BR112021012665A2 - Polipeptídeos úteis para edição de genes e métodos de uso - Google Patents
Polipeptídeos úteis para edição de genes e métodos de usoInfo
- Publication number
- BR112021012665A2 BR112021012665A2 BR112021012665A BR112021012665A BR112021012665A2 BR 112021012665 A2 BR112021012665 A2 BR 112021012665A2 BR 112021012665 A BR112021012665 A BR 112021012665A BR 112021012665 A BR112021012665 A BR 112021012665A BR 112021012665 A2 BR112021012665 A2 BR 112021012665A2
- Authority
- BR
- Brazil
- Prior art keywords
- interest
- target sequence
- binding
- methods
- crispr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862785391P | 2018-12-27 | 2018-12-27 | |
| US201962790256P | 2019-01-09 | 2019-01-09 | |
| US201962790266P | 2019-01-09 | 2019-01-09 | |
| US201962790258P | 2019-01-09 | 2019-01-09 | |
| US201962790262P | 2019-01-09 | 2019-01-09 | |
| US201962790261P | 2019-01-09 | 2019-01-09 | |
| US201962932169P | 2019-11-07 | 2019-11-07 | |
| PCT/US2019/068079 WO2020139783A2 (en) | 2018-12-27 | 2019-12-20 | Polypeptides useful for gene editing and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021012665A2 true BR112021012665A2 (pt) | 2021-11-03 |
Family
ID=69182752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021012665A BR112021012665A2 (pt) | 2018-12-27 | 2019-12-20 | Polipeptídeos úteis para edição de genes e métodos de uso |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20220145296A1 (https=) |
| EP (2) | EP4339286A3 (https=) |
| JP (3) | JP7572360B2 (https=) |
| KR (1) | KR20210149686A (https=) |
| CN (1) | CN113631704A (https=) |
| AU (2) | AU2019416108B2 (https=) |
| BR (1) | BR112021012665A2 (https=) |
| ES (1) | ES2970169T3 (https=) |
| IL (2) | IL312708A (https=) |
| MX (1) | MX2021007835A (https=) |
| NZ (1) | NZ778392A (https=) |
| SG (1) | SG11202106977PA (https=) |
| TW (1) | TW202039847A (https=) |
| WO (1) | WO2020139783A2 (https=) |
| ZA (1) | ZA202105281B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PL3802807T3 (pl) * | 2018-06-05 | 2025-03-31 | Life Edit Therapeutics, Inc. | Nukleazy kierowane rna i ich aktywne fragmenty oraz warianty i sposoby ich zastosowania |
| TW202208626A (zh) | 2020-04-24 | 2022-03-01 | 美商生命編輯公司 | Rna引導核酸酶及其活性片段與變體，以及使用方法 |
| AU2021300378A1 (en) | 2020-07-01 | 2023-01-19 | Elevatebio Technologies, Inc. | Compositions and methods for cellular reprogramming using circular RNA |
| US20240247242A1 (en) * | 2020-07-15 | 2024-07-25 | LifeEDIT Therapeutics, Inc. | Uracil stabilizing proteins and active fragments and variants thereof and methods of use |
| MX2023002848A (es) * | 2020-09-11 | 2023-03-22 | Lifeedit Therapeutics Inc | Enzimas modificadoras del acido desoxirribonucleico (adn) y fragmentos activos y sus variantes y metodos de uso. |
| US20240301385A1 (en) * | 2021-03-22 | 2024-09-12 | LifeEDIT Therapeutics, Inc. | Dna modifying enzymes and active fragments and variants thereof and methods of use |
| AU2022272250A1 (en) * | 2021-05-14 | 2023-11-30 | Beam Therapeutics Inc. | Compositions and methods for treating transthyretin amyloidosis |
| EP4101928A1 (en) * | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| AU2022290382A1 (en) * | 2021-06-11 | 2023-11-23 | Bayer Aktiengesellschaft | Type v rna programmable endonuclease systems |
| EP4352215A1 (en) | 2021-06-11 | 2024-04-17 | LifeEDIT Therapeutics, Inc. | Rna polymerase iii promoters and methods of use |
| AU2022336615A1 (en) | 2021-09-02 | 2024-04-11 | Sanofi Pasteur Inc. | Compositions and methods for rna affinity purification |
| WO2023057444A1 (en) | 2021-10-05 | 2023-04-13 | Sanofi | METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME |
| EP4453191A1 (en) * | 2021-12-23 | 2024-10-30 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| CA3248846A1 (en) | 2022-01-17 | 2023-07-20 | Sanofi | Lipid Compounds and Their Uses |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| CA3243220A1 (en) * | 2022-01-24 | 2023-07-27 | LifeEDIT Therapeutics, Inc. | RNA-GUIDED NUCLEASE AND ACTIVE FRAGMENTS, ASSOCIATED VARIANTS AND METHODS OF USE |
| JP2025520538A (ja) | 2022-06-17 | 2025-07-03 | サノフィ パスツール インコーポレイテッド | 環状ｒｎａ親和性精製のための組成物及び方法 |
| JP2025525569A (ja) | 2022-07-18 | 2025-08-05 | レナゲード セラピューティクス マネージメント インコーポレイテッド | 遺伝子編集成分、システム、及び使用方法 |
| EP4569093A1 (en) | 2022-08-12 | 2025-06-18 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| CA3265664A1 (en) | 2022-08-25 | 2024-02-29 | Life Edit Therapeutics, Inc. | CHEMICAL MODIFICATION OF GUIDE RNA WITH A LOCKED NUCLEIC ACID FOR RNA-GUIDED NUCLEASE-MEDIATED GENE EDITING |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| KR20250126155A (ko) | 2022-11-04 | 2025-08-22 | 라이프 에디트 테라퓨틱스, 인크. | 내부 삽입 부위를 갖는 진화된 아데닌 데아미나제 및 rna-가이드 뉴클레아제 융합 단백질 및 사용 방법 |
| WO2024127370A1 (en) | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
| EP4634383A1 (en) | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2024235991A1 (en) * | 2023-05-15 | 2024-11-21 | UCB Biopharma SRL | Rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases |
| WO2025003344A1 (en) * | 2023-06-28 | 2025-01-02 | Alia Therapeutics Srl | Type ii cas proteins and applications thereof |
| WO2025022367A2 (en) | 2023-07-27 | 2025-01-30 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| AU2024357861A1 (en) | 2023-10-12 | 2026-04-23 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025083619A1 (en) | 2023-10-18 | 2025-04-24 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and acive fragments and variants thereof and methods of use |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025174908A1 (en) | 2024-02-12 | 2025-08-21 | Life Edit Therapeutics, Inc. | Novel rna-guided nucleases and proteins for polymerase editing |
| CN120608040A (zh) * | 2024-03-07 | 2025-09-09 | 清华大学 | 一种用于基因编辑和/或抵抗噬菌体的系统及其应用 |
| WO2025231360A1 (en) * | 2024-05-03 | 2025-11-06 | Modernatx, Inc. | Novel cas nucleases and polynucleotides encoding the same |
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| EP3572525A4 (en) * | 2017-01-17 | 2020-09-30 | Institute for Basic Science | PROCEDURE FOR IDENTIFYING AN OFF-TARGET BASIC EDITING SITE BY BREAKING A SINGLE DNA STRAND |
| SG11201906297QA (en) * | 2017-03-24 | 2019-10-30 | Curevac Ag | Nucleic acids encoding crispr-associated proteins and uses thereof |
| WO2018213726A1 (en) * | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CN109957569B (zh) * | 2017-12-22 | 2022-10-25 | 苏州齐禾生科生物科技有限公司 | 基于cpf1蛋白的碱基编辑系统和方法 |
| CN109337904B (zh) * | 2018-11-02 | 2020-12-25 | 中国科学院动物研究所 | 基于C2c1核酸酶的基因组编辑系统和方法 |
| WO2021030344A1 (en) * | 2019-08-12 | 2021-02-18 | Lifeedit, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
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