JPWO2020065614A5

JPWO2020065614A5 -

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Publication number: JPWO2020065614A5
Authority: JP; Japan
Prior art keywords: methyl; hexahydro; methanone; epiminocycloocta; pyrazol
Prior art date: 2023-03-23
Legal status : Granted

Application number

JP2021517338A

Other languages

English (en)

Japanese (ja)

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JP2022502440A (ja

JP7413368B2 (ja

Publication date

2023-03-23

2019-09-27 Application filed filed Critical

2019-09-27 Priority claimed from PCT/IB2019/058241 external-priority patent/WO2020065614A1/en

2022-01-11 Publication of JP2022502440A publication Critical patent/JP2022502440A/ja

2023-03-23 Publication of JPWO2020065614A5 publication Critical patent/JPWO2020065614A5/ja

2023-12-27 Priority to JP2023220520A priority Critical patent/JP2024038151A/ja

2024-01-15 Application granted granted Critical

2024-01-15 Publication of JP7413368B2 publication Critical patent/JP7413368B2/ja

Status Active legal-status Critical Current

2039-09-27 Anticipated expiration legal-status Critical

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-1 N(C═O)CH 3 Chemical group 0.000 claims description 683
CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims description 359
125000000217 alkyl group Chemical group 0.000 claims description 134
150000001875 compounds Chemical class 0.000 claims description 113
125000001188 haloalkyl group Chemical group 0.000 claims description 64
125000001475 halogen functional group Chemical group 0.000 claims description 44
125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 claims description 29
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 22
125000001072 heteroaryl group Chemical group 0.000 claims description 16
150000001204 N-oxides Chemical class 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 14
239000012453 solvate Substances 0.000 claims description 14
229910052757 nitrogen Inorganic materials 0.000 claims description 9
125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 7
125000004076 pyridyl group Chemical group 0.000 claims description 6
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 6
125000000714 pyrimidinyl group Chemical group 0.000 claims description 6
125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 5
125000001424 substituent group Chemical group 0.000 claims description 5
ZIYVWOCHDPPRQB-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ZIYVWOCHDPPRQB-APWZRJJASA-N 0.000 claims description 4
QSLOKEHAMWJXEF-ZHRRBRCNSA-N [(1S,8R)-5-(3,5-difluoro-4-methoxyphenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)OC)F)C)[C@@H]1CCC2 QSLOKEHAMWJXEF-ZHRRBRCNSA-N 0.000 claims description 4
CLLSRYUCUFLWKX-VFNWGFHPSA-N [4-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 CLLSRYUCUFLWKX-VFNWGFHPSA-N 0.000 claims description 4
VMSHGFHYFZVTSU-VFNWGFHPSA-N [5-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 VMSHGFHYFZVTSU-VFNWGFHPSA-N 0.000 claims description 4
125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims description 4
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 4
VUAOIXANWIFYCU-UHFFFAOYSA-N quinoline-6-carbaldehyde Chemical compound N1=CC=CC2=CC(C=O)=CC=C21 VUAOIXANWIFYCU-UHFFFAOYSA-N 0.000 claims description 3
UYQHZWKFJGZZBM-AEFFLSMTSA-N (1,4-dimethylpyrazol-3-yl)-[(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C(C(=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 UYQHZWKFJGZZBM-AEFFLSMTSA-N 0.000 claims description 2
JSTMUBIVINYHMT-ACJLOTCBSA-N (1,5-dimethylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC(=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 JSTMUBIVINYHMT-ACJLOTCBSA-N 0.000 claims description 2
UUBAEQMFLZTPPX-IRLDBZIGSA-N (1-benzyl-1,2,4-triazol-3-yl)-[(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C1=CC=CC=C1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 UUBAEQMFLZTPPX-IRLDBZIGSA-N 0.000 claims description 2
DUTXTOWDMVGKGV-QRWLVFNGSA-N (1-cyclopropyl-3-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)N1N=C(C(=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C DUTXTOWDMVGKGV-QRWLVFNGSA-N 0.000 claims description 2
CFUHMYWXLDHWDB-QRWLVFNGSA-N (1-cyclopropyl-5-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)N1N=CC(=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 CFUHMYWXLDHWDB-QRWLVFNGSA-N 0.000 claims description 2
FLDNYTKEKCUQAU-JPYJTQIMSA-N (1-methylindol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=CC2=C(C=CC=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 FLDNYTKEKCUQAU-JPYJTQIMSA-N 0.000 claims description 2
GWCNNMCJPPEJPT-ACJLOTCBSA-N (1-methylpyrazolo[3,4-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GWCNNMCJPPEJPT-ACJLOTCBSA-N 0.000 claims description 2
OKULNJZMDNWODB-YJYMSZOUSA-N (1-methylpyrazolo[3,4-b]pyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OKULNJZMDNWODB-YJYMSZOUSA-N 0.000 claims description 2
GPWZUDCSWJWCBM-PXAZEXFGSA-N (1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC=2C1=NC=NC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GPWZUDCSWJWCBM-PXAZEXFGSA-N 0.000 claims description 2
DDLKOLSDQUNKHU-VLIAUNLRSA-N (1-methylpyrrolo[2,3-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DDLKOLSDQUNKHU-VLIAUNLRSA-N 0.000 claims description 2
HBAQDEJGMLYXRY-VLIAUNLRSA-N (1-methylpyrrolo[2,3-b]pyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1C=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HBAQDEJGMLYXRY-VLIAUNLRSA-N 0.000 claims description 2
SNWXFJBSGGNIDS-UZLBHIALSA-N (2,7-dimethylimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1N=C2N(C=CC(=C2)C)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 SNWXFJBSGGNIDS-UZLBHIALSA-N 0.000 claims description 2
VYGUZLXROVRBEK-BEFAXECRSA-N (2,7-dimethylimidazo[1,2-b]pyridazin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1N=C2N(N=CC(=C2)C)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 VYGUZLXROVRBEK-BEFAXECRSA-N 0.000 claims description 2
ANEHJIIOBFCNGB-QRWLVFNGSA-N (2,7-dimethylpyrazolo[1,5-a]pyrimidin-5-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=NN2C(N=C(C=C2C)C(=O)N2[C@H]3CC=4C(=NN(C=4C4=CC(=C(C(=C4)F)F)F)C)[C@@H]2CCC3)=C1 ANEHJIIOBFCNGB-QRWLVFNGSA-N 0.000 claims description 2
OQEOJLWLRWDGGS-APWZRJJASA-N (2-amino-1,3-benzoxazol-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1OC2=C(N=1)C=CC(=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 OQEOJLWLRWDGGS-APWZRJJASA-N 0.000 claims description 2
ZIYVWOCHDPPRQB-QFBILLFUSA-N (2-chloro-3-methoxyphenyl)-[(1R,8S)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@H]1CCC2 ZIYVWOCHDPPRQB-QFBILLFUSA-N 0.000 claims description 2
BQULOSOPSNXQGL-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)F)C)[C@@H]1CCC2 BQULOSOPSNXQGL-APWZRJJASA-N 0.000 claims description 2
TWLFLJJQGNUSMF-APWZRJJASA-N (2-chloro-3-methoxyphenyl)-[(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 TWLFLJJQGNUSMF-APWZRJJASA-N 0.000 claims description 2
UYIUAUOTIIXXKS-KNQAVFIVSA-N (2-chloroquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=NC2=CC=C(C=C2C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 UYIUAUOTIIXXKS-KNQAVFIVSA-N 0.000 claims description 2
TTYTYEPMUUULHR-XCLFUZPHSA-N (2-fluoro-4-methoxyphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=CC(=C1)OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TTYTYEPMUUULHR-XCLFUZPHSA-N 0.000 claims description 2
AEBPYHPPZHLPJY-VLIAUNLRSA-N (2-fluoro-4-methylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=CC(=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AEBPYHPPZHLPJY-VLIAUNLRSA-N 0.000 claims description 2
RXKCPUIGFQDHLL-ZHRRBRCNSA-N (2-imidazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RXKCPUIGFQDHLL-ZHRRBRCNSA-N 0.000 claims description 2
AHFXOBXKMMUQFY-VLIAUNLRSA-N (2-methylindazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=C2C=CC=CC2=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AHFXOBXKMMUQFY-VLIAUNLRSA-N 0.000 claims description 2
WTWXHNLCGACQHJ-OFNKIYASSA-N (3-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C=NC2=CC=C(C=C2C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 WTWXHNLCGACQHJ-OFNKIYASSA-N 0.000 claims description 2
YNZSLNYIBIKCMQ-DIFFPNOSSA-N (3-chloro-5-fluoropyridin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=NC=C(C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F YNZSLNYIBIKCMQ-DIFFPNOSSA-N 0.000 claims description 2
LYVXQMJKAGWYOQ-QRWLVFNGSA-N (3-chloro-5-methoxyphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=C(C=C(C=1)OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 LYVXQMJKAGWYOQ-QRWLVFNGSA-N 0.000 claims description 2
VYXXLGQUZRBVAO-KUHUBIRLSA-N (3-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C VYXXLGQUZRBVAO-KUHUBIRLSA-N 0.000 claims description 2
WTVJKYYXGHSAQJ-WBMJQRKESA-N (3-fluoro-1,5-dimethylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=NN(C(=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C)C WTVJKYYXGHSAQJ-WBMJQRKESA-N 0.000 claims description 2
LVIGGIBAJSAOPT-VGSWGCGISA-N (3-fluoro-5-pyrazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=C(C=1)N1N=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 LVIGGIBAJSAOPT-VGSWGCGISA-N 0.000 claims description 2
YSUQHTKAGRVBQK-GGAORHGYSA-N (3-imidazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 YSUQHTKAGRVBQK-GGAORHGYSA-N 0.000 claims description 2
MDFFCSOQJKECLA-PXAZEXFGSA-N (3-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C MDFFCSOQJKECLA-PXAZEXFGSA-N 0.000 claims description 2
AYTVIBWMKNIZOS-IERDGZPVSA-N (3-methyl-5-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)(C)C1=NC=2N(C(=C1)C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC(=C(C(=C4)F)F)F)C)[C@@H]1CCC3)N=CC=2C AYTVIBWMKNIZOS-IERDGZPVSA-N 0.000 claims description 2
HPNWDHDDCVRIPG-JPYJTQIMSA-N (4-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 HPNWDHDDCVRIPG-JPYJTQIMSA-N 0.000 claims description 2
KLTMYKUSHJCLRE-BEFAXECRSA-N (4-chloro-1H-pyrrolo[2,3-b]pyridin-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C2C(=NC=C1C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC=CC=C4)C)[C@@H]1CCC3)NC=C2 KLTMYKUSHJCLRE-BEFAXECRSA-N 0.000 claims description 2
APEKZRRGJPOOTR-ACJLOTCBSA-N (4-chloro-2-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C(=NC=C1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 APEKZRRGJPOOTR-ACJLOTCBSA-N 0.000 claims description 2
YNAYEVBYYNJYNJ-ACJLOTCBSA-N (4-chloro-5-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=NC=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YNAYEVBYYNJYNJ-ACJLOTCBSA-N 0.000 claims description 2
WCEAPYPDSWPKOQ-JPYJTQIMSA-N (4-chloroquinolin-6-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 WCEAPYPDSWPKOQ-JPYJTQIMSA-N 0.000 claims description 2
ZAHTYSSHIVUTIH-BEFAXECRSA-N (4-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C2C(=NC=C1C(=O)N1[C@H]3CC=4C(=NN(C=4C4=CC=CC=C4)C)[C@@H]1CCC3)NC=C2 ZAHTYSSHIVUTIH-BEFAXECRSA-N 0.000 claims description 2
CCXYIPREYDZNPJ-YJYMSZOUSA-N (4-fluoropyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=2N(C=CC=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 CCXYIPREYDZNPJ-YJYMSZOUSA-N 0.000 claims description 2
IYMMEIPWFRVFNU-QRWLVFNGSA-N (4-methoxy-5-pyrazol-1-ylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NC=C1N1N=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 IYMMEIPWFRVFNU-QRWLVFNGSA-N 0.000 claims description 2
NEJLNCPINLSJBO-KUHUBIRLSA-N (4-methoxypyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=2N(C=CC=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 NEJLNCPINLSJBO-KUHUBIRLSA-N 0.000 claims description 2
UXZLLJSREZAKHR-YJYMSZOUSA-N (4-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UXZLLJSREZAKHR-YJYMSZOUSA-N 0.000 claims description 2
RIWYFBUYMNNACH-ACJLOTCBSA-N (4-methoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RIWYFBUYMNNACH-ACJLOTCBSA-N 0.000 claims description 2
ZCSHXPNCIRZDQN-ACJLOTCBSA-N (5,6-dimethoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=NC=1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 ZCSHXPNCIRZDQN-ACJLOTCBSA-N 0.000 claims description 2
KWSYXNMWCMBCEU-KDOFPFPSSA-N (5,6-dimethoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=C(C=NC=1OC)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KWSYXNMWCMBCEU-KDOFPFPSSA-N 0.000 claims description 2
ZKONBDSQJCFLDX-APWZRJJASA-N (5-aminopyridin-2-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1C=CC(=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 ZKONBDSQJCFLDX-APWZRJJASA-N 0.000 claims description 2
JNRDRTNNAGZSQT-PBHICJAKSA-N (5-chloro-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 JNRDRTNNAGZSQT-PBHICJAKSA-N 0.000 claims description 2
SWSONSGLFXJJIH-VGSWGCGISA-N (5-chloro-1H-indol-6-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC=1C=C2C=CNC2=CC=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 SWSONSGLFXJJIH-VGSWGCGISA-N 0.000 claims description 2
ABZLOKFORXLDQN-XLIONFOSSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ABZLOKFORXLDQN-XLIONFOSSA-N 0.000 claims description 2
CDKPMNQGLHHMTG-XLIONFOSSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-5-(3,5-dichlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)Cl)Cl)C)[C@@H]1CCC2 CDKPMNQGLHHMTG-XLIONFOSSA-N 0.000 claims description 2
QTQGIJHIKJISJS-RDGATRHJSA-N (5-cyclopropyl-1-phenylpyrazol-4-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 QTQGIJHIKJISJS-RDGATRHJSA-N 0.000 claims description 2
MZSUQKXMJRRSQS-APWZRJJASA-N (5-cyclopropyl-1H-pyrazol-4-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 MZSUQKXMJRRSQS-APWZRJJASA-N 0.000 claims description 2
BBHNQOMBKUQJJV-YJYMSZOUSA-N (5-ethyl-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BBHNQOMBKUQJJV-YJYMSZOUSA-N 0.000 claims description 2
IPMJMGUBODZWRM-UTKZUKDTSA-N (5-ethyl-1-phenyl-1,2,4-triazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)C1=NC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 IPMJMGUBODZWRM-UTKZUKDTSA-N 0.000 claims description 2
UQCMUCZOOFDMGE-ZHRRBRCNSA-N (5-fluoro-2-pyrazol-1-ylphenyl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=C1 UQCMUCZOOFDMGE-ZHRRBRCNSA-N 0.000 claims description 2
GNBSGWXOHPVJKB-PXAZEXFGSA-N (5-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GNBSGWXOHPVJKB-PXAZEXFGSA-N 0.000 claims description 2
NMTXGFOHHDBDSC-QAPCUYQASA-N (5-methoxy-1-methylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 NMTXGFOHHDBDSC-QAPCUYQASA-N 0.000 claims description 2
FBACIAVAIHWSAM-UZLBHIALSA-N (5-methoxy-1-phenyl-1,2,4-triazol-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=NC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 FBACIAVAIHWSAM-UZLBHIALSA-N 0.000 claims description 2
VBFJWMRAOCWYNA-OFNKIYASSA-N (5-methoxy-1-phenylpyrazol-3-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NN1C1=CC=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 VBFJWMRAOCWYNA-OFNKIYASSA-N 0.000 claims description 2
KVIRCWNPBNGNGJ-KUHUBIRLSA-N (5-methoxy-4-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C KVIRCWNPBNGNGJ-KUHUBIRLSA-N 0.000 claims description 2
MNHDNBUQUVXVNE-YJYMSZOUSA-N (5-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MNHDNBUQUVXVNE-YJYMSZOUSA-N 0.000 claims description 2
BRGULWTXWYMWDG-ZHRRBRCNSA-N (6-cyclopropyl-2-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=CC=C(C(=N1)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BRGULWTXWYMWDG-ZHRRBRCNSA-N 0.000 claims description 2
GOPCRFISLSUSLN-VLIAUNLRSA-N (6-fluoropyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC=2N(C=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GOPCRFISLSUSLN-VLIAUNLRSA-N 0.000 claims description 2
AUAXYJJIFZPFBV-UZLBHIALSA-N (6-imidazol-1-ylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1(C=NC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AUAXYJJIFZPFBV-UZLBHIALSA-N 0.000 claims description 2
SPPWHSGBNMUREF-BEFAXECRSA-N (6-methoxy-5-methylpyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C SPPWHSGBNMUREF-BEFAXECRSA-N 0.000 claims description 2
HHLUQRDNNRCZML-SZNDQCEHSA-N (6-methoxypyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC=2N(C=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HHLUQRDNNRCZML-SZNDQCEHSA-N 0.000 claims description 2
FACWDLUVSKSTMT-ACJLOTCBSA-N (6-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC=CC(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 FACWDLUVSKSTMT-ACJLOTCBSA-N 0.000 claims description 2
HLTTZNDUNMRTGX-KDOFPFPSSA-N (6-methoxypyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HLTTZNDUNMRTGX-KDOFPFPSSA-N 0.000 claims description 2
DPEXPEWNJXENAW-PXAZEXFGSA-N (6-methoxypyrimidin-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=CC(=NC=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DPEXPEWNJXENAW-PXAZEXFGSA-N 0.000 claims description 2
BSMWQTHOKXWRNJ-IERDGZPVSA-N (6-methyl-3-pyrazol-1-ylpyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC=C(C(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=C1 BSMWQTHOKXWRNJ-IERDGZPVSA-N 0.000 claims description 2
STNGODDQHJMZKH-KDOFPFPSSA-N (7-chloroimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=CC=2N(C=C1)C(=CN=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 STNGODDQHJMZKH-KDOFPFPSSA-N 0.000 claims description 2
HWMBLPHBACRLRY-IERDGZPVSA-N (7-cyclopropyl-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=CC(=NC=2N1N=C(C=2)C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HWMBLPHBACRLRY-IERDGZPVSA-N 0.000 claims description 2
KKCXYGXHUCNMDA-KDOFPFPSSA-N (7-fluoroimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC=2N(C=C1)C(=CN=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KKCXYGXHUCNMDA-KDOFPFPSSA-N 0.000 claims description 2
SUMLJNNGEBCOKU-CTNGQTDRSA-N (7-methyl-1H-indazol-5-yl)-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=C(C=C2C=NNC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 SUMLJNNGEBCOKU-CTNGQTDRSA-N 0.000 claims description 2
GXZPFNAOVAMOBW-KNQAVFIVSA-N (8-aminoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound NC=1C=C(C=C2C=CC=NC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 GXZPFNAOVAMOBW-KNQAVFIVSA-N 0.000 claims description 2
NHBIFYVPGJZXQW-KNQAVFIVSA-N (8-bromoquinolin-6-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C=C(C=C2C=CC=NC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 NHBIFYVPGJZXQW-KNQAVFIVSA-N 0.000 claims description 2
IDBMXXDFJWXYMN-UZLBHIALSA-N 1-[5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridin-2-yl]cyclopropane-1-carbonitrile Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=CC(=NC=1)C1(CC1)C#N IDBMXXDFJWXYMN-UZLBHIALSA-N 0.000 claims description 2
BZFYTDHYKDCYCD-IERDGZPVSA-N 1-[5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridin-3-yl]pyrrolidin-2-one Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C(C=NC=1)N1C(CCC1)=O BZFYTDHYKDCYCD-IERDGZPVSA-N 0.000 claims description 2
MBZFOWYEVPOOKN-QRWLVFNGSA-N 3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound O1CCCC2=NC=C(C=C21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MBZFOWYEVPOOKN-QRWLVFNGSA-N 0.000 claims description 2
125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims description 2
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 2
125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 2
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
TVRMGWPIAASKEM-ACJLOTCBSA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=C(C=C2OCCCN21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TVRMGWPIAASKEM-ACJLOTCBSA-N 0.000 claims description 2
BQZGDDFKISDIAH-ACJLOTCBSA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=CC(=C2OCCCN21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BQZGDDFKISDIAH-ACJLOTCBSA-N 0.000 claims description 2
GPGPAAGDFXXDND-KUHUBIRLSA-N 6-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]pyridine-2-carbonitrile Chemical compound CN1N=C2C(=C1C1=CC(=C(C(=C1)F)F)F)C[C@H]1CCC[C@@H]2N1C(=O)C1=CC=CC(=N1)C#N GPGPAAGDFXXDND-KUHUBIRLSA-N 0.000 claims description 2
OMRIFXBBGZBOCC-GCJKJVERSA-N 6-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-1H-quinolin-4-one Chemical compound OC1=CC=NC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 OMRIFXBBGZBOCC-GCJKJVERSA-N 0.000 claims description 2
AKIOQQVCDGVFQN-YKSBVNFPSA-N 6-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-1-(2-fluoroethyl)quinolin-4-one Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C(C=CN(C2=CC=1)CCF)=O AKIOQQVCDGVFQN-YKSBVNFPSA-N 0.000 claims description 2
OMMGAXVUOQTYRZ-QUCCMNQESA-N 6-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]-4-methyl-1,4-benzoxazin-3-one Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=CC2=C(OCC(N2C)=O)C=C1 OMMGAXVUOQTYRZ-QUCCMNQESA-N 0.000 claims description 2
DCXBIZUASUMXQQ-VGSWGCGISA-N N-[3-methoxy-5-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-diene-12-carbonyl]phenyl]acetamide Chemical compound COC=1C=C(C=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)NC(C)=O DCXBIZUASUMXQQ-VGSWGCGISA-N 0.000 claims description 2
ZKCOGWDAZHCDSI-RDGATRHJSA-N [(1S,8R)-4-cyclopropyl-5-(3-fluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound C1(CC1)N1N=C2C(=C1C1=CC(=CC=C1)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 ZKCOGWDAZHCDSI-RDGATRHJSA-N 0.000 claims description 2
HGDHJSATEJUOLI-UZLBHIALSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(2-pyrazol-1-ylpyridin-4-yl)methanone Chemical compound N1(N=CC=C1)C1=NC=CC(=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HGDHJSATEJUOLI-UZLBHIALSA-N 0.000 claims description 2
WEANNUCJQVYULB-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(4-pyrazol-1-ylpyridin-2-yl)methanone Chemical compound N1(N=CC=C1)C1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WEANNUCJQVYULB-IERDGZPVSA-N 0.000 claims description 2
KDMXKJBNBZMCBN-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(4-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C1=C(C=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 KDMXKJBNBZMCBN-VFNWGFHPSA-N 0.000 claims description 2
DWZCHFFRTPZKOH-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-propan-2-yloxypyridin-3-yl)methanone Chemical compound C(C)(C)OC=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 DWZCHFFRTPZKOH-IERDGZPVSA-N 0.000 claims description 2
AUIQQRPQYBVUAW-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 AUIQQRPQYBVUAW-IERDGZPVSA-N 0.000 claims description 2
XXSIWIALDYQTQO-VLIAUNLRSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-propan-2-ylpyrimidin-4-yl)methanone Chemical compound C(C)(C)C1=CC(=NC=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XXSIWIALDYQTQO-VLIAUNLRSA-N 0.000 claims description 2
BHUYGBCUWIPUOY-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrazol-1-ylpyridin-2-yl)methanone Chemical compound N1(N=CC=C1)C1=CC=CC(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BHUYGBCUWIPUOY-QRWLVFNGSA-N 0.000 claims description 2
UGYVPNGSRATLKA-UZLBHIALSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound N1(N=CC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UGYVPNGSRATLKA-UZLBHIALSA-N 0.000 claims description 2
OASYIQAYBFOKDP-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(6-pyrrol-1-ylpyridin-3-yl)methanone Chemical compound N1(C=CC=C1)C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OASYIQAYBFOKDP-UTKZUKDTSA-N 0.000 claims description 2
YYWCUXGWJAGEIJ-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[1,5-a]pyridin-7-yl)methanone Chemical compound N=1C=NN2C=1C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YYWCUXGWJAGEIJ-KDOFPFPSSA-N 0.000 claims description 2
BAZKUEQYIZPOIS-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[4,3-a]pyridin-7-yl)methanone Chemical compound N=1N=CN2C=1C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 BAZKUEQYIZPOIS-KDOFPFPSSA-N 0.000 claims description 2
MRNRBXURUVCVOW-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=C(C=C(C=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MRNRBXURUVCVOW-VFNWGFHPSA-N 0.000 claims description 2
NLQNNVNESZKTPT-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 NLQNNVNESZKTPT-VFNWGFHPSA-N 0.000 claims description 2
WZIFKSFXBMKMPH-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-1-yl)phenyl]methanone Chemical compound N1(N=NC=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WZIFKSFXBMKMPH-VFNWGFHPSA-N 0.000 claims description 2
XKDKCEDYXTXVOP-VLIAUNLRSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-3-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XKDKCEDYXTXVOP-VLIAUNLRSA-N 0.000 claims description 2
QXEGWMZTYWEQFY-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-4-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC(=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 QXEGWMZTYWEQFY-QRWLVFNGSA-N 0.000 claims description 2
PJCQKNJCMGYSGN-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=C(C=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 PJCQKNJCMGYSGN-VFNWGFHPSA-N 0.000 claims description 2
TWNOKRKAONVJLC-VFNWGFHPSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 TWNOKRKAONVJLC-VFNWGFHPSA-N 0.000 claims description 2
PHTFSKSFIYBJBN-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 PHTFSKSFIYBJBN-UTKZUKDTSA-N 0.000 claims description 2
XSKZYWKJCGZPCL-IERDGZPVSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XSKZYWKJCGZPCL-IERDGZPVSA-N 0.000 claims description 2
MRVZBRAIYIPGHU-KDOFPFPSSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(triazol-2-yl)pyridin-2-yl]methanone Chemical compound N=1N(N=CC=1)C=1C(=NC=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 MRVZBRAIYIPGHU-KDOFPFPSSA-N 0.000 claims description 2
YAGVMJYDXFQQNS-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-4-yl)pyridin-2-yl]methanone Chemical compound N=1N=CN(C=1)C1=CC(=NC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YAGVMJYDXFQQNS-QRWLVFNGSA-N 0.000 claims description 2
HWLKHBGZSPQVCJ-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[5-(1,2,4-triazol-4-yl)pyridin-3-yl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HWLKHBGZSPQVCJ-QRWLVFNGSA-N 0.000 claims description 2
ZEJWYIRSDCXJOC-QRWLVFNGSA-N [(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[5-(triazol-2-yl)pyridin-3-yl]methanone Chemical compound N=1N(N=CC=1)C=1C=C(C=NC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 ZEJWYIRSDCXJOC-QRWLVFNGSA-N 0.000 claims description 2
IWBMKXVHKSBTPS-APWZRJJASA-N [(1S,8R)-4-methyl-5-[5-(trifluoromethyl)thiophen-2-yl]-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C=1SC(=CC=1)C(F)(F)F)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 IWBMKXVHKSBTPS-APWZRJJASA-N 0.000 claims description 2
XTHICEHCXHRCAQ-ZBFHGGJFSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 XTHICEHCXHRCAQ-ZBFHGGJFSA-N 0.000 claims description 2
WISHDWNJDGSLMM-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methylpyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 WISHDWNJDGSLMM-UTKZUKDTSA-N 0.000 claims description 2
NUBCSOOBBRZRJO-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-methylpyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1C=CC=2C1=NC=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 NUBCSOOBBRZRJO-UTKZUKDTSA-N 0.000 claims description 2
PAVXQOCCFZCZMI-CTNGQTDRSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=NN(C=N1)C1=CC=CC=C1 PAVXQOCCFZCZMI-CTNGQTDRSA-N 0.000 claims description 2
YIOXWQULFGEGPF-OFNKIYASSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenylpyrazol-3-yl)methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=NN(C=C1)C1=CC=CC=C1 YIOXWQULFGEGPF-OFNKIYASSA-N 0.000 claims description 2
PXLRUFWKWINRMY-AEFFLSMTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-([1,2,4]triazolo[1,5-a]pyridin-5-yl)methanone Chemical compound N=1C=NN2C=1C=CC=C2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 PXLRUFWKWINRMY-AEFFLSMTSA-N 0.000 claims description 2
BTUQNOJKVBZKIH-GCJKJVERSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 BTUQNOJKVBZKIH-GCJKJVERSA-N 0.000 claims description 2
GFBDPLNOSDXAHI-XLIONFOSSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(trifluoromethyl)-1,8-naphthyridin-3-yl]methanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C(=NC2=NC=CC=C2C=1)C(F)(F)F GFBDPLNOSDXAHI-XLIONFOSSA-N 0.000 claims description 2
RTERZJOQNPMPAP-IRLDBZIGSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 RTERZJOQNPMPAP-IRLDBZIGSA-N 0.000 claims description 2
ZMSVXHVARRPOOK-IRLDBZIGSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C1=CC=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2 ZMSVXHVARRPOOK-IRLDBZIGSA-N 0.000 claims description 2
HQWCVNCKTOJMIR-KNQAVFIVSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinazolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=NC=NC2=CC=1 HQWCVNCKTOJMIR-KNQAVFIVSA-N 0.000 claims description 2
NGTUNMOWIRHVDP-OFNKIYASSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2C=CC=NC2=CC=1 NGTUNMOWIRHVDP-OFNKIYASSA-N 0.000 claims description 2
AQEYEVXVCDXQJV-UTKZUKDTSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-5-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C1=C2N=CC=NC2=CC=C1 AQEYEVXVCDXQJV-UTKZUKDTSA-N 0.000 claims description 2
FCVJXRXVWWAENR-GCJKJVERSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2C(=C1C1=CC=CC=C1)C[C@H]1CCC[C@@H]2N1C(=O)C=1C=C2N=CC=NC2=CC=1 FCVJXRXVWWAENR-GCJKJVERSA-N 0.000 claims description 2
OBXQIVVIJCBYFA-ZHRRBRCNSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C=C3)F)F)C)[C@@H]1CCC2 OBXQIVVIJCBYFA-ZHRRBRCNSA-N 0.000 claims description 2
YZGXBUQGMROJOV-JPYJTQIMSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 YZGXBUQGMROJOV-JPYJTQIMSA-N 0.000 claims description 2
WMRFKCKRLJSOIJ-ZHRRBRCNSA-N [(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2N=CC=NC2=CC=1 WMRFKCKRLJSOIJ-ZHRRBRCNSA-N 0.000 claims description 2
BZRJOSCAOZJAHY-IRLDBZIGSA-N [(1S,8R)-5-(3,5-dichlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)Cl)Cl)C)[C@@H]1CCC2 BZRJOSCAOZJAHY-IRLDBZIGSA-N 0.000 claims description 2
ABQRWYYEZAJLCK-OFNKIYASSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-oxidoquinolin-1-ium-6-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=[N+](C2=CC=1)[O-] ABQRWYYEZAJLCK-OFNKIYASSA-N 0.000 claims description 2
DYHSEBDUEXPEPD-XXBNENTESA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(2-pyrimidin-2-ylphenyl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=C(C=CC=C1)C1=NC=CC=N1 DYHSEBDUEXPEPD-XXBNENTESA-N 0.000 claims description 2
LRPFHSBMTDVKSD-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-ethyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)CC)C1=CC=CC=C1 LRPFHSBMTDVKSD-IRLDBZIGSA-N 0.000 claims description 2
JLMIZUIXBMPXOO-QAPCUYQASA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-methoxy-1-methylpyrazol-4-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=NN(C=1OC)C JLMIZUIXBMPXOO-QAPCUYQASA-N 0.000 claims description 2
SFQDPXIUOFLESM-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(5-methyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)C)C1=CC=CC=C1 SFQDPXIUOFLESM-IRLDBZIGSA-N 0.000 claims description 2
BAYCHQXMTBCYGZ-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=N1)C)C1=CC=C(C=C1)F BAYCHQXMTBCYGZ-IRLDBZIGSA-N 0.000 claims description 2
JJCVDVSZKLITPX-QAPCUYQASA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-ethyl-5-(trifluoromethyl)pyrazol-3-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C(=C1)C(F)(F)F)CC JJCVDVSZKLITPX-QAPCUYQASA-N 0.000 claims description 2
SBSCNBYELAVCPM-UTKZUKDTSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(1H-1,2,4-triazol-5-yl)phenyl]methanone Chemical compound N1N=CN=C1C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 SBSCNBYELAVCPM-UTKZUKDTSA-N 0.000 claims description 2
QIKQZDQLKVCZTG-GCJKJVERSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 QIKQZDQLKVCZTG-GCJKJVERSA-N 0.000 claims description 2
KKKQZMAFAZDGHH-IRLDBZIGSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 KKKQZMAFAZDGHH-IRLDBZIGSA-N 0.000 claims description 2
PUMUSGNPLSGQMY-OFNKIYASSA-N [(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 PUMUSGNPLSGQMY-OFNKIYASSA-N 0.000 claims description 2
NHNCPYZDAMDSIT-VGSWGCGISA-N [(1S,8R)-5-(3-chloro-4-methoxyphenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C=C3)OC)Cl)C)[C@@H]1CCC2 NHNCPYZDAMDSIT-VGSWGCGISA-N 0.000 claims description 2
FSYNGJIZQRTJGN-GGAORHGYSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(3-pyrazol-1-ylphenyl)methanone Chemical compound N1(N=CC=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 FSYNGJIZQRTJGN-GGAORHGYSA-N 0.000 claims description 2
SPEAHADODNSPJL-CTNGQTDRSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[1-(3-chlorophenyl)-1,2,4-triazol-3-yl]methanone Chemical compound ClC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 SPEAHADODNSPJL-CTNGQTDRSA-N 0.000 claims description 2
XWDGISPRYNTBPG-GCJKJVERSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-chloro-5-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound ClC1=C(C=C(C=C1)N1C=NN=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 XWDGISPRYNTBPG-GCJKJVERSA-N 0.000 claims description 2
UCWVSSSHPOULGQ-IRLDBZIGSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 UCWVSSSHPOULGQ-IRLDBZIGSA-N 0.000 claims description 2
GBHNIFLOXGZILO-GGAORHGYSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(1H-pyrazol-4-yl)phenyl]methanone Chemical compound N1N=CC(=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 GBHNIFLOXGZILO-GGAORHGYSA-N 0.000 claims description 2
HHOKJUWUYFOCEN-CTNGQTDRSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[3-(tetrazol-1-yl)phenyl]methanone Chemical compound N1(N=NN=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 HHOKJUWUYFOCEN-CTNGQTDRSA-N 0.000 claims description 2
KLNLWOKKDKRIQS-IRLDBZIGSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[4-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound N=1N=CN(C=1)C1=CC=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC=C3)Cl)C)[C@@H]1CCC2 KLNLWOKKDKRIQS-IRLDBZIGSA-N 0.000 claims description 2
VHOTYKSATLJGFZ-OFNKIYASSA-N [(1S,8R)-5-(3-chlorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 VHOTYKSATLJGFZ-OFNKIYASSA-N 0.000 claims description 2
QBLGRFBMMPNLBT-CTNGQTDRSA-N [(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C1=NN(C=N1)C1=CC=CC=C1 QBLGRFBMMPNLBT-CTNGQTDRSA-N 0.000 claims description 2
XDVYLRGGKQYXSW-OFNKIYASSA-N [(1S,8R)-5-(3-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 XDVYLRGGKQYXSW-OFNKIYASSA-N 0.000 claims description 2
XXKMBABMWSXVBU-GCJKJVERSA-N [(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=C(C=C3)F)C)[C@@H]1CCC2 XXKMBABMWSXVBU-GCJKJVERSA-N 0.000 claims description 2
JSTXJKQJHPPMNZ-OFNKIYASSA-N [(1S,8R)-5-(4-fluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC1=CC=C(C=C1)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1 JSTXJKQJHPPMNZ-OFNKIYASSA-N 0.000 claims description 2
PNEKPBPWWFWLSJ-JPYJTQIMSA-N [(1S,8R)-5-[3-(difluoromethyl)-4-fluorophenyl]-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinolin-6-ylmethanone Chemical compound FC(C=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2C=CC=NC2=CC=1)F PNEKPBPWWFWLSJ-JPYJTQIMSA-N 0.000 claims description 2
NTDUJOKVIDTUFW-ZHRRBRCNSA-N [(1S,8R)-5-[3-(difluoromethyl)-4-fluorophenyl]-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]-quinoxalin-6-ylmethanone Chemical compound FC(C=1C=C(C=CC=1F)C1=C2C(=NN1C)[C@@H]1CCC[C@H](C2)N1C(=O)C=1C=C2N=CC=NC2=CC=1)F NTDUJOKVIDTUFW-ZHRRBRCNSA-N 0.000 claims description 2
XPKYEGDQLHBJPD-QRWLVFNGSA-N [1-(2-methoxyphenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC1=C(C=CC=C1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 XPKYEGDQLHBJPD-QRWLVFNGSA-N 0.000 claims description 2
OAPNJFZJQWEPOA-UZLBHIALSA-N [1-(3-fluorophenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 OAPNJFZJQWEPOA-UZLBHIALSA-N 0.000 claims description 2
UXTNOTGXPQVVON-IERDGZPVSA-N [1-(3-methoxyphenyl)-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=C(C=CC=1)N1N=C(N=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UXTNOTGXPQVVON-IERDGZPVSA-N 0.000 claims description 2
YFLJTQLASQZXJD-UTKZUKDTSA-N [1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC=C(C=C1)N1N=C(N=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 YFLJTQLASQZXJD-UTKZUKDTSA-N 0.000 claims description 2
HBQVCCALVGCLRW-ACJLOTCBSA-N [1-tert-butyl-5-(trifluoromethyl)pyrazol-4-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C(C)(C)(C)N1N=CC(=C1C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 HBQVCCALVGCLRW-ACJLOTCBSA-N 0.000 claims description 2
SMUJAXFFFBWAGB-ZHRRBRCNSA-N [2-(4-methyltriazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=NN(N=C1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 SMUJAXFFFBWAGB-ZHRRBRCNSA-N 0.000 claims description 2
IBICNCNPGNRPLE-UZLBHIALSA-N [2-(5-chloro-1H-1,2,4-triazol-3-yl)phenyl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound ClC1=NC(=NN1)C1=C(C=CC=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 IBICNCNPGNRPLE-UZLBHIALSA-N 0.000 claims description 2
BJMKJAUWMFZXMB-DYVFJYSZSA-N [2-(difluoromethyl)imidazo[1,2-a]pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC(C=1N=C2N(C=CC=C2)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F BJMKJAUWMFZXMB-DYVFJYSZSA-N 0.000 claims description 2
QLRHHXHYQKNZPK-XXBNENTESA-N [3-(1-methylpyrazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN1N=CC(=C1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 QLRHHXHYQKNZPK-XXBNENTESA-N 0.000 claims description 2
WKBUTNQMYFYMIP-GCJKJVERSA-N [3-(4-fluoropyrazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=NN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WKBUTNQMYFYMIP-GCJKJVERSA-N 0.000 claims description 2
GFLTUKCQSILKKZ-JPYJTQIMSA-N [3-(4-methoxypyrazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=NN(C=1)C=1C=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GFLTUKCQSILKKZ-JPYJTQIMSA-N 0.000 claims description 2
XCEAPQVSARFZLX-XLIONFOSSA-N [3-cyclopropyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=NN(C=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2)CC(F)(F)F XCEAPQVSARFZLX-XLIONFOSSA-N 0.000 claims description 2
DTTKPYHUDABKDU-VLIAUNLRSA-N [3-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 DTTKPYHUDABKDU-VLIAUNLRSA-N 0.000 claims description 2
IEKUSQDQFFMKNX-VLIAUNLRSA-N [3-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 IEKUSQDQFFMKNX-VLIAUNLRSA-N 0.000 claims description 2
RYVHLCZBIVILJL-IERDGZPVSA-N [3-fluoro-5-(1,2,4-triazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=C(C=C(C=1)N1C=NN=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 RYVHLCZBIVILJL-IERDGZPVSA-N 0.000 claims description 2
VLTSBNJWZWWQDD-QRWLVFNGSA-N [3-methoxy-2-(triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=NC=C1 VLTSBNJWZWWQDD-QRWLVFNGSA-N 0.000 claims description 2
UCHBKKSHFMPYMC-QRWLVFNGSA-N [3-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 UCHBKKSHFMPYMC-QRWLVFNGSA-N 0.000 claims description 2
ILGCAPJQUOFKIK-IERDGZPVSA-N [3-methyl-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C(=C(C=CC=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 ILGCAPJQUOFKIK-IERDGZPVSA-N 0.000 claims description 2
FENXXKPOIXTISX-HIFRSBDPSA-N [4-bromo-2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-[(1S,8R)-4-methyl-5-phenyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound BrC=1C(=NN(C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CCC2)C)C(F)(F)F FENXXKPOIXTISX-HIFRSBDPSA-N 0.000 claims description 2
NKJZSRRTCWOSNM-QRWLVFNGSA-N [4-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 NKJZSRRTCWOSNM-QRWLVFNGSA-N 0.000 claims description 2
SQGVYFNSRZTARU-QRWLVFNGSA-N [4-fluoro-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 SQGVYFNSRZTARU-QRWLVFNGSA-N 0.000 claims description 2
RCAGAILWWRIITL-QRWLVFNGSA-N [4-fluoro-3-(1,2,4-triazol-4-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC1=C(C=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1C=NN=C1 RCAGAILWWRIITL-QRWLVFNGSA-N 0.000 claims description 2
NQLOFXQHDPWBDZ-IERDGZPVSA-N [4-methyl-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC(=C(C=C1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 NQLOFXQHDPWBDZ-IERDGZPVSA-N 0.000 claims description 2
NWMRUPWIFRKUPF-BZNIZROVSA-N [5-(difluoromethyl)-1-methylpyrazol-4-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC(C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)F NWMRUPWIFRKUPF-BZNIZROVSA-N 0.000 claims description 2
WQMUHNCYLFCFEM-NQIIRXRSSA-N [5-cyclopropyl-1-(2-hydroxyethyl)pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1CCO)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 WQMUHNCYLFCFEM-NQIIRXRSSA-N 0.000 claims description 2
ZEDUXVVSVQPKCY-BWKNWUBXSA-N [5-cyclopropyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C1=CC(=CC=C1)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CCC2 ZEDUXVVSVQPKCY-BWKNWUBXSA-N 0.000 claims description 2
KIYFMEBGRDOBMX-VFNWGFHPSA-N [5-fluoro-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound FC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 KIYFMEBGRDOBMX-VFNWGFHPSA-N 0.000 claims description 2
STJVWUYZONMQCK-QRQCRPRQSA-N [5-methoxy-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 STJVWUYZONMQCK-QRQCRPRQSA-N 0.000 claims description 2
IOECBWNHQRIVDY-QRQCRPRQSA-N [5-methoxy-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound COC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 IOECBWNHQRIVDY-QRQCRPRQSA-N 0.000 claims description 2
GLDOYCATHXYWPZ-ZHRRBRCNSA-N [5-methyl-2-(1,2,4-triazol-1-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 GLDOYCATHXYWPZ-ZHRRBRCNSA-N 0.000 claims description 2
OCMAOQYMABIBSW-ZHRRBRCNSA-N [5-methyl-2-(triazol-2-yl)phenyl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC=1C=CC(=C(C=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 OCMAOQYMABIBSW-ZHRRBRCNSA-N 0.000 claims description 2
ZOOIBWVMJIQEFP-BEFAXECRSA-N [6-(dimethylamino)pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CN(C1=CC=C(C=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)C ZOOIBWVMJIQEFP-BEFAXECRSA-N 0.000 claims description 2
DHJQQZUIAOKNOQ-QRWLVFNGSA-N [6-methyl-3-(1,2,4-triazol-1-yl)pyridin-2-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC=C(C(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CN=C1 DHJQQZUIAOKNOQ-QRWLVFNGSA-N 0.000 claims description 2
JZBSYAWPULCYNA-BEFAXECRSA-N [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound CC1=CC=C(C(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2)N1N=CC=N1 JZBSYAWPULCYNA-BEFAXECRSA-N 0.000 claims description 2
VXRUSJVPXBKRGR-VFNWGFHPSA-N cinnolin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=NC(=CC2=CC=CC=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 VXRUSJVPXBKRGR-VFNWGFHPSA-N 0.000 claims description 2
WKKPDCMNNWTDNA-IERDGZPVSA-N cinnolin-6-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N1=NC=CC2=CC(=CC=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 WKKPDCMNNWTDNA-IERDGZPVSA-N 0.000 claims description 2
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 2
UFYDDMNFSPEGFZ-KDOFPFPSSA-N imidazo[1,2-a]pyridin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=C(N2C=1C=CC=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UFYDDMNFSPEGFZ-KDOFPFPSSA-N 0.000 claims description 2
IXVGKARTGQSQOW-KDOFPFPSSA-N imidazo[1,2-a]pyridin-5-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=CN2C=1C=CC=C2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 IXVGKARTGQSQOW-KDOFPFPSSA-N 0.000 claims description 2
JRHHOWRPRBACOO-BEFAXECRSA-N imidazo[1,2-a]pyridin-6-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=CN2C=1C=CC(=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 JRHHOWRPRBACOO-BEFAXECRSA-N 0.000 claims description 2
NHBPHKYINLMHPO-DYVFJYSZSA-N imidazo[1,2-a]pyrimidin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=C(N2C=1N=CC=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 NHBPHKYINLMHPO-DYVFJYSZSA-N 0.000 claims description 2
PLPWFJKWHDUQBX-DYVFJYSZSA-N imidazo[1,2-b]pyridazin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=C(N2N=CC=CC2=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 PLPWFJKWHDUQBX-DYVFJYSZSA-N 0.000 claims description 2
QWZDUWIZFQBLGP-ACJLOTCBSA-N imidazo[1,2-b]pyridazin-6-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound N=1C=CN2N=C(C=CC2=1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 QWZDUWIZFQBLGP-ACJLOTCBSA-N 0.000 claims description 2
GKUUCBODTJRFPT-KUHUBIRLSA-N imidazo[1,5-a]pyridin-5-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C=1N=CN2C=1C=CC=C2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 GKUUCBODTJRFPT-KUHUBIRLSA-N 0.000 claims description 2
VPUFZKXWHDURNA-QRWLVFNGSA-N imidazo[1,5-a]pyridin-6-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C=1N=CN2C=1C=CC(=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 VPUFZKXWHDURNA-QRWLVFNGSA-N 0.000 claims description 2
UXJKSIXPHSUZRR-QRWLVFNGSA-N imidazo[1,5-a]pyridin-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C=1N=CN2C=1C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 UXJKSIXPHSUZRR-QRWLVFNGSA-N 0.000 claims description 2
CAKXYBMANAFARD-UTKZUKDTSA-N indolizin-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C=1C=CN2C=CC(=CC=12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 CAKXYBMANAFARD-UTKZUKDTSA-N 0.000 claims description 2
VQRZWEUKUSGDAT-IERDGZPVSA-N isoquinolin-1-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,12-triazatricyclo[6.3.1.02,6]dodeca-2,5-dien-12-yl]methanone Chemical compound C1(=NC=CC2=CC=CC=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CCC2 VQRZWEUKUSGDAT-IERDGZPVSA-N 0.000 claims description 2
125000004551 isoquinolin-3-yl group Chemical group C1=NC(=CC2=CC=CC=C12)* 0.000 claims description 2
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 2
125000004546 quinazolin-4-yl group Chemical group N1=CN=C(C2=CC=CC=C12)* 0.000 claims description 2
125000004547 quinazolin-6-yl group Chemical group N1=CN=CC2=CC(=CC=C12)* 0.000 claims description 2
125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims description 2
125000004262 quinoxalin-2-yl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1* 0.000 claims description 2
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 6
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 16
125000000753 cycloalkyl group Chemical group 0.000 description 12
201000010099 disease Diseases 0.000 description 8
208000035475 disorder Diseases 0.000 description 8
230000001404 mediated effect Effects 0.000 description 8
238000000034 method Methods 0.000 description 8
102000005962 receptors Human genes 0.000 description 8
108020003175 receptors Proteins 0.000 description 8
239000008194 pharmaceutical composition Substances 0.000 description 7
239000000546 pharmaceutical excipient Substances 0.000 description 5
WMPDAIZRQDCGFH-UHFFFAOYSA-N 3-methoxybenzaldehyde Chemical compound COC1=CC=CC(C=O)=C1 WMPDAIZRQDCGFH-UHFFFAOYSA-N 0.000 description 2
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 2
208000020925 Bipolar disease Diseases 0.000 description 2
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208000002193 Pain Diseases 0.000 description 2
208000028552 Treatment-Resistant Depressive disease Diseases 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
230000000694 effects Effects 0.000 description 2
208000024714 major depressive disease Diseases 0.000 description 2
230000000926 neurological effect Effects 0.000 description 2
208000020016 psychiatric disease Diseases 0.000 description 2
SMKBVRQXEAKJDU-PXAZEXFGSA-N (1,5-dimethylpyrazol-4-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound CN1N=CC(=C1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 SMKBVRQXEAKJDU-PXAZEXFGSA-N 0.000 description 1
RMOCNTPCPVGMFX-PXAZEXFGSA-N (1-methylpyrazolo[3,4-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound CN1N=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 RMOCNTPCPVGMFX-PXAZEXFGSA-N 0.000 description 1
UYMQHMRVZALWRL-YJYMSZOUSA-N (1-methylpyrrolo[2,3-b]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 UYMQHMRVZALWRL-YJYMSZOUSA-N 0.000 description 1
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FZIMZOBHWNIMLX-KUHUBIRLSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-5-(3,4-difluorophenyl)-4-methyl-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C=C3)F)F)C)[C@@H]1CC2 FZIMZOBHWNIMLX-KUHUBIRLSA-N 0.000 description 1
SAAWQIULIAGEHF-APWZRJJASA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-5-(3,5-difluorophenyl)-4-methyl-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)F)F)C)[C@@H]1CC2 SAAWQIULIAGEHF-APWZRJJASA-N 0.000 description 1
CVXVQTWSHBGFNU-XLIONFOSSA-N (5-cyclopropyl-1-methylpyrazol-4-yl)-[(1S,8R)-5-(3-fluoro-5-methylphenyl)-4-methyl-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound C1(CC1)C1=C(C=NN1C)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=CC(=C3)C)F)C)[C@@H]1CC2 CVXVQTWSHBGFNU-XLIONFOSSA-N 0.000 description 1
MHBGYGXGSLNCGP-ACJLOTCBSA-N (6-fluoro-1H-indol-7-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound FC1=CC=C2C=CNC2=C1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 MHBGYGXGSLNCGP-ACJLOTCBSA-N 0.000 description 1
AEVASBPXRFRPDB-XCLFUZPHSA-N (6-methoxypyrazolo[1,5-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound COC=1C=CC=2N(C=1)N=CC=2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 AEVASBPXRFRPDB-XCLFUZPHSA-N 0.000 description 1
BLDUWDCDVXOKAL-PXAZEXFGSA-N (6-methoxypyridin-2-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound COC1=CC=CC(=N1)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 BLDUWDCDVXOKAL-PXAZEXFGSA-N 0.000 description 1
JATYOFMODBDYFK-ACJLOTCBSA-N (7-methoxyimidazo[1,2-a]pyridin-3-yl)-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound COC1=CC=2N(C=C1)C(=CN=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 JATYOFMODBDYFK-ACJLOTCBSA-N 0.000 description 1
JPCYNOCAOGYXAY-XIKOKIGWSA-N 1H-benzimidazol-4-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound N1C=NC2=C1C(=CC=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 JPCYNOCAOGYXAY-XIKOKIGWSA-N 0.000 description 1
NBHFAQLRKJGABV-ACJLOTCBSA-N 1H-indazol-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound N1N=CC2=CC=CC(=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 NBHFAQLRKJGABV-ACJLOTCBSA-N 0.000 description 1
SFIPXABGOMYQNR-KUHUBIRLSA-N 1H-indol-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound N1C=CC2=CC=CC(=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 SFIPXABGOMYQNR-KUHUBIRLSA-N 0.000 description 1
DEDXGZVQWHZMBO-KDOFPFPSSA-N 2,3-dihydro-1,4-benzodioxin-6-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound O1C2=C(OCC1)C=C(C=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 DEDXGZVQWHZMBO-KDOFPFPSSA-N 0.000 description 1
JSBWLHLFMAMYPJ-UTKZUKDTSA-N 3,4-dihydro-1H-isochromen-7-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound C1OCCC2=CC=C(C=C12)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 JSBWLHLFMAMYPJ-UTKZUKDTSA-N 0.000 description 1
AMVILYUICGNDGE-UZLBHIALSA-N [(1S,8R)-4-methyl-5-phenyl-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]-(1-methylpyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1C=C(C=2C1=NC=CC=2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC=CC=C3)C)[C@@H]1CC2 AMVILYUICGNDGE-UZLBHIALSA-N 0.000 description 1
YCFDHNOMWWHEQE-WBMJQRKESA-N [2-(difluoromethyl)imidazo[1,2-a]pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound FC(C=1N=C2N(C=CC=C2)C=1C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2)F YCFDHNOMWWHEQE-WBMJQRKESA-N 0.000 description 1
FYQMKGKYHGDBTF-DYVFJYSZSA-N [5-methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound CC1=CC=CC=2N1C(=C(N=2)C(F)(F)F)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 FYQMKGKYHGDBTF-DYVFJYSZSA-N 0.000 description 1
DUQBATTVGHATOI-PXAZEXFGSA-N furo[3,2-c]pyridin-4-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound O1C=CC=2C(=NC=CC=21)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 DUQBATTVGHATOI-PXAZEXFGSA-N 0.000 description 1
BPPAWZMGQCKBIR-DYVFJYSZSA-N imidazo[1,2-a]pyridin-3-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound N=1C=C(N2C=1C=CC=C2)C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 BPPAWZMGQCKBIR-DYVFJYSZSA-N 0.000 description 1
MQCIAWDINRJYLO-DYVFJYSZSA-N imidazo[1,2-a]pyridin-5-yl-[(1S,8R)-4-methyl-5-(3,4,5-trifluorophenyl)-3,4,11-triazatricyclo[6.2.1.02,6]undeca-2,5-dien-11-yl]methanone Chemical compound N=1C=CN2C=1C=CC=C2C(=O)N1[C@H]2CC=3C(=NN(C=3C3=CC(=C(C(=C3)F)F)F)C)[C@@H]1CC2 MQCIAWDINRJYLO-DYVFJYSZSA-N 0.000 description 1
XNGYMORBKJLAQE-UHFFFAOYSA-N quinoxaline-5-carbaldehyde Chemical compound C1=CN=C2C(C=O)=CC=CC2=N1 XNGYMORBKJLAQE-UHFFFAOYSA-N 0.000 description 1

JP2021517338A 2018-09-28 2019-09-27 モノアシルグリセロールリパーゼ調節因子 Active JP7413368B2 (ja)