MX2021001771A - Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos. - Google Patents
Polipéptidos del receptor de antígeno quimérico en combinación con moléculas del metabolismo trans que modulan el ciclo de krebs y usos terapéuticos de los mismos.Info
- Publication number
- MX2021001771A MX2021001771A MX2021001771A MX2021001771A MX2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A MX 2021001771 A MX2021001771 A MX 2021001771A
- Authority
- MX
- Mexico
- Prior art keywords
- modulate
- trans
- combination
- chimeric antigen
- krebs cycle
- Prior art date
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
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- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
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| US201862718491P | 2018-08-14 | 2018-08-14 | |
| PCT/US2019/046550 WO2020037066A1 (en) | 2018-08-14 | 2019-08-14 | Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof |
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| KR20230031981A (ko) | 2019-05-14 | 2023-03-07 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| CN115867570A (zh) * | 2020-06-15 | 2023-03-28 | 莫诺帕医疗公司 | 精确放射免疫治疗靶向尿激酶纤溶酶原激活剂受体(uPAR)以治疗严重COVID-19疾病 |
| US20230265205A1 (en) * | 2020-08-10 | 2023-08-24 | Arizona Board Of Regents On Behalf Of Arizona State University | Metabolism-based chimeric antigen receptors and methods of treatment |
| KR20240069799A (ko) | 2021-09-27 | 2024-05-20 | 소티오 바이오테크 인크. | 해당과정 경로 밖으로 포도당 대사산물을 재지향시키는 트랜스 대사 분자와 조합되는 키메라 수용체 폴리펩타이드 및 이의 치료적 용도 |
| JP2024545363A (ja) | 2021-11-16 | 2024-12-05 | ソティオ・バイオテック・インコーポレイテッド | 粘液型/円形細胞型脂肪肉腫患者の治療 |
| EP4249588A1 (en) * | 2022-03-22 | 2023-09-27 | Universität Basel Vizerektorat Forschung | Cellular therapy |
| JP2025523107A (ja) * | 2022-07-15 | 2025-07-17 | アルバート アインシュタイン カレッジ オブ メディスン | Tmigd2共刺激ドメインを含むキメラ抗原受容体及びその使用方法 |
| WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
| EP4572787A1 (en) | 2022-08-19 | 2025-06-25 | SOTIO Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
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| EP1024198A3 (en) | 1992-12-03 | 2002-05-29 | Genzyme Corporation | Pseudo-adenoviral vectors for the gene therapy of haemophiliae |
| JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
| JPH09501055A (ja) | 1993-07-30 | 1997-02-04 | ユニバーシティ オブ メディシン アンド デンティストリー オブ ニュージャージー | 初代リンパ球への効率的遺伝子転移 |
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| WO2017123808A1 (en) * | 2016-01-15 | 2017-07-20 | The J. David Gladstone Institutes | Methods of treating disease by metabolic control of t-cell differentiation |
| WO2017161333A1 (en) | 2016-03-18 | 2017-09-21 | Unum Therapeutics | Modified chimeric receptors and uses thereof in immune therapy |
| SG11201808831TA (en) | 2016-04-15 | 2018-11-29 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
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| JP2024545363A (ja) * | 2021-11-16 | 2024-12-05 | ソティオ・バイオテック・インコーポレイテッド | 粘液型/円形細胞型脂肪肉腫患者の治療 |
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| AU2019321540A1 (en) | 2021-02-11 |
| KR20210045418A (ko) | 2021-04-26 |
| US20240376442A1 (en) | 2024-11-14 |
| EP3837353A4 (en) | 2022-05-18 |
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