JPWO2020180645A5 - - Google Patents

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JPWO2020180645A5
JPWO2020180645A5 JP2021551748A JP2021551748A JPWO2020180645A5 JP WO2020180645 A5 JPWO2020180645 A5 JP WO2020180645A5 JP 2021551748 A JP2021551748 A JP 2021551748A JP 2021551748 A JP2021551748 A JP 2021551748A JP WO2020180645 A5 JPWO2020180645 A5 JP WO2020180645A5
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nucleic acid
oligonucleotide
probe
sequence
acid probe
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JP7602473B2 (ja
JP2022522480A5 (https=
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JP2021551748A 2019-03-01 2020-02-28 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット Active JP7602473B2 (ja)

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JP2024213070A JP2025060638A (ja) 2019-03-01 2024-12-06 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット

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US201962812928P 2019-03-01 2019-03-01
US62/812,928 2019-03-01
PCT/US2020/020288 WO2020180645A1 (en) 2019-03-01 2020-02-28 Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same

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JP2024213070A Division JP2025060638A (ja) 2019-03-01 2024-12-06 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット

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JP2022522480A JP2022522480A (ja) 2022-04-19
JPWO2020180645A5 true JPWO2020180645A5 (https=) 2023-03-06
JP2022522480A5 JP2022522480A5 (https=) 2023-03-06
JP7602473B2 JP7602473B2 (ja) 2024-12-18

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JP2021551748A Active JP7602473B2 (ja) 2019-03-01 2020-02-28 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット
JP2024213070A Pending JP2025060638A (ja) 2019-03-01 2024-12-06 免疫測定法で使用するための電気化学発光標識プローブ、当該プローブを使用する方法および該プローブを含むキット

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US (1) US12553887B2 (https=)
EP (1) EP3931201A1 (https=)
JP (2) JP7602473B2 (https=)
KR (2) KR20260021093A (https=)
CN (2) CN120098057A (https=)
AU (1) AU2020232954B2 (https=)
CA (1) CA3132154A1 (https=)
TW (2) TWI860333B (https=)
WO (1) WO2020180645A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
WO2015175856A1 (en) 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Improved assay methods
US11445631B2 (en) * 2020-03-19 2022-09-13 Baidu Usa Llc High performance computing based holistic liquid cooled rack cost optimization
WO2021222827A1 (en) 2020-05-01 2021-11-04 Meso Scale Technologies, Llc. Methods and kits for virus detection
US12411064B2 (en) 2020-05-08 2025-09-09 Waters Technologies Corporation Methods for heat-assisted enzyme digestion
CN115552215A (zh) 2020-05-08 2022-12-30 沃特世科技公司 用于热辅助酶消化的方法
WO2022099314A1 (en) 2020-11-09 2022-05-12 Meso Scale Technologies, Llc. Methods and kits for detecting tau
JP2024507652A (ja) 2021-01-11 2024-02-21 メソ スケール テクノロジーズ エルエルシー アッセイシステムの較正システム及び方法
US20220404360A1 (en) 2021-05-21 2022-12-22 Meso Scale Technologies, Llc. Assays for viral strain determination
EP4356132B1 (en) * 2021-06-17 2025-10-01 F. Hoffmann-La Roche AG Method for immunosensing on a lipid layer
WO2022263544A1 (en) * 2021-06-17 2022-12-22 Roche Diagnostics Gmbh Method for immunosensing on a lipid layer using magnetic tunnel junctions
CN117501121A (zh) * 2021-06-17 2024-02-02 豪夫迈·罗氏有限公司 用于使用磁性隧道结ii对脂质层进行免疫传感的方法
EP4502179A3 (en) * 2021-06-24 2025-04-02 Moleculent Ab Spatial analysis of a planar biological sample
JPWO2023100567A1 (https=) * 2021-12-02 2023-06-08
WO2023196927A1 (en) 2022-04-07 2023-10-12 Meso Scale Technologies, Llc. Methods and kits for assessing alzheimer's disease
CN115819486B (zh) * 2022-05-12 2024-08-02 厦门大学 一种砷-巯基分子信标化合物及其应用
JP7832621B2 (ja) * 2022-05-13 2026-03-18 国立大学法人北海道大学 フォン・ヴィレブランド因子の情報を取得する方法、測定試料の調製方法及び試薬キット
WO2023245184A1 (en) 2022-06-17 2023-12-21 Meso Scale Technologies, Llc. Viral strain serology assays
CN115356312B (zh) * 2022-08-16 2025-04-08 南京大学 一种单细胞表面抗原的检测方法及应用
WO2024044739A2 (en) * 2022-08-26 2024-02-29 Board Of Regents, The University Of Texas System Compositions and methods for glycorna imaging via proximity ligation assay
CN115386362B (zh) * 2022-08-30 2024-09-03 合肥工业大学 一种核黄素-氧化石墨烯荧光探针及其应用
US20240103002A1 (en) 2022-09-23 2024-03-28 Meso Scale Technologies, Llc. Orthopoxvirus serology assays
CN115575386B (zh) * 2022-09-26 2025-03-21 重庆医科大学 用于乳腺癌her2-ecd检测的电致化学发光能量共振转移适体传感器
EP4638775A1 (en) 2022-12-20 2025-10-29 Meso Scale Technologies, LLC Assay methods and kits
WO2025049305A1 (en) 2023-08-25 2025-03-06 Meso Scale Technologies, Llc. Viral strain serology assays
TWI871128B (zh) * 2023-12-08 2025-01-21 陳乃銘 可準確提供循環腫瘤細胞(ctc)所需藥物種類之方法
WO2025155756A1 (en) * 2024-01-17 2025-07-24 Cellsbin, Inc. Devices for biological analysis
WO2025168224A1 (en) * 2024-02-08 2025-08-14 Leica Microsystems Cms Gmbh Marker and method for analysing a biological sample
WO2025260043A1 (en) * 2024-06-14 2025-12-18 Meso Scale Technologies, Llc. Methods and kits for measuring three or more tau epitopes
WO2026039455A1 (en) 2024-08-13 2026-02-19 Meso Scale Technologies, Llc. Detection of nucleic acids
CN119818652B (zh) * 2025-03-18 2025-07-11 上海水大技术转移有限公司 一种治疗阿尔茨海默症的药物组合物

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4442204A (en) 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US4595661A (en) 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5026653A (en) 1985-04-02 1991-06-25 Leeco Diagnostic, Inc. Scavenger antibody mixture and its use for immunometric assay
US5356774A (en) 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US5635347A (en) 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US6165729A (en) 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5591581A (en) 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
JPH04222599A (ja) 1990-04-20 1992-08-12 Syntex Usa Inc 二重受容体ポリヌクレオチド検定方法
HUT64623A (en) 1990-05-04 1994-01-28 Chiron Corp Protein and nucleinic acid samples and immunic essays containing them
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
JP3080178B2 (ja) 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
JPH0534345A (ja) 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
US5665539A (en) 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
ZA929351B (en) 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
DE69327454T2 (de) 1992-10-09 2000-05-11 Vysis, Inc. Analytisches verfahren
FR2699537B1 (fr) 1992-12-18 1995-02-17 Pasteur Institut Protéine conférant une résistance de type inductible, à des glycopeptides, notamment chez des bactéries à gram-positif. Séquences de nucléotides codant pour cette protéine.
EP0688366B1 (en) 1993-01-15 2002-05-22 The Public Health Research Institute Of The City Of New York, Inc. Sensitive nucleic acid sandwich hybridization assays and kits
EP0682716A4 (en) 1993-01-15 1999-10-27 New York Health Res Inst RNA ASSAYS USING BINARY RNA PROBES AND A RIBOZYME-LIGASE.
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US6077668A (en) 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
DE69432419T2 (de) 1993-09-22 2004-01-08 Igen International, Inc. Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5561043A (en) 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
USRE38442E1 (en) 1994-06-22 2004-02-24 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
WO1995035390A1 (en) 1994-06-22 1995-12-28 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US20070269799A9 (en) 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5786141A (en) 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US5660991A (en) 1994-10-28 1997-08-26 Lakowicz; Joseph R. Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research
SE9404166D0 (sv) 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5641623A (en) 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US5643713A (en) 1995-06-07 1997-07-01 Liang; Pam Electrochemiluminescent monitoring of compounds
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
EP0821726B1 (en) 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5667974A (en) 1995-06-07 1997-09-16 Abbott Laboratories Method for detecting nucleic acid sequences using competitive amplification
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
DE69638321D1 (de) 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
AU714486B2 (en) 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
GB9606850D0 (en) 1996-04-01 1996-06-05 Univ Liverpool An assay system and novel labelled compounds for use therwith
SE9601676D0 (sv) 1996-04-30 1996-04-30 Ulf Landegren Improved probing of specific mucleic acids
SE9603171D0 (sv) 1996-08-30 1996-08-30 Marek Kwiatkowski Solid phase synthesis
JP2001523111A (ja) 1997-05-05 2001-11-20 サード ウェーブ テクノロジーズ,インコーポレーテッド 構造体架橋オリゴヌクレオチドを使用した標的依存型反応
US7314711B2 (en) 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
FR2764381A1 (fr) 1997-06-09 1998-12-11 Univ De Neuchatel Detecteur electrochimioluminescent
US6031098A (en) 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6413783B1 (en) 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
US6054274A (en) 1997-11-12 2000-04-25 Hewlett-Packard Company Method of amplifying the signal of target nucleic acid sequence analyte
EP1985714B1 (en) 1998-03-25 2012-02-29 Olink AB Method and kit for detecting a target molecule employing at least two affinity probes and rolling circle replication of padlock probes
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US8063190B2 (en) 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
EP0962773A1 (en) 1998-06-03 1999-12-08 Mark Howard Jones Electrochemical based assay processes instrument and labels
GB9815042D0 (en) 1998-07-10 1998-09-09 Imperial College Detector
WO2000004193A1 (en) 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
EP1114184A2 (en) 1998-09-15 2001-07-11 Yale University Molecular cloning using rolling circle amplification
US6214552B1 (en) 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
FR2788282B1 (fr) 1999-01-08 2002-12-13 Centre Nat Rech Scient Construction de recombinant de grande taille au moyen d'agents compactant l'adn
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
WO2001035100A2 (en) 1999-11-12 2001-05-17 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
JP2003515149A (ja) 1999-11-26 2003-04-22 キュラジェン コーポレイション 核酸プローブアレイ
US7309569B2 (en) 1999-12-21 2007-12-18 Ingeneus, Inc. Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6368801B1 (en) 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
SE0001670D0 (sv) 2000-05-04 2000-05-04 Forskarpatent I Syd Ab Mass-spectrometry-based biosensor
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6323009B1 (en) 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
EP1390530A2 (en) 2001-01-05 2004-02-25 Genomicfx, Inc. Method for relative quantification of attached nucleic acids
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6800608B2 (en) 2001-06-22 2004-10-05 Beckman Coulter, Inc. Homogeneous assay of vancomycin using a stable particle-vancomycin conjugate, a novel rate enhancer, and a novel dose response modulator
US6808939B2 (en) 2001-06-29 2004-10-26 Igen International, Inc. ECL labels having improved non-specific binding properties, methods of using and kits containing the same
WO2003001889A2 (en) 2001-06-29 2003-01-09 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
WO2003023360A2 (en) 2001-09-10 2003-03-20 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
US8013134B2 (en) 2001-11-23 2011-09-06 Olink Ab Kit for proximity probing with multivalent proximity probes
EP1490514A4 (en) 2002-03-29 2008-12-17 Nugen Technologies Inc THROUGH ISOTHERME SINGLE PRIMER NUCLEIC ACID AMPLIFICATION IMPROVED DETECTION AND QUANTIFICATION OF ANALYTES
EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
AU2003291249A1 (en) 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
EP1583950B1 (en) 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
US7192703B2 (en) 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
US7195875B2 (en) 2003-04-18 2007-03-27 Beckman Coulter, Inc. Oligonucleotide pairs for multiplexed binding assays
AU2004232976B2 (en) 2003-04-18 2011-02-10 Becton, Dickinson And Company Immuno-amplification
US20040248103A1 (en) 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
CN101208437B (zh) 2003-12-12 2012-07-04 圣路易斯大学 检测大分子和其它分析物的生物传感器
CN101198707A (zh) 2004-05-12 2008-06-11 内诺斯佩尔公司 基于生物条形码检测靶分析物
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
US7776583B2 (en) 2004-06-03 2010-08-17 Meso Scale Technologies, Llc Methods and apparatuses for conducting assays
GB0421529D0 (en) 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
EP1871897B1 (en) 2005-04-12 2010-09-29 Olink AB Methods for production of oligonucleotides
KR20080028886A (ko) 2005-05-26 2008-04-02 앙상블 디스커버리 코포레이션 핵산-템플레이팅된 화학 반응에 의한 생검출
DE602006018622D1 (de) 2005-06-30 2011-01-13 Ge Healthcare Bio Sciences Nachweisverfahren für die genexpression
US7883848B2 (en) 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
US20070161029A1 (en) 2005-12-05 2007-07-12 Panomics, Inc. High throughput profiling of methylation status of promoter regions of genes
US8551697B1 (en) 2005-12-09 2013-10-08 Applied Biosystems, Llc Electrochemical polynucleotide detection comprising ligation
WO2007076023A2 (en) 2005-12-21 2007-07-05 Meso Scale Technologies, Llc Assay modules having assay reagents and methods of making and using same
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
GB0605584D0 (en) 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
EP2511383B1 (en) 2006-03-31 2013-12-25 Columbia University Binary probes for fluorescent analysis of nucleic acids
EP2010475A2 (en) 2006-04-27 2009-01-07 Intezyne Technologies Incorporated Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
US8338776B2 (en) 2007-06-25 2012-12-25 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
WO2009029073A1 (en) 2007-08-30 2009-03-05 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
JP2010539982A (ja) 2007-10-01 2010-12-24 アプライド バイオシステムズ, エルエルシー チェイスライゲーション配列決定法
JP2009106220A (ja) 2007-10-31 2009-05-21 Genodive Pharma Kk 基板上での等温増幅反応による標的塩基配列の捕捉及び検出方法
US20120003632A1 (en) 2007-11-21 2012-01-05 Life Science Patents fret-probes and use thereof
US8617806B2 (en) 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
JP5435878B2 (ja) 2008-02-12 2014-03-05 富士フイルム株式会社 断片化抗体を標識物質に固定した標識粒子
JP2009222712A (ja) 2008-02-21 2009-10-01 Univ Nagoya メチシリン耐性ブドウ球菌の検出法、検出用試薬及び検出用キット
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
EP2294196A1 (en) 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
WO2010056577A1 (en) 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
EP2350657A4 (en) 2008-11-21 2013-06-12 Univ Saint Louis BIOSENSOR FOR DETECTING MULTIPLE EPITOPES ON ONE TARGET
US9976177B2 (en) 2009-04-01 2018-05-22 Dxterity Diagnostics Incorporated Chemical ligation dependent probe amplification (CLPA)
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
WO2010124157A1 (en) 2009-04-24 2010-10-28 Ambit Biosciences Corporation Cellular assay employing detectable protein
EP2459994A4 (en) 2009-07-27 2017-11-22 Meso Scale Technologies, LLC Assay information management methods and devices
KR101029343B1 (ko) 2009-07-30 2011-04-13 한국과학기술연구원 면역분석 기반의 항원 검출용 키트 및 항원 검출 방법
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
EP4459241A3 (en) 2009-12-07 2025-01-01 Meso Scale Technologies, LLC. Assay cartridge reader
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011143583A1 (en) 2010-05-13 2011-11-17 Illumina, Inc. Binding assays for markers
WO2012006476A2 (en) 2010-07-07 2012-01-12 Aethlon Medical, Inc. Methods and compositions for quantifying exosomes
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
CN108491681A (zh) 2010-07-27 2018-09-04 梅索磅秤技术有限公司 消耗品数据管理
CA2806930A1 (en) 2010-07-30 2012-02-02 Technische Universitat Dortmund Polymeric complements to b-amyloid peptides
EP2627781B1 (en) 2010-10-15 2017-02-22 Olink Bioscience AB Dynamic range methods
WO2012060083A1 (ja) 2010-11-05 2012-05-10 株式会社ニコン 照明装置、露光装置、プログラムおよび照明方法
US9731297B2 (en) 2011-01-06 2017-08-15 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
EP2500435B1 (en) 2011-03-18 2016-09-21 miacom Diagnostics GmbH Identification of antibiotic resistance in micro organisms
GB201107863D0 (en) * 2011-05-11 2011-06-22 Olink Ab Method and product
GB201108678D0 (en) * 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
KR101329127B1 (ko) 2011-06-30 2013-11-14 한국생명공학연구원 올리고뉴클레오타이드 결합 항체를 이용한 당단백질 검증방법
EP3467500B1 (en) 2011-11-11 2021-05-12 Eli N. Glezer Co-binder assisted assay methods
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
JP6630566B2 (ja) 2012-07-05 2020-01-15 メソ スケール テクノロジーズ エルエルシー 分析評価カートリッジのバルブシステム
CN104822696B (zh) 2012-08-02 2017-09-22 霍夫曼-拉罗奇有限公司 用于ecl的新型铱基配合物
WO2014031984A1 (en) 2012-08-24 2014-02-27 Baylor Research Institute Immunological detection methods and compositions
US10281678B2 (en) 2013-01-04 2019-05-07 Meso Scale Technologies, Llc Assay apparatuses, methods and reagants
CN105378477B9 (zh) * 2013-03-11 2021-08-06 梅索磅秤技术有限公司 用于进行多路测定法的改进方法
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
WO2015175856A1 (en) * 2014-05-15 2015-11-19 Meso Scale Technologies, Llc. Improved assay methods
ES2904514T3 (es) 2015-04-06 2022-04-05 Meso Scale Technologies Llc Sistema de alto rendimiento para realizar ensayos mediante el uso de electroquimioluminiscencia que incluye un aparato de agitación de consumibles
WO2018017156A1 (en) 2016-07-22 2018-01-25 Meso Scale Technologies, Llc. Integrated consumable data management system & platform
KR102658441B1 (ko) 2015-07-23 2024-04-16 메소 스케일 테크놀러지즈, 엘엘시 통합된 소모품 데이터 관리 시스템 및 플랫폼
JP6967006B2 (ja) 2016-01-15 2021-11-17 クアンタポール, インコーポレイテッド 低減されたバックグラウンドの光学に基づくナノポア分析
CN108374052A (zh) 2018-03-20 2018-08-07 徐州工程学院 用于生物芯片检测金黄色葡萄球菌的探针组序列
CN113557309A (zh) 2018-10-31 2021-10-26 斯坦福大学托管董事会 用于使用寡核苷酸缀合抗体检测细胞的方法和试剂盒
EP3906412A1 (en) 2019-01-03 2021-11-10 Meso Scale Technologies, LLC Compositions and methods for carrying out assay measurements
WO2022051485A2 (en) 2020-09-02 2022-03-10 Meso Scale Technologies,Llc. Kits for detecting one or more target analytes in a sample and methods of making and using the same

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