UY27602A1 - Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales" - Google Patents

Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales"

Info

Publication number
UY27602A1
UY27602A1 UY27602A UY27602A UY27602A1 UY 27602 A1 UY27602 A1 UY 27602A1 UY 27602 A UY27602 A UY 27602A UY 27602 A UY27602 A UY 27602A UY 27602 A1 UY27602 A1 UY 27602A1
Authority
UY
Uruguay
Prior art keywords
peptides
hpv
tumors
treatment
ckii
Prior art date
Application number
UY27602A
Other languages
English (en)
Inventor
Moro Soria Alejandro
Santos Salvio Alicia
Perea Rodriguez Silvio Ernesto
Reyes Acosta Osvaldo
Santiago Vispo Nelso Frrncisco
Puchades Izaguirre Yaquelin
Silva Rodriguez Ricardo
Gonzalez Lopez Luis Javier
Gonzalez Barrios Beklis
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Publication of UY27602A1 publication Critical patent/UY27602A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Abstract

Péptidos útiles para el tratamiento de tumores de origen epitelias y especialmente los asociados a tipos oncogénicos de Virus Papiloma (VPH). Identificación de péptidos cuya estructura permita el bloqueo del dominio de fosforilación por Caseina Kinasa II (CKII) mediante la interacción directa con dicho sitio. En la presente invención se muestran once péptidos de estructura cíclica y secuencia aminoacidica diferente, los cuales inhiben el sitio de fosforilación por CKII in Vitro, producen citotoxicidad en células de carcinoma de cuello uterino humano transformadas por VPH-16 (CaSki) y además incrementan la sensibilidad de dichas células al efecto citostático del interferón (IFN). La invención se relaciona además con el uso de estos péptidos conjugados o fusionados a otros péptidos y compuestos químicos de penetración intracelular así como con el uso de moléculas miméticas tanto de origen peptidico como de origen químico.
UY27602A 2001-12-20 2002-12-20 Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales" UY27602A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20010309A CU23225A1 (es) 2001-12-20 2001-12-20 PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES

Publications (1)

Publication Number Publication Date
UY27602A1 true UY27602A1 (es) 2003-04-30

Family

ID=40091679

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27602A UY27602A1 (es) 2001-12-20 2002-12-20 Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales"

Country Status (34)

Country Link
US (2) US7374767B2 (es)
EP (2) EP2383282A1 (es)
JP (1) JP4056476B2 (es)
KR (1) KR100642437B1 (es)
CN (1) CN100368431C (es)
AR (1) AR037825A1 (es)
AT (1) ATE520704T1 (es)
AU (1) AU2002361922B2 (es)
BR (1) BRPI0215213C1 (es)
CA (1) CA2471110C (es)
CR (1) CR7361A (es)
CU (1) CU23225A1 (es)
DK (1) DK1491553T3 (es)
DO (1) DOP2002000548A (es)
ES (1) ES2371239T3 (es)
HK (1) HK1068901A1 (es)
HN (1) HN2002000377A (es)
HR (1) HRP20040663B1 (es)
IL (2) IL162633A0 (es)
IS (1) IS2906B (es)
MA (1) MA27868A1 (es)
MX (1) MXPA04005832A (es)
MY (1) MY133530A (es)
NO (1) NO333259B1 (es)
NZ (1) NZ534170A (es)
PE (1) PE20030861A1 (es)
PT (1) PT1491553E (es)
RU (1) RU2290410C2 (es)
SI (1) SI1491553T1 (es)
TN (1) TNSN04114A1 (es)
UA (1) UA81403C2 (es)
UY (1) UY27602A1 (es)
WO (1) WO2003054002A1 (es)
ZA (1) ZA200405514B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23225A1 (es) * 2001-12-20 2007-08-30 Ct Ingenieria Genetica Biotech PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES
CU23431B6 (es) * 2005-05-12 2009-10-16 Ct Ingenieria Genetica Biotech Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer
GB2433740A (en) 2005-12-23 2007-07-04 Rapid Biosensor Systems Ltd Detection of tuberculosis infection
CU23511B6 (es) * 2006-02-28 2010-04-13 Biorec B V Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas
GB2441131A (en) * 2006-08-24 2008-02-27 Univ Dundee Modulation of binding of CK2a to NDPK
CN100522992C (zh) * 2007-02-12 2009-08-05 中国科学院昆明动物研究所 一种环状小肽ba
JP4670107B2 (ja) 2007-03-27 2011-04-13 大幸薬品株式会社 感染性皮膚および粘膜疾患治療薬
WO2010096751A1 (en) 2009-02-23 2010-08-26 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta
EP2406379A4 (en) * 2009-03-13 2012-09-26 Egen Inc COMPOSITIONS AND METHODS FOR RELEASING BIOLOGICALLY ACTIVE RNA
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
CU20200103A7 (es) * 2020-12-18 2022-07-08 Ct Ingenieria Genetica Biotecnologia Péptido sintético para la inducción de inmunidad antitumoral y antiviral
CU20210058A7 (es) 2021-07-09 2023-02-13 Ct Ingenieria Genetica Biotecnologia Péptidos lineales que inhiben la fosforilación mediada por ck2 y composiciones que los comprenden

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902820A1 (en) * 1989-08-07 1991-02-27 Merck & Co Inc Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins
CA2077322A1 (en) 1991-09-04 1993-03-05 Allen I. Oliff Peptide inhibitors of human papilloma virus protein binding to retinoblastoma gene proteins
GB9313556D0 (en) * 1993-07-01 1993-08-18 British Tech Group Synthetic peptides of human papillomavirus
US5625031A (en) 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
ATE235509T1 (de) * 1998-06-30 2003-04-15 Deutsches Krebsforsch Peptide zur inhibition von hpv e7 proteinen
US6641994B2 (en) * 1999-08-25 2003-11-04 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
AU2001238347A1 (en) * 2000-02-28 2001-09-12 Hyseq, Inc. Novel nucleic acids and polypeptides
CU23225A1 (es) * 2001-12-20 2007-08-30 Ct Ingenieria Genetica Biotech PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES

Also Published As

Publication number Publication date
DOP2002000548A (es) 2003-06-30
UA81403C2 (en) 2008-01-10
JP2005525090A (ja) 2005-08-25
AU2002361922B2 (en) 2007-04-05
IS2906B (is) 2014-11-15
MY133530A (en) 2007-11-30
CU23225A1 (es) 2007-08-30
IL162633A (en) 2011-02-28
ZA200405514B (en) 2005-03-30
CR7361A (es) 2005-02-18
CN1620464A (zh) 2005-05-25
BRPI0215213B1 (pt) 2018-09-11
BRPI0215213C1 (pt) 2021-05-25
CN100368431C (zh) 2008-02-13
US7374767B2 (en) 2008-05-20
NZ534170A (en) 2006-08-31
ATE520704T1 (de) 2011-09-15
IL162633A0 (es) 2005-11-20
PE20030861A1 (es) 2003-12-02
NO333259B1 (no) 2013-04-22
MA27868A1 (fr) 2006-05-02
NO20043112L (no) 2004-07-20
IS7320A (is) 2004-06-16
KR100642437B1 (ko) 2006-11-06
TNSN04114A1 (en) 2006-06-01
HRP20040663B1 (hr) 2013-05-31
US20090005294A1 (en) 2009-01-01
EP2383282A1 (en) 2011-11-02
BR0215213A (pt) 2004-12-07
EP1491553A1 (en) 2004-12-29
ES2371239T3 (es) 2011-12-28
PT1491553E (pt) 2011-11-25
HN2002000377A (es) 2003-04-10
MXPA04005832A (es) 2004-09-13
WO2003054002A1 (es) 2003-07-03
US7947287B2 (en) 2011-05-24
DK1491553T3 (da) 2011-12-05
JP4056476B2 (ja) 2008-03-05
HK1068901A1 (en) 2005-05-06
CA2471110A1 (en) 2003-07-03
SI1491553T1 (sl) 2011-12-30
AU2002361922A1 (en) 2003-07-09
KR20050002811A (ko) 2005-01-10
RU2290410C2 (ru) 2006-12-27
CA2471110C (en) 2017-01-31
AR037825A1 (es) 2004-12-09
EP1491553B1 (en) 2011-08-17
US20060233742A1 (en) 2006-10-19
RU2004122084A (ru) 2005-03-27
HRP20040663A2 (en) 2005-08-31

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Effective date: 20170307