|
US4217344A
(en)
|
1976-06-23 |
1980-08-12 |
L'oreal |
Compositions containing aqueous dispersions of lipid spheres
|
|
US4196265A
(en)
|
1977-06-15 |
1980-04-01 |
The Wistar Institute |
Method of producing antibodies
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4186183A
(en)
|
1978-03-29 |
1980-01-29 |
The United States Of America As Represented By The Secretary Of The Army |
Liposome carriers in chemotherapy of leishmaniasis
|
|
US4261975A
(en)
|
1979-09-19 |
1981-04-14 |
Merck & Co., Inc. |
Viral liposome particle
|
|
US4485054A
(en)
|
1982-10-04 |
1984-11-27 |
Lipoderm Pharmaceuticals Limited |
Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5380831A
(en)
|
1986-04-04 |
1995-01-10 |
Mycogen Plant Science, Inc. |
Synthetic insecticidal crystal protein gene
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5569597A
(en)
|
1985-05-13 |
1996-10-29 |
Ciba Geigy Corp. |
Methods of inserting viral DNA into plant material
|
|
US4774085A
(en)
|
1985-07-09 |
1988-09-27 |
501 Board of Regents, Univ. of Texas |
Pharmaceutical administration systems containing a mixture of immunomodulators
|
|
US4853331A
(en)
|
1985-08-16 |
1989-08-01 |
Mycogen Corporation |
Cloning and expression of Bacillus thuringiensis toxin gene toxic to beetles of the order Coleoptera
|
|
US5268463A
(en)
|
1986-11-11 |
1993-12-07 |
Jefferson Richard A |
Plant promoter α-glucuronidase gene construct
|
|
US5608142A
(en)
|
1986-12-03 |
1997-03-04 |
Agracetus, Inc. |
Insecticidal cotton plants
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5039523A
(en)
|
1988-10-27 |
1991-08-13 |
Mycogen Corporation |
Novel Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
|
|
EP0388186A1
(en)
|
1989-03-17 |
1990-09-19 |
E.I. Du Pont De Nemours And Company |
External regulation of gene expression
|
|
ATE225853T1
(de)
|
1990-04-12 |
2002-10-15 |
Syngenta Participations Ag |
Gewebe-spezifische promotoren
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5498830A
(en)
|
1990-06-18 |
1996-03-12 |
Monsanto Company |
Decreased oil content in plant seeds
|
|
CA2051562C
(en)
|
1990-10-12 |
2003-12-02 |
Jewel M. Payne |
Bacillus thuringiensis isolates active against dipteran pests
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5399680A
(en)
|
1991-05-22 |
1995-03-21 |
The Salk Institute For Biological Studies |
Rice chitinase promoter
|
|
US5604121A
(en)
|
1991-08-27 |
1997-02-18 |
Agricultural Genetics Company Limited |
Proteins with insecticidal properties against homopteran insects and their use in plant protection
|
|
TW261517B
(https=)
|
1991-11-29 |
1995-11-01 |
Mitsubishi Shozi Kk |
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5789156A
(en)
|
1993-06-14 |
1998-08-04 |
Basf Ag |
Tetracycline-regulated transcriptional inhibitors
|
|
US5814618A
(en)
|
1993-06-14 |
1998-09-29 |
Basf Aktiengesellschaft |
Methods for regulating gene expression
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5608144A
(en)
|
1994-08-12 |
1997-03-04 |
Dna Plant Technology Corp. |
Plant group 2 promoters and uses thereof
|
|
US5659026A
(en)
|
1995-03-24 |
1997-08-19 |
Pioneer Hi-Bred International |
ALS3 promoter
|
|
US6072050A
(en)
|
1996-06-11 |
2000-06-06 |
Pioneer Hi-Bred International, Inc. |
Synthetic promoters
|
|
AR014072A1
(es)
|
1998-02-26 |
2001-01-31 |
Pioneer Hi Bred Int |
Molecula de acido nucleico aislada que tiene una secuencia nucleotidica para un promotor que es capaz de iniciar una transcripcion constitutiva en unacelula de planta, construccion adn, vector, celula huesped, metodo para expresar en forma constitutiva una secuencia nucleotidica heteroloca en una
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6555655B1
(en)
|
1999-05-04 |
2003-04-29 |
Monsanto Technology, Llc |
Coleopteran-toxic polypeptide compositions and insect-resistant transgenic plants
|
|
US6593293B1
(en)
|
1999-09-15 |
2003-07-15 |
Monsanto Technology, Llc |
Lepidopteran-active Bacillus thuringiensis δ-endotoxin compositions and methods of use
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
US20050183161A1
(en)
|
2003-10-14 |
2005-08-18 |
Athenix Corporation |
AXMI-010, a delta-endotoxin gene and methods for its use
|
|
WO2005066202A2
(en)
|
2003-12-22 |
2005-07-21 |
E.I. Du Pont De Nemours And Company |
Bacillus cry9 family members
|
|
AU2007260716B2
(en)
|
2006-06-14 |
2013-05-02 |
BASF Agricultural Solutions Seed US LLC |
Axmi-031, axmi-039, axmi-040 and axmi-049, a family of delta-endotoxin genes and methods for their use
|
|
US8383604B2
(en)
|
2008-09-15 |
2013-02-26 |
Children's Medical Center Corporation |
Modulation of BCL11A for treatment of hemoglobinopathies
|
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
|
ES2609332T3
(es)
|
2009-07-02 |
2017-04-19 |
Athenix Corporation |
Gen pesticida AXMI-205 y métodos para su uso
|
|
EP2513296A4
(en)
*
|
2009-12-18 |
2013-05-22 |
Univ Leland Stanford Junior |
USE OF CYTIDINE DAMINASE ASSOCIATED ACTIVITIES TO PROMOTE DEMETHYLATION AND CELL REPROGRAMMEIRING
|
|
WO2011084324A2
(en)
|
2009-12-21 |
2011-07-14 |
Pioneer Hi-Bred International, Inc. |
Novel bacillus thuringiensis gene with lepidopteran activity
|
|
WO2012024200A2
(en)
|
2010-08-19 |
2012-02-23 |
Pioneer Hi-Bred International, Inc. |
Novel bacillus thuringiensis gene with lepidopteran activity
|
|
US9405700B2
(en)
|
2010-11-04 |
2016-08-02 |
Sonics, Inc. |
Methods and apparatus for virtualization in an integrated circuit
|
|
JP6224689B2
(ja)
*
|
2012-03-15 |
2017-11-01 |
ニユー・イングランド・バイオレイブス・インコーポレイテツド |
シトシンとこれの修飾物とを識別するための、およびメチローム分析のための方法および組成物
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP3196301B1
(en)
|
2012-07-11 |
2018-10-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of monogenic diseases
|
|
CN113355357B
(zh)
*
|
2012-12-12 |
2024-12-03 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
AU2015101792A4
(en)
*
|
2014-12-24 |
2016-01-28 |
Massachusetts Institute Of Technology |
Engineering of systems, methods and optimized enzyme and guide scaffolds for sequence manipulation
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CN116555254A
(zh)
*
|
2015-10-09 |
2023-08-08 |
孟山都技术公司 |
新颖的rna导向性核酸酶及其用途
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3426778A1
(en)
*
|
2016-03-11 |
2019-01-16 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
KR102622411B1
(ko)
*
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
US20200385753A1
(en)
*
|
2016-12-23 |
2020-12-10 |
Institute For Basic Science |
Composition for base editing for animal embryo and base editing method
|
|
EP3572525A4
(en)
*
|
2017-01-17 |
2020-09-30 |
Institute for Basic Science |
PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND
|
|
SG11201906297QA
(en)
*
|
2017-03-24 |
2019-10-30 |
Curevac Ag |
Nucleic acids encoding crispr-associated proteins and uses thereof
|
|
WO2018213726A1
(en)
*
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CN109957569B
(zh)
*
|
2017-12-22 |
2022-10-25 |
苏州齐禾生科生物科技有限公司 |
基于cpf1蛋白的碱基编辑系统和方法
|
|
CN109337904B
(zh)
*
|
2018-11-02 |
2020-12-25 |
中国科学院动物研究所 |
基于C2c1核酸酶的基因组编辑系统和方法
|
|
WO2021030344A1
(en)
*
|
2019-08-12 |
2021-02-18 |
Lifeedit, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|