|
US4039388A
(en)
|
1976-06-04 |
1977-08-02 |
The United States Of America As Represented By The Government |
Diagnostic test for Niemann-Pick disease
|
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
WO1988002026A1
(en)
|
1986-09-08 |
1988-03-24 |
Applied Biotechnology, Inc. |
Empty viral capsid vaccines
|
|
US4968603A
(en)
|
1986-12-31 |
1990-11-06 |
The Regents Of The University Of California |
Determination of status in neoplastic disease
|
|
WO1990005142A1
(en)
|
1988-11-10 |
1990-05-17 |
Imperial Cancer Research Technology Ltd. |
Polypeptides
|
|
US5916563A
(en)
|
1988-11-14 |
1999-06-29 |
United States Of America |
Parvovirus protein presenting capsids
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
ES2026826A6
(es)
|
1991-03-26 |
1992-05-01 |
Ercros Sa |
Procedimiento para la produccion de una vacuna subunidad contra el parvovirus canino y otros virus relacionados.
|
|
US5773278A
(en)
|
1991-05-03 |
1998-06-30 |
Mount Sinai Medical Center |
Acid sphingomyelinase gene
|
|
US5858784A
(en)
|
1991-12-17 |
1999-01-12 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol- and liposome-based delivery
|
|
US5478745A
(en)
|
1992-12-04 |
1995-12-26 |
University Of Pittsburgh |
Recombinant viral vector system
|
|
WO1995013365A1
(en)
|
1993-11-09 |
1995-05-18 |
Targeted Genetics Corporation |
Generation of high titers of recombinant aav vectors
|
|
US5869248A
(en)
|
1994-03-07 |
1999-02-09 |
Yale University |
Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
|
|
DE69535703T2
(de)
|
1994-04-13 |
2009-02-19 |
The Rockefeller University |
AAV-vermittelte Zufuhr von DNA an Zellen des Nervensystems
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5599706A
(en)
|
1994-09-23 |
1997-02-04 |
Stinchcomb; Dan T. |
Ribozymes targeted to apo(a) mRNA
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
|
ATE452981T1
(de)
|
1995-06-07 |
2010-01-15 |
Univ North Carolina |
Die transduktion von myoblasten mittels vektoren aus adenoassoziierten viren
|
|
US6083702A
(en)
|
1995-12-15 |
2000-07-04 |
Intronn Holdings Llc |
Methods and compositions for use in spliceosome mediated RNA trans-splicing
|
|
JP4321877B2
(ja)
|
1995-12-15 |
2009-08-26 |
バークシス コーポレイション |
トランス―スプライスにより生成される治療用分子
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
CA2265460A1
(en)
|
1996-09-11 |
1998-03-19 |
The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services |
Aav4 vector and uses thereof
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
WO1999001555A1
(en)
|
1997-07-03 |
1999-01-14 |
The United States Of America Represented By The Secretary, Department Of Health And Human Services |
Genes for niemann-pick type c disease
|
|
ATE402254T1
(de)
|
1998-05-28 |
2008-08-15 |
Us Gov Health & Human Serv |
Aav5 vektoren und deren verwendung
|
|
US6984517B1
(en)
|
1998-05-28 |
2006-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector and uses thereof
|
|
US6562958B1
(en)
|
1998-06-09 |
2003-05-13 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics
|
|
US8299321B2
(en)
|
1998-06-16 |
2012-10-30 |
Monsanto Technology Llc |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US20100293663A2
(en)
|
1998-06-16 |
2010-11-18 |
Thomas La Rosa |
Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6544785B1
(en)
|
1998-09-14 |
2003-04-08 |
Mount Sinai School Of Medicine Of New York University |
Helper-free rescue of recombinant negative strand RNA viruses
|
|
CA2347129A1
(en)
|
1998-09-22 |
2000-03-30 |
University Of Florida |
Methods for large-scale production of recombinant aav vectors
|
|
GB9822763D0
(en)
|
1998-10-20 |
1998-12-16 |
Univ Sheffield |
Immunoglobin variant
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
EP1127150B1
(en)
|
1998-11-05 |
2007-05-16 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
JP2002538770A
(ja)
|
1998-11-10 |
2002-11-19 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
ウイルスベクターとその製造及び投与の方法
|
|
US6822071B1
(en)
|
1998-11-12 |
2004-11-23 |
The Regents Of The University Of California |
Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
|
|
US6387368B1
(en)
*
|
1999-02-08 |
2002-05-14 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV virus and methods of use thereof
|
|
EP1887081A2
(en)
|
1999-02-25 |
2008-02-13 |
Ceres Incorporated |
DNA Sequences
|
|
EP1033405A3
(en)
|
1999-02-25 |
2001-08-01 |
Ceres Incorporated |
Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
|
|
US20080229439A1
(en)
|
1999-05-06 |
2008-09-18 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement
|
|
US20110214206A1
(en)
|
1999-05-06 |
2011-09-01 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with plants
|
|
US20090087878A9
(en)
|
1999-05-06 |
2009-04-02 |
La Rosa Thomas J |
Nucleic acid molecules associated with plants
|
|
US20130326723A1
(en)
|
1999-05-06 |
2013-12-05 |
Thomas J. La Rosa |
Soy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US20110093981A9
(en)
|
1999-05-06 |
2011-04-21 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement
|
|
US20040031072A1
(en)
|
1999-05-06 |
2004-02-12 |
La Rosa Thomas J. |
Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7314912B1
(en)
|
1999-06-21 |
2008-01-01 |
Medigene Aktiengesellschaft |
AAv scleroprotein, production and use thereof
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
CA2379166C
(en)
|
1999-08-09 |
2013-03-26 |
Targeted Genetics Corporation |
Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
|
|
AU2138601A
(en)
|
1999-12-22 |
2001-07-03 |
Aventis Pasteur Limited |
Chlamydia antigens and corresponding DNA fragments and uses thereof
|
|
US6468524B1
(en)
|
2000-03-22 |
2002-10-22 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
AAV4 vector and uses thereof
|
|
US20140130203A1
(en)
|
2000-04-19 |
2014-05-08 |
Thomas J. La Rosa |
Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
WO2001081581A2
(en)
|
2000-04-21 |
2001-11-01 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of acne vulgaris
|
|
ES2505700T3
(es)
|
2000-06-01 |
2014-10-10 |
University Of North Carolina At Chapel Hill |
Vectores de parvovirus duplicados
|
|
CA2410901C
(en)
|
2000-06-01 |
2012-03-20 |
University Of North Carolina At Chapel Hill |
Methods and compounds for controlled release of recombinant parvovirus vectors
|
|
US7214786B2
(en)
|
2000-12-14 |
2007-05-08 |
Kovalic David K |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
AU2002248297A1
(en)
|
2001-01-05 |
2002-07-16 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
AU2002256388A1
(en)
|
2001-04-30 |
2002-11-11 |
Cell Genesys, Inc. |
Viral-mediated delivery and in vivo expression of polynucleotides encoding anti-angiogenic proteins
|
|
AU2002345250A1
(en)
|
2001-06-22 |
2003-01-08 |
Syngenta Participations Ag |
Plant disease resistance genes
|
|
EP1402042A2
(en)
|
2001-06-22 |
2004-03-31 |
Syngenta Participations AG |
Abiotic stress responsive polynucleotides and polypeptides
|
|
US6623729B2
(en)
|
2001-07-09 |
2003-09-23 |
Korea Advanced Institute Of Science And Technology |
Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
|
|
AU2001289843A1
(en)
|
2001-08-28 |
2002-02-13 |
Bayer Cropscience Ag |
Polypeptides for identifying herbicidally active compounds
|
|
WO2003033515A1
(en)
|
2001-10-15 |
2003-04-24 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of acne vulgaris
|
|
CA2467959C
(en)
|
2001-11-09 |
2009-03-10 |
Robert M. Kotin |
Production of adeno-associated virus in insect cells
|
|
NZ618298A
(en)
|
2001-11-13 |
2015-04-24 |
Univ Pennsylvania |
A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
|
|
CA2469053C
(en)
|
2001-12-17 |
2011-08-23 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
ES2975413T3
(es)
|
2001-12-17 |
2024-07-05 |
Univ Pennsylvania |
Secuencias de serotipo 8 de virus adenoasociado (AAV), vectores que las contienen y usos de las mismas
|
|
AU2003223766A1
(en)
|
2002-04-30 |
2003-11-17 |
University Of North Carolina At Chapel Hill |
Secretion signal vectors
|
|
ATE405295T1
(de)
|
2002-05-01 |
2008-09-15 |
Univ Florida |
Verbesserte raav-expressionssysteme für die genetische modifikation spezifischer capsidproteine
|
|
ITRM20020253A1
(it)
|
2002-05-08 |
2003-11-10 |
Univ Roma |
Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche.
|
|
JP2005185101A
(ja)
|
2002-05-30 |
2005-07-14 |
National Institute Of Agrobiological Sciences |
植物の全長ｃＤＮＡおよびその利用
|
|
WO2003104413A2
(en)
|
2002-06-05 |
2003-12-18 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
CA2510895A1
(en)
|
2002-12-20 |
2004-07-15 |
Applera Corporation |
Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
|
|
CN101014364B
(zh)
|
2002-12-24 |
2012-01-18 |
里纳特神经系统学公司 |
抗ngf抗体及其使用方法
|
|
US7459547B2
(en)
|
2003-06-02 |
2008-12-02 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of RNA silencing
|
|
ES2629380T3
(es)
|
2003-06-19 |
2017-08-09 |
Genzyme Corporation |
Viriones de AAV con inmunorreactividad reducida y usos de los mismos
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US7473531B1
(en)
|
2003-08-08 |
2009-01-06 |
Colora Corporation |
Pancreatic cancer targets and uses thereof
|
|
US20060107345A1
(en)
|
2003-09-30 |
2006-05-18 |
Nickolai Alexandrov |
Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
SI2206728T1
(en)
|
2004-04-07 |
2018-07-31 |
Rinat Neuroscience Corp. |
Methods for the treatment of bone cancer pain by administration of an antagonist nerve growth factor
|
|
US20060171926A1
(en)
|
2004-04-30 |
2006-08-03 |
Passini Marco A |
Gene therapy for neurometabolic disorders
|
|
FR2874384B1
(fr)
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
JP4346526B2
(ja)
|
2004-08-31 |
2009-10-21 |
株式会社東芝 |
半導体集積回路装置
|
|
CA2579519A1
(en)
|
2004-09-09 |
2006-03-16 |
The General Hospital Corporation |
Modulating phosphatase activity in cardiac cells
|
|
EP1828390B1
(en)
|
2004-12-15 |
2012-06-13 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
JP4798663B2
(ja)
|
2005-01-05 |
2011-10-19 |
塩野義製薬株式会社 |
新規血管新生抑制因子
|
|
WO2006092449A2
(en)
|
2005-03-02 |
2006-09-08 |
Metanomics Gmbh |
Process for the production of fine chemicals
|
|
US20140199313A1
(en)
|
2005-03-02 |
2014-07-17 |
Metanomics Gmbh |
Process for the Production of Fine Chemicals
|
|
US8283151B2
(en)
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
AU2006242371A1
(en)
|
2005-04-29 |
2006-11-09 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for regulated expression of nucleic acid at post-transcriptional level
|
|
EP2478760A1
(en)
|
2005-05-10 |
2012-07-25 |
Monsanto Technology LLC |
Genes and uses for plant improvement
|
|
US20100095387A1
(en)
|
2005-07-15 |
2010-04-15 |
Martin Smith |
Methods and reagents for screening new drugs and for treating ion pump associated disorders and diseases
|
|
EP1981548A4
(en)
|
2006-01-20 |
2010-03-24 |
Univ North Carolina |
REINFORCED PRODUCTION OF INFECTIOUS PARVOVIRUS VECTORS IN INSECT CELLS
|
|
US7867484B2
(en)
|
2006-01-27 |
2011-01-11 |
University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
EP1986661B1
(en)
|
2006-02-08 |
2018-08-29 |
Genzyme Corporation |
Gene therapy for niemann-pick disease type a
|
|
CN101437833A
(zh)
|
2006-02-10 |
2009-05-20 |
辛辛那提大学 |
作为心脏功能调节剂的磷酸酶抑制剂蛋白-1
|
|
WO2007120542A2
(en)
|
2006-03-30 |
2007-10-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Aav capsid library and aav capsid proteins
|
|
EP2016174A2
(en)
|
2006-04-28 |
2009-01-21 |
The Trustees of the University of Pennsylvania |
Modified aav vectors having reduced capsid immunogenicity and use thereof
|
|
ES2400235T3
(es)
|
2006-04-28 |
2013-04-08 |
The Trustees Of The University Of Pennsylvania |
Método de producción escalable de AAV
|
|
EP3705577A1
(en)
|
2006-06-21 |
2020-09-09 |
uniQure IP B.V. |
Aav vectors with improved rep coding sequences for production in insect cells
|
|
EP2125006B1
(en)
|
2007-01-18 |
2013-10-16 |
University of Missouri-Columbia |
Synthetic mini/micro-dystrophin genes to restore nnos to the sarcolemma
|
|
US20120322861A1
(en)
|
2007-02-23 |
2012-12-20 |
Barry John Byrne |
Compositions and Methods for Treating Diseases
|
|
EP3492596A1
(en)
|
2007-04-09 |
2019-06-05 |
University of Florida Research Foundation, Inc. |
Raav vector compositions having tyrosine-modified capsid proteins and methods for use
|
|
US9611302B2
(en)
|
2007-04-09 |
2017-04-04 |
University Of Florida Research Foundation, Inc. |
High-transduction-efficiency RAAV vectors, compositions, and methods of use
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
KR100911624B1
(ko)
|
2007-05-14 |
2009-08-12 |
연세대학교 산학협력단 |
Ｉｌ－１２ 및 ｉｌ－２３의 효율적인 공동발현 방법
|
|
US8664475B2
(en)
|
2007-09-18 |
2014-03-04 |
Basf Plant Science Gmbh |
Plants with increased yield
|
|
EP2058401A1
(en)
|
2007-10-05 |
2009-05-13 |
Genethon |
Widespread gene delivery to motor neurons using peripheral injection of AAV vectors
|
|
US10526627B2
(en)
|
2007-11-30 |
2020-01-07 |
Corn Products Development, Inc |
Method for producing high molecular weight reduced viscosity starch pastes
|
|
US20090221620A1
(en)
|
2008-02-20 |
2009-09-03 |
Celera Corporation |
Gentic polymorphisms associated with stroke, methods of detection and uses thereof
|
|
CA2715397A1
(en)
|
2008-02-20 |
2009-08-27 |
Ceres, Inc. |
Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants
|
|
US20090215879A1
(en)
|
2008-02-26 |
2009-08-27 |
University Of North Carolina At Chapel Hill |
Methods and compositions for adeno-associated virus (aav) with hi loop mutations
|
|
MX2010012592A
(es)
|
2008-05-20 |
2011-05-05 |
Eos Neuroscience Inc |
Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas.
|
|
JP2010002479A
(ja)
|
2008-06-18 |
2010-01-07 |
Crossfor:Kk |
メガネレンズ用装飾体およびメガネ用装飾体装着具
|
|
US9415121B2
(en)
|
2008-12-19 |
2016-08-16 |
Nationwide Children's Hospital |
Delivery of MECP2 polynucleotide using recombinant AAV9
|
|
EP2396343B1
(en)
|
2009-02-11 |
2017-05-17 |
The University of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
US8679837B2
(en)
|
2009-04-02 |
2014-03-25 |
University Of Florida Research Foundation, Inc. |
Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors
|
|
FI4342992T3
(fi)
|
2009-05-02 |
2025-08-12 |
Genzyme Corp |
Geenihoito neurodegeneratiivisiin sairauksiin
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
US20120252877A1
(en)
|
2009-08-14 |
2012-10-04 |
Theramind Research, Llc |
Methods and compositions for treatment of tuberous sclerosis complex
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
WO2011122950A1
(en)
|
2010-04-01 |
2011-10-06 |
Amsterdam Molecular Therapeutics (Amt) Ip B.V. |
Monomeric duplex aav vectors
|
|
JP5963743B2
(ja)
|
2010-04-23 |
2016-08-03 |
ユニバーシティ オブ マサチューセッツ |
Ｃｎｓターゲティングａａｖベクターおよびその使用方法
|
|
US8927514B2
(en)
|
2010-04-30 |
2015-01-06 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
US8628966B2
(en)
|
2010-04-30 |
2014-01-14 |
City Of Hope |
CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer
|
|
US9839696B2
(en)
|
2010-04-30 |
2017-12-12 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
US9453241B2
(en)
*
|
2010-05-04 |
2016-09-27 |
Wayne State University |
AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
|
|
CN107828820B
(zh)
|
2010-10-27 |
2022-06-07 |
学校法人自治医科大学 |
用于向神经系统细胞导入基因的腺相关病毒粒子
|
|
ES2684307T3
(es)
|
2010-11-05 |
2018-10-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas
|
|
WO2012064960A2
(en)
|
2010-11-10 |
2012-05-18 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
|
|
EP4234571A3
(en)
*
|
2011-02-10 |
2023-09-27 |
The University of North Carolina at Chapel Hill |
Viral vectors with modified transduction profiles and methods of making and using the same
|
|
ES2685611T3
(es)
|
2011-02-14 |
2018-10-10 |
The Children's Hospital Of Philadelphia |
Vector VAA8 mejorado con una actividad funcional aumentada y métodos de utilización del mismo
|
|
TR201908020T4
(tr)
*
|
2011-02-17 |
2019-06-21 |
Univ Pennsylvania |
Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler.
|
|
US9598468B2
(en)
|
2011-05-18 |
2017-03-21 |
University Of Florida Research Foundation, Incorporated |
Polypeptides and vectors for targeting HER2/neu expressing cells and uses thereof
|
|
WO2012178173A1
(en)
|
2011-06-24 |
2012-12-27 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
WO2013016315A1
(en)
|
2011-07-28 |
2013-01-31 |
Trustees Of Dartmouth College |
Methods for treating niemann-pick type c disease
|
|
CA3177736A1
(en)
|
2011-08-23 |
2013-02-28 |
Evogene Ltd. |
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
|
|
AU2012340567B2
(en)
|
2011-11-22 |
2017-11-23 |
The Children's Hospital Of Philadelphia |
Virus vectors for highly efficient transgene delivery
|
|
FI124176B
(en)
|
2011-12-01 |
2014-04-15 |
Helsingin Yliopisto |
Polypeptide, polynucleotide, expression cassette, vector, host cell, plant and uses
|
|
US20140350087A9
(en)
|
2012-03-22 |
2014-11-27 |
Halozyme, Inc. |
Oncovector Nucleic Acid Molecules and Methods of Use
|
|
SG11201405545XA
(en)
|
2012-03-27 |
2014-11-27 |
Curevac Gmbh |
Artificial nucleic acid molecules comprising a 5'top utr
|
|
PL2839014T3
(pl)
|
2012-04-18 |
2021-08-23 |
The Children's Hospital Of Philadelphia |
Kompozycja i sposoby na wysoko wydajny transfer genu za pomocą kapsydu wariantów aav
|
|
EP2660325A3
(en)
|
2012-05-02 |
2014-02-12 |
Christian Medical College |
AAV vectors and corresponding nucleotide sequences and methods
|
|
JP6385920B2
(ja)
|
2012-05-09 |
2018-09-05 |
オレゴン ヘルス アンド サイエンス ユニバーシティー |
アデノ随伴ウイルスプラスミド及びベクター
|
|
US10294281B2
(en)
|
2012-05-15 |
2019-05-21 |
University Of Florida Research Foundation, Incorporated |
High-transduction-efficiency rAAV vectors, compositions, and methods of use
|
|
EP2492347A1
(en)
|
2012-05-22 |
2012-08-29 |
Laboratorios Del. Dr. Esteve, S.A. |
Methods for the production of vectors
|
|
JP6417322B2
(ja)
|
2012-06-21 |
2018-11-07 |
アソシアシオン・アンスティテュ・ドゥ・ミオロジーＡｓｓｏｃｉａｔｉｏｎ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｍｙｏｌｏｇｉｅ |
遺伝子治療ベクターの広範な遺伝子送達
|
|
IN2015KN00074A
(enrdf_load_stackoverflow)
|
2012-07-06 |
2015-07-31 |
Univ Iowa Res Found |
|
|
DK2872625T3
(en)
|
2012-07-11 |
2017-02-06 |
Sangamo Biosciences Inc |
METHODS AND COMPOSITIONS FOR TREATING LYSOSOMAL STORAGE DISEASES
|
|
US9683268B2
(en)
|
2012-09-19 |
2017-06-20 |
Beth Israel Deaconess |
Viruses associated with immunodeficiency and enteropathy and methods using same
|
|
JP5971661B2
(ja)
|
2012-09-19 |
2016-08-17 |
国立大学法人 東京大学 |
神経活動依存的プロモータ活性を有するｄｎａ、及びこれを含むベクター
|
|
US9636370B2
(en)
|
2012-09-28 |
2017-05-02 |
The University Of North Carolina At Chapel Hill |
AAV vectors targeted to oligodendrocytes
|
|
US9066966B2
(en)
|
2013-02-01 |
2015-06-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia
|
|
ES2741502T3
(es)
|
2013-02-08 |
2020-02-11 |
Univ Pennsylvania |
Cápside de AAV8 modificada para la transferencia génica para terapias de retina
|
|
US10266845B2
(en)
|
2013-02-08 |
2019-04-23 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
WO2014153083A1
(en)
|
2013-03-14 |
2014-09-25 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for predicting age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect
|
|
CA2904396A1
(en)
|
2013-03-15 |
2014-09-18 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dual glycan binding aav vectors
|
|
KR102298579B1
(ko)
|
2013-05-21 |
2021-09-07 |
유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 |
캡시드-변형된 raav3 벡터 조성물, 및 인간 간암의 유전자 요법에서의 용도
|
|
CA2907799A1
(en)
|
2013-05-31 |
2014-12-04 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
US9840719B2
(en)
|
2013-07-22 |
2017-12-12 |
The Children's Hospital Of Philadelphia |
Variant AAV and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
US9585971B2
(en)
|
2013-09-13 |
2017-03-07 |
California Institute Of Technology |
Recombinant AAV capsid protein
|
|
US20160369298A1
(en)
|
2013-09-26 |
2016-12-22 |
University Of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
WO2015044704A1
(en)
|
2013-09-30 |
2015-04-02 |
Sanofi |
Use of neuroglobin agonist for preventing or treating mitochondrial rcci and/or rcciii deficiency disease
|
|
ES2714535T3
(es)
|
2013-10-11 |
2019-05-28 |
Massachusetts Eye & Ear Infirmary |
Métodos para predecir secuencias de virus ancestrales y usos de los mismos
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
US10072251B2
(en)
|
2014-02-19 |
2018-09-11 |
University Of Massachusetts |
Recombinant AAVS having useful transcytosis properties
|
|
WO2015126972A1
(en)
|
2014-02-21 |
2015-08-27 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
US10308957B2
(en)
|
2014-03-04 |
2019-06-04 |
University Of Florida Research Foundation, Inc. |
rAAV vectors and methods for transduction of photoreceptors and RPE cells
|
|
US10746742B2
(en)
|
2014-04-25 |
2020-08-18 |
Oregon Health & Science University |
Methods of viral neutralizing antibody epitope mapping
|
|
IL292951B2
(en)
|
2014-05-02 |
2024-10-01 |
Genzyme Corp |
Aav vectors for retinal and cns gene therapy
|
|
US20170088852A1
(en)
|
2014-05-28 |
2017-03-30 |
Evogene Ltd. |
Isolated polynucleotides, polypeptides and methods of using same for increasing abiotic stress tolerance, biomass and yield of plants
|
|
WO2015191508A1
(en)
|
2014-06-09 |
2015-12-17 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
EP4148083A1
(en)
|
2014-06-25 |
2023-03-15 |
Acuitas Therapeutics Inc. |
Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
US9818383B2
(en)
|
2014-07-28 |
2017-11-14 |
University Of Connecticut |
Methods and systems for non-destructive analysis of objects and production of replica objects
|
|
SG10201902574RA
(en)
|
2014-09-24 |
2019-04-29 |
Hope City |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016054557A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Novel high efficiency library-identified aav vectors
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
CN107532173A
(zh)
|
2014-11-21 |
2018-01-02 |
北卡罗来纳-查佩尔山大学 |
靶向中枢神经系统的aav载体
|
|
CA2972807C
(en)
|
2015-01-14 |
2024-01-16 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
EP3632923A1
(en)
|
2015-01-16 |
2020-04-08 |
Voyager Therapeutics, Inc. |
Central nervous system targeting polynucleotides
|
|
US20180030096A1
(en)
|
2015-02-03 |
2018-02-01 |
University Of Florida Research Foundation, Inc. |
Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof
|
|
GB201502306D0
(en)
|
2015-02-12 |
2015-04-01 |
Hansa Medical Ab |
Protein
|
|
GB201502305D0
(en)
|
2015-02-12 |
2015-04-01 |
Hansa Medical Ab |
Protein
|
|
WO2016134338A1
(en)
|
2015-02-19 |
2016-08-25 |
University Of Florida Research Foundation, Inc. |
Recombinant aav vectors for gene therapy of human hematopoietic disorders
|
|
HK1249067A1
(zh)
|
2015-03-02 |
2018-10-26 |
Adverum Biotechnologies, Inc. |
用於將多核苷酸玻璃體內遞送到視網膜視錐的組合物和方法
|
|
WO2016150964A1
(en)
|
2015-03-23 |
2016-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia
|
|
MX388331B
(es)
|
2015-03-24 |
2025-03-19 |
Univ California |
Variantes de virus adenoasociado y métodos de uso de estas
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
ES2755725T3
(es)
*
|
2015-04-08 |
2020-04-23 |
Us Health |
Terapia génica viral como tratamiento para una enfermedad o un trastorno por almacenamiento de colesterol
|
|
EP4491733A3
(en)
*
|
2015-04-23 |
2025-03-26 |
University of Massachusetts |
Modulation of aav vector transgene expression
|
|
WO2016172008A1
(en)
|
2015-04-24 |
2016-10-27 |
University Of Massachusetts |
Modified aav constructions and uses thereof
|
|
EP3294890A4
(en)
|
2015-05-08 |
2018-10-03 |
Children's Medical Research Institute |
Promoters for expression of heterologous genes
|
|
GB201508026D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Capsid
|
|
GB201508025D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Fabry disease gene therapy
|
|
CA2985786A1
(en)
|
2015-05-12 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav isolate and fusion protein comprising nerve growth factor signal peptide and parathyroid hormone
|
|
WO2017015102A1
(en)
|
2015-07-17 |
2017-01-26 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
WO2017013648A1
(en)
|
2015-07-19 |
2017-01-26 |
Yeda Research And Development Co. Ltd. |
SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE
|
|
US20180214576A1
(en)
|
2015-07-28 |
2018-08-02 |
University Of Massachusetts |
Transgenic expression of dnasei in vivo delivered by an adeno-associated virus vector
|
|
US10738087B2
(en)
|
2015-07-30 |
2020-08-11 |
Massachusetts Eye And Ear Infirmary |
Ancestral virus sequences and uses thereof
|
|
CN108137655B
(zh)
|
2015-09-28 |
2022-04-22 |
北卡罗来纳-查佩尔山大学 |
逃避抗体的病毒载体的方法和组合物
|
|
WO2017066764A2
(en)
|
2015-10-16 |
2017-04-20 |
William Marsh Rice University |
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
|
|
EP3364996B1
(en)
|
2015-10-22 |
2021-08-25 |
University of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
SG11201802408RA
(en)
|
2015-11-05 |
2018-05-30 |
Bamboo Therapeutics Inc |
Modified friedreich ataxia genes and vectors for gene therapy
|
|
CO2018006699A2
(es)
|
2015-12-01 |
2018-09-20 |
Spark Therapeutics Inc |
Métodos escalables para producir un vector viral adenoasociado (aav) recombinante en un sistema de cultivo celular en suspensión sin suero adecuado para uso clínico
|
|
US10406244B2
(en)
|
2015-12-02 |
2019-09-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
AAV vectors with expanded packaging capacity
|
|
EP3384034B1
(en)
|
2015-12-02 |
2020-07-08 |
The Board of Trustees of the Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
IL259842B
(en)
*
|
2015-12-11 |
2022-08-01 |
California Inst Of Techn |
Targeting peptides for directing adeno-associated viruses -aavs-
|
|
MX395524B
(es)
|
2015-12-14 |
2025-03-25 |
Univ North Carolina Chapel Hill |
Proteinas de cápside modificadas para un suministro mejorado de vectores de parvovirus.
|
|
EP4094780A3
(en)
|
2016-02-12 |
2023-02-08 |
University of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
AU2017219865B2
(en)
|
2016-02-16 |
2023-04-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
|
|
RU2018132517A
(ru)
|
2016-02-22 |
2020-03-24 |
Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл |
Aav-idua вектор для лечения ассоциированной с mps i слепоты
|
|
EP3443108A4
(en)
|
2016-04-15 |
2019-11-20 |
The Trustees of The University of Pennsylvania |
NOVEL AAV8 MUTANT CAPSIDES AND COMPOSITIONS THEREOF
|
|
US11866462B2
(en)
|
2016-05-04 |
2024-01-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
CR20180589A
(es)
|
2016-05-13 |
2019-02-27 |
4D Molecular Therapeutics Inc |
Cápsulas variantes de virus adenoasociados y métodos de uso de estas
|
|
JP7066635B2
(ja)
|
2016-05-18 |
2022-05-13 |
ボイジャー セラピューティクス インコーポレイテッド |
調節性ポリヌクレオチド
|
|
RU2768045C2
(ru)
|
2016-07-21 |
2022-03-23 |
Спарк Терапьютикс, Инк. |
СПОСОБ ПОЛУЧЕНИЯ ЧАСТИЦ РЕКОМБИНАНТНОГО АДЕНОАССОЦИИРОВАННОГО ВИРУСНОГО ВЕКТОРА (rAAV)
|
|
EP3491008A2
(en)
|
2016-07-26 |
2019-06-05 |
BioMarin Pharmaceutical Inc. |
Novel adeno-associated virus capsid proteins
|
|
WO2018035213A1
(en)
|
2016-08-16 |
2018-02-22 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
EP4248979A3
(en)
|
2016-09-08 |
2023-12-20 |
2seventy bio, Inc. |
Pd-1 homing endonuclease variants, compositions, and methods of use
|
|
WO2018064624A1
(en)
|
2016-09-29 |
2018-04-05 |
University Of Florida Research Foundation, Incorporated |
Aavrh.10 variants with host antibody escape capabilities and altered tissue targeting properties
|
|
CA3040179A1
(en)
|
2016-10-19 |
2018-04-26 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
|
EP3558393A4
(en)
|
2016-12-22 |
2020-11-11 |
Oregon Health & Science University |
ADENO-ASSOCIATED VIRAL VECTORS
|
|
KR20190117571A
(ko)
|
2017-02-15 |
2019-10-16 |
더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 |
혈관계를 통한 유전자 전달 방법 및 조성물
|
|
PE20191362A1
(es)
|
2017-02-28 |
2019-10-01 |
Univ Pennsylvania |
Novedoso vector del subtipo f del virus adenoasociado (aav) y usos de este
|
|
JP7132934B2
(ja)
|
2017-03-15 |
2022-09-07 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
ポリプロイド性アデノ随伴ウイルスベクターならびにその作製および使用の方法
|
|
US10550405B2
(en)
|
2017-03-15 |
2020-02-04 |
The University Of North Carolina At Chapel Hill |
Rational polyploid adeno-associated virus vectors and methods of making and using the same
|
|
GB201707212D0
(en)
*
|
2017-05-05 |
2017-06-21 |
Ucl Business Plc |
Gene therapy for ciliopathies
|
|
US20210254056A1
(en)
|
2017-05-05 |
2021-08-19 |
Camp4 Therapeutics Corporation |
Identification and targeted modulation of gene signaling networks
|
|
CA3061968A1
(en)
|
2017-05-10 |
2018-11-15 |
Massachusetts Eye And Ear Infirmary |
Methods and compositions for modifying assembly-activating protein (aap)-dependence of viruses
|
|
WO2018226785A1
(en)
|
2017-06-06 |
2018-12-13 |
University Of Massachusetts |
Self-regulating aav vectors for safe expression of mecp2 in rett syndrome
|
|
WO2018237066A1
(en)
|
2017-06-20 |
2018-12-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
CODON OPTIMIZED HUMAN NPC1 GENES FOR THE TREATMENT OF C1-TYPE NIEMANN-PICK DISEASE AND ASSOCIATED STATES
|
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
US20210228738A1
(en)
|
2017-07-17 |
2021-07-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
|
|
EP4445954A3
(en)
|
2017-07-31 |
2025-01-08 |
Reflection Biotechnologies Limited |
Cellular models of and therapies for ocular diseases
|
|
BR112020014625A2
(pt)
|
2018-01-17 |
2020-12-08 |
Meiragtx Uk Ii Limited |
Proteína de capsídeo de raav modificada para terapia gênica
|
|
IL276859B1
(en)
|
2018-02-27 |
2025-08-01 |
Univ Pennsylvania |
Novel adeno-associated virus (AAV) vectors, AAV vectors with reduced capsid deamidation and uses therefor
|
|
MX2020008932A
(es)
|
2018-02-27 |
2020-10-01 |
Univ Pennsylvania |
Novedosos vectores de virus adenoasociado (aav), vectores de aav que tienen una desamidacion reducida de la capside y usos de estos.
|
|
AU2019227896A1
(en)
|
2018-02-28 |
2020-08-20 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for antibody-evading virus vectors
|
|
EP3762500A1
(en)
|
2018-03-06 |
2021-01-13 |
Voyager Therapeutics, Inc. |
Insect cell manufactured partial self-complementary aav genomes
|
|
AU2019231711A1
(en)
|
2018-03-06 |
2020-09-24 |
University Of Florida Research Foundation, Incorporated |
AAV chimeras
|
|
AU2019234918B2
(en)
|
2018-03-16 |
2025-08-14 |
Research Institute At Nationwide Children's Hospital |
Increasing tissue specific gene delivery by capsid modification
|
|
CA3094311A1
(en)
|
2018-04-03 |
2019-10-10 |
Stridebio, Inc. |
Antibody-evading virus vectors
|
|
KR20210007963A
(ko)
*
|
2018-04-03 |
2021-01-20 |
스트라이드바이오 인코포레이티드 |
항체-회피 바이러스 벡터
|
|
JP7425738B2
(ja)
|
2018-04-03 |
2024-01-31 |
ギンコ バイオワークス インコーポレイテッド |
眼組織を標的とするウイルスベクター
|
|
US20210214749A1
(en)
|
2018-05-16 |
2021-07-15 |
Voyager Therapeutics, Inc. |
Directed evolution
|
|
EP3883954A4
(en)
|
2018-11-21 |
2022-08-10 |
Stridebio, Inc. |
Recombinant viral vectors and nucleic acids for producing the same
|
|
DK3906066T5
(da)
|
2019-01-04 |
2024-08-05 |
Ultragenyx Pharmaceutical Inc |
Geneterapikonstruktioner til behandling af wilsons sygdom
|
|
BR112021018776A2
(pt)
|
2019-03-21 |
2021-11-30 |
Stridebio Inc |
Vetores de vírus adenoassociado recombinante
|
|
CA3140049A1
(en)
|
2019-05-14 |
2020-11-19 |
Duke University |
Compositions and methods for the treatment of atpase-mediated diseases
|
|
CA3157702A1
(en)
|
2019-10-17 |
2021-04-22 |
Stridebio, Inc. |
Aav transfer cassette
|
|
TW202227632A
(zh)
|
2020-08-19 |
2022-07-16 |
美商史崔德生物公司 |
用於治療雷特症候群之腺相關病毒載體
|