JPWO2020037066A5 - - Google Patents
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- JPWO2020037066A5 JPWO2020037066A5 JP2021507503A JP2021507503A JPWO2020037066A5 JP WO2020037066 A5 JPWO2020037066 A5 JP WO2020037066A5 JP 2021507503 A JP2021507503 A JP 2021507503A JP 2021507503 A JP2021507503 A JP 2021507503A JP WO2020037066 A5 JPWO2020037066 A5 JP WO2020037066A5
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- Prior art keywords
- genetically engineered
- engineered hematopoietic
- cell
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 46
- 108020004707 nucleic acids Proteins 0.000 claims 26
- 102000039446 nucleic acids Human genes 0.000 claims 26
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- 229920001184 polypeptide Polymers 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 239000002773 nucleotide Substances 0.000 claims 17
- 125000003729 nucleotide group Chemical group 0.000 claims 17
- 230000011664 signaling Effects 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 9
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 9
- 108700010039 chimeric receptor Proteins 0.000 claims 9
- -1 kappa chain Proteins 0.000 claims 8
- 230000000139 costimulatory effect Effects 0.000 claims 7
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 230000001086 cytosolic effect Effects 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 230000004102 tricarboxylic acid cycle Effects 0.000 claims 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 3
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 claims 3
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 claims 3
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims 3
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims 2
- 101710096214 Alanine aminotransferase 1 Proteins 0.000 claims 2
- 102100034193 Aspartate aminotransferase, mitochondrial Human genes 0.000 claims 2
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
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- 108010073324 Glutaminase Proteins 0.000 claims 2
- 101000799549 Homo sapiens Aspartate aminotransferase, mitochondrial Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000734572 Homo sapiens Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Proteins 0.000 claims 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- 102100034796 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Human genes 0.000 claims 2
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 claims 2
- 101800001494 Protease 2A Proteins 0.000 claims 2
- 101800001066 Protein 2A Proteins 0.000 claims 2
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- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
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- 108010088694 phosphoserine aminotransferase Proteins 0.000 claims 2
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
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- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
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- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
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- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 1
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- 101710088083 Glomulin Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 1
- 102100032530 Glypican-3 Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 1
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 1
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- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000929698 Homo sapiens Aspartate aminotransferase, cytoplasmic Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
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- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 1
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 1
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 1
- 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 1
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 1
- 101001056308 Homo sapiens Malate dehydrogenase, cytoplasmic Proteins 0.000 claims 1
- 101001033820 Homo sapiens Malate dehydrogenase, mitochondrial Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 1
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 1
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
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- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000904228 Homo sapiens Vesicle transport protein GOT1A Proteins 0.000 claims 1
- 101000904204 Homo sapiens Vesicle transport protein GOT1B Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
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- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
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- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
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- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
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- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
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- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
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- 101100341510 Mus musculus Itgal gene Proteins 0.000 claims 1
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- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
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- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 1
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- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
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- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862718491P | 2018-08-14 | 2018-08-14 | |
| US201862718579P | 2018-08-14 | 2018-08-14 | |
| US62/718,579 | 2018-08-14 | ||
| US62/718,491 | 2018-08-14 | ||
| PCT/US2019/046550 WO2020037066A1 (en) | 2018-08-14 | 2019-08-14 | Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534740A JP2021534740A (ja) | 2021-12-16 |
| JPWO2020037066A5 true JPWO2020037066A5 (enExample) | 2022-08-22 |
| JP7456638B2 JP7456638B2 (ja) | 2024-03-27 |
Family
ID=69524868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021507503A Active JP7456638B2 (ja) | 2018-08-14 | 2019-08-14 | クレブス回路を調節するトランス代謝分子と組み合わせたキメラ抗原受容体ポリペプチド、及び、それらの治療的使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12077785B2 (enExample) |
| EP (1) | EP3837353A4 (enExample) |
| JP (1) | JP7456638B2 (enExample) |
| KR (1) | KR20210045418A (enExample) |
| CN (1) | CN112840019B (enExample) |
| AU (1) | AU2019321540B2 (enExample) |
| BR (1) | BR112021001694A2 (enExample) |
| CA (1) | CA3108126A1 (enExample) |
| IL (1) | IL280322B2 (enExample) |
| MX (1) | MX2021001771A (enExample) |
| NZ (1) | NZ772146A (enExample) |
| SG (1) | SG11202101284UA (enExample) |
| WO (1) | WO2020037066A1 (enExample) |
| ZA (1) | ZA202100993B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| EP4165070A4 (en) * | 2020-06-15 | 2025-04-02 | Monopar Therapeutics Inc. | PRECISION RADIOMUNOTHERAPY TARGETING OF THE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (UPAR) FOR THE TREATMENT OF SEVERE COVID-19 |
| CA3188526A1 (en) * | 2020-08-10 | 2022-02-17 | Abhinav Acharya | Metabolism-based chimeric antigen receptors and methods of treatment |
| IL311712A (en) | 2021-09-27 | 2024-05-01 | Sotio Biotech Inc | Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof |
| US20250000906A1 (en) | 2021-11-16 | 2025-01-02 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| EP4249588A1 (en) * | 2022-03-22 | 2023-09-27 | Universität Basel Vizerektorat Forschung | Cellular therapy |
| KR20250066487A (ko) * | 2022-07-15 | 2025-05-13 | 앨버트 아인슈타인 컬리지 오브 메디신 | 공동자극 도메인을 포함하는 키메라 항원 수용체 및 그의 연관된 사용 방법 |
| WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
| EP4572787A1 (en) | 2022-08-19 | 2025-06-25 | SOTIO Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
| WO2024215989A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
| EP0832980B1 (en) | 1989-01-23 | 2002-06-19 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| CA2115742A1 (en) | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| JPH07507689A (ja) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 特定組織のターゲティング方法及び組成物 |
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