JPWO2020232256A5 - - Google Patents
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- JPWO2020232256A5 JPWO2020232256A5 JP2021567815A JP2021567815A JPWO2020232256A5 JP WO2020232256 A5 JPWO2020232256 A5 JP WO2020232256A5 JP 2021567815 A JP2021567815 A JP 2021567815A JP 2021567815 A JP2021567815 A JP 2021567815A JP WO2020232256 A5 JPWO2020232256 A5 JP WO2020232256A5
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- cancer
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- alkyl
- optionally substituted
- pharmaceutically acceptable
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- 125000000217 alkyl group Chemical group 0.000 claims description 62
- 150000001875 compounds Chemical class 0.000 claims description 56
- 150000003839 salts Chemical class 0.000 claims description 52
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 229910052799 carbon Inorganic materials 0.000 claims description 30
- 125000004043 oxo group Chemical group O=* 0.000 claims description 24
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 18
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 18
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 18
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 125000003003 spiro group Chemical group 0.000 claims description 12
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims description 10
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962848114P | 2019-05-15 | 2019-05-15 | |
| US62/848,114 | 2019-05-15 | ||
| PCT/US2020/032904 WO2020232256A1 (en) | 2019-05-15 | 2020-05-14 | Triaryl compounds for treatment of pd-l1 diseases |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022531970A JP2022531970A (ja) | 2022-07-12 |
| JP2022531970A5 JP2022531970A5 (https=) | 2023-05-19 |
| JPWO2020232256A5 true JPWO2020232256A5 (https=) | 2023-05-19 |
| JP7656547B2 JP7656547B2 (ja) | 2025-04-03 |
Family
ID=73289294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567815A Active JP7656547B2 (ja) | 2019-05-15 | 2020-05-14 | Ｐｄ－ｌ１疾患治療用のトリアリール化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11266643B2 (https=) |
| EP (1) | EP3968996A4 (https=) |
| JP (1) | JP7656547B2 (https=) |
| KR (1) | KR20220009420A (https=) |
| CN (1) | CN114340633B (https=) |
| AU (2) | AU2020276277B2 (https=) |
| BR (1) | BR112021022659A2 (https=) |
| CA (1) | CA3139526A1 (https=) |
| IL (1) | IL287843B2 (https=) |
| MA (1) | MA55974A (https=) |
| MX (1) | MX2021013819A (https=) |
| SG (1) | SG11202112310TA (https=) |
| WO (1) | WO2020232256A1 (https=) |
| ZA (1) | ZA202108626B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018005374A1 (en) | 2016-06-27 | 2018-01-04 | Chemocentryx, Inc. | Immunomodulator compounds |
| AU2018306619B2 (en) | 2017-07-28 | 2022-06-02 | Chemocentryx, Inc. | Immunomodulator compounds |
| CN111225665B (zh) | 2017-08-08 | 2023-12-08 | 凯莫森特里克斯股份有限公司 | 大环免疫调节剂 |
| JP7387616B2 (ja) | 2018-02-22 | 2023-11-28 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１アンタゴニストとしてのインダン－アミン |
| AU2020276277B2 (en) * | 2019-05-15 | 2025-03-20 | Chemocentryx, Inc. | Triaryl compounds for treatment of PD-L1 diseases |
| SG11202112875UA (en) | 2019-06-20 | 2021-12-30 | Chemocentryx Inc | Compounds for treatment of pd-l1 diseases |
| BR112021025888A2 (pt) | 2019-07-10 | 2022-04-26 | Chemocentryx Inc | Indanos como inibidores de pd-l1 |
| CN114555080B (zh) | 2019-10-16 | 2025-10-10 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的杂芳基联苯胺 |
| AU2020368393B2 (en) * | 2019-10-16 | 2026-01-08 | Chemocentryx, Inc. | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases |
| WO2021093817A1 (zh) * | 2019-11-15 | 2021-05-20 | 杭州和正医药有限公司 | 免疫调节化合物、组合物及其应用 |
| CA3163389A1 (en) * | 2020-01-03 | 2021-07-08 | Mi ZENG | Biphenyl derivative inhibitor, preparation method therefor and use thereof |
| WO2021262627A1 (en) * | 2020-06-23 | 2021-12-30 | Chemocentryx, Inc. | Methods of treating cancer using heteroaryl-biphenyl amide derivatives |
| CN116710460B (zh) * | 2021-01-18 | 2025-09-19 | 上海齐鲁制药研究中心有限公司 | 联苯衍生物及其应用 |
| BR112023026747A2 (pt) * | 2021-06-18 | 2024-03-12 | Aligos Therapeutics Inc | Métodos e composições para direcionamento de pd-l1 |
| US12319655B2 (en) | 2021-12-09 | 2025-06-03 | Deciphera Pharmaceuticals, Llc | RAF kinase inhibitors and methods of use thereof |
| CA3240346A1 (en) | 2021-12-16 | 2023-06-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN115010658B (zh) * | 2022-05-11 | 2023-06-27 | 南方医科大学 | 一种化合物及其制备方法与应用 |
| WO2024018403A1 (en) * | 2022-07-21 | 2024-01-25 | Arbutus Biopharma Corporation | Substituted imidazoamide compounds, and methods using same |
| WO2024134466A1 (en) * | 2022-12-21 | 2024-06-27 | Arbutus Biopharma Corporation | Substituted arylamine compounds, substituted heteroarylamine compounds, and methods using same |
| US20240277706A1 (en) * | 2023-01-20 | 2024-08-22 | Aligos Therapeutics, Inc. | Methods and compostitions for targeting pd-l1 |
| WO2025015063A1 (en) * | 2023-07-13 | 2025-01-16 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN116903489B (zh) * | 2023-07-14 | 2025-09-02 | 北京汉典制药有限公司 | 三联苯类化合物、其制备方法及其应用 |
| PL449370A1 (pl) * | 2024-07-26 | 2026-02-02 | Uniwersytet Jagielloński | Nowe pochodne N-terfenylopikolinamidu oraz ich zastosowanie |
Family Cites Families (94)
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|---|---|---|---|---|
| GB9604926D0 (en) * | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| EP2402320A1 (en) | 2006-03-31 | 2012-01-04 | Novartis AG | Anorectic agents |
| ES2333539T3 (es) | 2006-04-21 | 2010-02-23 | Cellzome Limited | Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer. |
| WO2008008059A1 (en) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents ans uses thereof |
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