JP2022530055A5 - - Google Patents

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Publication number
JP2022530055A5
JP2022530055A5 JP2021563030A JP2021563030A JP2022530055A5 JP 2022530055 A5 JP2022530055 A5 JP 2022530055A5 JP 2021563030 A JP2021563030 A JP 2021563030A JP 2021563030 A JP2021563030 A JP 2021563030A JP 2022530055 A5 JP2022530055 A5 JP 2022530055A5
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JP
Japan
Prior art keywords
host cell
amino acid
dna sequence
variant
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021563030A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530055A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/029855 external-priority patent/WO2020219908A1/en
Publication of JP2022530055A publication Critical patent/JP2022530055A/ja
Publication of JP2022530055A5 publication Critical patent/JP2022530055A5/ja
Pending legal-status Critical Current

Links

JP2021563030A 2019-04-25 2020-04-24 拡張されたｄｎａ標的化範囲を有する操作されたｃａｓ９ Pending JP2022530055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962838498P 2019-04-25 2019-04-25
US62/838,498 2019-04-25
PCT/US2020/029855 WO2020219908A1 (en) 2019-04-25 2020-04-24 Engineered cas9 with broadened dna targeting range

Publications (2)

Publication Number Publication Date
JP2022530055A JP2022530055A (ja) 2022-06-27
JP2022530055A5 true JP2022530055A5 (https=) 2023-04-20

Family

ID=72941444

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021563030A Pending JP2022530055A (ja) 2019-04-25 2020-04-24 拡張されたｄｎａ標的化範囲を有する操作されたｃａｓ９

Country Status (12)

Country Link
US (1) US20220204954A1 (https=)
EP (1) EP3958914A4 (https=)
JP (1) JP2022530055A (https=)
KR (1) KR20220025708A (https=)
CN (1) CN114206394A (https=)
AU (1) AU2020261071A1 (https=)
BR (1) BR112021021306A2 (https=)
CA (1) CA3137903A1 (https=)
IL (1) IL287541A (https=)
MX (1) MX2021012966A (https=)
SG (1) SG11202111814XA (https=)
WO (1) WO2020219908A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
EP3823633A4 (en) 2018-06-29 2023-05-03 Editas Medicine, Inc. SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
CN115083532B (zh) * 2022-06-21 2024-08-27 中国科学技术大学 基于分子动力学模拟获取rsv f突变体的方法
CN115927439B (zh) * 2022-08-29 2026-04-21 中国农业科学院作物科学研究所 CRISPR/SaCas9系统在大豆基因编辑中的应用
US20250001010A1 (en) 2023-06-30 2025-01-02 Christiana Care Gene Editing Institute, Inc. Nras gene knockout for treatment of cancer
CN117866926B (zh) * 2024-03-07 2024-08-16 珠海舒桐医疗科技有限公司 一种CRISPR-FrCas9蛋白突变体及应用
US20250319206A1 (en) 2024-04-04 2025-10-16 Christina Care Gene Editing Institute, Inc. Crispr/cas gene editing of neh4 and/or neh5 domains in nrf2
WO2025226816A1 (en) 2024-04-23 2025-10-30 Christiana Care Gene Editing Institute, Inc. Methods of identifying and correlating crispr-induced exon skipping to phenotypic outcomes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230156800A (ko) * 2015-03-03 2023-11-14 더 제너럴 하스피탈 코포레이션 변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
US9512446B1 (en) * 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
CN110214183A (zh) * 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
KR20230125856A (ko) * 2016-12-23 2023-08-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Pcsk9의 유전자 편집
EP3680331A4 (en) * 2017-09-05 2021-06-09 The University Of Tokyo MODIFIED CAS9 PROTEIN AND USE OF IT

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