JP2023036848A5 - - Google Patents
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- Publication number
- JP2023036848A5 JP2023036848A5 JP2022208226A JP2022208226A JP2023036848A5 JP 2023036848 A5 JP2023036848 A5 JP 2023036848A5 JP 2022208226 A JP2022208226 A JP 2022208226A JP 2022208226 A JP2022208226 A JP 2022208226A JP 2023036848 A5 JP2023036848 A5 JP 2023036848A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- amino acids
- polypeptide
- amino acid
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940024606 amino acid Drugs 0.000 claims 60
- 235000001014 amino acid Nutrition 0.000 claims 60
- 150000001413 amino acids Chemical class 0.000 claims 60
- 229920001184 polypeptide Polymers 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 11
- 235000009582 asparagine Nutrition 0.000 claims 10
- 229960001230 asparagine Drugs 0.000 claims 10
- 235000018102 proteins Nutrition 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 8
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 8
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 6
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical group OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 6
- 235000003704 aspartic acid Nutrition 0.000 claims 6
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Chemical group OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 6
- 229930024421 Adenine Natural products 0.000 claims 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- 229960000643 adenine Drugs 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 4
- 229940035893 uracil Drugs 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 2
- 102000034287 fluorescent proteins Human genes 0.000 claims 2
- 108091006047 fluorescent proteins Proteins 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024109757A JP7749763B2 (ja) | 2019-05-29 | 2024-07-08 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| JP2025158040A JP2025181985A (ja) | 2019-05-29 | 2025-09-24 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019100553 | 2019-05-29 | ||
| JP2019100553 | 2019-05-29 | ||
| JP2021521908A JP7308468B2 (ja) | 2019-05-29 | 2020-05-29 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| PCT/JP2020/021473 WO2020241877A1 (ja) | 2019-05-29 | 2020-05-29 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521908A Division JP7308468B2 (ja) | 2019-05-29 | 2020-05-29 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109757A Division JP7749763B2 (ja) | 2019-05-29 | 2024-07-08 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023036848A JP2023036848A (ja) | 2023-03-14 |
| JP2023036848A5 true JP2023036848A5 (https=) | 2023-06-05 |
| JP7526399B2 JP7526399B2 (ja) | 2024-08-01 |
Family
ID=73552159
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521908A Active JP7308468B2 (ja) | 2019-05-29 | 2020-05-29 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| JP2022208226A Active JP7526399B2 (ja) | 2019-05-29 | 2022-12-26 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| JP2024109757A Active JP7749763B2 (ja) | 2019-05-29 | 2024-07-08 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| JP2025158040A Pending JP2025181985A (ja) | 2019-05-29 | 2025-09-24 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521908A Active JP7308468B2 (ja) | 2019-05-29 | 2020-05-29 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024109757A Active JP7749763B2 (ja) | 2019-05-29 | 2024-07-08 | 凝集の少ないｐｐｒタンパク質及びその利用 |
| JP2025158040A Pending JP2025181985A (ja) | 2019-05-29 | 2025-09-24 | 凝集の少ないｐｐｒタンパク質及びその利用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12559528B2 (https=) |
| EP (1) | EP3977849A4 (https=) |
| JP (4) | JP7308468B2 (https=) |
| KR (1) | KR102898966B1 (https=) |
| CN (1) | CN113966340A (https=) |
| AU (2) | AU2020283367B2 (https=) |
| CA (1) | CA3142303A1 (https=) |
| IL (2) | IL288417B2 (https=) |
| SG (1) | SG11202113057XA (https=) |
| WO (1) | WO2020241877A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7125727B1 (ja) | 2021-09-07 | 2022-08-25 | 国立大学法人千葉大学 | 核酸配列改変用組成物および核酸配列の標的部位を改変する方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006188507A (ja) * | 2004-12-10 | 2006-07-20 | Tokyo Univ Of Agriculture & Technology | 蛋白質の溶解度向上方法 |
| WO2013058404A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人九州大学 | Pprモチーフを利用したrna結合性蛋白質の設計方法及びその利用 |
| KR102893770B1 (ko) * | 2013-04-22 | 2025-11-28 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | 피피알 단백질을 이용하는 dna 결합성 단백질 및 그의 이용 |
| WO2017209122A1 (ja) | 2016-06-03 | 2017-12-07 | 国立大学法人九州大学 | 標的ｍＲＮＡからのタンパク質発現量を向上させるための融合タンパク質 |
| JPWO2018030488A1 (ja) | 2016-08-10 | 2019-06-13 | 富士フイルム和光純薬株式会社 | Ｐｐｒモチーフを利用したｄｎａ結合性タンパク質およびその利用 |
| JP6918686B2 (ja) | 2017-11-28 | 2021-08-11 | 東芝ライフスタイル株式会社 | 冷蔵庫 |
| KR102568600B1 (ko) | 2018-02-19 | 2023-08-23 | 삼성디스플레이 주식회사 | 표시 장치, 이를 포함하는 적층 기판, 및 표시 장치 제조방법 |
| CN114729017A (zh) * | 2019-05-29 | 2022-07-08 | 日商基因编辑力股份有限公司 | Ppr蛋白的有效制作方法及其应用 |
-
2020
- 2020-05-29 EP EP20812826.4A patent/EP3977849A4/en active Pending
- 2020-05-29 CA CA3142303A patent/CA3142303A1/en active Pending
- 2020-05-29 AU AU2020283367A patent/AU2020283367B2/en active Active
- 2020-05-29 IL IL288417A patent/IL288417B2/en unknown
- 2020-05-29 SG SG11202113057XA patent/SG11202113057XA/en unknown
- 2020-05-29 WO PCT/JP2020/021473 patent/WO2020241877A1/ja not_active Ceased
- 2020-05-29 US US17/614,236 patent/US12559528B2/en active Active
- 2020-05-29 CN CN202080040065.2A patent/CN113966340A/zh active Pending
- 2020-05-29 KR KR1020217040376A patent/KR102898966B1/ko active Active
- 2020-05-29 IL IL312349A patent/IL312349B2/en unknown
- 2020-05-29 JP JP2021521908A patent/JP7308468B2/ja active Active
-
2022
- 2022-12-26 JP JP2022208226A patent/JP7526399B2/ja active Active
-
2024
- 2024-07-08 JP JP2024109757A patent/JP7749763B2/ja active Active
-
2025
- 2025-07-07 AU AU2025205185A patent/AU2025205185A1/en active Pending
- 2025-09-24 JP JP2025158040A patent/JP2025181985A/ja active Pending
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