CN115335407A - 结合cd19的嵌合抗原受体及其用途 - Google Patents
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Abstract
提供了一种分离的抗原结合结构域，其包括能够结合抗原的单链可变区片段，其包括轻链可变区和重链可变区；和一个或多个保护性肽。还提供了嵌合抗原受体，包括铰链区、穿膜区、共刺激信号结构域以及胞内信号转导结构域，以及相应的的核酸分子、载体、细胞、组合物、制备方法和用于制备治疗癌症或病毒感染等疾病的药物。
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102208423 | 2020-03-25 | ||
| CN202010220842 | 2020-03-25 | ||
| PCT/CN2021/082683 WO2021190551A1 (zh) | 2020-03-25 | 2021-03-24 | 结合cd19的嵌合抗原受体及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115335407A true CN115335407A (zh) | 2022-11-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN202180019189.7A Pending CN115335407A (zh) | 2020-03-25 | 2021-03-24 | 结合cd19的嵌合抗原受体及其用途 |
| CN202180019196.7A Pending CN115867581A (zh) | 2020-03-25 | 2021-03-24 | 含有保护肽的嵌合抗原受体及其用途 |
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| CN202180019196.7A Pending CN115867581A (zh) | 2020-03-25 | 2021-03-24 | 含有保护肽的嵌合抗原受体及其用途 |
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| Country | Link |
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| CN (2) | CN115335407A (zh) |
| WO (2) | WO2021190551A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116836282A (zh) * | 2023-02-13 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 抗体、嵌合抗原受体及其用途 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7439280B2 (ja) * | 2020-02-13 | 2024-02-27 | イミュノファーム テクノロジー カンパニー リミテッド | キメラ抗原受容体の最適化 |
| CN117143248A (zh) * | 2022-05-24 | 2023-12-01 | 合源康华医药科技(北京)有限公司 | 靶向bcma-cd19的双特异性嵌合抗原受体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101270163B (zh) * | 2008-04-22 | 2011-08-03 | 中山大学 | 一种单链片段抗体-多肽融合蛋白及其应用 |
| CN113354744A (zh) * | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| CN103910799B (zh) * | 2014-03-06 | 2016-03-23 | 中国人民解放军第四军医大学 | 一种基于抗egfr单链抗体及精氨酸九聚体的融合蛋白与应用 |
| CN117165532A (zh) * | 2018-11-29 | 2023-12-05 | 浙江煦顼技术有限公司 | 具有增强的迁移能力的修饰的细胞 |
| CN110903401A (zh) * | 2019-11-20 | 2020-03-24 | 浙江大学 | 一种靶向cd19的二代嵌合抗原受体及其表达载体与应用 |
-
2021
- 2021-03-24 WO PCT/CN2021/082683 patent/WO2021190551A1/zh active Application Filing
- 2021-03-24 CN CN202180019189.7A patent/CN115335407A/zh active Pending
- 2021-03-24 WO PCT/CN2021/082682 patent/WO2021190550A1/zh active Application Filing
- 2021-03-24 CN CN202180019196.7A patent/CN115867581A/zh active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116836282A (zh) * | 2023-02-13 | 2023-10-03 | 北京艺妙神州医药科技有限公司 | 抗体、嵌合抗原受体及其用途 |
| CN116836282B (zh) * | 2023-02-13 | 2024-03-29 | 北京艺妙神州医药科技有限公司 | 抗体、嵌合抗原受体及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021190550A1 (zh) | 2021-09-30 |
| WO2021190551A1 (zh) | 2021-09-30 |
| CN115867581A (zh) | 2023-03-28 |
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