JP2022516130A5 - - Google Patents

Info

Publication number
JP2022516130A5
JP2022516130A5 JP2021538143A JP2021538143A JP2022516130A5 JP 2022516130 A5 JP2022516130 A5 JP 2022516130A5 JP 2021538143 A JP2021538143 A JP 2021538143A JP 2021538143 A JP2021538143 A JP 2021538143A JP 2022516130 A5 JP2022516130 A5 JP 2022516130A5
Authority
JP
Japan
Application number
JP2021538143A
Other languages
Japanese (ja)
Other versions
JPWO2020139783A5 (https=
JP7572360B2 (ja
JP2022516130A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/068079 external-priority patent/WO2020139783A2/en
Publication of JP2022516130A publication Critical patent/JP2022516130A/ja
Publication of JPWO2020139783A5 publication Critical patent/JPWO2020139783A5/ja
Publication of JP2022516130A5 publication Critical patent/JP2022516130A5/ja
Priority to JP2024008844A priority Critical patent/JP2024050676A/ja
Priority to JP2024112452A priority patent/JP2024137967A/ja
Application granted granted Critical
Publication of JP7572360B2 publication Critical patent/JP7572360B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021538143A 2018-12-27 2019-12-20 遺伝子編集に有用なポリペプチドと利用方法 Active JP7572360B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024008844A JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201862785391P 2018-12-27 2018-12-27
US62/785,391 2018-12-27
US201962790266P 2019-01-09 2019-01-09
US201962790256P 2019-01-09 2019-01-09
US201962790261P 2019-01-09 2019-01-09
US201962790262P 2019-01-09 2019-01-09
US201962790258P 2019-01-09 2019-01-09
US62/790,258 2019-01-09
US62/790,266 2019-01-09
US62/790,261 2019-01-09
US62/790,256 2019-01-09
US62/790,262 2019-01-09
US201962932169P 2019-11-07 2019-11-07
US62/932,169 2019-11-07
PCT/US2019/068079 WO2020139783A2 (en) 2018-12-27 2019-12-20 Polypeptides useful for gene editing and methods of use

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2024008844A Division JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A Division JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Publications (4)

Publication Number Publication Date
JP2022516130A JP2022516130A (ja) 2022-02-24
JPWO2020139783A5 JPWO2020139783A5 (https=) 2022-12-27
JP2022516130A5 true JP2022516130A5 (https=) 2022-12-27
JP7572360B2 JP7572360B2 (ja) 2024-10-23

Family

ID=69182752

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021538143A Active JP7572360B2 (ja) 2018-12-27 2019-12-20 遺伝子編集に有用なポリペプチドと利用方法
JP2024008844A Pending JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A Pending JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024008844A Pending JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A Pending JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Country Status (15)

Country Link
US (4) US20220145296A1 (https=)
EP (2) EP3902911B1 (https=)
JP (3) JP7572360B2 (https=)
KR (1) KR20210149686A (https=)
CN (1) CN113631704A (https=)
AU (2) AU2019416108B2 (https=)
BR (1) BR112021012665A2 (https=)
ES (1) ES2970169T3 (https=)
IL (2) IL312708A (https=)
MX (1) MX2021007835A (https=)
NZ (1) NZ778392A (https=)
SG (1) SG11202106977PA (https=)
TW (1) TW202039847A (https=)
WO (1) WO2020139783A2 (https=)
ZA (1) ZA202105281B (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020024863A2 (pt) * 2018-06-05 2022-02-01 Lifeedit Inc Nucleases guiadas por rna, fragmentos ativos e variantes das mesmas e métodos de uso
TW202208626A (zh) * 2020-04-24 2022-03-01 美商生命編輯公司 Rna引導核酸酶及其活性片段與變體,以及使用方法
CA3174356A1 (en) 2020-07-01 2022-01-06 Santosh NARAYAN Compositions and methods for cellular reprogramming using circular rna
JP2023534693A (ja) * 2020-07-15 2023-08-10 ライフエディット セラピューティクス,インコーポレイティド ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法
TWI910226B (zh) * 2020-09-11 2026-01-01 美商生命編輯治療學公司 Dna修飾酶及活性片段,及其變異體與使用方法
CN117295817A (zh) 2021-03-22 2023-12-26 生命编辑制药股份有限公司 Dna修饰酶及其活性片段和变体以及使用方法
WO2022241270A2 (en) * 2021-05-14 2022-11-17 Beam Therapeutics Inc. Compositions and methods for treating transthyretin amyloidosis
AU2022290278A1 (en) 2021-06-11 2024-01-04 LifeEDIT Therapeutics, Inc. Rna polymerase iii promoters and methods of use
EP4101928A1 (en) * 2021-06-11 2022-12-14 Bayer AG Type v rna programmable endonuclease systems
US20240141312A1 (en) * 2021-06-11 2024-05-02 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
AU2022336615A1 (en) 2021-09-02 2024-04-11 Sanofi Pasteur Inc. Compositions and methods for rna affinity purification
AU2022359812A1 (en) 2021-10-05 2024-05-16 Sanofi Pasteur Inc. METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME
WO2023118068A1 (en) * 2021-12-23 2023-06-29 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems
CN118829624A (zh) 2022-01-17 2024-10-22 赛诺菲 脂质化合物及其用途
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
CN119317713A (zh) 2022-01-24 2025-01-14 生命编辑制药股份有限公司 Rna引导核酸酶、其活性片段与变体,及使用方法
EP4539858A1 (en) 2022-06-17 2025-04-23 Sanofi Pasteur Inc. Compositions and methods for circular rna affinity purification
JP2025525569A (ja) 2022-07-18 2025-08-05 レナゲード セラピューティクス マネージメント インコーポレイテッド 遺伝子編集成分、システム、及び使用方法
CA3264752A1 (en) 2022-08-12 2024-02-15 Life Edit Therapeutics, Inc. RNA-GUIDED NUCLEASE AND ACTIVE FRAGMENTS, ASSOCIATED VARIANTS AND METHODS OF USE
TW202424186A (zh) 2022-08-25 2024-06-16 美商生命編輯治療學公司 Rna引導核酸酶中介基因編輯用之具鎖核酸引導 rna之化學修飾
WO2024044723A1 (en) 2022-08-25 2024-02-29 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
EP4612284A2 (en) 2022-11-04 2025-09-10 Life Edit Therapeutics, Inc. Evolved adenine deaminases and rna-guided nuclease fusion proteins with internal insertion sites and methods of use
CA3277009A1 (en) 2022-12-16 2024-06-20 Life Edit Therapeutics, Inc. RNA GUIDELINES TARGETING THE TRAC GENE AND METHODS OF USE
EP4634383A1 (en) 2022-12-16 2025-10-22 Life Edit Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
WO2024178397A2 (en) 2023-02-24 2024-08-29 Elevatebio Technologies, Inc. Modified immune effector cells and methods of use
WO2024235991A1 (en) * 2023-05-15 2024-11-21 UCB Biopharma SRL Rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases
WO2025003344A1 (en) * 2023-06-28 2025-01-02 Alia Therapeutics Srl Type ii cas proteins and applications thereof
WO2025022367A2 (en) 2023-07-27 2025-01-30 Life Edit Therapeutics, Inc. Rna-guided nucleases and active fragments and variants thereof and methods of use
WO2025081042A1 (en) 2023-10-12 2025-04-17 Renagade Therapeutics Management Inc. Nickase-retron template-based precision editing system and methods of use
WO2025083619A1 (en) 2023-10-18 2025-04-24 Life Edit Therapeutics, Inc. Rna-guided nucleases and acive fragments and variants thereof and methods of use
WO2025155753A2 (en) 2024-01-17 2025-07-24 Renagade Therapeutics Management Inc. Improved gene editing system, guides, and methods
TW202546224A (zh) 2024-02-12 2025-12-01 美商生命編輯治療學公司 新穎的rna引導之核酸酶及用於聚合酶編輯之蛋白質
CN120608040A (zh) * 2024-03-07 2025-09-09 清华大学 一种用于基因编辑和/或抵抗噬菌体的系统及其应用
WO2025231360A1 (en) * 2024-05-03 2025-11-06 Modernatx, Inc. Novel cas nucleases and polynucleotides encoding the same

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4261975A (en) 1979-09-19 1981-04-14 Merck & Co., Inc. Viral liposome particle
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5569597A (en) 1985-05-13 1996-10-29 Ciba Geigy Corp. Methods of inserting viral DNA into plant material
US4774085A (en) 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
US4853331A (en) 1985-08-16 1989-08-01 Mycogen Corporation Cloning and expression of Bacillus thuringiensis toxin gene toxic to beetles of the order Coleoptera
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5608142A (en) 1986-12-03 1997-03-04 Agracetus, Inc. Insecticidal cotton plants
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5039523A (en) 1988-10-27 1991-08-13 Mycogen Corporation Novel Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
EP0463056A1 (en) 1989-03-17 1992-01-02 E.I. Du Pont De Nemours And Company External regulation of gene expression
EP0452269B1 (en) 1990-04-12 2002-10-09 Syngenta Participations AG Tissue-preferential promoters
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1991017424A1 (en) 1990-05-03 1991-11-14 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
US5498830A (en) 1990-06-18 1996-03-12 Monsanto Company Decreased oil content in plant seeds
CA2051562C (en) 1990-10-12 2003-12-02 Jewel M. Payne Bacillus thuringiensis isolates active against dipteran pests
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5399680A (en) 1991-05-22 1995-03-21 The Salk Institute For Biological Studies Rice chitinase promoter
CA2116449C (en) 1991-08-27 2005-04-05 Vaughan Alan Hilder Proteins with insecticidal properties against homopteran insects and their use in plant protection
TW261517B (https=) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5789156A (en) 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5608144A (en) 1994-08-12 1997-03-04 Dna Plant Technology Corp. Plant group 2 promoters and uses thereof
US5659026A (en) 1995-03-24 1997-08-19 Pioneer Hi-Bred International ALS3 promoter
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
CA2315546C (en) 1998-02-26 2008-04-29 Pioneer Hi-Bred International, Inc. Constitutive maize promoters
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
CZ20013894A3 (cs) 1999-05-04 2002-04-17 Monsanto Technology Llc Polypeptidové kompozice toxické pro hmyz z řádu Coleoptera a transgenní rostliny rezistentní proti hmyzu
AU7491600A (en) 1999-09-15 2001-04-17 Monsanto Technology Llc Lepidopteran-active bacillus thuringiensis delta-endotoxin compositions and methods of use
DK2359869T3 (en) 2001-12-17 2019-04-15 Univ Pennsylvania Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof
US20050183161A1 (en) 2003-10-14 2005-08-18 Athenix Corporation AXMI-010, a delta-endotoxin gene and methods for its use
US7629504B2 (en) 2003-12-22 2009-12-08 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry9 nucleic acids
NZ573398A (en) 2006-06-14 2011-11-25 Athenix Corp Axmi-031, axmi-039, axmi-040 and axmi-049, a family of delta-endotoxin genes and methods for their use
EP2334794B8 (en) 2008-09-15 2017-04-19 The Children's Medical Center Corporation Modulation of bcl11a for treatment of hemoglobinopathies
WO2010132092A2 (en) 2009-05-12 2010-11-18 The Scripps Research Institute Cytidine deaminase fusions and related methods
MX346215B (es) 2009-07-02 2017-03-10 Athenix Corp Gen plaguicida axmi-205 y metodos para su uso.
US20130011380A1 (en) * 2009-12-18 2013-01-10 Blau Helen M Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming
WO2011084324A2 (en) 2009-12-21 2011-07-14 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis gene with lepidopteran activity
WO2012024200A2 (en) 2010-08-19 2012-02-23 Pioneer Hi-Bred International, Inc. Novel bacillus thuringiensis gene with lepidopteran activity
US9405700B2 (en) 2010-11-04 2016-08-02 Sonics, Inc. Methods and apparatus for virtualization in an integrated circuit
WO2013138644A2 (en) * 2012-03-15 2013-09-19 New England Biolabs, Inc. Methods and compositions for discrimination between cytosine and modifications thereof, and for methylome analysis
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
DK3444342T3 (da) 2012-07-11 2020-08-24 Sangamo Therapeutics Inc Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
CA2894684A1 (en) * 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
EP3633032A3 (en) 2014-08-28 2020-07-29 North Carolina State University Novel cas9 proteins and guiding features for dna targeting and genome editing
AU2015101792A4 (en) * 2014-12-24 2016-01-28 Massachusetts Institute Of Technology Engineering of systems, methods and optimized enzyme and guide scaffolds for sequence manipulation
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
EP4400597A3 (en) * 2015-10-09 2024-10-16 Monsanto Technology LLC Novel rna-guided nucleases and uses thereof
JP7109784B2 (ja) * 2015-10-23 2022-08-01 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したCas9蛋白質
CA3010628A1 (en) * 2016-03-11 2017-09-14 Pioneer Hi-Bred International, Inc. Novel cas9 systems and methods of use
KR102547316B1 (ko) 2016-08-03 2023-06-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
EP3526320A1 (en) * 2016-10-14 2019-08-21 President and Fellows of Harvard College Aav delivery of nucleobase editors
KR102151065B1 (ko) * 2016-12-23 2020-09-02 기초과학연구원 동물 배아의 염기 교정용 조성물 및 염기 교정 방법
EP3572525A4 (en) * 2017-01-17 2020-09-30 Institute for Basic Science PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND
AU2018240515B2 (en) * 2017-03-24 2024-07-25 CureVac SE Nucleic acids encoding CRISPR-associated proteins and uses thereof
EP3625342B1 (en) * 2017-05-18 2022-08-24 The Broad Institute, Inc. Systems, methods, and compositions for targeted nucleic acid editing
CN109957569B (zh) * 2017-12-22 2022-10-25 苏州齐禾生科生物科技有限公司 基于cpf1蛋白的碱基编辑系统和方法
CN112961853B (zh) * 2018-11-02 2024-09-06 中国科学院动物研究所 基于C2c1核酸酶的基因组编辑系统和方法
KR20220062289A (ko) * 2019-08-12 2022-05-16 라이프에디트 테라퓨틱스, 인크. Rna-가이드된 뉴클레아제 및 그의 활성 단편 및 변이체 및 사용 방법

Similar Documents

Publication Publication Date Title
JP2022516130A5 (https=)
BR112019017762A2 (https=)
BR112021017339A2 (https=)
BR112021018450A2 (https=)
BR112021017637A2 (https=)
BR112021017892A2 (https=)
BR112021017782A2 (https=)
BR112021017939A2 (https=)
BR112021017738A2 (https=)
BR112021008711A2 (https=)
BR112019016141A2 (https=)
BR112021017728A2 (https=)
AU2020104490A5 (https=)
BR112021013944A2 (https=)
BR112021018452A2 (https=)
BR112021017703A2 (https=)
BR112021018102A2 (https=)
BR112019016142A2 (https=)
BR112019016138A2 (https=)
BR112021017732A2 (https=)
BR112021017355A2 (https=)
BR112021018168A2 (https=)
BR112021018093A2 (https=)
BR112021012348A2 (https=)
BR112021018250A2 (https=)