JPWO2022138891A5 - - Google Patents
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- Publication number
- JPWO2022138891A5 JPWO2022138891A5 JP2022571664A JP2022571664A JPWO2022138891A5 JP WO2022138891 A5 JPWO2022138891 A5 JP WO2022138891A5 JP 2022571664 A JP2022571664 A JP 2022571664A JP 2022571664 A JP2022571664 A JP 2022571664A JP WO2022138891 A5 JPWO2022138891 A5 JP WO2022138891A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- acid residue
- resin
- amino acid
- solid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 239000011347 resin Substances 0.000 claims 16
- 229920005989 resin Polymers 0.000 claims 16
- 238000010532 solid phase synthesis reaction Methods 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 125000000539 amino acid group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 239000003875 Wang resin Substances 0.000 claims 1
- NERFNHBZJXXFGY-UHFFFAOYSA-N [4-[(4-methylphenyl)methoxy]phenyl]methanol Chemical compound C1=CC(C)=CC=C1COC1=CC=C(CO)C=C1 NERFNHBZJXXFGY-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020217157 | 2020-12-25 | ||
| JP2021078395 | 2021-05-06 | ||
| JP2021177528 | 2021-10-29 | ||
| PCT/JP2021/048093 WO2022138891A1 (ja) | 2020-12-25 | 2021-12-24 | Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022138891A1 JPWO2022138891A1 (https=) | 2022-06-30 |
| JPWO2022138891A5 true JPWO2022138891A5 (https=) | 2025-01-06 |
Family
ID=82157997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571664A Pending JPWO2022138891A1 (https=) | 2020-12-25 | 2021-12-24 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240124517A1 (https=) |
| EP (1) | EP4269422A4 (https=) |
| JP (1) | JPWO2022138891A1 (https=) |
| KR (1) | KR20230124935A (https=) |
| TW (1) | TW202235429A (https=) |
| WO (1) | WO2022138891A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3878836B1 (en) | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| US12312379B2 (en) | 2021-05-07 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| JP7823181B2 (ja) | 2022-05-06 | 2026-03-03 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
| TW202430539A (zh) * | 2022-10-13 | 2024-08-01 | 日商中外製藥股份有限公司 | 包含ｎ－取代胺基酸殘基的環狀胜肽化合物的製造方法 |
| TW202430537A (zh) * | 2022-10-20 | 2024-08-01 | 日商中外製藥股份有限公司 | 環狀胜肽的結晶的製造方法 |
| JPWO2024096023A1 (https=) | 2022-11-01 | 2024-05-10 | ||
| WO2024143514A1 (ja) | 2022-12-28 | 2024-07-04 | 中外製薬株式会社 | 環状ペプチドの精製法及び製造法 |
| CN120936619A (zh) * | 2023-04-20 | 2025-11-11 | 中外制药株式会社 | 用于生产环肽化合物的方法 |
| TW202523345A (zh) | 2023-09-28 | 2025-06-16 | 日商中外製藥股份有限公司 | 使用混合酸酐法的胜肽化合物的製造方法 |
| TW202535901A (zh) | 2023-12-27 | 2025-09-16 | 日商中外製藥股份有限公司 | 使用獨立型縮合劑的胜肽化合物的製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1527096A2 (en) * | 2002-08-06 | 2005-05-04 | AplaGen GmbH | Binding molecules |
| JP4793644B2 (ja) * | 2006-06-12 | 2011-10-12 | 独立行政法人産業技術総合研究所 | ケージドペプチドの合成法 |
| EP2377579A1 (en) * | 2007-05-30 | 2011-10-19 | Eli Lilly and Company | Cyclic peptide CXCR4 antagonists |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| JP6382488B2 (ja) * | 2013-02-21 | 2018-08-29 | ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． | 側鎖結合を介する固相ペプチド合成 |
| GB201622029D0 (en) | 2016-12-22 | 2017-02-08 | Nederlands Inst Voor Ecologie (Nioo-Knaw) See Scientia Terrae Vzw Nordic Semiconductor Asa | Voltage sampling circuits |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| KR20250007021A (ko) * | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| WO2020122182A1 (ja) | 2018-12-12 | 2020-06-18 | 中外製薬株式会社 | 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法 |
-
2021
- 2021-12-24 WO PCT/JP2021/048093 patent/WO2022138891A1/ja not_active Ceased
- 2021-12-24 TW TW110148606A patent/TW202235429A/zh unknown
- 2021-12-24 EP EP21911028.5A patent/EP4269422A4/en active Pending
- 2021-12-24 JP JP2022571664A patent/JPWO2022138891A1/ja active Pending
- 2021-12-24 US US18/268,737 patent/US20240124517A1/en active Pending
- 2021-12-24 KR KR1020237021960A patent/KR20230124935A/ko active Pending
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