RU2007112876A - Модифицированные белки, сконструированные токсины и способы их получения - Google Patents

Модифицированные белки, сконструированные токсины и способы их получения Download PDF

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RU2007112876A
RU2007112876A RU2007112876/13A RU2007112876A RU2007112876A RU 2007112876 A RU2007112876 A RU 2007112876A RU 2007112876/13 A RU2007112876/13 A RU 2007112876/13A RU 2007112876 A RU2007112876 A RU 2007112876A RU 2007112876 A RU2007112876 A RU 2007112876A
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immunotoxin
cell
antibody
malignant
scfvmel
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RU2432358C2 (ru
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Майкл Г. РОЗЕНБЛЮМ (US)
Майкл Г. РОЗЕНБЛЮМ
Лоренс ЧЕУНГ (US)
Лоренс ЧЕУНГ
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Рисерч Дивелопмент Фаундейшн (US)
Рисерч Дивелопмент Фаундейшн
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Reproductive Health (AREA)
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  • Neurosurgery (AREA)
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Claims (17)

1. Способ лизиса злокачественной клетки, предусматривающий обеспечение этой клетке эффективного количества иммунотоксина, содержащего коровую область токсина гелонина и одноцепочечное антитело, которое специфически нацелено на эту злокачественную клетку.
2. Способ по п.1, где иммунотоксин содержит SEQ ID NO:1.
3. Способ по п.1, где антитело нацелено на опухолевый антиген.
4. Способ по п.1, где антитело является мышиным антителом.
5. Способ по п.1, где злокачественная клетка является клеткой меланомы.
6. Способ по п.5, где антитело содержит 9.2.27 или ZME-018.
7. Способ по п.5, где иммунотоксин является scfvMEL-2018 или scfvMEL-2025.
8. Способ по п.1, где клетка находится у пациента.
9. Способ по п.8, где иммунотоксин находится в фармацевтически приемлемой композиции.
10. Способ по п.1, где иммунотоксин доставляется в клетку введением в злокачественную клетку экспрессирующей конструкции, способной экспрессировать этот иммунотоксин.
11. Способ по п.10, где экспрессирующая конструкция является вирусным вектором.
12. Способ по п.11, где вирусный вектор является аденовирусным вектором, аденоассоциированным вирусным вектором, вирусом гепатита, герпесвирусом, лентивирусом, ретровирусом или вирусом коровьей оспы.
13. Способ лечения злокачественных опухолей у пациента, предусматривающий введение этому пациенту эффективного количества композиции, содержащей иммунотоксин, содержащий коровую область токсина гелонина и одноцепочечное антитело, которое специфически нацелено на злокачественную клетку.
14. Способ по п.13, где злокачественная опухоль является злокачественной опухолью предстательной железы, легкого, головного мозга, кожи, печени, молочной железы, лимфоидного органа, желудка, яичек, яичников, поджелудочной железы, костной ткани, костного мозга, головы и шеи, шейки матки, пищевода, глаза, желчного пузыря, почки, надпочечников, сердца, ободочной кишки или крови.
15. Способ по п.13, где иммунотоксин содержит SEQ ID NO:1.
16. Способ по п.13, где антитело нацелено на клетку меланомы.
17. Способ по п.16, где иммунотоксин является scfvMEL-2018 или scfvMEL-2025.
RU2007112876/10A 2001-02-12 2002-02-12 Способ уничтожения злокачественной клетки RU2432358C2 (ru)

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US60/268,402 2001-02-12

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EP (1) EP1406644A4 (ru)
JP (1) JP2005514000A (ru)
KR (2) KR20040022208A (ru)
CN (1) CN100413885C (ru)
AU (1) AU2002306477B2 (ru)
CA (1) CA2438143C (ru)
IL (1) IL157228A0 (ru)
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US20030176331A1 (en) 2003-09-18
US20070036780A1 (en) 2007-02-15
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US20080292544A1 (en) 2008-11-27
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