JPWO2020065613A5 - - Google Patents
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- Publication number
- JPWO2020065613A5 JPWO2020065613A5 JP2021517202A JP2021517202A JPWO2020065613A5 JP WO2020065613 A5 JPWO2020065613 A5 JP WO2020065613A5 JP 2021517202 A JP2021517202 A JP 2021517202A JP 2021517202 A JP2021517202 A JP 2021517202A JP WO2020065613 A5 JPWO2020065613 A5 JP WO2020065613A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- pyrazolo
- methanone
- dimethyl
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 144
- 125000000217 alkyl group Chemical group 0.000 claims description 124
- -1 isotopes Chemical class 0.000 claims description 110
- 229910052739 hydrogen Inorganic materials 0.000 claims description 75
- 125000001188 haloalkyl group Chemical group 0.000 claims description 66
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 57
- 125000001475 halogen functional group Chemical group 0.000 claims description 55
- 125000001072 heteroaryl group Chemical group 0.000 claims description 45
- CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims description 31
- 229910052799 carbon Inorganic materials 0.000 claims description 30
- 150000001204 N-oxides Chemical class 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 28
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 20
- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims description 19
- 229910052801 chlorine Inorganic materials 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 14
- 125000004361 3,4,5-trifluorophenyl group Chemical group [H]C1=C(F)C(F)=C(F)C([H])=C1* 0.000 claims description 12
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 5
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- JNLZPNFRJMRALU-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C2=NC=CC=C21)C)C JNLZPNFRJMRALU-NSHDSACASA-N 0.000 claims description 4
- QCCZDVWOKJCPRQ-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(2-fluoroethyl)pyrrolo[2,3-b]pyridin-4-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C2C(=NC=C1)N(C=C2)CCF)C)C QCCZDVWOKJCPRQ-AWEZNQCLSA-N 0.000 claims description 4
- XXHDVIZVAYOMKF-ZDUSSCGKSA-N [2-chloro-3-(2-fluoroethoxy)phenyl]-[(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound ClC1=C(C=CC=C1OCCF)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC(=C1)F)F)C XXHDVIZVAYOMKF-ZDUSSCGKSA-N 0.000 claims description 4
- BCXBASVTKXMNTJ-LBPRGKRZSA-N (1,2-dimethylpyrrol-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1C(=C(C=C1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C BCXBASVTKXMNTJ-LBPRGKRZSA-N 0.000 claims description 2
- JQSBEMATFNHQTG-NSHDSACASA-N (1,3-dimethylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C(C(=C1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C JQSBEMATFNHQTG-NSHDSACASA-N 0.000 claims description 2
- OWCWBANOULDSGT-LBPRGKRZSA-N (1,3-dimethylpyrazolo[3,4-b]pyridin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C(C=2C1=NC=CC=2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C OWCWBANOULDSGT-LBPRGKRZSA-N 0.000 claims description 2
- ASRRUGVGKAEVHN-UHFFFAOYSA-N (1,5-dimethylpyrazol-4-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CN1N=CC(=C1C)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 ASRRUGVGKAEVHN-UHFFFAOYSA-N 0.000 claims description 2
- XPTGZMJYXZNQGP-NSHDSACASA-N (1,5-dimethylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=CC(=C1C)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C XPTGZMJYXZNQGP-NSHDSACASA-N 0.000 claims description 2
- YMIDEVJJIULAGK-AWEZNQCLSA-N (1,5-dimethylpyrazol-4-yl)-[(7S)-3-(3-fluoro-5-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=CC(=C1C)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC(=C1)C)F)C YMIDEVJJIULAGK-AWEZNQCLSA-N 0.000 claims description 2
- PZRHNPLBBAGYOZ-LBPRGKRZSA-N (1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=CC=2C1=NC(=CC=2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C PZRHNPLBBAGYOZ-LBPRGKRZSA-N 0.000 claims description 2
- JCSBLXUNZFOYMJ-NSHDSACASA-N (1-cyclopropylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound C1(CC1)N1N=CC(=C1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C JCSBLXUNZFOYMJ-NSHDSACASA-N 0.000 claims description 2
- AWHXXMRZGIMPNU-UHFFFAOYSA-N (1-methylindazol-3-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CN1N=C(C2=CC=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 AWHXXMRZGIMPNU-UHFFFAOYSA-N 0.000 claims description 2
- VTGFKAKHRSNCBU-UHFFFAOYSA-N (1-methylindol-3-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CN1C=C(C2=CC=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 VTGFKAKHRSNCBU-UHFFFAOYSA-N 0.000 claims description 2
- VAIXWXAOFACVLN-UHFFFAOYSA-N (1-methylindol-4-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CN1C=CC2=C(C=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 VAIXWXAOFACVLN-UHFFFAOYSA-N 0.000 claims description 2
- RIQSBKYTSOOULI-UHFFFAOYSA-N (2,2-difluoro-1,3-benzodioxol-4-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound FC1(OC2=C(O1)C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1)F RIQSBKYTSOOULI-UHFFFAOYSA-N 0.000 claims description 2
- BGAPCXKCMYZKSB-AWEZNQCLSA-N (2,3-dimethylquinoxalin-6-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC1=NC2=CC=C(C=C2N=C1C)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C BGAPCXKCMYZKSB-AWEZNQCLSA-N 0.000 claims description 2
- HKPAPKWGDCCUQI-ZDUSSCGKSA-N (2,4-dimethylpyrazolo[1,5-a]pyrazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC1=NN2C(C(=NC=C2)C)=C1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C HKPAPKWGDCCUQI-ZDUSSCGKSA-N 0.000 claims description 2
- LJLCXKBJLQXXSI-AWEZNQCLSA-N (2,4-dimethylpyrrolo[1,2-a]pyrimidin-8-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC1=NC=2N(C(=C1)C)C=CC=2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C LJLCXKBJLQXXSI-AWEZNQCLSA-N 0.000 claims description 2
- YSVPRPRWVWVHHX-AWEZNQCLSA-N (2,6-dimethylimidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC=1N=C2N(C=C(C=C2)C)C=1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C YSVPRPRWVWVHHX-AWEZNQCLSA-N 0.000 claims description 2
- NGEAPFZLOLAOSG-UHFFFAOYSA-N (2,7-dimethyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-quinolin-6-ylmethanone Chemical compound CN1N=C2C(N(CCC2=C1C1=CC=CC=C1)C(=O)C=1C=C2C=CC=NC2=CC=1)C NGEAPFZLOLAOSG-UHFFFAOYSA-N 0.000 claims description 2
- WXZUHHOCJLOARS-AWEZNQCLSA-N (2,7-dimethylimidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC=1N=C2N(C=CC(=C2)C)C=1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C WXZUHHOCJLOARS-AWEZNQCLSA-N 0.000 claims description 2
- QTBQMDKTPBHUEB-ZDUSSCGKSA-N (2,7-dimethylimidazo[1,2-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC=1N=C2N(N=CC(=C2)C)C=1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C QTBQMDKTPBHUEB-ZDUSSCGKSA-N 0.000 claims description 2
- MUHLZOCSORLQLY-AWEZNQCLSA-N (2,8-dimethylimidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC=1N=C2N(C=CC=C2C)C=1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C MUHLZOCSORLQLY-AWEZNQCLSA-N 0.000 claims description 2
- XRDVMXUBAJXBPB-ZDUSSCGKSA-N (2,8-dimethylimidazo[1,2-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CC=1N=C2N(N=CC=C2C)C=1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C XRDVMXUBAJXBPB-ZDUSSCGKSA-N 0.000 claims description 2
- UXAFYWIIDDYVLJ-UHFFFAOYSA-N (2-amino-3-methylphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound NC1=C(C=CC=C1C)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 UXAFYWIIDDYVLJ-UHFFFAOYSA-N 0.000 claims description 2
- JYFBVJUPSWDDTO-UHFFFAOYSA-N (2-chloro-3-hydroxyphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound ClC1=C(C=CC=C1O)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 JYFBVJUPSWDDTO-UHFFFAOYSA-N 0.000 claims description 2
- DMKKOFJOEZOUMH-UHFFFAOYSA-N (2-chloro-3-methoxyphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 DMKKOFJOEZOUMH-UHFFFAOYSA-N 0.000 claims description 2
- MVBQMXUCEOERDM-NSHDSACASA-N (2-chloro-3-methoxyphenyl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound ClC1=C(C=CC=C1OC)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C MVBQMXUCEOERDM-NSHDSACASA-N 0.000 claims description 2
- FEQVGLBDEXEBOY-UHFFFAOYSA-N (2-chloro-6-methoxyphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound ClC1=C(C(=CC=C1)OC)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 FEQVGLBDEXEBOY-UHFFFAOYSA-N 0.000 claims description 2
- HTVQGAGEZGDEGC-ZDUSSCGKSA-N (2-cyclopropyl-4-methylpyrazolo[1,5-a]pyrazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound C1(CC1)C1=NN2C(C(=NC=C2)C)=C1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C HTVQGAGEZGDEGC-ZDUSSCGKSA-N 0.000 claims description 2
- JDPMHSDUGHGVLQ-ZDUSSCGKSA-N (2-cyclopropyl-4-methylpyrazolo[1,5-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound C1(CC1)C1=NN2N=CC=C(C2=C1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C JDPMHSDUGHGVLQ-ZDUSSCGKSA-N 0.000 claims description 2
- WUSYQDUFCJEJAZ-ZDUSSCGKSA-N (2-cyclopropyl-5-methylpyrazolo[1,5-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound C1(CC1)C1=NN2N=CC(=CC2=C1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)C WUSYQDUFCJEJAZ-ZDUSSCGKSA-N 0.000 claims description 2
- VVBSPXQTQSPKTA-AWEZNQCLSA-N (2-cyclopropyl-7-methylpyrazolo[1,5-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound C1(CC1)C1=NN2C(C=CC=C2C)=C1C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C VVBSPXQTQSPKTA-AWEZNQCLSA-N 0.000 claims description 2
- REGFGYINRHHSSO-LZKFFOJCSA-N (2-deuterioquinoxalin-6-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound [2H]C1=NC2=CC=C(C=C2N=C1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C REGFGYINRHHSSO-LZKFFOJCSA-N 0.000 claims description 2
- HAFHMNIBDFZJAC-UHFFFAOYSA-N (2-ethyl-3-methoxyphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C(C)C1=C(C=CC=C1OC)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 HAFHMNIBDFZJAC-UHFFFAOYSA-N 0.000 claims description 2
- LOIHTFIFGMFUJH-UHFFFAOYSA-N (2-ethyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-quinolin-6-ylmethanone Chemical compound C(C)N1N=C2CN(CCC2=C1C1=CC=CC=C1)C(=O)C=1C=C2C=CC=NC2=CC=1 LOIHTFIFGMFUJH-UHFFFAOYSA-N 0.000 claims description 2
- RGQKNBYPQYKYNY-UHFFFAOYSA-N (2-methoxy-3-methylphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound COC1=C(C=CC=C1C)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 RGQKNBYPQYKYNY-UHFFFAOYSA-N 0.000 claims description 2
- NZQOXSUXCGFYQR-UHFFFAOYSA-N (2-methyl-3-morpholin-4-ylphenyl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CC1=C(C=CC=C1N1CCOCC1)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 NZQOXSUXCGFYQR-UHFFFAOYSA-N 0.000 claims description 2
- BRACSLVOGNHUKU-UHFFFAOYSA-N (2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-(1-methylpyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1C=CC=2C1=NC=CC=2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 BRACSLVOGNHUKU-UHFFFAOYSA-N 0.000 claims description 2
- XOCFDESLFGNMNZ-UHFFFAOYSA-N (2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C2CN(CCC2=C1C1=CC=CC=C1)C(=O)C1=NN(C=N1)C1=CC=CC=C1 XOCFDESLFGNMNZ-UHFFFAOYSA-N 0.000 claims description 2
- PGOQNBIALZWEHJ-UHFFFAOYSA-N (2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-(1H-pyrrolo[3,2-c]pyridin-3-yl)methanone Chemical compound CN1N=C2CN(CCC2=C1C1=CC=CC=C1)C(=O)C1=CNC2=C1C=NC=C2 PGOQNBIALZWEHJ-UHFFFAOYSA-N 0.000 claims description 2
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- ZZJZGOXXSMOJPV-UHFFFAOYSA-N (6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CN1N=C2CN(CCC2=C1C1=CC=CC=C1)C(=O)C1=C(N=C2SC=CN21)C ZZJZGOXXSMOJPV-UHFFFAOYSA-N 0.000 claims description 2
- QEENDACYLGRAGI-UHFFFAOYSA-N (7-chloro-1H-indol-3-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound ClC=1C=CC=C2C(=CNC=12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 QEENDACYLGRAGI-UHFFFAOYSA-N 0.000 claims description 2
- UYBIZKNEXPWQOR-UHFFFAOYSA-N (7-chloro-2H-indazol-3-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound ClC=1C=CC=C2C(=NNC=12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 UYBIZKNEXPWQOR-UHFFFAOYSA-N 0.000 claims description 2
- SZGWIFIPWWIRLR-UHFFFAOYSA-N (7-methyl-1H-indol-2-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound CC=1C=CC=C2C=C(NC=12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 SZGWIFIPWWIRLR-UHFFFAOYSA-N 0.000 claims description 2
- AYDWHIDTMMGUGG-UHFFFAOYSA-N (7-methyl-2,3-diphenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)-quinolin-6-ylmethanone Chemical compound CC1N(CCC=2C1=NN(C=2C1=CC=CC=C1)C1=CC=CC=C1)C(=O)C=1C=C2C=CC=NC2=CC=1 AYDWHIDTMMGUGG-UHFFFAOYSA-N 0.000 claims description 2
- GPOBLXKBUYHNDW-ZDUSSCGKSA-N (8-bromoquinoxalin-6-yl)-[(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound BrC=1C=C(C=C2N=CC=NC=12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC=C1)Cl)C GPOBLXKBUYHNDW-ZDUSSCGKSA-N 0.000 claims description 2
- DFNIGEUSVNZWAV-UHFFFAOYSA-N (8-fluoroquinolin-4-yl)-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound FC=1C=CC=C2C(=CC=NC=12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 DFNIGEUSVNZWAV-UHFFFAOYSA-N 0.000 claims description 2
- NEAVMKLUMSQPBZ-UHFFFAOYSA-N 1,2-benzothiazol-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1N=C(C2=C1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 NEAVMKLUMSQPBZ-UHFFFAOYSA-N 0.000 claims description 2
- ZWPZLRISWNYEDA-UHFFFAOYSA-N 1,2-benzoxazol-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1N=C(C2=C1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 ZWPZLRISWNYEDA-UHFFFAOYSA-N 0.000 claims description 2
- PSVPEHUUCICGEP-NSHDSACASA-N 1,2-benzoxazol-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1N=C(C2=C1C=CC=C2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C PSVPEHUUCICGEP-NSHDSACASA-N 0.000 claims description 2
- JUFHPDFTGMCNCW-UHFFFAOYSA-N 1,2-benzoxazol-3-yl-[2-methyl-3-(5-methylthiophen-2-yl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1N=C(C2=C1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C=1SC(=CC=1)C JUFHPDFTGMCNCW-UHFFFAOYSA-N 0.000 claims description 2
- CWQUJQBFHWFYPO-UHFFFAOYSA-N 1,3-benzodioxol-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1COC2=C1C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 CWQUJQBFHWFYPO-UHFFFAOYSA-N 0.000 claims description 2
- PDSLKHAMFLHLII-ZDUSSCGKSA-N 1,3-benzodioxol-4-yl-[(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1COC2=C1C=CC=C2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC=C1)Cl)C PDSLKHAMFLHLII-ZDUSSCGKSA-N 0.000 claims description 2
- TXAODVOKQZIHLX-UHFFFAOYSA-N 1,3-benzodioxol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1COC2=C1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 TXAODVOKQZIHLX-UHFFFAOYSA-N 0.000 claims description 2
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- UXSMUNOMKQJLTB-UHFFFAOYSA-N 1,3-benzothiazol-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C=NC2=C1C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 UXSMUNOMKQJLTB-UHFFFAOYSA-N 0.000 claims description 2
- AYOHPGQPEZSCAH-UHFFFAOYSA-N 1,3-benzothiazol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C=NC2=C1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 AYOHPGQPEZSCAH-UHFFFAOYSA-N 0.000 claims description 2
- GRCFDMPBRVGROS-UHFFFAOYSA-N 1,3-benzothiazol-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C=NC2=C1C(=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 GRCFDMPBRVGROS-UHFFFAOYSA-N 0.000 claims description 2
- SNCSFPAHIVGZSK-UHFFFAOYSA-N 1,3-benzoxazol-2-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C(=NC2=C1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 SNCSFPAHIVGZSK-UHFFFAOYSA-N 0.000 claims description 2
- DBLGDCQKVDLUGM-UHFFFAOYSA-N 1,3-benzoxazol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=NC2=C1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 DBLGDCQKVDLUGM-UHFFFAOYSA-N 0.000 claims description 2
- SWWQRPZIEKAUTI-UHFFFAOYSA-N 1,3-benzoxazol-6-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=NC2=C1C=C(C=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 SWWQRPZIEKAUTI-UHFFFAOYSA-N 0.000 claims description 2
- CYKJEWSBTCBTND-UHFFFAOYSA-N 1-benzofuran-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=C(C2=C1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 CYKJEWSBTCBTND-UHFFFAOYSA-N 0.000 claims description 2
- UAKLLMZLEICAGL-UHFFFAOYSA-N 1-benzofuran-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=CC2=C1C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 UAKLLMZLEICAGL-UHFFFAOYSA-N 0.000 claims description 2
- CSOXLNWFRAANHZ-UHFFFAOYSA-N 1-benzofuran-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=CC2=C1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 CSOXLNWFRAANHZ-UHFFFAOYSA-N 0.000 claims description 2
- SAIUISQVTGZWLO-UHFFFAOYSA-N 1-benzofuran-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound O1C=CC2=C1C(=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 SAIUISQVTGZWLO-UHFFFAOYSA-N 0.000 claims description 2
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- NZKUTGKTIRGHHF-UHFFFAOYSA-N 1-benzothiophen-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C2=C(C=C1)C(=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 NZKUTGKTIRGHHF-UHFFFAOYSA-N 0.000 claims description 2
- UZFLABKVSRAYIB-UHFFFAOYSA-N 1-benzothiophen-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C2=C(C=C1)C=C(C=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 UZFLABKVSRAYIB-UHFFFAOYSA-N 0.000 claims description 2
- OUIWSHSLCFNDMQ-UHFFFAOYSA-N 1-benzothiophen-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound S1C2=C(C=C1)C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 OUIWSHSLCFNDMQ-UHFFFAOYSA-N 0.000 claims description 2
- WGSXKYXKAARAKD-UHFFFAOYSA-N 1-fluoro-3-isocyanato-5-(trifluoromethyl)benzene Chemical group FC1=CC(N=C=O)=CC(C(F)(F)F)=C1 WGSXKYXKAARAKD-UHFFFAOYSA-N 0.000 claims description 2
- ZUOUOTUGTXCJEL-UHFFFAOYSA-N 1H-indazol-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1N=C(C2=CC=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 ZUOUOTUGTXCJEL-UHFFFAOYSA-N 0.000 claims description 2
- XXJPNIVOTZTJJO-UHFFFAOYSA-N 1H-indazol-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1N=CC2=C(C=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 XXJPNIVOTZTJJO-UHFFFAOYSA-N 0.000 claims description 2
- CXEFPYXNABZBPW-UHFFFAOYSA-N 1H-indazol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1N=CC2=CC(=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 CXEFPYXNABZBPW-UHFFFAOYSA-N 0.000 claims description 2
- WYEYLYHKPVSPJR-UHFFFAOYSA-N 1H-indazol-6-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1N=CC2=CC=C(C=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 WYEYLYHKPVSPJR-UHFFFAOYSA-N 0.000 claims description 2
- HRQINYMFOKZEAK-UHFFFAOYSA-N 1H-indazol-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1N=CC2=CC=CC(=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 HRQINYMFOKZEAK-UHFFFAOYSA-N 0.000 claims description 2
- NZAMBZKNRUOUFU-UHFFFAOYSA-N 1H-indol-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=C(C2=CC=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 NZAMBZKNRUOUFU-UHFFFAOYSA-N 0.000 claims description 2
- VNJUAVFHERCOMB-UHFFFAOYSA-N 1H-indol-4-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=CC2=C(C=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 VNJUAVFHERCOMB-UHFFFAOYSA-N 0.000 claims description 2
- GCHFFRLGVGPPGG-UHFFFAOYSA-N 1H-indol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=CC2=CC(=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 GCHFFRLGVGPPGG-UHFFFAOYSA-N 0.000 claims description 2
- OMAKRMSNESHBFP-UHFFFAOYSA-N 1H-indol-6-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=CC2=CC=C(C=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 OMAKRMSNESHBFP-UHFFFAOYSA-N 0.000 claims description 2
- IYZFYQHMBWGPJT-UHFFFAOYSA-N 1H-indol-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=CC2=CC=CC(=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 IYZFYQHMBWGPJT-UHFFFAOYSA-N 0.000 claims description 2
- MMFOZWYDRJFLML-UHFFFAOYSA-N 2,1-benzoxazol-3-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N=1OC(=C2C=1C=CC=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 MMFOZWYDRJFLML-UHFFFAOYSA-N 0.000 claims description 2
- NYPNKPYAGOOZLL-NSHDSACASA-N 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCOC2=NC=C(C=C21)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C NYPNKPYAGOOZLL-NSHDSACASA-N 0.000 claims description 2
- ZZDWOPPUVQVKJZ-NSHDSACASA-N 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCOC2=NC=CC(=C21)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C ZZDWOPPUVQVKJZ-NSHDSACASA-N 0.000 claims description 2
- MKFKHMOMMHEMCI-JTQLQIEISA-N 2H-benzotriazol-4-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1N=NC2=C1C=CC=C2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C MKFKHMOMMHEMCI-JTQLQIEISA-N 0.000 claims description 2
- JJBWHXCKCNMHGR-ZDUSSCGKSA-N 3,4-dihydro-1H-isochromen-5-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2CCOCC2=CC=C1)C JJBWHXCKCNMHGR-ZDUSSCGKSA-N 0.000 claims description 2
- FRNVSLWLABBTFM-ZDUSSCGKSA-N 3,4-dihydro-1H-isochromen-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2CCOCC2=CC=1)C FRNVSLWLABBTFM-ZDUSSCGKSA-N 0.000 claims description 2
- DQYBIIQBCCBZSU-ZDUSSCGKSA-N 3,4-dihydro-1H-isochromen-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C2CCOCC2=C1)C DQYBIIQBCCBZSU-ZDUSSCGKSA-N 0.000 claims description 2
- MYGWUWFXHNBSMK-ZDUSSCGKSA-N 3,4-dihydro-1H-isochromen-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2CCOCC=12)C MYGWUWFXHNBSMK-ZDUSSCGKSA-N 0.000 claims description 2
- ICYMKBUSZOASTN-ZDUSSCGKSA-N 3,4-dihydro-2H-chromen-5-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC2=C(C=CC=C12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C ICYMKBUSZOASTN-ZDUSSCGKSA-N 0.000 claims description 2
- LYKVEXLFXVHAFV-ZDUSSCGKSA-N 3,4-dihydro-2H-chromen-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC2=CC(=CC=C12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C LYKVEXLFXVHAFV-ZDUSSCGKSA-N 0.000 claims description 2
- VYWVHPVPHCKOEB-ZDUSSCGKSA-N 3,4-dihydro-2H-chromen-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC2=CC=C(C=C12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C VYWVHPVPHCKOEB-ZDUSSCGKSA-N 0.000 claims description 2
- FGTQKGWNUJQTCS-HNNXBMFYSA-N 3,4-dihydro-2H-chromen-7-yl-[(7S)-3-(3-fluoro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC2=CC=C(C=C12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC(=C1)OC)F)C FGTQKGWNUJQTCS-HNNXBMFYSA-N 0.000 claims description 2
- AIDRUQLABDMGMJ-ZDUSSCGKSA-N 3,4-dihydro-2H-chromen-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC2=CC=CC(=C12)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C AIDRUQLABDMGMJ-ZDUSSCGKSA-N 0.000 claims description 2
- WBXDGQBSBRVALH-LBPRGKRZSA-N 3,4-dihydro-2H-pyrano[2,3-b]pyridin-5-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC=2C1=NC=CC=2C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C WBXDGQBSBRVALH-LBPRGKRZSA-N 0.000 claims description 2
- HISWVEGOLRTIHC-LBPRGKRZSA-N 3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC=2C1=NC=C(C=2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C HISWVEGOLRTIHC-LBPRGKRZSA-N 0.000 claims description 2
- XAMHDZMNJKYTSK-LBPRGKRZSA-N 3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1CCCC=2C1=CN=C(C=2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C XAMHDZMNJKYTSK-LBPRGKRZSA-N 0.000 claims description 2
- PFTVSYPGJYCKJK-NSHDSACASA-N 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound O1C2=C(NCC1)N=CC(=C2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C PFTVSYPGJYCKJK-NSHDSACASA-N 0.000 claims description 2
- CYMWFUGQUWKKJV-LBPRGKRZSA-N 3-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-N-methylbenzamide Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C(C(=O)NC)C=CC=1)C CYMWFUGQUWKKJV-LBPRGKRZSA-N 0.000 claims description 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
- BMAUSTCGGHOSGK-UHFFFAOYSA-N 3H-benzimidazol-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound N1C=NC2=C1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 BMAUSTCGGHOSGK-UHFFFAOYSA-N 0.000 claims description 2
- BARQWQDHXIBTLM-NSHDSACASA-N 4-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3-methyl-1,3-benzoxazol-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC2=C1N(C(O2)=O)C)C BARQWQDHXIBTLM-NSHDSACASA-N 0.000 claims description 2
- XBSZJYYVLWIUNA-JTQLQIEISA-N 4-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC2=C1NC(O2)=O)C XBSZJYYVLWIUNA-JTQLQIEISA-N 0.000 claims description 2
- ZXHMVFBYOYRNSV-NSHDSACASA-N 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N=1N2C(=C(C=1)C(=O)N1[C@H](C=3C(CC1)=C(N(N=3)C)C1=CC(=C(C(=C1)F)F)F)C)CCC2 ZXHMVFBYOYRNSV-NSHDSACASA-N 0.000 claims description 2
- WRLFXNFOIFUPMW-UHFFFAOYSA-N 5-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl)-4H-1,4-benzoxazin-3-one Chemical compound CN1N=C2CN(CCC2=C1C1=CC=CC=C1)C(=O)C1=CC=CC=2OCC(NC=21)=O WRLFXNFOIFUPMW-UHFFFAOYSA-N 0.000 claims description 2
- BGYLAFUTNBEGNJ-JTQLQIEISA-N 5-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC2=C(NC(O2)=O)C=1)C BGYLAFUTNBEGNJ-JTQLQIEISA-N 0.000 claims description 2
- ZWGSYHUYAJNCQI-NSHDSACASA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1=C(C=C2OCCCN21)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C ZWGSYHUYAJNCQI-NSHDSACASA-N 0.000 claims description 2
- ZUBSBWIBVSDVHE-NSHDSACASA-N 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1=CC(=C2OCCCN21)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C ZUBSBWIBVSDVHE-NSHDSACASA-N 0.000 claims description 2
- GCTLQVURVOUEBX-NSHDSACASA-N 6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1=C2N(C(=C1)C(=O)N1[C@H](C=3C(CC1)=C(N(N=3)C)C1=CC(=C(C(=C1)F)F)F)C)CCC2 GCTLQVURVOUEBX-NSHDSACASA-N 0.000 claims description 2
- FMQXCQKOBZORBL-NSHDSACASA-N 6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N=1C=C(N2C=1COCC2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C FMQXCQKOBZORBL-NSHDSACASA-N 0.000 claims description 2
- CGECFYXNPGAPFD-LBPRGKRZSA-N 6,8-dihydro-5H-pyrano[3,4-b]pyridin-2-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1=C2C(=CC=C1C(=O)N1[C@H](C=3C(CC1)=C(N(N=3)C)C1=CC(=C(C(=C1)F)F)F)C)CCOC2 CGECFYXNPGAPFD-LBPRGKRZSA-N 0.000 claims description 2
- SMUDQJKRUZTTFR-LBPRGKRZSA-N 6-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-1H-quinolin-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC(=NC2=CC=1)O)C SMUDQJKRUZTTFR-LBPRGKRZSA-N 0.000 claims description 2
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- NCJHTAGNTZBFFI-JTQLQIEISA-N 6-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC2=C(NC(O2)=O)C=C1)C NCJHTAGNTZBFFI-JTQLQIEISA-N 0.000 claims description 2
- FALFKIYENMMVBK-LBPRGKRZSA-N 6-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-4-methyl-1,4-benzoxazin-3-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC2=C(OCC(N2C)=O)C=C1)C FALFKIYENMMVBK-LBPRGKRZSA-N 0.000 claims description 2
- CLLZLGODHVSZLY-LBPRGKRZSA-N 6-[(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC2=C(NC(O2)=O)C=C1)C)C CLLZLGODHVSZLY-LBPRGKRZSA-N 0.000 claims description 2
- DRCWLHHGDACWCS-LBPRGKRZSA-N 7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound N1=C2C(=CC(=C1)C(=O)N1[C@H](C=3C(CC1)=C(N(N=3)C)C1=CC(=C(C(=C1)F)F)F)C)COCC2 DRCWLHHGDACWCS-LBPRGKRZSA-N 0.000 claims description 2
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- QLLOEDAVNBEHAU-NSHDSACASA-N 7-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3-methyl-1,3-benzoxazol-2-one Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC=2N(C(OC=21)=O)C)C QLLOEDAVNBEHAU-NSHDSACASA-N 0.000 claims description 2
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- PCEFOSSMUXUVLH-CYBMUJFWSA-N [(7R)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C PCEFOSSMUXUVLH-CYBMUJFWSA-N 0.000 claims description 2
- NGEAPFZLOLAOSG-MRXNPFEDSA-N [(7R)-2,7-dimethyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@H](N(CCC2=C1C1=CC=CC=C1)C(=O)C=1C=C2C=CC=NC2=CC=1)C NGEAPFZLOLAOSG-MRXNPFEDSA-N 0.000 claims description 2
- WNDDFKKRXIUJDO-GFCCVEGCSA-N [(7R)-2-(difluoromethyl)-7-methyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC(N1N=C2[C@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C)F WNDDFKKRXIUJDO-GFCCVEGCSA-N 0.000 claims description 2
- FVAXSILSMIMLTC-CQSZACIVSA-N [(7R)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C FVAXSILSMIMLTC-CQSZACIVSA-N 0.000 claims description 2
- DNYJCHXKDADZGE-CYBMUJFWSA-N [(7R)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C DNYJCHXKDADZGE-CYBMUJFWSA-N 0.000 claims description 2
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- UUVMOYYKYYUZLH-CYBMUJFWSA-N [(7R)-3-(3-chloro-5-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)F)C=1N(N=C2[C@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C UUVMOYYKYYUZLH-CYBMUJFWSA-N 0.000 claims description 2
- AMOZTJYLTNPCPM-CYBMUJFWSA-N [(7R)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-furo[3,2-b]pyridin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@H](N(CCC2=1)C(=O)C=1C=C2C(=NC=1)C=CO2)C)C AMOZTJYLTNPCPM-CYBMUJFWSA-N 0.000 claims description 2
- HABHYPGNQTXZBW-CQSZACIVSA-N [(7R)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C HABHYPGNQTXZBW-CQSZACIVSA-N 0.000 claims description 2
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- IRGLTSINPUISLO-INIZCTEOSA-N [(7S)-2,7-dimethyl-3-(2-methylpyridin-4-yl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=NC=C1)C)C(=O)C=1C=C2C=CC=NC2=CC=1)C IRGLTSINPUISLO-INIZCTEOSA-N 0.000 claims description 2
- YDQOWLNQMRIMMZ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,2,3,4-tetrahydroisoquinolin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2CCNCC2=CC=C1)C YDQOWLNQMRIMMZ-ZDUSSCGKSA-N 0.000 claims description 2
- GUTBYLGBWKORHB-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,2,3,4-tetrahydroisoquinolin-8-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2CCNCC=12)C GUTBYLGBWKORHB-ZDUSSCGKSA-N 0.000 claims description 2
- XCXIESYOMNCYEX-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN(C=1C)C)C)C XCXIESYOMNCYEX-LBPRGKRZSA-N 0.000 claims description 2
- LTLCNQJZQJZVCK-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC2=CC=CN=C2C=C1)C LTLCNQJZQJZVCK-LBPRGKRZSA-N 0.000 claims description 2
- CKDYOTYEGZQEKE-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC2=CC=CN=C2C=1)C CKDYOTYEGZQEKE-LBPRGKRZSA-N 0.000 claims description 2
- KCHCRELEPKNYCT-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=NC2=CC=CN=C12)C KCHCRELEPKNYCT-LBPRGKRZSA-N 0.000 claims description 2
- WUAVRRMTOIFGEI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,6-naphthyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC2=CC=NC=C2C=1)C WUAVRRMTOIFGEI-LBPRGKRZSA-N 0.000 claims description 2
- SSETWMFEVBPRNL-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,6-naphthyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CC=NC2=CC=N1)C SSETWMFEVBPRNL-LBPRGKRZSA-N 0.000 claims description 2
- ZYPTYGVXVLTYAG-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,6-naphthyridin-8-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC=C2C=CC=NC=12)C ZYPTYGVXVLTYAG-LBPRGKRZSA-N 0.000 claims description 2
- JLLYNQZJUDIJFK-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,7-naphthyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CC=NC2=CN=C1)C JLLYNQZJUDIJFK-LBPRGKRZSA-N 0.000 claims description 2
- CJNMLBOGDPXKMI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,8-naphthyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC2=NC=CC=C2C=1)C CJNMLBOGDPXKMI-LBPRGKRZSA-N 0.000 claims description 2
- NIYAPKOERGYNRW-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,8-naphthyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=NC2=NC=CC=C12)C NIYAPKOERGYNRW-LBPRGKRZSA-N 0.000 claims description 2
- RDMHCAVTMIHJNF-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methyl-4-phenylimidazol-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N(C=C(N=1)C1=CC=CC=C1)C)C RDMHCAVTMIHJNF-AWEZNQCLSA-N 0.000 claims description 2
- QADFFOBPCGMYDT-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methyl-5-propan-2-ylpyrazol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN(C=1C(C)C)C)C QADFFOBPCGMYDT-LBPRGKRZSA-N 0.000 claims description 2
- VHYKYBGUHRLZBP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylbenzimidazol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC=2N(C=NC=21)C)C VHYKYBGUHRLZBP-LBPRGKRZSA-N 0.000 claims description 2
- OQHVQSSFAWJXAQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylindazol-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=NN(C2=CC=1)C)C OQHVQSSFAWJXAQ-LBPRGKRZSA-N 0.000 claims description 2
- ZGAJLKGHBXADRA-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylindazol-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2C=NN(C=12)C)C ZGAJLKGHBXADRA-LBPRGKRZSA-N 0.000 claims description 2
- ACGZBAIYZFMWOC-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylindol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CN(C2=CC=C1)C)C ACGZBAIYZFMWOC-ZDUSSCGKSA-N 0.000 claims description 2
- BGZNNMJSCSQMLL-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylindol-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2C=CN(C=12)C)C BGZNNMJSCSQMLL-ZDUSSCGKSA-N 0.000 claims description 2
- LLSUKHWFORCYDT-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-b]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C(=NC=1)N(N=C2)C)C LLSUKHWFORCYDT-NSHDSACASA-N 0.000 claims description 2
- BSGQEXIIUNOKGX-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C2=CN=CC=C21)C)C BSGQEXIIUNOKGX-NSHDSACASA-N 0.000 claims description 2
- RKCUZSXFIRLVSW-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-c]pyridin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CC=C2C=1N(N=C2)C)C RKCUZSXFIRLVSW-NSHDSACASA-N 0.000 claims description 2
- ZEDJZMWRLHUGPA-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=N1)N(N=C2)C)C ZEDJZMWRLHUGPA-JTQLQIEISA-N 0.000 claims description 2
- VCDFMCKXUVQWEO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-b]pyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=2C(=NC=CC=2)N1C)C VCDFMCKXUVQWEO-LBPRGKRZSA-N 0.000 claims description 2
- JWWYXWUVOXEPDQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN(C2=NC=CC=C21)C)C JWWYXWUVOXEPDQ-LBPRGKRZSA-N 0.000 claims description 2
- AENSNBXPWLIQPI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1)N(C=C2)C)C AENSNBXPWLIQPI-LBPRGKRZSA-N 0.000 claims description 2
- IDWMCMJQOQYOOV-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-b]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C(=NC=1)N(C=C2)C)C IDWMCMJQOQYOOV-LBPRGKRZSA-N 0.000 claims description 2
- LECHMFHSECIFEG-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN(C2=CN=CC=C21)C)C LECHMFHSECIFEG-LBPRGKRZSA-N 0.000 claims description 2
- GTMYVKLOHHPPPH-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[2,3-c]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=CN=C1)N(C=C2)C)C GTMYVKLOHHPPPH-LBPRGKRZSA-N 0.000 claims description 2
- MKBFMZKTPFKMPL-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[3,2-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN(C=2C1=NC=CC=2)C)C MKBFMZKTPFKMPL-LBPRGKRZSA-N 0.000 claims description 2
- REMBFVRBFBNGRZ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[3,2-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN(C2=C1C=NC=C2)C)C REMBFVRBFBNGRZ-LBPRGKRZSA-N 0.000 claims description 2
- ZSXZYUDYSNCCSR-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrrolo[3,2-c]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC2=C1C=CN2C)C ZSXZYUDYSNCCSR-LBPRGKRZSA-N 0.000 claims description 2
- PMFHKCPBWGFVHF-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-oxidoquinolin-1-ium-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC=[N+](C2=CC=1)[O-])C PMFHKCPBWGFVHF-ZDUSSCGKSA-N 0.000 claims description 2
- CKHLLSMOCUXVAO-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-phenylimidazol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CN(C=1)C1=CC=CC=C1)C CKHLLSMOCUXVAO-AWEZNQCLSA-N 0.000 claims description 2
- QJKVRUVEFVGCAA-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-pyridin-2-yl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C=N1)C1=NC=CC=C1)C QJKVRUVEFVGCAA-LBPRGKRZSA-N 0.000 claims description 2
- GIBJAXJVUCMVOL-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-indazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=CC=CC=C12)C GIBJAXJVUCMVOL-NSHDSACASA-N 0.000 claims description 2
- RLBJQIWKWOKMAB-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-indazol-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2C=NNC=12)C RLBJQIWKWOKMAB-NSHDSACASA-N 0.000 claims description 2
- RMAZJYKWEWKSNI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-indol-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2C=CNC=12)C RMAZJYKWEWKSNI-LBPRGKRZSA-N 0.000 claims description 2
- VSIYEWWZDVVFHT-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-b]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1)NN=C2)C VSIYEWWZDVVFHT-JTQLQIEISA-N 0.000 claims description 2
- RWNLIHITLLGORX-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-b]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C(=NC=1)NN=C2)C RWNLIHITLLGORX-JTQLQIEISA-N 0.000 claims description 2
- RWZSBNJJSTVWBL-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=CN=CC=C21)C RWZSBNJJSTVWBL-JTQLQIEISA-N 0.000 claims description 2
- SRXYOTSBIVIDOV-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-c]pyridin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CC=C2C=1NN=C2)C SRXYOTSBIVIDOV-JTQLQIEISA-N 0.000 claims description 2
- QYVXUFSYNOFTEA-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC=2C1=NC=CC=2)C QYVXUFSYNOFTEA-JTQLQIEISA-N 0.000 claims description 2
- LTMDOYUMODDCMQ-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=C1C=NC=C2)C LTMDOYUMODDCMQ-JTQLQIEISA-N 0.000 claims description 2
- IJPOPDYAQWDJSR-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-c]pyridin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C2=C(C=NC=1)C=NN2)C IJPOPDYAQWDJSR-JTQLQIEISA-N 0.000 claims description 2
- YHUCNXGLYSDEFN-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=NC=CC=C21)C YHUCNXGLYSDEFN-NSHDSACASA-N 0.000 claims description 2
- GVFVPDYDPSSVEO-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-b]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C(=NC=1)NC=C2)C GVFVPDYDPSSVEO-NSHDSACASA-N 0.000 claims description 2
- QEEBKZGWAAVHIF-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-c]pyridin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CC=C2C=1NC=C2)C QEEBKZGWAAVHIF-NSHDSACASA-N 0.000 claims description 2
- UAZOOZYPDDGCMB-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[3,2-c]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=C1C=NC=C2)C UAZOOZYPDDGCMB-NSHDSACASA-N 0.000 claims description 2
- JORXZQYKIYWMGF-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[3,2-c]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC2=C1C=CN2)C JORXZQYKIYWMGF-NSHDSACASA-N 0.000 claims description 2
- IPXBYTMTOCUBNX-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2,5,8-trimethylimidazo[1,2-a]pyrazin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C(=CN=C2C)C)C)C IPXBYTMTOCUBNX-AWEZNQCLSA-N 0.000 claims description 2
- LVYUGUMDMXCYBW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2,6,6-trimethyl-4,7-dihydropyrazolo[5,1-c][1,4]oxazin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN2C=1COC(C2)(C)C)C)C LVYUGUMDMXCYBW-ZDUSSCGKSA-N 0.000 claims description 2
- IGWXCEKXWUIYAD-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-fluoro-4-methoxyphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=C(C=C1)OC)F)C IGWXCEKXWUIYAD-NSHDSACASA-N 0.000 claims description 2
- GYYSNAYPPYXGPD-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-fluoro-6-pyrazol-1-ylphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1N1N=CC=C1)F)C GYYSNAYPPYXGPD-ZDUSSCGKSA-N 0.000 claims description 2
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- HCTOTKBREVEKOZ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxyphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1)OC)C HCTOTKBREVEKOZ-LBPRGKRZSA-N 0.000 claims description 2
- GAGSVFQHYKRBOL-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxypyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=NC=C1)OC)C GAGSVFQHYKRBOL-NSHDSACASA-N 0.000 claims description 2
- NQOGYPHZKHIBHT-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxyquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=NC2=CC=CC=C12)OC)C NQOGYPHZKHIBHT-ZDUSSCGKSA-N 0.000 claims description 2
- LKCFMUZWRRCOHK-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-1,6-naphthyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CC(=NC2=CC=N1)C)C LKCFMUZWRRCOHK-ZDUSSCGKSA-N 0.000 claims description 2
- PCKVWARKXPCCQG-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(NC2=NC=CC=C21)C)C PCKVWARKXPCCQG-LBPRGKRZSA-N 0.000 claims description 2
- ZDNHWNGRNQSKGQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=CC=C2)C)C ZDNHWNGRNQSKGQ-ZDUSSCGKSA-N 0.000 claims description 2
- NLLVYMKJOYIZQW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC=2N1C=C(N=2)C)C NLLVYMKJOYIZQW-ZDUSSCGKSA-N 0.000 claims description 2
- CWSQQMRSCBETAM-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyrimidin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=CC=N2)C)C CWSQQMRSCBETAM-LBPRGKRZSA-N 0.000 claims description 2
- GXMOQUCEZAQUBO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-b]pyridazin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1N=CC=C2)C)C GXMOQUCEZAQUBO-LBPRGKRZSA-N 0.000 claims description 2
- RNSUANHSIKFZJP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-b]pyridazin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=2N(N=1)C=C(N=2)C)C RNSUANHSIKFZJP-LBPRGKRZSA-N 0.000 claims description 2
- ZRGWRFNQTSBAPW-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylindazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N(N=C2C=CC=CC=12)C)C ZRGWRFNQTSBAPW-LBPRGKRZSA-N 0.000 claims description 2
- VIJVUOLQADCJNQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN2C=1C=CC=C2)C)C VIJVUOLQADCJNQ-ZDUSSCGKSA-N 0.000 claims description 2
- WNGMBPPZBHQARP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN2C=1N=CC=C2)C)C WNGMBPPZBHQARP-LBPRGKRZSA-N 0.000 claims description 2
- NCNKSXPWZQWOFZ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-b]pyridazin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN2N=CC=CC2=1)C)C NCNKSXPWZQWOFZ-LBPRGKRZSA-N 0.000 claims description 2
- HGJUOJZCKLVLOY-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[3,4-c]pyridin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC=2C1=NN(C=2)C)C HGJUOJZCKLVLOY-NSHDSACASA-N 0.000 claims description 2
- CPURTXVNTSBORP-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=NC2=CC=CC=C12)C)C CPURTXVNTSBORP-AWEZNQCLSA-N 0.000 claims description 2
- DZMJQPYDRGSMFN-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinolin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC(=NC2=CC=1)C)C DZMJQPYDRGSMFN-AWEZNQCLSA-N 0.000 claims description 2
- KGFCXUKTWSDPKQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinoxalin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2N=CC(=NC2=CC=C1)C)C KGFCXUKTWSDPKQ-ZDUSSCGKSA-N 0.000 claims description 2
- PEDOQBBUVXJVCU-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinoxalin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2N=CC(=NC2=CC=1)C)C PEDOQBBUVXJVCU-ZDUSSCGKSA-N 0.000 claims description 2
- XWXYOUYWKNVNPQ-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2H-pyrazolo[3,4-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=NC=CC=C21)C XWXYOUYWKNVNPQ-JTQLQIEISA-N 0.000 claims description 2
- PBCUODVZCBDSNW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3,6,6-trimethyl-4,7-dihydropyrazolo[5,1-c][1,4]oxazin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN2C(COC(C2)(C)C)=C1C)C PBCUODVZCBDSNW-ZDUSSCGKSA-N 0.000 claims description 2
- PMQOVFPIWTZDED-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1)NC=C2F)C PMQOVFPIWTZDED-JTQLQIEISA-N 0.000 claims description 2
- AXIYUUXZJLUVQP-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-2-methoxypyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C(=NC=C1)OC)F)C AXIYUUXZJLUVQP-JTQLQIEISA-N 0.000 claims description 2
- BCHYZVFFPUYIIX-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-5-methoxypyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=NC=C1OC)F)C BCHYZVFFPUYIIX-JTQLQIEISA-N 0.000 claims description 2
- GFYWCLSHMMCOIE-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoropyrazolo[1,5-a]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CC=1)N=CC=2F)C GFYWCLSHMMCOIE-NSHDSACASA-N 0.000 claims description 2
- ZRRYWSDNLZAWNW-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoropyrazolo[1,5-a]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=2N(C=C1)N=CC=2F)C ZRRYWSDNLZAWNW-NSHDSACASA-N 0.000 claims description 2
- WJQJAADQQGPJSP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxy-2-methylpyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C(=NC=C1)C)OC)C WJQJAADQQGPJSP-LBPRGKRZSA-N 0.000 claims description 2
- GKYWOIKIKHJWCQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxyphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)OC)C GKYWOIKIKHJWCQ-LBPRGKRZSA-N 0.000 claims description 2
- FQJXRFDXXBLRGK-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxypyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC=C1OC)C FQJXRFDXXBLRGK-NSHDSACASA-N 0.000 claims description 2
- IPRAFBQUANPIAI-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxypyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=NC=C1)OC)C IPRAFBQUANPIAI-NSHDSACASA-N 0.000 claims description 2
- DVKZUPHMDDYPHJ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methyl-2-pyridin-2-ylimidazol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N(C(=NC=1)C1=NC=CC=C1)C)C DVKZUPHMDDYPHJ-ZDUSSCGKSA-N 0.000 claims description 2
- CWHNMKKINOPUSE-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN2C(OCCC2)=C1C)C CWHNMKKINOPUSE-LBPRGKRZSA-N 0.000 claims description 2
- NQVZHRUFYLWECH-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,2-a]pyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=C2N(C=CC=C2)C=1C)C NQVZHRUFYLWECH-LBPRGKRZSA-N 0.000 claims description 2
- GIUSSJXCCZLVSA-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a]pyrazin-1-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=C(N2C=1C=NC=C2)C)C GIUSSJXCCZLVSA-NSHDSACASA-N 0.000 claims description 2
- FZPBGCBCQQRFQG-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a]pyridin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=2N(C=1)C(=NC=2)C)C FZPBGCBCQQRFQG-LBPRGKRZSA-N 0.000 claims description 2
- FYAMBRNVXPQGEO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a]pyrimidin-8-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CN2C=1N=CC(=C2)C)C FYAMBRNVXPQGEO-LBPRGKRZSA-N 0.000 claims description 2
- SQOPXHSMNOEAJU-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylpyrazolo[1,5-a]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CC=1)N=CC=2C)C SQOPXHSMNOEAJU-ZDUSSCGKSA-N 0.000 claims description 2
- NLNOBXTWOPGXRF-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylquinoxalin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2N=C(C=NC2=CC=C1)C)C NLNOBXTWOPGXRF-ZDUSSCGKSA-N 0.000 claims description 2
- DTRDDFWAQPIXEJ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1CCCC2)C DTRDDFWAQPIXEJ-LBPRGKRZSA-N 0.000 claims description 2
- YDELVJIHYZFBLJ-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-fluoro-1H-indazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=CC=CC(=C12)F)C YDELVJIHYZFBLJ-JTQLQIEISA-N 0.000 claims description 2
- CVJMXVSORUFFQG-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-fluoro-1H-indol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=CC=CC(=C12)F)C CVJMXVSORUFFQG-NSHDSACASA-N 0.000 claims description 2
- UIWMGSAFUJKXJV-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-imidazol-1-ylphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C(C=C1)N1C=NC=C1)C UIWMGSAFUJKXJV-AWEZNQCLSA-N 0.000 claims description 2
- FZIFBLBELSCRMF-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxy-3-methylpyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC(=C1C)OC)C FZIFBLBELSCRMF-LBPRGKRZSA-N 0.000 claims description 2
- JAVWQGBBIJMRGT-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxyphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C(C=C1)OC)C JAVWQGBBIJMRGT-LBPRGKRZSA-N 0.000 claims description 2
- XCRNXPZIHYGQGA-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C(=CC=C2)OC)C XCRNXPZIHYGQGA-LBPRGKRZSA-N 0.000 claims description 2
- OTLGJCKAEIJPNI-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxypyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC(=C1)OC)C OTLGJCKAEIJPNI-NSHDSACASA-N 0.000 claims description 2
- GPQZKMJSTDETAJ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=2OCCN(C=2N=C1)C)C GPQZKMJSTDETAJ-LBPRGKRZSA-N 0.000 claims description 2
- PAEKOPXKIFIIFZ-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methylquinolin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C(=CC=NC2=CC=1)C)C PAEKOPXKIFIIFZ-AWEZNQCLSA-N 0.000 claims description 2
- BPAXWXJERYQSIB-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1CCCC2)C BPAXWXJERYQSIB-LBPRGKRZSA-N 0.000 claims description 2
- DYNCLGKWHTYJHU-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-ethyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C(=N1)CC)C1=CC=CC=C1)C DYNCLGKWHTYJHU-AWEZNQCLSA-N 0.000 claims description 2
- IHZPGTQZPOZIMJ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1-methylindol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN(C2=CC=C(C=C12)F)C)C IHZPGTQZPOZIMJ-LBPRGKRZSA-N 0.000 claims description 2
- KKQWBGZEFRIGTN-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1-methylpyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1F)N(C=C2)C)C KKQWBGZEFRIGTN-NSHDSACASA-N 0.000 claims description 2
- DZFAIYVUMVOFFF-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=CC=C(C=C12)F)C DZFAIYVUMVOFFF-JTQLQIEISA-N 0.000 claims description 2
- LSALPGYCUSRFHF-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=CC=C(C=C12)F)C LSALPGYCUSRFHF-NSHDSACASA-N 0.000 claims description 2
- IZUZROKJODWDAL-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indol-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=C2C=CNC2=C1)F)C IZUZROKJODWDAL-NSHDSACASA-N 0.000 claims description 2
- XRYSAINYLUPGNU-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=NC=C(C=C21)F)C XRYSAINYLUPGNU-JTQLQIEISA-N 0.000 claims description 2
- XBCWGXBVBBZGPD-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1F)NC=C2)C XBCWGXBVBBZGPD-JTQLQIEISA-N 0.000 claims description 2
- OHZHALXPPPDWKE-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-2-pyrazol-1-ylphenyl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)F)N1N=CC=C1)C OHZHALXPPPDWKE-ZDUSSCGKSA-N 0.000 claims description 2
- BDILFDJEDMCRHQ-VIFPVBQESA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=NC=C(C=C21)F)C BDILFDJEDMCRHQ-VIFPVBQESA-N 0.000 claims description 2
- GGVRKYQNLBRQHX-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoroquinolin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC2=CC=CC(=C2C=1)F)C GGVRKYQNLBRQHX-LBPRGKRZSA-N 0.000 claims description 2
- DJUYIMFKPDTKOW-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-1-methylpyrazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C(=C1)OC)C)C DJUYIMFKPDTKOW-JTQLQIEISA-N 0.000 claims description 2
- MYPTWGYWDZKLEM-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-2-methylpyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NC=C(C=1)OC)C)C MYPTWGYWDZKLEM-LBPRGKRZSA-N 0.000 claims description 2
- LPAPSCJRJVBFQX-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-4-methylpyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC=C(C=1C)OC)C LPAPSCJRJVBFQX-LBPRGKRZSA-N 0.000 claims description 2
- CFTUMQLKLBKFDC-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-6-methylpyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC(=C(C=1)OC)C)C CFTUMQLKLBKFDC-LBPRGKRZSA-N 0.000 claims description 2
- NWOZZEMUNBXNPH-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxypyrazin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=C(N=C1)OC)C NWOZZEMUNBXNPH-JTQLQIEISA-N 0.000 claims description 2
- HDLROMMXLKTGOQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=C(C=C2)OC)C HDLROMMXLKTGOQ-LBPRGKRZSA-N 0.000 claims description 2
- ACKVECFGIFCABX-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxypyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=C(C=C1)OC)C ACKVECFGIFCABX-NSHDSACASA-N 0.000 claims description 2
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- FWPSHMAHEGTESO-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C2=C(N=CN=1)NC=C2C)C FWPSHMAHEGTESO-NSHDSACASA-N 0.000 claims description 2
- XSFCYZIWQDFMLG-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=NC=2N1N=CN=2)C)C XSFCYZIWQDFMLG-NSHDSACASA-N 0.000 claims description 2
- GNPHCBLWOHACIQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1C(=CC=C2)C)C GNPHCBLWOHACIQ-ZDUSSCGKSA-N 0.000 claims description 2
- JDIQCBDXUKVAKO-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylpyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=C(C=C2)C)C JDIQCBDXUKVAKO-ZDUSSCGKSA-N 0.000 claims description 2
- OMYNTHPPCSBGLI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylpyrazolo[1,5-b]pyridazin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2N=CC(=CC2=1)C)C OMYNTHPPCSBGLI-LBPRGKRZSA-N 0.000 claims description 2
- XZMQZCPCCBJTNN-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-propan-2-yloxypyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC=C(C=1)OC(C)C)C XZMQZCPCCBJTNN-ZDUSSCGKSA-N 0.000 claims description 2
- SQPOFFNVQUMMOE-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-pyrazol-1-ylpyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC=C(C=1)N1N=CC=C1)C SQPOFFNVQUMMOE-ZDUSSCGKSA-N 0.000 claims description 2
- LTXUBTHXHCESDQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-pyridin-2-ylthiophen-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1SC(=CC=1)C1=NC=CC=C1)C LTXUBTHXHCESDQ-ZDUSSCGKSA-N 0.000 claims description 2
- FYSNOJOOGIPIHY-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-1H-indazol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NNC2=CC(=CC=C12)F)C FYSNOJOOGIPIHY-JTQLQIEISA-N 0.000 claims description 2
- IRSVCNFPAFAUBU-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-1H-indol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=CC(=CC=C12)F)C IRSVCNFPAFAUBU-NSHDSACASA-N 0.000 claims description 2
- FNFXSKXSZCZERJ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=C(C(=C2)C)F)C)C FNFXSKXSZCZERJ-ZDUSSCGKSA-N 0.000 claims description 2
- CZHGKACQCOYRQA-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2,8-dimethylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=C(C=C2C)F)C)C CZHGKACQCOYRQA-ZDUSSCGKSA-N 0.000 claims description 2
- SQJOUQNKHTZDGD-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=C(C=C2)F)C)C SQJOUQNKHTZDGD-LBPRGKRZSA-N 0.000 claims description 2
- VQTNQGUDNSIPNC-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoropyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=CC(=C2)F)C VQTNQGUDNSIPNC-NSHDSACASA-N 0.000 claims description 2
- HNDCHBTWLXUQSH-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=C(C=C2)OC)C)C HNDCHBTWLXUQSH-ZDUSSCGKSA-N 0.000 claims description 2
- ZCWRUSCBAJVNSL-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-2-methylpyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NC(=CC=1)OC)C)C ZCWRUSCBAJVNSL-LBPRGKRZSA-N 0.000 claims description 2
- CFBZGVFDJOLATP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-3-methylpyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC(=CC=C1C)OC)C CFBZGVFDJOLATP-LBPRGKRZSA-N 0.000 claims description 2
- LTLRCOPMWPQUHM-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=CC(=C2)OC)C LTLRCOPMWPQUHM-LBPRGKRZSA-N 0.000 claims description 2
- AQMQEJUQIRYWNR-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxypyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC(=CC=1)OC)C AQMQEJUQIRYWNR-NSHDSACASA-N 0.000 claims description 2
- QXKFAUXXKRSYNT-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methyl-1H-indol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=CC(=CC=C12)C)C QXKFAUXXKRSYNT-ZDUSSCGKSA-N 0.000 claims description 2
- RGAHSGZZIDGLJK-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1C=C(C=C2)C)C RGAHSGZZIDGLJK-ZDUSSCGKSA-N 0.000 claims description 2
- FTVYTXDMOYQGBV-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylimidazo[1,5-a]pyrimidin-8-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=C(N2C=1N=CC=C2)C)C FTVYTXDMOYQGBV-NSHDSACASA-N 0.000 claims description 2
- UMAYUENDZORBQD-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1N=CC(=C2)C)C UMAYUENDZORBQD-LBPRGKRZSA-N 0.000 claims description 2
- RQPDJUWQDMFIGC-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-pyrazol-1-ylpyridin-2-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC(=CC=C1)N1N=CC=C1)C RQPDJUWQDMFIGC-ZDUSSCGKSA-N 0.000 claims description 2
- AYHIKBBCTNWKAF-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-1H-indol-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CNC2=C(C=CC=C12)F)C AYHIKBBCTNWKAF-NSHDSACASA-N 0.000 claims description 2
- UKYUAKPLFPONEP-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-1H-indol-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CNC2=C(C=C1)F)C UKYUAKPLFPONEP-NSHDSACASA-N 0.000 claims description 2
- FUSHQRRKCQAEBU-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=CC(=C2)F)C)C FUSHQRRKCQAEBU-LBPRGKRZSA-N 0.000 claims description 2
- QEUFOGJANFFQSY-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoroimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1C=CC(=C2)F)C QEUFOGJANFFQSY-NSHDSACASA-N 0.000 claims description 2
- YPCDGGGOVCPCMY-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=CC=C2OC)C YPCDGGGOVCPCMY-LBPRGKRZSA-N 0.000 claims description 2
- IZYKSNVBRGMDCL-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methyl-1H-indazol-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=NNC2=C(C=1)C)C IZYKSNVBRGMDCL-LBPRGKRZSA-N 0.000 claims description 2
- MLNRCVGKBUGIHW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1C=CC(=C2)C)C MLNRCVGKBUGIHW-ZDUSSCGKSA-N 0.000 claims description 2
- SRTJHHCQSPUORU-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylimidazo[1,5-a]pyridin-1-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CN2C=1C=C(C=C2)C)C SRTJHHCQSPUORU-ZDUSSCGKSA-N 0.000 claims description 2
- PMDZICMTDCSIOG-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=CC=C2C)C PMDZICMTDCSIOG-ZDUSSCGKSA-N 0.000 claims description 2
- DPTJDMBNZYJTCS-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1N=CC=C2C)C DPTJDMBNZYJTCS-LBPRGKRZSA-N 0.000 claims description 2
- MVHPTYWBWHZMIF-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrrolo[2,3-d]pyrimidin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C2=C(N=CN=1)N(C=C2)C)C MVHPTYWBWHZMIF-NSHDSACASA-N 0.000 claims description 2
- TUNWUKOUSVEVHW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylquinoxalin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2N=CC=NC2=CC=1C)C TUNWUKOUSVEVHW-ZDUSSCGKSA-N 0.000 claims description 2
- OJJKFMVZSHWONQ-VIFPVBQESA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7H-purin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2NC=NC2=NC=N1)C OJJKFMVZSHWONQ-VIFPVBQESA-N 0.000 claims description 2
- PPXRTVWLINGLLT-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoro-2-methylquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=NC2=C(C=CC=C12)F)C)C PPXRTVWLINGLLT-ZDUSSCGKSA-N 0.000 claims description 2
- YCNRRNXIOZFSIY-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoroisoquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=CC2=C(C=CC=C12)F)C YCNRRNXIOZFSIY-LBPRGKRZSA-N 0.000 claims description 2
- VJHNXHSJRNEWMJ-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoroquinazolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=NC2=C(C=CC=C12)F)C VJHNXHSJRNEWMJ-NSHDSACASA-N 0.000 claims description 2
- CFEOSHXSACMBAK-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoroquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=NC2=C(C=CC=C12)F)C CFEOSHXSACMBAK-LBPRGKRZSA-N 0.000 claims description 2
- WUBYODYMWMGJFM-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-methoxyquinolin-4-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=NC2=C(C=CC=C12)OC)C WUBYODYMWMGJFM-ZDUSSCGKSA-N 0.000 claims description 2
- RXMQZXTYCJCWNX-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(9-methylpurin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2N=CN(C2=NC=N1)C)C RXMQZXTYCJCWNX-JTQLQIEISA-N 0.000 claims description 2
- QQEXOJSRHKOVSO-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN=C2N1C=CC=C2)C QQEXOJSRHKOVSO-NSHDSACASA-N 0.000 claims description 2
- VCLKNOFPKWKRSZ-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-5-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC=2N1C=NN=2)C VCLKNOFPKWKRSZ-NSHDSACASA-N 0.000 claims description 2
- UELCMQXAQRJKFI-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-6-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=2N(C=1)C=NN=2)C UELCMQXAQRJKFI-NSHDSACASA-N 0.000 claims description 2
- OVLDMAVUNUKKHD-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(triazolo[1,5-a]pyridin-3-yl)methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=NN2C=1C=CC=C2)C OVLDMAVUNUKKHD-NSHDSACASA-N 0.000 claims description 2
- OWZAYVSVERJACB-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(3-fluoropyridin-2-yl)-1,2,4-triazol-3-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C=N1)C1=NC=CC=C1F)C OWZAYVSVERJACB-NSHDSACASA-N 0.000 claims description 2
- LMSIVSYPKPLNKE-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NN(C(=N1)C)C1=CC=C(C=C1)F)C LMSIVSYPKPLNKE-LBPRGKRZSA-N 0.000 claims description 2
- IYWVJPMWKQTQLD-VIFPVBQESA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(trifluoromethyl)pyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN(C=1)C(F)(F)F)C IYWVJPMWKQTQLD-VIFPVBQESA-N 0.000 claims description 2
- XVRDFMCOCHLSEH-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-methyl-3-(1-methylcyclopropyl)pyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN(C=1)C)C1(CC1)C)C XVRDFMCOCHLSEH-LBPRGKRZSA-N 0.000 claims description 2
- PBUYFQIGAFQJBO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-methyl-5-(1-methylcyclopropyl)pyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN(C=1C1(CC1)C)C)C PBUYFQIGAFQJBO-LBPRGKRZSA-N 0.000 claims description 2
- NQJRQSZEEXRFCO-VIFPVBQESA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-methyl-5-(trifluoromethyl)pyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN(C=1C(F)(F)F)C)C NQJRQSZEEXRFCO-VIFPVBQESA-N 0.000 claims description 2
- GNSZADLLVMOZMK-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1)N1N=CN=C1)C GNSZADLLVMOZMK-ZDUSSCGKSA-N 0.000 claims description 2
- ZKQGLGRERCBJIO-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1)N1C=NN=C1)C ZKQGLGRERCBJIO-ZDUSSCGKSA-N 0.000 claims description 2
- KKPWXYOBPMWYEG-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(trifluoromethoxy)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1)OC(F)(F)F)C KKPWXYOBPMWYEG-NSHDSACASA-N 0.000 claims description 2
- XDQVRUYGTZAUCH-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C=CC=C2)C(F)(F)F)C XDQVRUYGTZAUCH-NSHDSACASA-N 0.000 claims description 2
- NOWOTOAQHJKZMI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1)N1N=C(N=C1)C(F)(F)F)C NOWOTOAQHJKZMI-LBPRGKRZSA-N 0.000 claims description 2
- LAGFSUIAPAYOCI-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-5-(1-methylpyrazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)C=1C=NN(C=1)C)F)C LAGFSUIAPAYOCI-ZDUSSCGKSA-N 0.000 claims description 2
- MTNBAIZNDDMOSQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-5-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)N1N=CC=N1)F)C MTNBAIZNDDMOSQ-LBPRGKRZSA-N 0.000 claims description 2
- QNYHMARUHITLDI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-6-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1N1N=CN=C1)F)C QNYHMARUHITLDI-LBPRGKRZSA-N 0.000 claims description 2
- LDWBXGXMUCEIRH-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC=C1N1N=CC=N1)F)C LDWBXGXMUCEIRH-LBPRGKRZSA-N 0.000 claims description 2
- YGWJBKPPROKJKU-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound N1(N=CN=C1)C=1C=C(C=CC=1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C YGWJBKPPROKJKU-ZDUSSCGKSA-N 0.000 claims description 2
- SPLJLWZQEPEFND-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)-4-(trifluoromethyl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=C(C=C1)C(F)(F)F)N1C=NN=C1)C SPLJLWZQEPEFND-LBPRGKRZSA-N 0.000 claims description 2
- WMOSLADWJKZHRP-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)C(F)(F)F)N1C=NN=C1)C WMOSLADWJKZHRP-LBPRGKRZSA-N 0.000 claims description 2
- DFBIGMAQKYJZFA-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)N1C=NN=C1)C DFBIGMAQKYJZFA-ZDUSSCGKSA-N 0.000 claims description 2
- IKMKQODOLSZXOZ-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1-fluorocyclopropyl)-1-methylpyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C(=NN(C=1)C)C1(CC1)F)C IKMKQODOLSZXOZ-NSHDSACASA-N 0.000 claims description 2
- DBIHJFABILJOHV-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1-methylpyrazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)C=1C=NN(C=1)C)C DBIHJFABILJOHV-AWEZNQCLSA-N 0.000 claims description 2
- IOGUZQMOEHJUAP-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1H-pyrazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)C=1C=NNC=1)C IOGUZQMOEHJUAP-ZDUSSCGKSA-N 0.000 claims description 2
- NVDCCJLIRDUOGW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1H-pyrazol-5-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)C1=NNC=C1)C NVDCCJLIRDUOGW-ZDUSSCGKSA-N 0.000 claims description 2
- NECSOBKHRYRTKQ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(3-methyl-1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)N1N=C(N=C1)C)C NECSOBKHRYRTKQ-ZDUSSCGKSA-N 0.000 claims description 2
- RGRMBCIQCQGTRW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(4-fluoropyrazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)N1N=CC(=C1)F)C RGRMBCIQCQGTRW-ZDUSSCGKSA-N 0.000 claims description 2
- UKIHUGXIRZCPCQ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(triazol-2-yl)-5-(trifluoromethyl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)C(F)(F)F)N1N=CC=N1)C UKIHUGXIRZCPCQ-LBPRGKRZSA-N 0.000 claims description 2
- CHVAFBOXQJGTOA-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)N1N=CC=N1)C CHVAFBOXQJGTOA-ZDUSSCGKSA-N 0.000 claims description 2
- OTOCABJRCKHGLR-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(trifluoromethoxy)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC=C1)OC(F)(F)F)C OTOCABJRCKHGLR-NSHDSACASA-N 0.000 claims description 2
- WOBNNQGIXOGHMI-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=C(N2C=1C=NC=C2)C(F)(F)F)C WOBNNQGIXOGHMI-JTQLQIEISA-N 0.000 claims description 2
- MPWFFRLJAGRXEA-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C(=CC=C1)F)N1N=CC=N1)C MPWFFRLJAGRXEA-LBPRGKRZSA-N 0.000 claims description 2
- GOKLFIIKBBFZEK-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1N=CN=C1)F)C GOKLFIIKBBFZEK-LBPRGKRZSA-N 0.000 claims description 2
- QYPIDFITUQCUBU-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1C=NN=C1)F)C QYPIDFITUQCUBU-LBPRGKRZSA-N 0.000 claims description 2
- AJABWCAHWLGDHI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1N=CC=N1)F)C AJABWCAHWLGDHI-LBPRGKRZSA-N 0.000 claims description 2
- YEOFZVWFVKMUEN-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methoxy-5-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1N=CN=C1)OC)C YEOFZVWFVKMUEN-ZDUSSCGKSA-N 0.000 claims description 2
- AJDSASRYQBUXTO-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methoxy-5-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1C=NN=C1)OC)C AJDSASRYQBUXTO-ZDUSSCGKSA-N 0.000 claims description 2
- CKFUBBARRGTARK-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methyl-5-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1C=NN=C1)C)C CKFUBBARRGTARK-AWEZNQCLSA-N 0.000 claims description 2
- UCGPRNCEFZRLFU-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methyl-5-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=CC(=C1)N1N=CC=N1)C)C UCGPRNCEFZRLFU-AWEZNQCLSA-N 0.000 claims description 2
- YIPGLCQNIPXHIP-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(1H-pyrazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C(C=C1)C=1C=NNC=1)C YIPGLCQNIPXHIP-ZDUSSCGKSA-N 0.000 claims description 2
- KZHRHZFDDDOFBP-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(1H-pyrazol-5-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C(C=C1)C1=CC=NN1)C KZHRHZFDDDOFBP-ZDUSSCGKSA-N 0.000 claims description 2
- WLPRUOBIKZECCR-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-fluoro-2-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=C(C=C1)F)N1N=CC=N1)C WLPRUOBIKZECCR-LBPRGKRZSA-N 0.000 claims description 2
- BJZMUYJQTWXLMI-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-fluoro-3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=C(C=C1)F)N1C=NN=C1)C BJZMUYJQTWXLMI-LBPRGKRZSA-N 0.000 claims description 2
- FZRFDZURKGRAFC-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methoxy-3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=C(C=C1)OC)N1C=NN=C1)C FZRFDZURKGRAFC-ZDUSSCGKSA-N 0.000 claims description 2
- CBKSAJYFHACBRI-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methoxy-3-(1-methylpyrazol-3-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=C(C=C1)OC)C1=NN(C=C1)C)C CBKSAJYFHACBRI-AWEZNQCLSA-N 0.000 claims description 2
- JLTBURMXSLMYAF-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methyl-3-(1,2,4-triazol-4-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC(=C(C=C1)C)N1C=NN=C1)C JLTBURMXSLMYAF-AWEZNQCLSA-N 0.000 claims description 2
- UGIBLEWXFTYPRA-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(1-fluorocyclopropyl)-1-methylpyrazol-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN(C=1C1(CC1)F)C)C UGIBLEWXFTYPRA-NSHDSACASA-N 0.000 claims description 2
- RQJCIYDEPYSYLZ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(methoxymethyl)pyridin-3-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NC=C(C=1)COC)C RQJCIYDEPYSYLZ-LBPRGKRZSA-N 0.000 claims description 2
- ODSMSDKQBVWNFF-JTQLQIEISA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C(=NC=C1C(F)(F)F)NC=C2)C ODSMSDKQBVWNFF-JTQLQIEISA-N 0.000 claims description 2
- QKLDQPKGAUGLFX-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-fluoro-2-(1,2,4-triazol-1-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)F)N1N=CN=C1)C QKLDQPKGAUGLFX-LBPRGKRZSA-N 0.000 claims description 2
- ZDKITGUYJZPNPG-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)OC)N1N=CC=N1)C ZDKITGUYJZPNPG-ZDUSSCGKSA-N 0.000 claims description 2
- TUSCAROEXUGJRA-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C TUSCAROEXUGJRA-AWEZNQCLSA-N 0.000 claims description 2
- QTTQTHLMFOSYKC-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C(N=C2N1C(=CC=C2)C)C(F)(F)F)C QTTQTHLMFOSYKC-LBPRGKRZSA-N 0.000 claims description 2
- CUIKCSNUTUGUFZ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[6-methyl-3-(triazol-2-yl)pyridin-2-yl]methanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC(=CC=C1N1N=CC=N1)C)C CUIKCSNUTUGUFZ-ZDUSSCGKSA-N 0.000 claims description 2
- PIXVCNYLURBLLX-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-furo[3,2-c]pyridin-4-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC2=C1C=CO2)C PIXVCNYLURBLLX-NSHDSACASA-N 0.000 claims description 2
- VXLSLICHAZLTTN-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-a]pyridin-3-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1C=CC=C2)C VXLSLICHAZLTTN-LBPRGKRZSA-N 0.000 claims description 2
- DQOOPGSPODVIPO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-a]pyridin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=2N(C=1)C=CN=2)C DQOOPGSPODVIPO-LBPRGKRZSA-N 0.000 claims description 2
- KVFMTZMBCJNXJR-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-a]pyridin-8-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CC=1)C=CN=2)C KVFMTZMBCJNXJR-LBPRGKRZSA-N 0.000 claims description 2
- IHIFNDATVXJNSD-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-b]pyridazin-3-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CN=C2N1N=CC=C2)C IHIFNDATVXJNSD-NSHDSACASA-N 0.000 claims description 2
- FIKYVEPFWQPHEP-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-b]pyridazin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=2N(N=1)C=CN=2)C FIKYVEPFWQPHEP-NSHDSACASA-N 0.000 claims description 2
- HUGKCPJMXSPJQC-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,5-a]pyridin-1-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1N=CN2C=1C=CC=C2)C HUGKCPJMXSPJQC-LBPRGKRZSA-N 0.000 claims description 2
- GUNZGTQQVSPPCO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,5-a]pyridin-8-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CC=1)C=NC=2)C GUNZGTQQVSPPCO-LBPRGKRZSA-N 0.000 claims description 2
- OMYCYOAVXACAEW-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isoquinolin-1-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC2=CC=CC=C12)C OMYCYOAVXACAEW-ZDUSSCGKSA-N 0.000 claims description 2
- KRBIRCABUWRPCE-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isoquinolin-5-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=C2C=CN=CC2=CC=C1)C KRBIRCABUWRPCE-ZDUSSCGKSA-N 0.000 claims description 2
- ZMAPXNLIYJRBGR-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isoquinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CN=CC2=CC=1)C ZMAPXNLIYJRBGR-ZDUSSCGKSA-N 0.000 claims description 2
- OZCUIKCVUAJQRN-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyrazin-3-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=NC=C2)C OZCUIKCVUAJQRN-NSHDSACASA-N 0.000 claims description 2
- KBYNGLDQRHUJMK-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyridin-3-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1C=CC=C2)C KBYNGLDQRHUJMK-LBPRGKRZSA-N 0.000 claims description 2
- WYJJWLJKJPOZNL-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyridin-4-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CC=1)N=CC=2)C WYJJWLJKJPOZNL-LBPRGKRZSA-N 0.000 claims description 2
- DHSREDIMBBZILZ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyridin-5-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=2N(C=C1)N=CC=2)C DHSREDIMBBZILZ-LBPRGKRZSA-N 0.000 claims description 2
- SFHYKDBJGXHUHQ-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyrimidin-3-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=NN2C=1N=CC=C2)C SFHYKDBJGXHUHQ-NSHDSACASA-N 0.000 claims description 2
- WMYFONWHDHNXDG-NSHDSACASA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrido[4,3-d]pyrimidin-5-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=CC=2N=CN=CC=21)C WMYFONWHDHNXDG-NSHDSACASA-N 0.000 claims description 2
- HZLWYCIOKNSFDE-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrrolo[1,2-a]pyrazin-1-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=2N(C=CN=1)C=CC=2)C HZLWYCIOKNSFDE-LBPRGKRZSA-N 0.000 claims description 2
- RBLCIVNRGRJTPT-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrrolo[1,2-a]pyrazin-8-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CN2C=1C=NC=C2)C RBLCIVNRGRJTPT-LBPRGKRZSA-N 0.000 claims description 2
- XNWNHJYRUNJGPO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-4-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC=NC2=CC=CC=C12)C XNWNHJYRUNJGPO-LBPRGKRZSA-N 0.000 claims description 2
- YBEHVSFDEYISFF-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=NC=NC2=CC=1)C YBEHVSFDEYISFF-LBPRGKRZSA-N 0.000 claims description 2
- WWBDKFGZWXQTOC-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-7-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=C2C=NC=NC2=C1)C WWBDKFGZWXQTOC-LBPRGKRZSA-N 0.000 claims description 2
- PCEFOSSMUXUVLH-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C PCEFOSSMUXUVLH-ZDUSSCGKSA-N 0.000 claims description 2
- UVIYGJQIRWFZOJ-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-8-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=CC=C2C=CC=NC=12)C UVIYGJQIRWFZOJ-ZDUSSCGKSA-N 0.000 claims description 2
- PKOOLRASZUDKNO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-2-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=NC2=CC=CC=C2N=C1)C PKOOLRASZUDKNO-LBPRGKRZSA-N 0.000 claims description 2
- REGFGYINRHHSSO-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C=1C=C2N=CC=NC2=CC=1)C REGFGYINRHHSSO-LBPRGKRZSA-N 0.000 claims description 2
- BNGJDDSPQVJVCU-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-spiro[3,4-dihydro-1,4-benzoxazine-2,1'-cyclopropane]-8-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=C(C(=C1)F)F)F)C(=O)C1=CC=CC=2NCC3(CC3)OC=21)C BNGJDDSPQVJVCU-ZDUSSCGKSA-N 0.000 claims description 2
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- MDXJOJSEZMBHEN-HNNXBMFYSA-N [(7S)-2,7-dimethyl-3-[3-(trifluoromethyl)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC(=CC=C1)C(F)(F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C MDXJOJSEZMBHEN-HNNXBMFYSA-N 0.000 claims description 2
- ZBROYVBSBLXZRP-HNNXBMFYSA-N [(7S)-2,7-dimethyl-3-[4-(trifluoromethoxy)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC=C(C=C1)OC(F)(F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C ZBROYVBSBLXZRP-HNNXBMFYSA-N 0.000 claims description 2
- PXHMEHRXIHFOIS-HNNXBMFYSA-N [(7S)-2,7-dimethyl-3-[4-(trifluoromethyl)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC=C(C=C1)C(F)(F)F)C(=O)C=1C=C2C=CC=NC2=CC=1)C PXHMEHRXIHFOIS-HNNXBMFYSA-N 0.000 claims description 2
- VVIRCJRSVPCYPJ-LBPRGKRZSA-N [(7S)-2,7-dimethyl-3-[5-(trifluoromethyl)furan-2-yl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C=1OC(=CC=1)C(F)(F)F)C(=O)C=1C=C2N=CC=NC2=CC=1)C VVIRCJRSVPCYPJ-LBPRGKRZSA-N 0.000 claims description 2
- CZQJIOZTKLMUEK-ZDUSSCGKSA-N [(7S)-2,7-dimethyl-3-[5-(trifluoromethyl)pyridin-3-yl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C=1C=NC=C(C=1)C(F)(F)F)C(=O)C=1C=C2N=CC=NC2=CC=1)C CZQJIOZTKLMUEK-ZDUSSCGKSA-N 0.000 claims description 2
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- NGEAPFZLOLAOSG-INIZCTEOSA-N [(7S)-2,7-dimethyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C1=CC=CC=C1)C(=O)C=1C=C2C=CC=NC2=CC=1)C NGEAPFZLOLAOSG-INIZCTEOSA-N 0.000 claims description 2
- HSRKENKBANBCGJ-AWEZNQCLSA-N [(7S)-2,7-dimethyl-3-pyridin-3-yl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound CN1N=C2[C@@H](N(CCC2=C1C=1C=NC=CC=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C HSRKENKBANBCGJ-AWEZNQCLSA-N 0.000 claims description 2
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- SBVWIJNLRLNBJP-INIZCTEOSA-N [(7S)-3-(1-benzofuran-6-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound O1C=CC2=C1C=C(C=C2)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C SBVWIJNLRLNBJP-INIZCTEOSA-N 0.000 claims description 2
- DLXQAMOFGKTPKC-INIZCTEOSA-N [(7S)-3-(1-benzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound O1C=CC2=C1C(=CC=C2)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C DLXQAMOFGKTPKC-INIZCTEOSA-N 0.000 claims description 2
- LWSGBRAHKZNPLS-INIZCTEOSA-N [(7S)-3-(1H-indol-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound N1C=CC2=CC=CC(=C12)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C LWSGBRAHKZNPLS-INIZCTEOSA-N 0.000 claims description 2
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- ACVJDHITWBLYEM-AWEZNQCLSA-N [(7S)-3-(2,3-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC1=C(C=CC=C1F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C ACVJDHITWBLYEM-AWEZNQCLSA-N 0.000 claims description 2
- KPNFXXGOWAWIJQ-INIZCTEOSA-N [(7S)-3-(2,3-dihydro-1-benzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound O1CCC2=C1C(=CC=C2)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C KPNFXXGOWAWIJQ-INIZCTEOSA-N 0.000 claims description 2
- ABOLBCJGNGDZHE-AWEZNQCLSA-N [(7S)-3-(2,4-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC1=C(C=CC(=C1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C ABOLBCJGNGDZHE-AWEZNQCLSA-N 0.000 claims description 2
- POMMZWCOWYQXSX-AWEZNQCLSA-N [(7S)-3-(2-chloro-4-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC1=C(C=CC(=C1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C POMMZWCOWYQXSX-AWEZNQCLSA-N 0.000 claims description 2
- PIGNHNBPODPLNC-HNNXBMFYSA-N [(7S)-3-(2-fluoro-3-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC1=C(C=CC=C1OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C PIGNHNBPODPLNC-HNNXBMFYSA-N 0.000 claims description 2
- XITJFCLXSPILHW-INIZCTEOSA-N [(7S)-3-(2-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound COC1=C(C=CC=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C XITJFCLXSPILHW-INIZCTEOSA-N 0.000 claims description 2
- MSVMXVROMILYHM-HNNXBMFYSA-N [(7S)-3-(2-methoxypyridin-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound COC1=NC=CC(=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C MSVMXVROMILYHM-HNNXBMFYSA-N 0.000 claims description 2
- HYRRWDMVZBETOW-AWEZNQCLSA-N [(7S)-3-(3,4-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C HYRRWDMVZBETOW-AWEZNQCLSA-N 0.000 claims description 2
- DNXILFXRFCWEBY-LBPRGKRZSA-N [(7S)-3-(3,5-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-b]pyridin-3-yl)methanone Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NN(C2=NC=CC=C21)C)C)C DNXILFXRFCWEBY-LBPRGKRZSA-N 0.000 claims description 2
- LEUBKVACTHMQSR-LBPRGKRZSA-N [(7S)-3-(3,5-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-1,3-benzoxazol-6-yl)methanone Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC2=C(N=C(O2)C)C=C1)C)C LEUBKVACTHMQSR-LBPRGKRZSA-N 0.000 claims description 2
- PVWZPSBPXDXJFJ-AWEZNQCLSA-N [(7S)-3-(3,5-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinoxalin-6-yl)methanone Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC(=NC2=CC=1)C)C)C PVWZPSBPXDXJFJ-AWEZNQCLSA-N 0.000 claims description 2
- YLDWOQDEYZKRNM-AWEZNQCLSA-N [(7S)-3-(3,5-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C YLDWOQDEYZKRNM-AWEZNQCLSA-N 0.000 claims description 2
- DCERAVXTRQODHE-ZDUSSCGKSA-N [(7S)-3-(3,5-dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)Cl)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C DCERAVXTRQODHE-ZDUSSCGKSA-N 0.000 claims description 2
- HPHZRWPSBWAUBT-AWEZNQCLSA-N [(7S)-3-(3,5-difluoro-4-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1C)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C HPHZRWPSBWAUBT-AWEZNQCLSA-N 0.000 claims description 2
- LCVLZFHLZKOEHI-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-2-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NC2=CC=CN=C2C=C1)C)C LCVLZFHLZKOEHI-ZDUSSCGKSA-N 0.000 claims description 2
- ANKZXJXXQODNIN-HNNXBMFYSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-ethyl-1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NN(C(=N1)CC)C1=CC=CC=C1)C)C ANKZXJXXQODNIN-HNNXBMFYSA-N 0.000 claims description 2
- ZOOBQWVHXMJHSQ-LBPRGKRZSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoroquinoxalin-6-yl)methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1F)C)C ZOOBQWVHXMJHSQ-LBPRGKRZSA-N 0.000 claims description 2
- NUQMNLZULYGPBE-HNNXBMFYSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(2-fluoroethyl)indol-4-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C2C=CN(C2=CC=C1)CCF)C)C NUQMNLZULYGPBE-HNNXBMFYSA-N 0.000 claims description 2
- KXIQGQOWVWGUGD-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(C=CC=C1)OCCF)C)C KXIQGQOWVWGUGD-AWEZNQCLSA-N 0.000 claims description 2
- MJTNPIBWRIKDGR-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(triazol-2-yl)phenyl]methanone Chemical compound N=1N(N=CC=1)C1=C(C=CC=C1)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC(=C1)F)F)C MJTNPIBWRIKDGR-AWEZNQCLSA-N 0.000 claims description 2
- IKXPJIBNOKLNQA-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-3-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(C(=CC=C1)OCCF)F)C)C IKXPJIBNOKLNQA-ZDUSSCGKSA-N 0.000 claims description 2
- NRXDSCDXMRLDHW-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-5-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(C=CC(=C1)OCCF)F)C)C NRXDSCDXMRLDHW-ZDUSSCGKSA-N 0.000 claims description 2
- ZNGFJFJGDASKDT-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC(=CC=C1)OCCF)C)C ZNGFJFJGDASKDT-AWEZNQCLSA-N 0.000 claims description 2
- QQOYNTVKGXNRFS-HNNXBMFYSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(2-fluoroethoxy)quinolin-6-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=C(C=NC2=CC=1)OCCF)C)C QQOYNTVKGXNRFS-HNNXBMFYSA-N 0.000 claims description 2
- RHCPQTZOXFSWKA-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(trifluoromethyl)quinolin-6-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=C(C=NC2=CC=1)C(F)(F)F)C)C RHCPQTZOXFSWKA-ZDUSSCGKSA-N 0.000 claims description 2
- QDYPYQAIWFPFAS-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC(=CC(=C1)OCCF)F)C)C QDYPYQAIWFPFAS-ZDUSSCGKSA-N 0.000 claims description 2
- HWVCWZSLNKAYJQ-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC=C(C=C1)OCCF)C)C HWVCWZSLNKAYJQ-AWEZNQCLSA-N 0.000 claims description 2
- YVFQKAARRBZAPK-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-fluoro-3-(2-fluoroethoxy)phenyl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC(=C(C=C1)F)OCCF)C)C YVFQKAARRBZAPK-ZDUSSCGKSA-N 0.000 claims description 2
- CUXLHWVEKFDEMO-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[8-(trifluoromethyl)quinolin-6-yl]methanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=C(C=1)C(F)(F)F)C)C CUXLHWVEKFDEMO-ZDUSSCGKSA-N 0.000 claims description 2
- FVAXSILSMIMLTC-AWEZNQCLSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C FVAXSILSMIMLTC-AWEZNQCLSA-N 0.000 claims description 2
- DNYJCHXKDADZGE-ZDUSSCGKSA-N [(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C DNYJCHXKDADZGE-ZDUSSCGKSA-N 0.000 claims description 2
- QOTIIKZBROOTHF-AWEZNQCLSA-N [(7S)-3-(3-chloro-4-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C QOTIIKZBROOTHF-AWEZNQCLSA-N 0.000 claims description 2
- WQEWYDFJBYUMCO-AWEZNQCLSA-N [(7S)-3-(3-chloro-4-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C WQEWYDFJBYUMCO-AWEZNQCLSA-N 0.000 claims description 2
- ZXWQGFXVOUNGIK-HNNXBMFYSA-N [(7S)-3-(3-chloro-4-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1C)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C ZXWQGFXVOUNGIK-HNNXBMFYSA-N 0.000 claims description 2
- TVRQTCLZMPXYOK-AWEZNQCLSA-N [(7S)-3-(3-chloro-5-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C TVRQTCLZMPXYOK-AWEZNQCLSA-N 0.000 claims description 2
- UUVMOYYKYYUZLH-ZDUSSCGKSA-N [(7S)-3-(3-chloro-5-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)F)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C UUVMOYYKYYUZLH-ZDUSSCGKSA-N 0.000 claims description 2
- ICONCLSQBCLZGJ-HNNXBMFYSA-N [(7S)-3-(3-chloro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound ClC=1C=C(C=C(C=1)OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(N=C2N1C=CC=C2)C)C)C ICONCLSQBCLZGJ-HNNXBMFYSA-N 0.000 claims description 2
- MNPVARUDICJQRM-AWEZNQCLSA-N [(7S)-3-(3-chloro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound ClC=1C=C(C=C(C=1)OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(N=C2N1C=C(C=C2)F)C)C)C MNPVARUDICJQRM-AWEZNQCLSA-N 0.000 claims description 2
- QDOMERGYLMJJRO-HNNXBMFYSA-N [(7S)-3-(3-chloro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC=1C=C(C=C(C=1)OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C QDOMERGYLMJJRO-HNNXBMFYSA-N 0.000 claims description 2
- QSARUZPIPKUPHX-AWEZNQCLSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-2-yl)methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NC2=CC=CN=C2C=C1)C)C QSARUZPIPKUPHX-AWEZNQCLSA-N 0.000 claims description 2
- IDAFDKUKMJBUPN-HNNXBMFYSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-phenyl-1,2,4-triazol-3-yl)methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NN(C=N1)C1=CC=CC=C1)C)C IDAFDKUKMJBUPN-HNNXBMFYSA-N 0.000 claims description 2
- AODYEWSJJFOOKL-ZDUSSCGKSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-b]pyridin-6-yl)methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC=C2C(=N1)NC=C2)C)C AODYEWSJJFOOKL-ZDUSSCGKSA-N 0.000 claims description 2
- JKBPUJAQGAEGSZ-HNNXBMFYSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-propan-2-yloxypyridin-3-yl)methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=NC=C(C=1)OC(C)C)C)C JKBPUJAQGAEGSZ-HNNXBMFYSA-N 0.000 claims description 2
- BAMAVQMLZSDCLB-HNNXBMFYSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-propan-2-yloxypyridin-3-yl)methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=NC(=CC=1)OC(C)C)C)C BAMAVQMLZSDCLB-HNNXBMFYSA-N 0.000 claims description 2
- KNXNGFMBIJICGC-LBPRGKRZSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-chloro-5-(trifluoromethoxy)phenyl]methanone Chemical compound ClC=1C=C(C=C(C=1)OC(F)(F)F)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=CC=C1)Cl)C KNXNGFMBIJICGC-LBPRGKRZSA-N 0.000 claims description 2
- AIQQOMWDTZDQGO-ZDUSSCGKSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(hydroxymethyl)pyridin-2-yl]methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NC=CC(=C1)CO)C)C AIQQOMWDTZDQGO-ZDUSSCGKSA-N 0.000 claims description 2
- ZJIWVRVVLOVMRY-AWEZNQCLSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(methoxymethyl)pyridin-3-yl]methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=NC=C(C=1)COC)C)C ZJIWVRVVLOVMRY-AWEZNQCLSA-N 0.000 claims description 2
- IYTMDXFKSKUYSQ-HNNXBMFYSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-ethyl-1-(2-fluorophenyl)-1,2,4-triazol-3-yl]methanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=NN(C(=N1)CC)C1=C(C=CC=C1)F)C)C IYTMDXFKSKUYSQ-HNNXBMFYSA-N 0.000 claims description 2
- JDNOIYMXDWBZCD-ZDUSSCGKSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-furo[3,2-b]pyridin-2-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC2=NC=CC=C2O1)C)C JDNOIYMXDWBZCD-ZDUSSCGKSA-N 0.000 claims description 2
- AMOZTJYLTNPCPM-ZDUSSCGKSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-furo[3,2-b]pyridin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C(=NC=1)C=CO2)C)C AMOZTJYLTNPCPM-ZDUSSCGKSA-N 0.000 claims description 2
- HABHYPGNQTXZBW-AWEZNQCLSA-N [(7S)-3-(3-chlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound ClC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C HABHYPGNQTXZBW-AWEZNQCLSA-N 0.000 claims description 2
- HEIPNKACCDRJCA-AWEZNQCLSA-N [(7S)-3-(3-fluoro-4-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=CC=1OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C HEIPNKACCDRJCA-AWEZNQCLSA-N 0.000 claims description 2
- QJLLVGHTVUDRRQ-AWEZNQCLSA-N [(7S)-3-(3-fluoro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methylpyridin-4-yl)methanone Chemical compound FC=1C=C(C=C(C=1)OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(C(=NC=C1)OC)C)C)C QJLLVGHTVUDRRQ-AWEZNQCLSA-N 0.000 claims description 2
- RMIWUIKGASMKRT-AWEZNQCLSA-N [(7S)-3-(3-fluoro-5-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)OC)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2N=CC=NC2=CC=1)C)C RMIWUIKGASMKRT-AWEZNQCLSA-N 0.000 claims description 2
- NCEXXLDOLPHIAM-INIZCTEOSA-N [(7S)-3-(3-fluoro-5-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-3-yl)methanone Chemical compound FC=1C=C(C=C(C=1)C)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(N=C2N1C=CC=C2)C)C)C NCEXXLDOLPHIAM-INIZCTEOSA-N 0.000 claims description 2
- IDBBLNIXHJNQFB-HNNXBMFYSA-N [(7S)-3-(3-fluoro-5-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxyphenyl)methanone Chemical compound FC=1C=C(C=C(C=1)C)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=CC=C(C=C1)OC)C)C IDBBLNIXHJNQFB-HNNXBMFYSA-N 0.000 claims description 2
- MIGKCXUQOTZUDD-AWEZNQCLSA-N [(7S)-3-(3-fluoro-5-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrrolo[2,3-d]pyrimidin-4-yl)methanone Chemical compound FC=1C=C(C=C(C=1)C)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C2=C(N=CN=1)N(C=C2)C)C)C MIGKCXUQOTZUDD-AWEZNQCLSA-N 0.000 claims description 2
- FTXVLUBRKDYUET-INIZCTEOSA-N [(7S)-3-(3-fluoro-5-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C=C(C=1)C)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C FTXVLUBRKDYUET-INIZCTEOSA-N 0.000 claims description 2
- CFPKFWKIKROIMS-INIZCTEOSA-N [(7S)-3-(3-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound COC=1C=C(C=CC=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C CFPKFWKIKROIMS-INIZCTEOSA-N 0.000 claims description 2
- QZCYWFLNRWNAEZ-ZDUSSCGKSA-N [(7S)-3-(4-chloro-2,3-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC1=C(C(=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C)F)F QZCYWFLNRWNAEZ-ZDUSSCGKSA-N 0.000 claims description 2
- RJMCEHZZBIUMQS-AWEZNQCLSA-N [(7S)-3-(4-chloro-3-fluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound ClC1=C(C=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C)F RJMCEHZZBIUMQS-AWEZNQCLSA-N 0.000 claims description 2
- UIBGBCSGAXIVHG-KRWDZBQOSA-N [(7S)-3-(4-ethoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound C(C)OC1=CC=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C UIBGBCSGAXIVHG-KRWDZBQOSA-N 0.000 claims description 2
- WAEOBECRLYPXAY-HNNXBMFYSA-N [(7S)-3-(4-fluoro-3-methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC1=C(C=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C)OC WAEOBECRLYPXAY-HNNXBMFYSA-N 0.000 claims description 2
- JDMLHNCTASUBHI-HNNXBMFYSA-N [(7S)-3-(4-fluoro-3-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methylpyridin-4-yl)methanone Chemical compound FC1=C(C=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C1=C(C(=NC=C1)OC)C)C)C)C JDMLHNCTASUBHI-HNNXBMFYSA-N 0.000 claims description 2
- MMRYOJFOCHXQEB-KRWDZBQOSA-N [(7S)-3-(4-methoxy-3-methylphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound COC1=C(C=C(C=C1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C)C MMRYOJFOCHXQEB-KRWDZBQOSA-N 0.000 claims description 2
- GCXQXXHTUYDZJK-HNNXBMFYSA-N [(7S)-3-(5-fluoro-1-benzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC=1C=C(C2=C(C=CO2)C=1)C=1N(N=C2[C@@H](N(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)C GCXQXXHTUYDZJK-HNNXBMFYSA-N 0.000 claims description 2
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- XIDFPVIYYQTEFW-JTQLQIEISA-N [3-(difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone Chemical compound FC(C1=NN=C2N1C=C(C=C2)C(=O)N1[C@H](C=2C(CC1)=C(N(N=2)C)C1=CC(=C(C(=C1)F)F)F)C)F XIDFPVIYYQTEFW-JTQLQIEISA-N 0.000 claims description 2
- YOQUNMZLPPPXEE-UHFFFAOYSA-N [3-[3-(difluoromethoxy)phenyl]-2-methyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinolin-6-ylmethanone Chemical compound FC(OC=1C=C(C=CC=1)C=1N(N=C2CN(CCC2=1)C(=O)C=1C=C2C=CC=NC2=CC=1)C)F YOQUNMZLPPPXEE-UHFFFAOYSA-N 0.000 claims description 2
- LMTNTFPHZIYTTO-UHFFFAOYSA-N [3-methoxy-5-(trifluoromethyl)phenyl]-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound COC=1C=C(C=C(C=1)C(F)(F)F)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 LMTNTFPHZIYTTO-UHFFFAOYSA-N 0.000 claims description 2
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- ZRSIRJNALQHECF-UHFFFAOYSA-N imidazo[1,5-a]pyridin-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C=1N=CN2C=1C=CC=C2C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 ZRSIRJNALQHECF-UHFFFAOYSA-N 0.000 claims description 2
- KSLRGPOZHZVGQM-UHFFFAOYSA-N imidazo[1,5-a]pyridin-6-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C=1N=CN2C=1C=CC(=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 KSLRGPOZHZVGQM-UHFFFAOYSA-N 0.000 claims description 2
- FHCNYCRWRNXDPK-UHFFFAOYSA-N imidazo[1,5-a]pyridin-7-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C=1N=CN2C=1C=C(C=C2)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 FHCNYCRWRNXDPK-UHFFFAOYSA-N 0.000 claims description 2
- WAWLZBJVPOWTEH-UHFFFAOYSA-N isoquinolin-1-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C1(=NC=CC2=CC=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 WAWLZBJVPOWTEH-UHFFFAOYSA-N 0.000 claims description 2
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- FKYRJTYXAFFBPL-UHFFFAOYSA-N isoquinolin-5-yl-(2-methyl-3-phenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl)methanone Chemical compound C1=NC=CC2=C(C=CC=C12)C(=O)N1CC=2C(CC1)=C(N(N=2)C)C1=CC=CC=C1 FKYRJTYXAFFBPL-UHFFFAOYSA-N 0.000 claims description 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 16
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EP3856179A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica N.V. | Monoacylglycerol lipase modulators |
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US11839663B2 (en) | 2019-09-30 | 2023-12-12 | Janssen Pharmaceutica Nv | Radiolabelled MGL pet ligands |
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2019
- 2019-09-27 WO PCT/IB2019/058240 patent/WO2020065613A1/en active Application Filing
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