JP2021503004A5 - - Google Patents
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- Publication number
- JP2021503004A5 JP2021503004A5 JP2020544372A JP2020544372A JP2021503004A5 JP 2021503004 A5 JP2021503004 A5 JP 2021503004A5 JP 2020544372 A JP2020544372 A JP 2020544372A JP 2020544372 A JP2020544372 A JP 2020544372A JP 2021503004 A5 JP2021503004 A5 JP 2021503004A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropyl
- indole
- piperidine
- pyridine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762585733P | 2017-11-14 | 2017-11-14 | |
| US62/585,733 | 2017-11-14 | ||
| PCT/US2018/060590 WO2019099336A1 (en) | 2017-11-14 | 2018-11-13 | Substituted indole compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021503004A JP2021503004A (ja) | 2021-02-04 |
| JP2021503004A5 true JP2021503004A5 (hu) | 2021-12-16 |
| JP7265554B2 JP7265554B2 (ja) | 2023-04-26 |
Family
ID=64565001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544372A Active JP7265554B2 (ja) | 2017-11-14 | 2018-11-13 | 置換インドール化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20210253593A1 (hu) |
| EP (1) | EP3710440B1 (hu) |
| JP (1) | JP7265554B2 (hu) |
| KR (1) | KR20200086709A (hu) |
| CN (1) | CN111448190B (hu) |
| ES (1) | ES2945435T3 (hu) |
| WO (1) | WO2019099336A1 (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| CA3085590A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Substituted indole compounds useful as tlr inhibitors |
| ES2904676T3 (es) * | 2017-12-20 | 2022-04-05 | Bristol Myers Squibb Co | Compuestos de amino indol útiles como inhibidores de TLR |
| MX2020005622A (es) * | 2017-12-20 | 2020-08-20 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con arilo y heteroarilo. |
| JP7382938B2 (ja) * | 2017-12-20 | 2023-11-17 | ブリストル－マイヤーズ スクイブ カンパニー | ジアザインドール化合物 |
| WO2019155042A1 (en) | 2018-02-12 | 2019-08-15 | F. Hoffmann-La Roche Ag | Novel sulfone compounds and derivatives for the treatment and prophylaxis of virus infection |
| EP3807270B1 (en) | 2018-06-12 | 2023-09-13 | F. Hoffmann-La Roche AG | Novel heteroaryl heterocyclyl compounds for the treatment of autoimmune disease |
| EP3826724B1 (en) | 2018-07-23 | 2022-10-05 | F. Hoffmann-La Roche AG | Novel piperazine compounds for the treatment of autoimmune disease |
| EP3847169A1 (en) | 2018-09-04 | 2021-07-14 | F. Hoffmann-La Roche AG | Benzothiazole compounds for the treatment of autoimmune diseases |
| EP3847170B1 (en) | 2018-09-06 | 2022-06-22 | F. Hoffmann-La Roche AG | Novel cyclic amidine compounds for the treatment of autoimmune disease |
| TW202028209A (zh) * | 2018-09-27 | 2020-08-01 | 大陸商重慶複創醫藥研究有限公司 | 作為RET激酶抑制劑的取代的咪唑[1,2-a]吡啶和[1,2,4]三唑[1,5-a]吡啶化合物 |
| WO2021067657A1 (en) * | 2019-10-04 | 2021-04-08 | Bristol-Myers Squibb Company | Substituted carbazole compounds |
| AU2022219934A1 (en) * | 2021-02-09 | 2023-08-10 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| CR20230478A (es) | 2021-04-16 | 2023-11-30 | Gilead Sciences Inc | Compuestos de tienopirrol. |
| TW202342016A (zh) * | 2022-02-18 | 2023-11-01 | 美商必治妥美雅史谷比公司 | 用作tlr9抑制劑之經取代雙環雜芳基化合物 |
| CN114591339B (zh) * | 2022-05-10 | 2022-08-02 | 上海维申医药有限公司 | 一类Toll样受体抑制剂及其制备和应用 |
| WO2024027712A1 (zh) * | 2022-08-01 | 2024-02-08 | 索智生物科技（浙江）有限公司 | 含氮杂环类化合物、其制备方法及其应用 |
| CN115417869B (zh) * | 2022-09-19 | 2024-06-11 | 安徽大学 | 一种6-溴咪唑[1.2a]吡啶-3-甲酰胺的合成方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| IL143801A0 (en) | 1998-12-18 | 2002-04-21 | Axys Pharm Inc | (hetero) aryl-bicyclic heteroaryl derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| MXPA02003887A (es) | 1999-10-19 | 2002-09-30 | Merck & Co Inc | Inhibidores de tirosina cinasa. |
| CN100503608C (zh) | 2002-01-07 | 2009-06-24 | 卫材R&D管理株式会社 | 脱氮嘌呤及其用途 |
| KR20060016817A (ko) | 2003-06-20 | 2006-02-22 | 콜리 파마슈티칼 게엠베하 | 소분자 톨-유사 수용체 (ｔｌｒ) 길항제 |
| WO2007115306A2 (en) | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
| US20060235037A1 (en) * | 2005-04-15 | 2006-10-19 | Purandare Ashok V | Heterocyclic inhibitors of protein arginine methyl transferases |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| US8027888B2 (en) | 2006-08-31 | 2011-09-27 | Experian Interactive Innovation Center, Llc | Online credit card prescreen systems and methods |
| DE602007012133D1 (de) | 2006-12-01 | 2011-03-03 | Andrew Burritt | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
| WO2008152471A1 (en) | 2007-06-12 | 2008-12-18 | Coley Pharmaceutical Group, Inc. | Quinazoline derivative useful as toll-like receptor antagonist |
| WO2009030996A1 (en) | 2007-09-05 | 2009-03-12 | Coley Pharmaceutical Group, Inc. | Triazole compounds as toll-like receptor (tlr) agonists |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| EP2350032B1 (en) | 2008-09-26 | 2016-05-25 | Eisai R&D Management Co., Ltd. | Benzoxazole compounds and methods of use |
| JP5529876B2 (ja) | 2008-10-17 | 2014-06-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| EP2453895B1 (en) | 2009-07-16 | 2018-05-23 | Mallinckrodt LLC | (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| CN102574788A (zh) | 2009-09-24 | 2012-07-11 | 弗·哈夫曼-拉罗切有限公司 | 作为crac调节剂的吲哚衍生物 |
| CA2777245A1 (en) | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
| US9241991B2 (en) | 2010-10-21 | 2016-01-26 | The Brigham And Women's Hospital, Inc. | Agents, compositions, and methods for treating pruritus and related skin conditions |
| BR112013017943A2 (pt) | 2011-01-12 | 2018-12-18 | Array Biopharma Inc | benzoazepinas substituídas como moduladores receptores do tipo toll |
| PT2663555T (pt) | 2011-01-12 | 2017-03-23 | Array Biopharma Inc | Benzoazepinas substituídas como moduladores de recetores tipo-toll |
| CA2837227C (en) | 2011-06-01 | 2022-05-10 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
| CA2837207A1 (en) | 2011-06-01 | 2012-12-06 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
| KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
| WO2013010904A1 (en) * | 2011-07-15 | 2013-01-24 | Janssen Pharmaceuticals, Inc. | Novel substituted indole derivatives as gamma secretase modulators |
| EP2763677B1 (en) | 2011-10-04 | 2020-02-26 | Janus Biotherapeutics, Inc. | Novel imidazole quinoline-based immune system modulators |
| WO2013172479A1 (en) | 2012-05-18 | 2013-11-21 | Dainippon Sumitomo Pharma Co., Ltd. | Carboxylic acid compounds |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| EP2738172A1 (en) | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
| US9428495B2 (en) | 2013-10-14 | 2016-08-30 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| JP2016540013A (ja) | 2013-12-13 | 2016-12-22 | 武田薬品工業株式会社 | Ｔｌｒ阻害剤としてのピロロ［３，２−ｃ］ピリジン誘導体 |
| BR112017002811B1 (pt) | 2014-08-15 | 2022-09-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Compostos de pirrolopirimidina usados como agonista de tlr7 e seu uso, composição farmacêutica e kit |
| US20170275287A1 (en) | 2014-08-22 | 2017-09-28 | Janus Biotherapeutics, Inc. | Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof |
| US10071079B2 (en) * | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| SG11201900619XA (en) | 2016-07-30 | 2019-02-27 | Bristol Myers Squibb Co | Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors |
| ES2902504T3 (es) | 2016-09-09 | 2022-03-28 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con piridilo |
-
2018
- 2018-11-13 JP JP2020544372A patent/JP7265554B2/ja active Active
- 2018-11-13 US US16/763,670 patent/US20210253593A1/en not_active Abandoned
- 2018-11-13 EP EP18812006.7A patent/EP3710440B1/en active Active
- 2018-11-13 WO PCT/US2018/060590 patent/WO2019099336A1/en unknown
- 2018-11-13 CN CN201880079072.6A patent/CN111448190B/zh active Active
- 2018-11-13 ES ES18812006T patent/ES2945435T3/es active Active
- 2018-11-13 KR KR1020207016702A patent/KR20200086709A/ko not_active Application Discontinuation
-
2022
- 2022-03-21 US US17/699,944 patent/US11739098B2/en active Active
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