schering Corporation Anti-tumor and anti-psoriatic agents

Also Published As

Publication number Publication date
NO924593L (no) 1993-06-01
MY114655A (en) 2002-12-31
PL304729A1 (en) 1995-01-09
JPH06128283A (ja) 1994-05-10
CZ350892A3 (en) 1993-10-13
YU48963B (sh) 2003-01-31
BG61036B1 (bg) 1996-09-30
NO178929C (no) 1996-07-03
IL103844A (en) 1997-09-30
EP0545195B1 (en) 1995-11-22
RO113469B1 (ro) 1998-07-30
GR3018527T3 (en) 1996-03-31
YU102692A (sh) 1996-02-19
HU217611B (hu) 2000-03-28
EP0545195A1 (en) 1993-06-09
NZ245203A (en) 1997-07-27
NO924593D0 (no) 1992-11-27
WO1993011145A1 (en) 1993-06-10
NO178929B (no) 1996-03-25
PL171468B1 (pl) 1997-05-30
DE69206242D1 (de) 1996-01-04
HU9203754D0 (en) 1993-03-29
CZ287304B6 (cs) 2000-10-11
AU650376B2 (en) 1994-06-16
JP2629542B2 (ja) 1997-07-09
SA93130351B1 (ar) 2005-10-16
HU211254A9 (en) 1995-11-28
DK0545195T3 (da) 1995-12-18
ES2079774T3 (es) 1996-01-16
ATE130617T1 (de) 1995-12-15
FI925422A0 (fi) 1992-11-27
IL103844A0 (en) 1993-04-04
KR930010039A (ko) 1993-06-21
DE69206242T2 (de) 1996-03-28
MX9206847A (es) 1993-06-30
DZ1634A1 (fr) 2002-02-17
FI925422L (fi) 1993-05-30
RU2117671C1 (ru) 1998-08-20
BG97970A (bg) 1994-04-29
AU2963792A (en) 1993-06-03
CA2083534C (en) 2003-01-28
FI106864B (fi) 2001-04-30
CA2083534A1 (en) 1993-05-30
TW224469B (cg-RX-API-DMAC10.html) 1994-06-01
HUT65699A (en) 1994-07-28

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