KR20210149686A - 유전자 편집에 유용한 폴리펩티드 및 사용 방법 - Google Patents
유전자 편집에 유용한 폴리펩티드 및 사용 방법 Download PDFInfo
- Publication number
- KR20210149686A KR20210149686A KR1020217023648A KR20217023648A KR20210149686A KR 20210149686 A KR20210149686 A KR 20210149686A KR 1020217023648 A KR1020217023648 A KR 1020217023648A KR 20217023648 A KR20217023648 A KR 20217023648A KR 20210149686 A KR20210149686 A KR 20210149686A
- Authority
- KR
- South Korea
- Prior art keywords
- seq
- sequence
- position corresponding
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862785391P | 2018-12-27 | 2018-12-27 | |
| US62/785,391 | 2018-12-27 | ||
| US201962790266P | 2019-01-09 | 2019-01-09 | |
| US201962790256P | 2019-01-09 | 2019-01-09 | |
| US201962790261P | 2019-01-09 | 2019-01-09 | |
| US201962790262P | 2019-01-09 | 2019-01-09 | |
| US201962790258P | 2019-01-09 | 2019-01-09 | |
| US62/790,258 | 2019-01-09 | ||
| US62/790,266 | 2019-01-09 | ||
| US62/790,261 | 2019-01-09 | ||
| US62/790,256 | 2019-01-09 | ||
| US62/790,262 | 2019-01-09 | ||
| US201962932169P | 2019-11-07 | 2019-11-07 | |
| US62/932,169 | 2019-11-07 | ||
| PCT/US2019/068079 WO2020139783A2 (en) | 2018-12-27 | 2019-12-20 | Polypeptides useful for gene editing and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210149686A true KR20210149686A (ko) | 2021-12-09 |
Family
ID=69182752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217023648A Pending KR20210149686A (ko) | 2018-12-27 | 2019-12-20 | 유전자 편집에 유용한 폴리펩티드 및 사용 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20220145296A1 (https=) |
| EP (2) | EP3902911B1 (https=) |
| JP (3) | JP7572360B2 (https=) |
| KR (1) | KR20210149686A (https=) |
| CN (1) | CN113631704A (https=) |
| AU (2) | AU2019416108B2 (https=) |
| BR (1) | BR112021012665A2 (https=) |
| ES (1) | ES2970169T3 (https=) |
| IL (2) | IL312708A (https=) |
| MX (1) | MX2021007835A (https=) |
| NZ (1) | NZ778392A (https=) |
| SG (1) | SG11202106977PA (https=) |
| TW (1) | TW202039847A (https=) |
| WO (1) | WO2020139783A2 (https=) |
| ZA (1) | ZA202105281B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BR112020024863A2 (pt) * | 2018-06-05 | 2022-02-01 | Lifeedit Inc | Nucleases guiadas por rna, fragmentos ativos e variantes das mesmas e métodos de uso |
| TW202208626A (zh) * | 2020-04-24 | 2022-03-01 | 美商生命編輯公司 | Rna引導核酸酶及其活性片段與變體，以及使用方法 |
| CA3174356A1 (en) | 2020-07-01 | 2022-01-06 | Santosh NARAYAN | Compositions and methods for cellular reprogramming using circular rna |
| JP2023534693A (ja) * | 2020-07-15 | 2023-08-10 | ライフエディット セラピューティクス，インコーポレイティド | ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法 |
| TWI910226B (zh) * | 2020-09-11 | 2026-01-01 | 美商生命編輯治療學公司 | Ｄｎａ修飾酶及活性片段，及其變異體與使用方法 |
| CN117295817A (zh) | 2021-03-22 | 2023-12-26 | 生命编辑制药股份有限公司 | Dna修饰酶及其活性片段和变体以及使用方法 |
| WO2022241270A2 (en) * | 2021-05-14 | 2022-11-17 | Beam Therapeutics Inc. | Compositions and methods for treating transthyretin amyloidosis |
| AU2022290278A1 (en) | 2021-06-11 | 2024-01-04 | LifeEDIT Therapeutics, Inc. | Rna polymerase iii promoters and methods of use |
| EP4101928A1 (en) * | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| US20240141312A1 (en) * | 2021-06-11 | 2024-05-02 | Bayer Aktiengesellschaft | Type v rna programmable endonuclease systems |
| AU2022336615A1 (en) | 2021-09-02 | 2024-04-11 | Sanofi Pasteur Inc. | Compositions and methods for rna affinity purification |
| AU2022359812A1 (en) | 2021-10-05 | 2024-05-16 | Sanofi Pasteur Inc. | METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME |
| WO2023118068A1 (en) * | 2021-12-23 | 2023-06-29 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| CN118829624A (zh) | 2022-01-17 | 2024-10-22 | 赛诺菲 | 脂质化合物及其用途 |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| CN119317713A (zh) | 2022-01-24 | 2025-01-14 | 生命编辑制药股份有限公司 | Rna引导核酸酶、其活性片段与变体，及使用方法 |
| EP4539858A1 (en) | 2022-06-17 | 2025-04-23 | Sanofi Pasteur Inc. | Compositions and methods for circular rna affinity purification |
| JP2025525569A (ja) | 2022-07-18 | 2025-08-05 | レナゲード セラピューティクス マネージメント インコーポレイテッド | 遺伝子編集成分、システム、及び使用方法 |
| CA3264752A1 (en) | 2022-08-12 | 2024-02-15 | Life Edit Therapeutics, Inc. | RNA-GUIDED NUCLEASE AND ACTIVE FRAGMENTS, ASSOCIATED VARIANTS AND METHODS OF USE |
| TW202424186A (zh) | 2022-08-25 | 2024-06-16 | 美商生命編輯治療學公司 | Rna引導核酸酶中介基因編輯用之具鎖核酸引導 rna之化學修飾 |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| EP4612284A2 (en) | 2022-11-04 | 2025-09-10 | Life Edit Therapeutics, Inc. | Evolved adenine deaminases and rna-guided nuclease fusion proteins with internal insertion sites and methods of use |
| CA3277009A1 (en) | 2022-12-16 | 2024-06-20 | Life Edit Therapeutics, Inc. | RNA GUIDELINES TARGETING THE TRAC GENE AND METHODS OF USE |
| EP4634383A1 (en) | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2024235991A1 (en) * | 2023-05-15 | 2024-11-21 | UCB Biopharma SRL | Rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases |
| WO2025003344A1 (en) * | 2023-06-28 | 2025-01-02 | Alia Therapeutics Srl | Type ii cas proteins and applications thereof |
| WO2025022367A2 (en) | 2023-07-27 | 2025-01-30 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025083619A1 (en) | 2023-10-18 | 2025-04-24 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and acive fragments and variants thereof and methods of use |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| TW202546224A (zh) | 2024-02-12 | 2025-12-01 | 美商生命編輯治療學公司 | 新穎的ｒｎａ引導之核酸酶及用於聚合酶編輯之蛋白質 |
| CN120608040A (zh) * | 2024-03-07 | 2025-09-09 | 清华大学 | 一种用于基因编辑和/或抵抗噬菌体的系统及其应用 |
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| EP3526320A1 (en) * | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
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| EP3625342B1 (en) * | 2017-05-18 | 2022-08-24 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| CN109957569B (zh) * | 2017-12-22 | 2022-10-25 | 苏州齐禾生科生物科技有限公司 | 基于cpf1蛋白的碱基编辑系统和方法 |
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| KR20220062289A (ko) * | 2019-08-12 | 2022-05-16 | 라이프에디트 테라퓨틱스, 인크. | Rna-가이드된 뉴클레아제 및 그의 활성 단편 및 변이체 및 사용 방법 |
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| EP3902911A2 (en) | 2021-11-03 |
| EP3902911B1 (en) | 2023-12-13 |
| ES2970169T3 (es) | 2024-05-27 |
| AU2019416108A1 (en) | 2021-08-12 |
| AU2025242270A1 (en) | 2025-10-30 |
| US12188018B2 (en) | 2025-01-07 |
| EP3902911C0 (en) | 2023-12-13 |
| SG11202106977PA (en) | 2021-07-29 |
| US20230272398A1 (en) | 2023-08-31 |
| AU2019416108B2 (en) | 2025-10-23 |
| JP7572360B2 (ja) | 2024-10-23 |
| CN113631704A (zh) | 2021-11-09 |
| US20250092398A1 (en) | 2025-03-20 |
| EP4339286A2 (en) | 2024-03-20 |
| JP2024137967A (ja) | 2024-10-07 |
| US20250066783A1 (en) | 2025-02-27 |
| JP2024050676A (ja) | 2024-04-10 |
| WO2020139783A2 (en) | 2020-07-02 |
| MX2021007835A (es) | 2021-08-11 |
| JP2022516130A (ja) | 2022-02-24 |
| ZA202105281B (en) | 2024-05-30 |
| IL312708A (en) | 2024-07-01 |
| NZ778392A (en) | 2025-11-28 |
| EP4339286A3 (en) | 2024-08-28 |
| IL284400A (en) | 2021-08-31 |
| TW202039847A (zh) | 2020-11-01 |
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