EP4269422A4 - Method for producing peptide compound containing n-substituted-amino acid residue - Google Patents

Method for producing peptide compound containing n-substituted-amino acid residue Download PDF

Info

Publication number
EP4269422A4
EP4269422A4 EP21911028.5A EP21911028A EP4269422A4 EP 4269422 A4 EP4269422 A4 EP 4269422A4 EP 21911028 A EP21911028 A EP 21911028A EP 4269422 A4 EP4269422 A4 EP 4269422A4
Authority
EP
European Patent Office
Prior art keywords
amino acid
acid residue
compound containing
substituted amino
peptide compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21911028.5A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4269422A1 (en
Inventor
Yuya Morita
Kenichi Nomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP4269422A1 publication Critical patent/EP4269422A1/en
Publication of EP4269422A4 publication Critical patent/EP4269422A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP21911028.5A 2020-12-25 2021-12-24 Method for producing peptide compound containing n-substituted-amino acid residue Pending EP4269422A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2020217157 2020-12-25
JP2021078395 2021-05-06
JP2021177528 2021-10-29
PCT/JP2021/048093 WO2022138891A1 (ja) 2020-12-25 2021-12-24 Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法

Publications (2)

Publication Number Publication Date
EP4269422A1 EP4269422A1 (en) 2023-11-01
EP4269422A4 true EP4269422A4 (en) 2024-11-27

Family

ID=82157997

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21911028.5A Pending EP4269422A4 (en) 2020-12-25 2021-12-24 Method for producing peptide compound containing n-substituted-amino acid residue

Country Status (6)

Country Link
US (1) US20240124517A1 (https=)
EP (1) EP4269422A4 (https=)
JP (1) JPWO2022138891A1 (https=)
KR (1) KR20230124935A (https=)
TW (1) TW202235429A (https=)
WO (1) WO2022138891A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues
JP7823181B2 (ja) 2022-05-06 2026-03-03 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物
TW202430539A (zh) * 2022-10-13 2024-08-01 日商中外製藥股份有限公司 包含ｎ－取代胺基酸殘基的環狀胜肽化合物的製造方法
TW202430537A (zh) * 2022-10-20 2024-08-01 日商中外製藥股份有限公司 環狀胜肽的結晶的製造方法
JPWO2024096023A1 (https=) 2022-11-01 2024-05-10
WO2024143514A1 (ja) 2022-12-28 2024-07-04 中外製薬株式会社 環状ペプチドの精製法及び製造法
CN120936619A (zh) * 2023-04-20 2025-11-11 中外制药株式会社 用于生产环肽化合物的方法
TW202523345A (zh) 2023-09-28 2025-06-16 日商中外製藥股份有限公司 使用混合酸酐法的胜肽化合物的製造方法
TW202535901A (zh) 2023-12-27 2025-09-16 日商中外製藥股份有限公司 使用獨立型縮合劑的胜肽化合物的製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080300177A1 (en) * 2007-05-30 2008-12-04 Wayne David Kohn Cyclic peptide cxcr4 antagonists
EP3636656A1 (en) * 2017-06-09 2020-04-15 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptide containing n-substituted amino acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1527096A2 (en) * 2002-08-06 2005-05-04 AplaGen GmbH Binding molecules
JP4793644B2 (ja) * 2006-06-12 2011-10-12 独立行政法人産業技術総合研究所 ケージドペプチドの合成法
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
JP6382488B2 (ja) * 2013-02-21 2018-08-29 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
GB201622029D0 (en) 2016-12-22 2017-02-08 Nederlands Inst Voor Ecologie (Nioo-Knaw) See Scientia Terrae Vzw Nordic Semiconductor Asa Voltage sampling circuits
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
WO2020122182A1 (ja) 2018-12-12 2020-06-18 中外製薬株式会社 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080300177A1 (en) * 2007-05-30 2008-12-04 Wayne David Kohn Cyclic peptide cxcr4 antagonists
EP3636656A1 (en) * 2017-06-09 2020-04-15 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptide containing n-substituted amino acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2022138891A1 *

Also Published As

Publication number Publication date
WO2022138891A1 (ja) 2022-06-30
KR20230124935A (ko) 2023-08-28
EP4269422A1 (en) 2023-11-01
JPWO2022138891A1 (https=) 2022-06-30
TW202235429A (zh) 2022-09-16
US20240124517A1 (en) 2024-04-18

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