|
US3030025A
(en)
|
|
1962-04-17 |
|
Thermostatic gas valve |
|
DE3381783D1
(de)
|
1982-03-03 |
1990-09-13 |
Genentech Inc |
Menschliches antithrombin iii, dns sequenzen dafuer, expressions- und klonierungsvektoren die solche sequenzen enthalten und damit transformierte zellkulturen, verfahren zur expression von menschlichem antithrombin iii und diese enthaltende pharmazeutische zusammensetzungen.
|
|
US20030206899A1
(en)
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US7067637B1
(en)
|
1992-02-12 |
2006-06-27 |
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh |
Antibody or antibody fragments specific for a protein of the TGF-β family
|
|
US5861499A
(en)
|
1994-02-10 |
1999-01-19 |
Imclone Systems Incorporated |
Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain
|
|
US6448077B1
(en)
|
1994-02-10 |
2002-09-10 |
Imclone Systems, Inc. |
Chimeric and humanized monoclonal antibodies specific to VEGF receptors
|
|
US6054287A
(en)
|
1994-05-27 |
2000-04-25 |
Methodist Hospital Of Indiana, Inc. |
Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6410690B1
(en)
*
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
JP4440344B2
(ja)
*
|
1996-08-16 |
2010-03-24 |
シェーリング コーポレイション |
哺乳動物細胞表面抗原；関連試薬
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
WO1998045331A2
(en)
|
1997-04-07 |
1998-10-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US6509173B1
(en)
|
1997-10-21 |
2003-01-21 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2
|
|
JP2002505082A
(ja)
|
1998-02-04 |
2002-02-19 |
トロンブ−イックス・ナムローゼ・フェンノートシャップ |
減少した免疫原性および／または減少したクリアランスを有するスタフィロキナーゼ誘導体の同定、製造および使用方法
|
|
CA2319236A1
(en)
|
1998-02-09 |
1999-08-12 |
Genentech, Inc. |
Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
|
|
US6376653B1
(en)
|
1998-09-28 |
2002-04-23 |
Smithkline Beecham Plc |
Tie2 antagonist antibodies
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
WO2001003720A2
(en)
|
1999-07-12 |
2001-01-18 |
Genentech, Inc. |
Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs
|
|
JP2001206899A
(ja)
|
1999-11-18 |
2001-07-31 |
Japan Tobacco Inc |
ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途
|
|
US6528959B2
(en)
|
2000-07-19 |
2003-03-04 |
Honda Giken Kogyo Kabushiki Kaisha |
Driving force control system for front-and-rear wheel drive vehicles
|
|
IL155204A0
(en)
|
2000-10-02 |
2003-11-23 |
Arizeke Pharmaceuticals Inc |
Compositions and methods for the transport of biologically active agents across cellular barriers
|
|
US7658924B2
(en)
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US7138370B2
(en)
*
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
US7521053B2
(en)
|
2001-10-11 |
2009-04-21 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US6874679B2
(en)
|
2001-10-12 |
2005-04-05 |
Innovative Packaging Designs, L.P. |
Container having sliding corner support
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
ATE475431T1
(de)
|
2002-03-04 |
2010-08-15 |
Imclone Llc |
Kdr-spezifische humane antikörper und deren anwendung
|
|
CA2384922C
(en)
|
2002-05-03 |
2008-09-02 |
Purepharm Inc. |
Topical glycopyrrolate product for the reduction of sweating
|
|
US7025982B2
(en)
|
2002-09-19 |
2006-04-11 |
Medtronic, Inc. |
Medical assembly suitable for long-term implantation and method for fabricating the same
|
|
AU2004205684A1
(en)
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
MXPA05012475A
(es)
|
2003-05-23 |
2006-05-25 |
Wyeth Corp |
Anticuerpos y moleculas relacionadas con el ligando para el receptor tnf inducido por glucorticoides (gitr) y el ligando (gitr) y usos de los mismos.
|
|
RS20050885A
(sr)
|
2003-05-30 |
2008-04-04 |
Genentech |
Lečenje sa anti-vegf antitelima
|
|
US20050048054A1
(en)
|
2003-07-11 |
2005-03-03 |
Shino Hanabuchi |
Lymphocytes; methods
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US7182135B2
(en)
|
2003-11-14 |
2007-02-27 |
Halliburton Energy Services, Inc. |
Plug systems and methods for using plugs in subterranean formations
|
|
JP2007518399A
(ja)
|
2003-12-02 |
2007-07-12 |
ジェンザイム コーポレイション |
肺癌を診断および治療する組成物並びに方法
|
|
MXPA06011199A
(es)
|
2004-03-31 |
2007-04-16 |
Genentech Inc |
Anticuerpos anti-tgf-beta humanizados.
|
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
|
WO2006083289A2
(en)
|
2004-06-04 |
2006-08-10 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
|
US20060009360A1
(en)
|
2004-06-25 |
2006-01-12 |
Robert Pifer |
New adjuvant composition
|
|
JP2008505928A
(ja)
*
|
2004-07-08 |
2008-02-28 |
アムジェン インコーポレーテッド |
治療用ペプチド
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP2325206B1
(en)
|
2004-11-12 |
2014-03-19 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
|
SG10201912554TA
(en)
|
2005-03-23 |
2020-02-27 |
Genmab As |
Antibodies against cd38 for treatment of multiple myeloma
|
|
EP1866339B8
(en)
|
2005-03-25 |
2021-12-01 |
GITR, Inc. |
Gitr binding molecules and uses therefor
|
|
PL1874818T3
(pl)
|
2005-04-22 |
2011-09-30 |
Lilly Co Eli |
Przeciwciała swoiste wobec TGF-beta 1
|
|
WO2006117910A1
(ja)
|
2005-04-28 |
2006-11-09 |
Mochida Pharmaceutical Co., Ltd. |
抗血小板膜糖蛋白質ⅵモノクローナル抗体
|
|
ITBS20050066A1
(it)
|
2005-06-01 |
2006-12-02 |
Sys Tec S R L |
Metodo e macchina per allineare lastre di stampa flessografica su cilindri di stampa
|
|
WO2006138627A2
(en)
|
2005-06-16 |
2006-12-28 |
Inhibitex, Inc. |
Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
|
|
JP2009521496A
(ja)
|
2005-12-23 |
2009-06-04 |
イーライ リリー アンド カンパニー |
ＴＧＦ−β結合組成物
|
|
US20110212086A1
(en)
|
2006-01-19 |
2011-09-01 |
Genzyme Corporation |
GITR Antibodies For The Treatment of Cancer
|
|
EP2175884B8
(en)
|
2007-07-12 |
2017-02-22 |
GITR, Inc. |
Combination therapies employing gitr binding molecules
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
JO2913B1
(en)
|
2008-02-20 |
2015-09-15 |
امجين إنك, |
Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
|
|
CA2729810A1
(en)
|
2008-07-02 |
2010-01-07 |
Emergent Product Development Seattle, Llc |
Tgf-.beta. antagonist multi-target binding proteins
|
|
WO2010019263A2
(en)
*
|
2008-08-15 |
2010-02-18 |
Genzyme Corporation |
Soluble flt constructs for treating cancers
|
|
JPWO2010030002A1
(ja)
|
2008-09-12 |
2012-02-02 |
国立大学法人三重大学 |
外来性ｇｉｔｒリガンド発現細胞
|
|
US8268314B2
(en)
*
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
DK2417156T3
(en)
|
2009-04-07 |
2015-03-02 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
CN102574924A
(zh)
|
2009-09-03 |
2012-07-11 |
先灵公司 |
抗-gitr抗体
|
|
GB0919074D0
(en)
|
2009-10-30 |
2009-12-16 |
Cambridge Reactor Design Ltd |
Crystallisation process and apparatus
|
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
|
SI2519543T1
(sl)
|
2009-12-29 |
2016-08-31 |
Emergent Product Development Seattle, Llc |
Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
|
|
JP6066732B2
(ja)
*
|
2010-03-05 |
2017-01-25 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
標的免疫調節抗体および融合タンパク質に基づく組成物および方法
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
CN103874709B
(zh)
|
2011-08-19 |
2016-12-21 |
瑞泽恩制药公司 |
抗tie2抗体及其用途
|
|
WO2013039954A1
(en)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anti-gitr antibodies
|
|
US8581886B2
(en)
|
2011-10-28 |
2013-11-12 |
Atmel Corporation |
Tuning algorithm for noise reduction in an active stylus
|
|
EP2793949B1
(en)
|
2011-12-23 |
2018-08-22 |
Innate Pharma |
Enzymatic conjugation of antibodies
|
|
EA031182B1
(ru)
|
2012-03-30 |
2018-11-30 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Ang2-связывающие молекулы
|
|
MY177331A
(en)
|
2012-06-15 |
2020-09-12 |
Pfizer |
Improved antagonist antibodies against gdf-8 and uses therefor
|
|
WO2014062659A2
(en)
*
|
2012-10-15 |
2014-04-24 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating ocular diseases
|
|
CN120365432A
(zh)
|
2012-11-21 |
2025-07-25 |
武汉友芝友生物制药股份有限公司 |
双特异性抗体
|
|
US20140308285A1
(en)
|
2013-03-15 |
2014-10-16 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
EP3010525A1
(en)
*
|
2013-06-20 |
2016-04-27 |
Novartis AG |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
RU2702108C2
(ru)
*
|
2013-07-16 |
2019-10-04 |
Дженентек, Инк. |
Способы лечения рака с использованием антагонистов, связывающих с осью pd-1, и ингибиторов tigit
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對ｐｄ-１的人類抗體
|
|
SI3105246T1
(sl)
|
2014-02-10 |
2021-11-30 |
Merck Patent Gmbh |
Ciljana inhibicija TGF BETA
|
|
WO2015142675A2
(en)
*
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
|
KR102349370B1
(ko)
|
2014-05-26 |
2022-01-10 |
삼성전자주식회사 |
인간화 또는 친화도 성숙된 항 앤지오포이에틴-2 항체 및 그의 용도
|
|
US20160355589A1
(en)
|
2014-08-19 |
2016-12-08 |
Merck Sharp & Dohme Corp. |
Anti-tigit antibodies
|
|
WO2016073282A1
(en)
*
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
JP6180663B2
(ja)
*
|
2014-12-23 |
2017-08-16 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
Ｔｉｇｉｔに対する抗体
|
|
US10361757B2
(en)
|
2015-04-10 |
2019-07-23 |
Lg Electronics Inc. |
Method for reporting channel state information in wireless communication system and device therefor
|
|
KR20190080992A
(ko)
*
|
2015-05-21 |
2019-07-08 |
하푼 테라퓨틱스, 인크. |
삼중특이성 결합 단백질 및 사용 방법
|
|
TWI715587B
(zh)
|
2015-05-28 |
2021-01-11 |
美商安可美德藥物股份有限公司 |
Ｔｉｇｉｔ結合劑和彼之用途
|
|
TWI773646B
(zh)
*
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
CN105111314B
(zh)
*
|
2015-08-13 |
2019-01-08 |
成都百世博生物技术有限公司 |
一种新型融合蛋白、药物组合物及其制备方法和用途
|
|
EP3344660B1
(en)
*
|
2015-08-31 |
2025-03-05 |
National Research Council of Canada |
Tgf-beta-receptor ectodomain fusion molecules and uses thereof
|
|
RU2744959C2
(ru)
|
2016-03-23 |
2021-03-17 |
Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд |
Новые анти-pd-l1 антитела
|
|
WO2017165681A1
(en)
*
|
2016-03-24 |
2017-09-28 |
Gensun Biopharma Inc. |
Trispecific inhibitors for cancer treatment
|
|
FI3468586T3
(fi)
|
2016-06-14 |
2024-10-29 |
Xencor Inc |
Bispesifisiä immuuniaktivaatiota vapauttavia vasta-aineita
|
|
JP7461741B2
(ja)
*
|
2016-06-20 |
2024-04-04 |
カイマブ・リミテッド |
抗ｐｄ－ｌ１およびｉｌ－２サイトカイン
|
|
WO2018128939A1
(en)
*
|
2017-01-05 |
2018-07-12 |
Gensun Biopharma Inc. |
Checkpoint regulator antagonists
|
|
US11001635B2
(en)
*
|
2018-06-29 |
2021-05-11 |
Gensun Biopharma Inc. |
Antitumor antagonists
|
|
EP3990116A1
(en)
*
|
2019-06-28 |
2022-05-04 |
Gensun Biopharma Inc. |
ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
|
|
CN116390940A
(zh)
*
|
2020-09-23 |
2023-07-04 |
海正生物制药有限公司 |
Tgfbr2-ecd突变体及包含其的融合蛋白与应用
|
|
WO2022256820A1
(en)
*
|
2021-06-03 |
2022-12-08 |
Gensun Biopharma Inc. |
Multispecific antagonists
|