JPWO2020241876A5 - - Google Patents
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- Publication number
- JPWO2020241876A5 JPWO2020241876A5 JP2021521907A JP2021521907A JPWO2020241876A5 JP WO2020241876 A5 JPWO2020241876 A5 JP WO2020241876A5 JP 2021521907 A JP2021521907 A JP 2021521907A JP 2021521907 A JP2021521907 A JP 2021521907A JP WO2020241876 A5 JPWO2020241876 A5 JP WO2020241876A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- sequence
- seq
- ppr motif
- ppr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 135
- 235000001014 amino acid Nutrition 0.000 claims 125
- 229940024606 amino acid Drugs 0.000 claims 125
- 238000006467 substitution reaction Methods 0.000 claims 28
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 16
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 16
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 16
- 239000004472 Lysine Substances 0.000 claims 13
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 13
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 12
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 11
- 235000013922 glutamic acid Nutrition 0.000 claims 11
- 239000004220 glutamic acid Substances 0.000 claims 11
- 235000018102 proteins Nutrition 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical group OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 9
- 235000003704 aspartic acid Nutrition 0.000 claims 9
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 9
- 229930024421 Adenine Natural products 0.000 claims 8
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 8
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 8
- 229960000643 adenine Drugs 0.000 claims 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 8
- 229940104302 cytosine Drugs 0.000 claims 8
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 8
- 229940035893 uracil Drugs 0.000 claims 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
- 229960000310 isoleucine Drugs 0.000 claims 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000004474 valine Substances 0.000 claims 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 125000002987 valine group Chemical class [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 1
- 101000611441 Solanum lycopersicum Pathogenesis-related leaf protein 6 Proteins 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023126196A JP7683865B2 (ja) | 2019-05-29 | 2023-08-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
| JP2025076735A JP2025107351A (ja) | 2019-05-29 | 2025-05-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019100551 | 2019-05-29 | ||
| JP2019100551 | 2019-05-29 | ||
| PCT/JP2020/021472 WO2020241876A1 (ja) | 2019-05-29 | 2020-05-29 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126196A Division JP7683865B2 (ja) | 2019-05-29 | 2023-08-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020241876A1 JPWO2020241876A1 (https=) | 2020-12-03 |
| JPWO2020241876A5 true JPWO2020241876A5 (https=) | 2022-06-30 |
| JP7491515B2 JP7491515B2 (ja) | 2024-05-28 |
Family
ID=73553200
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521907A Active JP7491515B2 (ja) | 2019-05-29 | 2020-05-29 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
| JP2023126196A Active JP7683865B2 (ja) | 2019-05-29 | 2023-08-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
| JP2025076735A Pending JP2025107351A (ja) | 2019-05-29 | 2025-05-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126196A Active JP7683865B2 (ja) | 2019-05-29 | 2023-08-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
| JP2025076735A Pending JP2025107351A (ja) | 2019-05-29 | 2025-05-02 | 効率的なｐｐｒタンパク質の作製方法及びその利用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220289795A1 (https=) |
| EP (1) | EP3978513A4 (https=) |
| JP (3) | JP7491515B2 (https=) |
| KR (1) | KR20220023985A (https=) |
| CN (1) | CN114729017A (https=) |
| AU (2) | AU2020283177B2 (https=) |
| BR (1) | BR112021023878A2 (https=) |
| CA (1) | CA3142299A1 (https=) |
| IL (1) | IL288426A (https=) |
| SG (1) | SG11202113055UA (https=) |
| WO (1) | WO2020241876A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3977849A4 (en) * | 2019-05-29 | 2023-06-28 | Editforce, Inc. | Ppr protein with less aggregation and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002322469B2 (en) * | 2001-07-12 | 2008-05-22 | Dna Landmarks, Inc. | Nuclear fertility restorer genes and methods of use in plants |
| JP2013128413A (ja) * | 2010-03-11 | 2013-07-04 | Kyushu Univ | Ｐｐｒモチーフを利用したｒｎａ結合性蛋白質の改変方法 |
| WO2013058404A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人九州大学 | Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用 |
| KR102893770B1 (ko) * | 2013-04-22 | 2025-11-28 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | 피피알 단백질을 이용하는 dna 결합성 단백질 및 그의 이용 |
| WO2017209122A1 (ja) | 2016-06-03 | 2017-12-07 | 国立大学法人九州大学 | 標的ｍＲＮＡからのタンパク質発現量を向上させるための融合タンパク質 |
| JPWO2018030488A1 (ja) * | 2016-08-10 | 2019-06-13 | 富士フイルム和光純薬株式会社 | Ｐｐｒモチーフを利用したｄｎａ結合性タンパク質およびその利用 |
| US12441770B2 (en) * | 2018-06-06 | 2025-10-14 | The University Of Western Australia | Proteins and their use for nucleotide binding |
-
2020
- 2020-05-29 CN CN202080039706.2A patent/CN114729017A/zh active Pending
- 2020-05-29 CA CA3142299A patent/CA3142299A1/en active Pending
- 2020-05-29 SG SG11202113055UA patent/SG11202113055UA/en unknown
- 2020-05-29 EP EP20815305.6A patent/EP3978513A4/en active Pending
- 2020-05-29 AU AU2020283177A patent/AU2020283177B2/en active Active
- 2020-05-29 US US17/614,231 patent/US20220289795A1/en active Pending
- 2020-05-29 WO PCT/JP2020/021472 patent/WO2020241876A1/ja not_active Ceased
- 2020-05-29 JP JP2021521907A patent/JP7491515B2/ja active Active
- 2020-05-29 KR KR1020217040377A patent/KR20220023985A/ko active Pending
- 2020-05-29 BR BR112021023878A patent/BR112021023878A2/pt unknown
-
2021
- 2021-11-25 IL IL288426A patent/IL288426A/en unknown
-
2023
- 2023-08-02 JP JP2023126196A patent/JP7683865B2/ja active Active
-
2025
- 2025-05-02 JP JP2025076735A patent/JP2025107351A/ja active Pending
- 2025-06-30 AU AU2025204992A patent/AU2025204992A1/en active Pending
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