RU2004122084A - Пептиды для лечения рака, ассоциированного с папилломавирусом (hpv) человека, и других эпителиальных опухолей - Google Patents
Пептиды для лечения рака, ассоциированного с папилломавирусом (hpv) человека, и других эпителиальных опухолей Download PDFInfo
- Publication number
- RU2004122084A RU2004122084A RU2004122084/13A RU2004122084A RU2004122084A RU 2004122084 A RU2004122084 A RU 2004122084A RU 2004122084/13 A RU2004122084/13 A RU 2004122084/13A RU 2004122084 A RU2004122084 A RU 2004122084A RU 2004122084 A RU2004122084 A RU 2004122084A
- Authority
- RU
- Russia
- Prior art keywords
- peptides
- hpv
- treatment
- cytokine
- ifn
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (13)
1. Пептиды, которые связывают и ингибируют фосфорилирующий участок казеинкиназы II (CKII), который представлен следующими последовательностями:
а. CSVRQGPVQKC;
b. CSSCQNSPALC;
c. CQIPQRTATRC;
d. CAKQRTDPGYC;
e. CWMSPRHLGTC;
f. CRNCTVIQFSC;
g. CHYIAGTVQGC;
h. CPLVSLRDHSC;
i. CKQSYLHHLLC;
j. CFQPLTPLCRC;
k. CQSYHELLLQS;
а также любой гомологичный или миметический вариант (синтетический или рекомбинантный) указанных пептидов.
2. Пептиды по п.1, которые представлены циклической структурой.
3. Пептиды по п.1 или 2, которые содержатся в слитом полипептиде.
4. Фармацевтическая композиция, которая включает в себя один или несколько пептидов по пп.1-3, а также подходящий носитель.
5. Фармацевтическая композиция по п.4, которая дополнительно содержит цитокин.
6. Фармацевтическая композиция по п.5, где указанный цитокин представляет собой интерферон (ИФН).
7. Применение пептидов по пп.1-3 для ингибирования пролиферации опухолевой клетки.
8. Применение по п.7 для лечения ассоциированных и не ассоциированных с HPV опухолей.
9. Применение пептидов для лечения HPV-ассоциированного поражения на стадиях, предшествующих озлокачествлению.
10. Применение по пп.7-9, где пептиды используются наряду с цитокинами.
11. Применение по п.10, где цитокин представляет собой ИФН.
12. Применение по пп.7-9, где пептиды используются для лечения пациентов, пораженных HPV и резистентных к лечению ИФН.
13. Экспрессирующий вектор млекопитающего, содержащий ДНК-последовательности, которые кодируют любой из пептидов по пп.1-3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20010309A CU23225A1 (es) | 2001-12-20 | 2001-12-20 | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
| CU0309/01 | 2001-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004122084A true RU2004122084A (ru) | 2005-03-27 |
| RU2290410C2 RU2290410C2 (ru) | 2006-12-27 |
Family
ID=40091679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004122084/13A RU2290410C2 (ru) | 2001-12-20 | 2002-12-04 | Пептид, обладающий способностью связывать фосфорилирующий участок казеинкиназы ii (ckii) и ингибировать фосфорилирование, слитый полипептид, их применение |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7374767B2 (ru) |
| EP (2) | EP1491553B1 (ru) |
| JP (1) | JP4056476B2 (ru) |
| KR (1) | KR100642437B1 (ru) |
| CN (1) | CN100368431C (ru) |
| AR (1) | AR037825A1 (ru) |
| AT (1) | ATE520704T1 (ru) |
| AU (1) | AU2002361922B2 (ru) |
| BR (1) | BRPI0215213C1 (ru) |
| CA (1) | CA2471110C (ru) |
| CR (1) | CR7361A (ru) |
| CU (1) | CU23225A1 (ru) |
| DK (1) | DK1491553T3 (ru) |
| DO (1) | DOP2002000548A (ru) |
| ES (1) | ES2371239T3 (ru) |
| HK (1) | HK1068901A1 (ru) |
| HN (1) | HN2002000377A (ru) |
| HR (1) | HRP20040663B1 (ru) |
| IL (2) | IL162633A0 (ru) |
| IS (1) | IS2906B (ru) |
| MA (1) | MA27868A1 (ru) |
| MX (1) | MXPA04005832A (ru) |
| MY (1) | MY133530A (ru) |
| NO (1) | NO333259B1 (ru) |
| NZ (1) | NZ534170A (ru) |
| PE (1) | PE20030861A1 (ru) |
| PT (1) | PT1491553E (ru) |
| RU (1) | RU2290410C2 (ru) |
| SI (1) | SI1491553T1 (ru) |
| TN (1) | TNSN04114A1 (ru) |
| UA (1) | UA81403C2 (ru) |
| UY (1) | UY27602A1 (ru) |
| WO (1) | WO2003054002A1 (ru) |
| ZA (1) | ZA200405514B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
| CU23431B6 (es) | 2005-05-12 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer |
| GB2433740A (en) * | 2005-12-23 | 2007-07-04 | Rapid Biosensor Systems Ltd | Detection of tuberculosis infection |
| CU23511B6 (es) * | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
| GB2441131A (en) * | 2006-08-24 | 2008-02-27 | Univ Dundee | Modulation of binding of CK2a to NDPK |
| CN100522992C (zh) * | 2007-02-12 | 2009-08-05 | 中国科学院昆明动物研究所 | 一种环状小肽ba |
| EP2133083A4 (en) | 2007-03-27 | 2012-02-15 | Taiko Pharmaceutical Co Ltd | THERAPEUTIC FOR SKIN OR MOLECULE INFECTIONS |
| WO2010096751A1 (en) | 2009-02-23 | 2010-08-26 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta |
| AU2010223888A1 (en) * | 2009-03-13 | 2011-10-06 | Egen, Inc. | Compositions and methods for the delivery of biologically active RNAs |
| AU2016381964B2 (en) | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| CU20200103A7 (es) * | 2020-12-18 | 2022-07-08 | Ct Ingenieria Genetica Biotecnologia | Péptido sintético para la inducción de inmunidad antitumoral y antiviral |
| CU20210058A7 (es) | 2021-07-09 | 2023-02-13 | Ct Ingenieria Genetica Biotecnologia | Péptidos lineales que inhiben la fosforilación mediada por ck2 y composiciones que los comprenden |
| CN118370805A (zh) * | 2024-04-29 | 2024-07-23 | 广州美达康生物医药科技有限公司 | 一种抑菌妇科凝胶及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE902820A1 (en) | 1989-08-07 | 1991-02-27 | Merck & Co Inc | Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins |
| EP0531080A3 (en) * | 1991-09-04 | 1993-12-29 | Merck & Co Inc | Peptide inhibitors of human papilloma virus protein binding to retinoblastoma gene protein |
| GB9313556D0 (en) * | 1993-07-01 | 1993-08-18 | British Tech Group | Synthetic peptides of human papillomavirus |
| US5625031A (en) * | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
| ATE235509T1 (de) * | 1998-06-30 | 2003-04-15 | Deutsches Krebsforsch | Peptide zur inhibition von hpv e7 proteinen |
| WO2001064835A2 (en) * | 2000-02-28 | 2001-09-07 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US6641994B2 (en) * | 1999-08-25 | 2003-11-04 | Pharmacia & Upjohn Company | Methods of identifying anti-viral agents |
| CU23225A1 (es) * | 2001-12-20 | 2007-08-30 | Ct Ingenieria Genetica Biotech | PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES |
-
2001
- 2001-12-20 CU CU20010309A patent/CU23225A1/es unknown
-
2002
- 2002-04-12 UA UA20040705927A patent/UA81403C2/uk unknown
- 2002-12-04 SI SI200230967T patent/SI1491553T1/sl unknown
- 2002-12-04 NZ NZ534170A patent/NZ534170A/en not_active IP Right Cessation
- 2002-12-04 AU AU2002361922A patent/AU2002361922B2/en not_active Ceased
- 2002-12-04 IL IL16263302A patent/IL162633A0/xx active IP Right Grant
- 2002-12-04 EP EP02796490A patent/EP1491553B1/en not_active Expired - Lifetime
- 2002-12-04 EP EP11168526A patent/EP2383282A1/en not_active Ceased
- 2002-12-04 RU RU2004122084/13A patent/RU2290410C2/ru active
- 2002-12-04 MX MXPA04005832A patent/MXPA04005832A/es active IP Right Grant
- 2002-12-04 DK DK02796490.7T patent/DK1491553T3/da active
- 2002-12-04 JP JP2003554718A patent/JP4056476B2/ja not_active Expired - Fee Related
- 2002-12-04 CA CA2471110A patent/CA2471110C/en not_active Expired - Lifetime
- 2002-12-04 ES ES02796490T patent/ES2371239T3/es not_active Expired - Lifetime
- 2002-12-04 BR BRPI0215213A patent/BRPI0215213C1/pt not_active IP Right Cessation
- 2002-12-04 PT PT02796490T patent/PT1491553E/pt unknown
- 2002-12-04 KR KR1020047009771A patent/KR100642437B1/ko active IP Right Grant
- 2002-12-04 US US10/499,458 patent/US7374767B2/en not_active Expired - Lifetime
- 2002-12-04 CN CNB028282698A patent/CN100368431C/zh not_active Expired - Lifetime
- 2002-12-04 AT AT02796490T patent/ATE520704T1/de active
- 2002-12-04 WO PCT/CU2002/000010 patent/WO2003054002A1/es active IP Right Grant
- 2002-12-11 MY MYPI20024638A patent/MY133530A/en unknown
- 2002-12-13 AR ARP020104844A patent/AR037825A1/es not_active Application Discontinuation
- 2002-12-17 DO DO2002000548A patent/DOP2002000548A/es unknown
- 2002-12-19 HN HN2002000377A patent/HN2002000377A/es unknown
- 2002-12-20 UY UY27602A patent/UY27602A1/es active IP Right Grant
-
2003
- 2003-01-06 PE PE2003000006A patent/PE20030861A1/es not_active Application Discontinuation
-
2004
- 2004-06-04 CR CR7361A patent/CR7361A/es unknown
- 2004-06-15 MA MA27740A patent/MA27868A1/fr unknown
- 2004-06-16 IS IS7320A patent/IS2906B/is unknown
- 2004-06-17 TN TNP2004000114A patent/TNSN04114A1/en unknown
- 2004-06-20 IL IL162633A patent/IL162633A/en not_active IP Right Cessation
- 2004-07-12 ZA ZA2004/05514A patent/ZA200405514B/en unknown
- 2004-07-19 HR HRP20040663AA patent/HRP20040663B1/hr not_active IP Right Cessation
- 2004-07-20 NO NO20043112A patent/NO333259B1/no not_active IP Right Cessation
-
2005
- 2005-02-24 HK HK05101552.3A patent/HK1068901A1/xx not_active IP Right Cessation
-
2008
- 2008-04-08 US US12/099,646 patent/US7947287B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2004122084A (ru) | Пептиды для лечения рака, ассоциированного с папилломавирусом (hpv) человека, и других эпителиальных опухолей | |
| YU47968B (sh) | Postupak za dobivanje faktora nekroze tumora | |
| ES2029171A6 (es) | Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh) | |
| DK1032668T3 (da) | Fibroblast vækstfaktor 19 | |
| ATE350049T1 (de) | Zusammensetzungen und verfahren zur behinderung der vervielfältigung von hiv-1 | |
| CA2283462A1 (en) | Vectors having enhanced expression and methods of making and uses thereof | |
| MY101852A (en) | Tumor necrosis factor, methods for its preparation, containing it, dna encoding it and assay method using such dna. | |
| RU2007112876A (ru) | Модифицированные белки, сконструированные токсины и способы их получения | |
| DE69834824D1 (de) | Nukleinsäure, welche einen von lektin abstammenden faktor zur präservierung von progenitorzellen kodiert | |
| RU2017127024A (ru) | Герпесвирус с измененным спектром мишеней, содержащий гибридный гликопротеин н | |
| HUP9903921A2 (hu) | Tumor nekrózis faktorral rokon ligandum | |
| CA2432971A1 (en) | Polypeptides | |
| FR2746110B1 (fr) | Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants | |
| EA200100395A1 (ru) | Фармацевтическая композиция, содержащая фрагменты днк, кодирующей антигенный белок, обладающая противоопухолевым действием | |
| DE69230881D1 (de) | Corticotropinauslösefaktor-bindendes protein | |
| JP2007511534A5 (ru) | ||
| JPWO2019152884A5 (ru) | ||
| RU2004106592A (ru) | Рекомбинантный модифицированный вирус вакцины анкара, способный экспрессировать структурные антигены вируса гепатита с | |
| Zheng et al. | Growth suppression of a cervical cancer cell line (TMCC-1) by the human wild-type p53 gene | |
| CN1618978A (zh) | 细胞因子il－24真核表达载体的构建及应用 | |
| RU2021135325A (ru) | Мультиспецифические белки | |
| CN104761636A (zh) | 一种HLA-A33限制性eEF2表位多肽及其应用 | |
| NO20005321L (no) | Vertskodet protein uttrykt i Mareks sykdoms (MDV) infiserte celler og antistoffer til dette | |
| RU2020122291A (ru) | Слитый белок, включающий белок il-2 и белок cd80, и его применение | |
| JP2008526194A5 (ru) |