KR0159071B1 - 감염증 진단용 프로브 - Google Patents
감염증 진단용 프로브Info
- Publication number
- KR0159071B1 KR0159071B1 KR1019950700098A KR19950700098A KR0159071B1 KR 0159071 B1 KR0159071 B1 KR 0159071B1 KR 1019950700098 A KR1019950700098 A KR 1019950700098A KR 19950700098 A KR19950700098 A KR 19950700098A KR 0159071 B1 KR0159071 B1 KR 0159071B1
- Authority
- KR
- South Korea
- Prior art keywords
- probe
- dna
- infectious diseases
- diagnosing
- retained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000003745 diagnosis Methods 0.000 title claims description 17
- 208000035473 Communicable disease Diseases 0.000 claims abstract description 40
- 239000002773 nucleotide Substances 0.000 claims abstract description 14
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 14
- 208000015181 infectious disease Diseases 0.000 claims description 28
- 230000000717 retained effect Effects 0.000 claims description 16
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- 241000588724 Escherichia coli Species 0.000 claims description 12
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- 206010035664 Pneumonia Diseases 0.000 claims description 7
- 241000191967 Staphylococcus aureus Species 0.000 claims description 7
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 abstract description 50
- 238000001514 detection method Methods 0.000 abstract description 14
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- 208000031729 Bacteremia Diseases 0.000 description 15
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000002585 base Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000003242 anti bacterial agent Substances 0.000 description 8
- 229940088710 antibiotic agent Drugs 0.000 description 8
- 239000002244 precipitate Substances 0.000 description 8
- 239000012678 infectious agent Substances 0.000 description 6
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- 206010040047 Sepsis Diseases 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000003298 DNA probe Substances 0.000 description 3
- 241000191963 Staphylococcus epidermidis Species 0.000 description 3
- 238000009640 blood culture Methods 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
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- 239000008103 glucose Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 241001502625 Endococcus Species 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 241001646716 Escherichia coli K-12 Species 0.000 description 1
- 238000003794 Gram staining Methods 0.000 description 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000014670 detection of bacterium Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 238000002372 labelling Methods 0.000 description 1
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- 239000004325 lysozyme Substances 0.000 description 1
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- 210000002540 macrophage Anatomy 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
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- 238000012216 screening Methods 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17971992 | 1992-07-07 | ||
| JP1992-179719 | 1992-07-07 | ||
| PCT/JP1993/000936 WO1994001583A1 (fr) | 1992-07-07 | 1993-07-07 | Sonde pour diagnostiquer des maladies infectieuses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950702640A KR950702640A (ko) | 1995-07-29 |
| KR0159071B1 true KR0159071B1 (ko) | 1998-11-16 |
Family
ID=16070679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950700098A Expired - Lifetime KR0159071B1 (ko) | 1992-07-07 | 1993-07-07 | 감염증 진단용 프로브 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US5807673A (enExample) |
| EP (10) | EP1160334B1 (enExample) |
| JP (4) | JP2798499B2 (enExample) |
| KR (1) | KR0159071B1 (enExample) |
| AT (10) | ATE314467T1 (enExample) |
| AU (1) | AU684250B2 (enExample) |
| CA (1) | CA2139847C (enExample) |
| DE (10) | DE69333887T2 (enExample) |
| DK (8) | DK1329518T3 (enExample) |
| TW (1) | TW256881B (enExample) |
| WO (1) | WO1994001583A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US6001564A (en) * | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| JP3571378B2 (ja) * | 1994-09-30 | 2004-09-29 | 扶桑薬品工業株式会社 | 感染症診断用プローブ |
| US6905670B2 (en) * | 1995-03-28 | 2005-06-14 | The General Hospital Corporation | Methods of screening compounds useful for prevention of infection or pathogenicity |
| AUPN350795A0 (en) * | 1995-06-13 | 1995-07-06 | Australian National University, The | Nucleic acid molecule and its uses in determining pathogenicity of Staphylococcus |
| US5994066A (en) * | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US6107071A (en) | 1996-09-24 | 2000-08-22 | Smithkline Beecham Corporation | Histidinol dehydrogenase |
| US5977085A (en) * | 1996-09-30 | 1999-11-02 | Smithkline Beecham P.L.C. | Vectors carrying coding sequence for the SpsB protein of Staphylococcus aureus |
| US20030049636A1 (en) | 1999-05-03 | 2003-03-13 | Bergeron Michel G. | Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| JP3520172B2 (ja) * | 1997-03-25 | 2004-04-19 | 扶桑薬品工業株式会社 | クレブシェラ・ニューモニエ菌に起因する感染症の診断用プローブ |
| EP0981625A2 (en) * | 1997-05-06 | 2000-03-01 | Human Genome Sciences, Inc. | $i(ENTEROCOCCUS FAECALIS) POLYNUCLEOTIDES AND POLYPEPTIDES |
| US7060458B1 (en) * | 1997-08-14 | 2006-06-13 | Wyeth | Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics |
| US6914131B1 (en) * | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| US6610836B1 (en) | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
| GB9911683D0 (en) * | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| CA2388461C (en) | 1999-09-28 | 2013-06-11 | Infectio Diagnostic (I.D.I.) Inc. | Highly conserved genes and their use to generate probes and primers for the detection of microorganisms |
| KR100353506B1 (ko) * | 1999-10-04 | 2002-09-19 | 제일제당주식회사 | 녹농균 동정 및 감염 진단용 프라이머 |
| US6703492B1 (en) * | 1999-11-09 | 2004-03-09 | Smithkline Beecham Corporation | Staphylococcus epidermidis nucleic acids and proteins |
| WO2001034809A2 (en) * | 1999-11-09 | 2001-05-17 | Glaxo Group Limited | Staphylococcus epidermidis nucleic acids and proteins |
| US20010028875A1 (en) * | 2000-02-25 | 2001-10-11 | Ausubel Frederick M. | Screening methods for gram-positive enterococcal virulence factors |
| CN101139590B (zh) * | 2000-02-28 | 2012-07-18 | 启龙股份公司 | 奈瑟球菌蛋白质的杂交表达 |
| US7078584B2 (en) * | 2000-03-17 | 2006-07-18 | The General Hospital Corporation | Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection |
| WO2001073038A2 (de) * | 2000-03-31 | 2001-10-04 | Lonza Ag | Verfahren zur biotechnologischen herstellung von l-alaninol |
| US7112716B2 (en) * | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
| ATE366824T1 (de) * | 2001-05-31 | 2007-08-15 | Fuso Pharmaceutical Ind | Verbessertes verfahren zum nachweis und zur identifizierung eines eine infektion verursachenden mikroorganismus |
| EP1795594A3 (en) * | 2001-05-31 | 2008-04-02 | Fuso Pharmaceutical Industries, Ltd. | Method of evaluating the function of phagocyte and utilization thereof |
| US20040161741A1 (en) | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| US6696254B2 (en) * | 2001-11-21 | 2004-02-24 | Kimberly-Clark Worldwide, Inc. | Detection and identification of enteric bacteria |
| JP2004089046A (ja) * | 2002-08-30 | 2004-03-25 | Fuso Pharmaceutical Industries Ltd | カンジダアルビカンス菌の検出用プローブおよびそれを用いた方法 |
| JP2004313181A (ja) * | 2003-04-02 | 2004-11-11 | Canon Inc | 感染症起炎菌検出用プローブ及びプローブセット、ならびに担体及び遺伝子検査方法 |
| US20090035767A1 (en) * | 2006-11-28 | 2009-02-05 | Canon Kabushiki Kaisha | Primer for bacterium genome amplification reaction |
| JP2010524454A (ja) | 2007-04-19 | 2010-07-22 | モレキュラー ディテクション インコーポレーテッド | 抗生物質耐性細菌の検出および分析のための方法、組成物、およびキット |
| WO2009152298A1 (en) * | 2008-06-13 | 2009-12-17 | Zeus Scientific, Inc. | Methods, compositions and and diagnostic kits for the detection and treatment for staphylococcal nasal decolonization using achromopeptidase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652517A (en) * | 1984-06-11 | 1987-03-24 | Diagnostic Research Limited Partnership | Methods for the in vitro detection and identification of unknown pathogens or genetic entities |
| US5047334A (en) * | 1987-06-30 | 1991-09-10 | Repligen Corporation | Novel prokaryotic expression and secretion system |
| US5004682A (en) * | 1987-11-02 | 1991-04-02 | Olin Corporation | Method and kit for detecting live microorganisms in chlorine- or bromine-treated water |
| US5358846A (en) * | 1988-04-20 | 1994-10-25 | Fuso Yakuhin Kogyo Kabushiki Kaisha | Methods for diagnosing infectous diseases and methods for detecting and identifying microorganisms |
| JPH03501326A (ja) * | 1988-06-20 | 1991-03-28 | ルミニス・プロプライアタリー・リミテッド | 血清型分類用ｄｎａプローブ |
| NL8900670A (nl) * | 1989-03-17 | 1990-10-16 | Stichting Tech Wetenschapp | Polynucleotide-probe, werkwijze en kit voor het identificeren en opsporen van gram-negatieve bacterien. |
| EP0426837B1 (en) * | 1989-05-23 | 1995-09-06 | Amoco Corporation | Nucleic acid probes for the detection of staphylococcus aureus |
| NL9002157A (nl) * | 1989-11-27 | 1991-06-17 | U Gene Research Bv | Dna fragmenten en daarop gebaseerde dna-probes en primers. |
| ATE108209T1 (de) * | 1990-02-10 | 1994-07-15 | Nestle Sa | Dns-sonde für lactobacillus helveticus. |
| WO1992005281A1 (fr) * | 1990-09-14 | 1992-04-02 | Chugai Seiyaku Kabushiki Kaisha | Procede de detection de staphylococcus aureus resistant au mesitylene-cephem |
-
1993
- 1993-07-07 DE DE69333887T patent/DE69333887T2/de not_active Expired - Lifetime
- 1993-07-07 DK DK03075757T patent/DK1329518T3/da active
- 1993-07-07 DK DK04077305T patent/DK1498495T3/da active
- 1993-07-07 DE DE69334018T patent/DE69334018T2/de not_active Expired - Lifetime
- 1993-07-07 AT AT03075758T patent/ATE314467T1/de not_active IP Right Cessation
- 1993-07-07 DE DE69334090T patent/DE69334090T2/de not_active Expired - Lifetime
- 1993-07-07 AU AU45135/93A patent/AU684250B2/en not_active Ceased
- 1993-07-07 DK DK93914968T patent/DK0652291T3/da active
- 1993-07-07 AT AT93914968T patent/ATE241702T1/de not_active IP Right Cessation
- 1993-07-07 AT AT04077305T patent/ATE328118T1/de not_active IP Right Cessation
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