JP2024511621A5 - - Google Patents
Info
- Publication number
- JP2024511621A5 JP2024511621A5 JP2023558369A JP2023558369A JP2024511621A5 JP 2024511621 A5 JP2024511621 A5 JP 2024511621A5 JP 2023558369 A JP2023558369 A JP 2023558369A JP 2023558369 A JP2023558369 A JP 2023558369A JP 2024511621 A5 JP2024511621 A5 JP 2024511621A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- cas9
- protein
- nucleic acid
- cas9 protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163164798P | 2021-03-23 | 2021-03-23 | |
| US63/164,798 | 2021-03-23 | ||
| PCT/US2022/021523 WO2022204268A2 (en) | 2021-03-23 | 2022-03-23 | Novel crispr enzymes, methods, systems and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024511621A JP2024511621A (ja) | 2024-03-14 |
| JP2024511621A5 true JP2024511621A5 (https=) | 2025-03-21 |
Family
ID=81326585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023558369A Pending JP2024511621A (ja) | 2021-03-23 | 2022-03-23 | 新規ｃｒｉｓｐｒ酵素、方法、システム、及びそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240167008A1 (https=) |
| EP (1) | EP4314265A2 (https=) |
| JP (1) | JP2024511621A (https=) |
| KR (1) | KR20230158531A (https=) |
| CN (1) | CN117529555A (https=) |
| AU (1) | AU2022245243A1 (https=) |
| CA (1) | CA3211495A1 (https=) |
| WO (1) | WO2022204268A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121079412A (zh) | 2023-04-28 | 2025-12-05 | 比姆医疗股份有限公司 | 经修饰的指导rna |
| AU2024274409A1 (en) * | 2023-05-12 | 2025-11-27 | Vertex Pharmaceuticals Incorporated | Compact proteins |
| WO2025024493A1 (en) | 2023-07-25 | 2025-01-30 | Flagship Pioneering Innovations Vii, Llc | Cas endonucleases and related methods |
| KR20260044217A (ko) | 2023-07-25 | 2026-04-01 | 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 | Cas 엔도뉴클레아제 및 관련 방법 |
| WO2025072331A1 (en) | 2023-09-26 | 2025-04-03 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| WO2025117877A2 (en) | 2023-12-01 | 2025-06-05 | Flagship Pioneering Innovations Vii, Llc | Cas nucleases and related methods |
| CN117866926B (zh) * | 2024-03-07 | 2024-08-16 | 珠海舒桐医疗科技有限公司 | 一种CRISPR-FrCas9蛋白突变体及应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5846946A (en) | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
| AU2005274948B2 (en) | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| US8404658B2 (en) | 2007-12-31 | 2013-03-26 | Nanocor Therapeutics, Inc. | RNA interference for the treatment of heart failure |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| CN105139759B (zh) | 2015-09-18 | 2017-10-10 | 京东方科技集团股份有限公司 | 一种拼接屏 |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| EP3592853A1 (en) * | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US20220307001A1 (en) * | 2018-02-27 | 2022-09-29 | President And Fellows Of Harvard College | Evolved cas9 variants and uses thereof |
-
2022
- 2022-03-23 CA CA3211495A patent/CA3211495A1/en active Pending
- 2022-03-23 EP EP22715917.5A patent/EP4314265A2/en active Pending
- 2022-03-23 WO PCT/US2022/021523 patent/WO2022204268A2/en not_active Ceased
- 2022-03-23 US US18/283,148 patent/US20240167008A1/en active Pending
- 2022-03-23 CN CN202280036959.3A patent/CN117529555A/zh active Pending
- 2022-03-23 AU AU2022245243A patent/AU2022245243A1/en active Pending
- 2022-03-23 JP JP2023558369A patent/JP2024511621A/ja active Pending
- 2022-03-23 KR KR1020237034367A patent/KR20230158531A/ko active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024511621A5 (https=) | ||
| CN111065647B (zh) | 用于提高碱基编辑精度的融合蛋白 | |
| EP3178935B1 (en) | Genome editing using campylobacter jejuni crispr/cas system-derived rgen | |
| JP2022546608A5 (https=) | ||
| JP2024546841A5 (https=) | ||
| KR20200121782A (ko) | 아데노신 염기 편집제의 용도 | |
| US20240141341A1 (en) | Systems and methods for genome-wide annotation of gene regulatory elements linked to cell fitness | |
| JP2022545950A5 (https=) | ||
| WO2017090724A1 (ja) | Ｄｎａメチル化編集用キットおよびｄｎａメチル化編集方法 | |
| WO2017215648A1 (zh) | 基因敲除方法 | |
| US20240058425A1 (en) | Systems and methods for genome-wide annotation of gene regulatory elements linked to cell fitness | |
| EP3974525A2 (en) | Single base substitution protein, and composition comprising same | |
| JP2025517515A (ja) | 新規核酸編集タンパク質 | |
| CN118871578A (zh) | 用于碱基编辑的脱氨酶及其变体 | |
| JPS61501747A (ja) | 核酸配列の検出方法 | |
| JP2021522825A5 (https=) | ||
| JP7698579B2 (ja) | デフルビーモナス属（Ｄｅｆｌｕｖｉｉｍｏｎａｓ）種由来のＣａｓ９タンパク質に基づくＤＮＡカット手段 | |
| JP7109009B2 (ja) | 遺伝子ノックアウト方法 | |
| JP7835414B2 (ja) | プライム編集システムを用いたゲノム編集のプロセスで起こり得るオフターゲットを予測するための方法 | |
| JP2025535373A (ja) | Ｃａｓタンパク質及び細菌毒素を含む融合タンパク質及びその使用 | |
| JP2024509446A (ja) | 細胞におけるタンパク質コード変異体の発現の分析 | |
| JP7621281B2 (ja) | 細菌、肺パスツレラ菌（Ｐａｓｔｅｕｒｅｌｌａ ｐｎｅｕｍｏｔｒｏｐｉｃａ）由来のＣａｓ９タンパク質に基づくＤＮＡカット剤 | |
| CN119162157B (zh) | 用于碱基编辑的脱氨酶及其变体 | |
| RU2788197C1 (ru) | Средство разрезания ДНК на основе Cas9 белка из бактерии Streptococcus uberis NCTC3858 | |
| RU2791447C1 (ru) | Средство разрезания ДНК на основе ScCas12a белка из бактерии Sedimentisphaera cyanobacteriorum |