JP2025510586A5 - - Google Patents
Info
- Publication number
- JP2025510586A5 JP2025510586A5 JP2024553739A JP2024553739A JP2025510586A5 JP 2025510586 A5 JP2025510586 A5 JP 2025510586A5 JP 2024553739 A JP2024553739 A JP 2024553739A JP 2024553739 A JP2024553739 A JP 2024553739A JP 2025510586 A5 JP2025510586 A5 JP 2025510586A5
- Authority
- JP
- Japan
- Prior art keywords
- cytosine deaminase
- sequence
- nucleic acid
- fusion protein
- clade
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210220832.9 | 2022-03-08 | ||
| CN202210220832 | 2022-03-08 | ||
| PCT/CN2023/080052 WO2023169410A1 (zh) | 2022-03-08 | 2023-03-07 | 胞嘧啶脱氨酶及其在碱基编辑中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025510586A JP2025510586A (ja) | 2025-04-15 |
| JP2025510586A5 true JP2025510586A5 (https=) | 2026-03-16 |
Family
ID=87495405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024553739A Pending JP2025510586A (ja) | 2022-03-08 | 2023-03-07 | シトシンデアミナーゼおよび塩基編集におけるその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250263684A1 (https=) |
| EP (1) | EP4491723A1 (https=) |
| JP (1) | JP2025510586A (https=) |
| KR (1) | KR20250007507A (https=) |
| CN (2) | CN116555237A (https=) |
| WO (1) | WO2023169410A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116721700B (zh) * | 2023-08-08 | 2024-01-12 | 中国人民解放军军事科学院军事医学研究院 | 鉴定新型双链dna胞苷脱氨酶的方法、装置及应用 |
| CN117210445A (zh) * | 2023-08-29 | 2023-12-12 | 苏州湃芮生物科技有限公司 | 一种基于rna特异性脱氨酶突变体及其应用 |
| CN117659210A (zh) * | 2023-11-30 | 2024-03-08 | 华南农业大学 | 一种用作植物双碱基编辑器的重组融合蛋白及其应用 |
| WO2025119306A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化工程化t细胞的碱基编辑系统及其应用 |
| KR20250140037A (ko) * | 2024-03-14 | 2025-09-24 | 재단법인 아산사회복지재단 | 박테리아 톡신 변이체 및 이의 용도 |
| WO2025213929A1 (zh) * | 2024-04-11 | 2025-10-16 | 上海交通大学医学院附属松江医院 | 一种工程化胞嘧啶脱氨酶及其制备方法和用途 |
| CN119912582B (zh) * | 2024-06-17 | 2025-11-04 | 中国农业大学 | 单碱基编辑器及其所用脱氨酶与应用 |
| CN119913132B (zh) * | 2024-06-17 | 2025-11-04 | 中国农业大学 | 胞嘧啶脱氨酶及其相关生物材料与应用 |
| CN121237206A (zh) * | 2024-09-19 | 2025-12-30 | 中国科学院遗传与发育生物学研究所 | 一种基于人工智能的酶工程方法、系统、设备及介质 |
| CN119517174B (zh) * | 2024-10-28 | 2025-11-21 | 南京大学 | 基于进化生物学与计算生物的rna进化前体筛选方法 |
| CN119286832A (zh) * | 2024-10-30 | 2025-01-10 | 安徽农业大学 | 一种胞嘧啶脱氨酶突变体及其碱基编辑系统和应用 |
| CN121518574B (zh) * | 2026-01-14 | 2026-04-24 | 中国农业科学院北京畜牧兽医研究所 | 胞嘧啶碱基编辑器介导的猪zscan4基因敲除方法及体系和应用 |
| CN121555485B (zh) * | 2026-01-21 | 2026-04-24 | 中国农业大学 | 源于宏基因组挖掘的胞嘧啶脱氨酶及其生物材料与应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2371320A (en) | 1945-03-13 | Temt office | ||
| EP1887081A2 (en) * | 1999-02-25 | 2008-02-13 | Ceres Incorporated | DNA Sequences |
| EP2414507B1 (en) * | 2009-04-03 | 2014-07-02 | Medical Research Council | Mutants of activation-induced cytidine deaminase (aid) and methods of use |
| SG10201804975PA (en) | 2013-12-12 | 2018-07-30 | Broad Inst Inc | Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| EP3530737A4 (en) * | 2016-09-13 | 2020-04-29 | Toolgen Incorporated | METHOD FOR IDENTIFYING DNA BASE EDITING USING CYTOSINE DEAMINASE |
| US20200385753A1 (en) * | 2016-12-23 | 2020-12-10 | Institute For Basic Science | Composition for base editing for animal embryo and base editing method |
| WO2018141835A1 (en) | 2017-02-03 | 2018-08-09 | The Broad Institute, Inc. | Compounds, compositions and methods for cancer treatment |
| EP3712272A4 (en) * | 2017-07-25 | 2021-10-13 | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences | METHOD FOR MODULATION OF RNA SPLICE BY INDUCTION OF A BASE MUTATION AT THE SPLICE POINT OR A BASE SUBSTITUTION IN THE POLYPYRIMIDINE REGION |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| CN112805385B (zh) * | 2018-07-24 | 2023-05-30 | 苏州齐禾生科生物科技有限公司 | 基于人apobec3a脱氨酶的碱基编辑器及其用途 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| EP3739065A1 (en) * | 2019-05-16 | 2020-11-18 | Fundació Centre de Regulació Genòmica | Somatic mutation-based classification of cancers |
| CN112239756B (zh) * | 2019-07-01 | 2022-04-19 | 科稷达隆(北京)生物技术有限公司 | 一组来源于植物的胞嘧啶脱氨酶和其在碱基编辑系统中的应用 |
| US20220411777A1 (en) * | 2019-08-30 | 2022-12-29 | The General Hospital Corporation | C-to-G Transversion DNA Base Editors |
| CN110734900B (zh) * | 2019-11-06 | 2022-09-30 | 上海科技大学 | 一种胞嘧啶碱基编辑工具及其用途 |
| US20250011748A1 (en) | 2020-01-28 | 2025-01-09 | The Broad Institute, Inc. | Base editors, compositions, and methods for modifying the mitochondrial genome |
| CN119842677A (zh) * | 2023-10-11 | 2025-04-18 | 中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心) | 结构导向挖掘的具有高编辑活性和无序列偏好性的胞嘧啶脱氨酶及其应用 |
| CN119889461A (zh) * | 2024-12-31 | 2025-04-25 | 中国农业科学院农业基因组研究所 | 一种基于机器学习模型预测胞嘧啶脱氨酶功能的方法及应用 |
-
2023
- 2023-03-07 US US18/845,255 patent/US20250263684A1/en active Pending
- 2023-03-07 KR KR1020247033542A patent/KR20250007507A/ko active Pending
- 2023-03-07 WO PCT/CN2023/080052 patent/WO2023169410A1/zh not_active Ceased
- 2023-03-07 EP EP23765988.3A patent/EP4491723A1/en active Pending
- 2023-03-07 CN CN202310220057.1A patent/CN116555237A/zh active Pending
- 2023-03-07 CN CN202511062015.5A patent/CN120944860A/zh active Pending
- 2023-03-07 JP JP2024553739A patent/JP2025510586A/ja active Pending
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