|
US4217344A
(en)
|
1976-06-23 |
1980-08-12 |
L'oreal |
Compositions containing aqueous dispersions of lipid spheres
|
|
US4196265A
(en)
|
1977-06-15 |
1980-04-01 |
The Wistar Institute |
Method of producing antibodies
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4186183A
(en)
|
1978-03-29 |
1980-01-29 |
The United States Of America As Represented By The Secretary Of The Army |
Liposome carriers in chemotherapy of leishmaniasis
|
|
US4261975A
(en)
|
1979-09-19 |
1981-04-14 |
Merck & Co., Inc. |
Viral liposome particle
|
|
US4485054A
(en)
|
1982-10-04 |
1984-11-27 |
Lipoderm Pharmaceuticals Limited |
Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5380831A
(en)
|
1986-04-04 |
1995-01-10 |
Mycogen Plant Science, Inc. |
Synthetic insecticidal crystal protein gene
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5569597A
(en)
|
1985-05-13 |
1996-10-29 |
Ciba Geigy Corp. |
Methods of inserting viral DNA into plant material
|
|
US4774085A
(en)
|
1985-07-09 |
1988-09-27 |
501 Board of Regents, Univ. of Texas |
Pharmaceutical administration systems containing a mixture of immunomodulators
|
|
US4853331A
(en)
|
1985-08-16 |
1989-08-01 |
Mycogen Corporation |
Cloning and expression of Bacillus thuringiensis toxin gene toxic to beetles of the order Coleoptera
|
|
US5268463A
(en)
|
1986-11-11 |
1993-12-07 |
Jefferson Richard A |
Plant promoter α-glucuronidase gene construct
|
|
US5608142A
(en)
|
1986-12-03 |
1997-03-04 |
Agracetus, Inc. |
Insecticidal cotton plants
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5039523A
(en)
|
1988-10-27 |
1991-08-13 |
Mycogen Corporation |
Novel Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
|
|
EP0388186A1
(en)
|
1989-03-17 |
1990-09-19 |
E.I. Du Pont De Nemours And Company |
External regulation of gene expression
|
|
ATE225853T1
(de)
|
1990-04-12 |
2002-10-15 |
Syngenta Participations Ag |
Gewebe-spezifische promotoren
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
US5498830A
(en)
|
1990-06-18 |
1996-03-12 |
Monsanto Company |
Decreased oil content in plant seeds
|
|
CA2051562C
(en)
|
1990-10-12 |
2003-12-02 |
Jewel M. Payne |
Bacillus thuringiensis isolates active against dipteran pests
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5399680A
(en)
|
1991-05-22 |
1995-03-21 |
The Salk Institute For Biological Studies |
Rice chitinase promoter
|
|
US5604121A
(en)
|
1991-08-27 |
1997-02-18 |
Agricultural Genetics Company Limited |
Proteins with insecticidal properties against homopteran insects and their use in plant protection
|
|
TW261517B
(https=)
|
1991-11-29 |
1995-11-01 |
Mitsubishi Shozi Kk |
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5789156A
(en)
|
1993-06-14 |
1998-08-04 |
Basf Ag |
Tetracycline-regulated transcriptional inhibitors
|
|
US5814618A
(en)
|
1993-06-14 |
1998-09-29 |
Basf Aktiengesellschaft |
Methods for regulating gene expression
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5608144A
(en)
|
1994-08-12 |
1997-03-04 |
Dna Plant Technology Corp. |
Plant group 2 promoters and uses thereof
|
|
US5659026A
(en)
|
1995-03-24 |
1997-08-19 |
Pioneer Hi-Bred International |
ALS3 promoter
|
|
US6072050A
(en)
|
1996-06-11 |
2000-06-06 |
Pioneer Hi-Bred International, Inc. |
Synthetic promoters
|
|
AR014072A1
(es)
|
1998-02-26 |
2001-01-31 |
Pioneer Hi Bred Int |
Molecula de acido nucleico aislada que tiene una secuencia nucleotidica para un promotor que es capaz de iniciar una transcripcion constitutiva en unacelula de planta, construccion adn, vector, celula huesped, metodo para expresar en forma constitutiva una secuencia nucleotidica heteroloca en una
|
|
US6484690B2
(en)
|
1999-01-06 |
2002-11-26 |
Hitachi, Ltd. |
Control equipment for internal combustion engines
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6555655B1
(en)
|
1999-05-04 |
2003-04-29 |
Monsanto Technology, Llc |
Coleopteran-toxic polypeptide compositions and insect-resistant transgenic plants
|
|
US6593293B1
(en)
|
1999-09-15 |
2003-07-15 |
Monsanto Technology, Llc |
Lepidopteran-active Bacillus thuringiensis δ-endotoxin compositions and methods of use
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
US20050183161A1
(en)
|
2003-10-14 |
2005-08-18 |
Athenix Corporation |
AXMI-010, a delta-endotoxin gene and methods for its use
|
|
WO2005066202A2
(en)
|
2003-12-22 |
2005-07-21 |
E.I. Du Pont De Nemours And Company |
Bacillus cry9 family members
|
|
AU2007260716B2
(en)
|
2006-06-14 |
2013-05-02 |
BASF Agricultural Solutions Seed US LLC |
Axmi-031, axmi-039, axmi-040 and axmi-049, a family of delta-endotoxin genes and methods for their use
|
|
US8383604B2
(en)
|
2008-09-15 |
2013-02-26 |
Children's Medical Center Corporation |
Modulation of BCL11A for treatment of hemoglobinopathies
|
|
US9392788B2
(en)
*
|
2008-11-07 |
2016-07-19 |
North Carolina State University |
Mosquito attractant compositions and methods
|
|
ES2609332T3
(es)
|
2009-07-02 |
2017-04-19 |
Athenix Corporation |
Gen pesticida AXMI-205 y métodos para su uso
|
|
WO2011084324A2
(en)
|
2009-12-21 |
2011-07-14 |
Pioneer Hi-Bred International, Inc. |
Novel bacillus thuringiensis gene with lepidopteran activity
|
|
WO2012024200A2
(en)
|
2010-08-19 |
2012-02-23 |
Pioneer Hi-Bred International, Inc. |
Novel bacillus thuringiensis gene with lepidopteran activity
|
|
US9405700B2
(en)
|
2010-11-04 |
2016-08-02 |
Sonics, Inc. |
Methods and apparatus for virtualization in an integrated circuit
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP3196301B1
(en)
|
2012-07-11 |
2018-10-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of monogenic diseases
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
AU2016263026A1
(en)
*
|
2015-05-15 |
2017-11-09 |
Pioneer Hi-Bred International, Inc. |
Guide RNA/Cas endonuclease systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
AU2016380351B2
(en)
*
|
2015-12-29 |
2023-04-06 |
Monsanto Technology Llc |
Novel CRISPR-associated transposases and uses thereof
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
SG11201906297QA
(en)
*
|
2017-03-24 |
2019-10-30 |
Curevac Ag |
Nucleic acids encoding crispr-associated proteins and uses thereof
|
|
WO2019165168A1
(en)
*
|
2018-02-23 |
2019-08-29 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 orthologs
|
|
WO2020139873A1
(en)
|
2018-12-24 |
2020-07-02 |
Virginia Polytechnic Institute And State University |
Tollip deficient neutrophils and uses thereof
|
|
KR20210149686A
(ko)
*
|
2018-12-27 |
2021-12-09 |
라이프에디트 테라퓨틱스, 인크. |
유전자 편집에 유용한 폴리펩티드 및 사용 방법
|
|
JP2023531384A
(ja)
*
|
2020-06-04 |
2023-07-24 |
エメンドバイオ・インコーポレイテッド |
新規なｏｍｎｉ－５９、６１、６７、７６、７９、８０、８１及び８２クリスパーヌクレアーゼ
|
|
EP4274894A2
(en)
|
2021-01-11 |
2023-11-15 |
The Broad Institute, Inc. |
Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision
|