IL280322B2 - Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof - Google Patents

Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof

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Publication number
IL280322B2
IL280322B2 IL280322A IL28032221A IL280322B2 IL 280322 B2 IL280322 B2 IL 280322B2 IL 280322 A IL280322 A IL 280322A IL 28032221 A IL28032221 A IL 28032221A IL 280322 B2 IL280322 B2 IL 280322B2
Authority
IL
Israel
Prior art keywords
cells
polypeptide
domain
cell
genetically engineered
Prior art date
Application number
IL280322A
Other languages
English (en)
Hebrew (he)
Other versions
IL280322B1 (en
IL280322A (en
Original Assignee
Sotio Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sotio Llc filed Critical Sotio Llc
Publication of IL280322A publication Critical patent/IL280322A/en
Publication of IL280322B1 publication Critical patent/IL280322B1/en
Publication of IL280322B2 publication Critical patent/IL280322B2/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
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    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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