JPWO2019230961A5 - - Google Patents

Info

Publication number

JPWO2019230961A5

JPWO2019230961A5 JP2020522634A JP2020522634A JPWO2019230961A5 JP WO2019230961 A5 JPWO2019230961 A5 JP WO2019230961A5 JP 2020522634 A JP2020522634 A JP 2020522634A JP 2020522634 A JP2020522634 A JP 2020522634A JP WO2019230961 A5 JPWO2019230961 A5 JP WO2019230961A5

Authority

JP

Japan

Prior art keywords

mol

general formula

sugar

monomer represented

hydroxyl groups

Prior art date

2019-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims 14
• 239000000178 monomer Substances 0.000 claims 12
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
• YQIGLEFUZMIVHU-UHFFFAOYSA-N 2-methyl-n-propan-2-ylprop-2-enamide Chemical group CC(C)NC(=O)C(C)=C YQIGLEFUZMIVHU-UHFFFAOYSA-N 0.000 claims 5
• 239000003349 gelling agent Substances 0.000 claims 5
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 229920006395 saturated elastomer Polymers 0.000 claims 4
• 238000012377 drug delivery Methods 0.000 claims 3
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
• 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 239000003431 cross linking reagent Substances 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 150000004676 glycans Polymers 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 125000001483 monosaccharide substituent group Chemical group 0.000 claims 2
• UUORTJUPDJJXST-UHFFFAOYSA-N n-(2-hydroxyethyl)prop-2-enamide Chemical compound OCCNC(=O)C=C UUORTJUPDJJXST-UHFFFAOYSA-N 0.000 claims 2
• 150000004804 polysaccharides Polymers 0.000 claims 2
• FCZRAAJZTGOYIC-UHFFFAOYSA-N 2,4-dimethylpent-2-enamide Chemical compound CC(C)C=C(C)C(N)=O FCZRAAJZTGOYIC-UHFFFAOYSA-N 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• VROCFBAGKYSGGQ-UHFFFAOYSA-N [3-fluoro-4-[2-(prop-2-enoylamino)ethylcarbamoyl]phenyl]boronic acid Chemical compound OB(O)C1=CC=C(C(=O)NCCNC(=O)C=C)C(F)=C1 VROCFBAGKYSGGQ-UHFFFAOYSA-N 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical group C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1
• 230000004043 responsiveness Effects 0.000 claims 1