RU2432358C2 - Способ уничтожения злокачественной клетки - Google Patents

Способ уничтожения злокачественной клетки Download PDF

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RU2432358C2
RU2432358C2 RU2007112876/10A RU2007112876A RU2432358C2 RU 2432358 C2 RU2432358 C2 RU 2432358C2 RU 2007112876/10 A RU2007112876/10 A RU 2007112876/10A RU 2007112876 A RU2007112876 A RU 2007112876A RU 2432358 C2 RU2432358 C2 RU 2432358C2
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immunotoxin
cell
malignant cell
antibody
viral vector
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Майкл Г. РОЗЕНБЛЮМ (US)
Майкл Г. РОЗЕНБЛЮМ
Лоренс ЧЕУНГ (US)
Лоренс ЧЕУНГ
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Abstract

Описан способ уничтожения злокачественной клетки с использованием эффективного количества иммунотоксина с известной структурой, содержащего коровую область токсина гелонина и одноцепочечное антитело, специфически нацеленное на злокачественную клетку. Иммунотоксин по изобретению может входить в состав фармацевтически приемлемой композиции. Иммунотоксин может доставляться к злокачественной клетке путем введения в клетку экспрессирующей иммунотоксин конструкции, являющейся вирусным вектором. Иммунотоксины по изобретению обладают сниженной антигенностью при сохранении биологической активности, поэтому способ и используемая в способе композиция имеют существенные положительные свойства для субъекта, нуждающегося в таком способе. 11 з.п. ф-лы, 11 ил., 9 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (12)

1. Способ уничтожения злокачественной клетки, предусматривающий обеспечение этой клетке эффективного количества иммунотоксина, содержащего коровую область токсина гелонина и одноцепочечное антитело, которое специфически нацелено на эту злокачественную клетку.
2. Способ по п.1, где иммунотоксин содержит SEQ ID NO:1.
3. Способ по п.1, где антитело нацелено на опухолевый антиген.
4. Способ по п.1, где антитело является мышиным антителом.
5. Способ по п.1, где злокачественная клетка является клеткой меланомы.
6. Способ по п.5, где антитело содержит 9.2.27 или ZME-018.
7. Способ по п.5, где иммунотоксин является scfvMEL-2018 или scfvMEL-2025.
8. Способ по п.1, где клетка находится у пациента.
9. Способ по п.8, где иммунотоксин находится в фармацевтически приемлемой композиции.
10. Способ по п.1, где иммунотоксин доставляется в клетку введением в злокачественную клетку экспрессирующей конструкции, способной экспрессировать этот иммунотоксин.
11. Способ по п.10, где экспрессирующая конструкция является вирусным вектором.
12. Способ по п.11, где вирусный вектор является аденовирусным вектором, аденоассоциированным вирусным вектором, вирусом гепатита, герпесвирусом, лентивирусом, ретровирусом или вирусом коровьей оспы.
RU2007112876/10A 2001-02-12 2002-02-12 Способ уничтожения злокачественной клетки RU2432358C2 (ru)

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