JP2016518868A5 - - Google Patents
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- Publication number
- JP2016518868A5 JP2016518868A5 JP2016500904A JP2016500904A JP2016518868A5 JP 2016518868 A5 JP2016518868 A5 JP 2016518868A5 JP 2016500904 A JP2016500904 A JP 2016500904A JP 2016500904 A JP2016500904 A JP 2016500904A JP 2016518868 A5 JP2016518868 A5 JP 2016518868A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid formulation
- sugar alcohol
- array
- starch
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012669 liquid formulation Substances 0.000 claims description 32
- 150000005846 sugar alcohols Chemical class 0.000 claims description 26
- 150000004676 glycans Chemical class 0.000 claims description 24
- 229920001282 polysaccharide Polymers 0.000 claims description 24
- 239000005017 polysaccharide Substances 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 15
- 229920002472 Starch Polymers 0.000 claims description 14
- 235000019698 starch Nutrition 0.000 claims description 14
- 239000008107 starch Substances 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 12
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 235000010356 sorbitol Nutrition 0.000 claims description 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 10
- 229920000881 Modified starch Polymers 0.000 claims description 9
- 235000019426 modified starch Nutrition 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 229920002307 Dextran Polymers 0.000 claims description 8
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 8
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 8
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 8
- 239000004368 Modified starch Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 239000004386 Erythritol Substances 0.000 claims description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 4
- 229920001503 Glucan Polymers 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 235000019414 erythritol Nutrition 0.000 claims description 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 4
- 229940009714 erythritol Drugs 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims description 4
- 239000000832 lactitol Substances 0.000 claims description 4
- 235000010448 lactitol Nutrition 0.000 claims description 4
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 4
- 229960003451 lactitol Drugs 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- XJCCHWKNFMUJFE-CGQAXDJHSA-N Maltotriitol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 XJCCHWKNFMUJFE-CGQAXDJHSA-N 0.000 claims description 2
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 230000009089 cytolysis Effects 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 229960004793 sucrose Drugs 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 2
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800543P | 2013-03-15 | 2013-03-15 | |
| US61/800,543 | 2013-03-15 | ||
| PCT/US2014/022087 WO2014150069A1 (en) | 2013-03-15 | 2014-03-07 | Microstructure array for delivery of active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016518868A JP2016518868A (ja) | 2016-06-30 |
| JP2016518868A5 true JP2016518868A5 (https=) | 2017-04-06 |
Family
ID=50390285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500904A Pending JP2016518868A (ja) | 2013-03-15 | 2014-03-07 | 活性剤の送達のための微細構造物のアレイ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140276378A1 (https=) |
| EP (2) | EP2967597B1 (https=) |
| JP (1) | JP2016518868A (https=) |
| KR (1) | KR102316739B1 (https=) |
| CN (1) | CN105188569B (https=) |
| AU (1) | AU2014237499B2 (https=) |
| BR (1) | BR112015022432B1 (https=) |
| CA (1) | CA2904335C (https=) |
| ES (1) | ES2921174T3 (https=) |
| IL (1) | IL241064A0 (https=) |
| MX (1) | MX2015012433A (https=) |
| RU (1) | RU2662432C2 (https=) |
| WO (1) | WO2014150069A1 (https=) |
| ZA (1) | ZA201506916B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| ES2817249T3 (es) | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| EP2429627B1 (en) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| AU2012323782B2 (en) | 2011-10-12 | 2017-04-06 | Vaxxas Pty Limited | Delivery device |
| EP2934660B1 (en) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Microarray for delivery of therapeutic agent and method of making same |
| EP4094799A1 (en) | 2013-03-12 | 2022-11-30 | Corium, Inc. | Microprojection applicators |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| EP2968119B1 (en) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US20160310412A1 (en) * | 2013-12-16 | 2016-10-27 | Takeda Pharmaceutical Company Limited | Microneedle |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| AU2015307284B2 (en) * | 2014-08-27 | 2018-11-01 | Neuronano Ab | Method of implantation of a medical device into neural tissue |
| CA2959506C (en) * | 2014-08-29 | 2022-10-18 | Corium International, Inc. | Microstructure array for delivery of active agents |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| JP6906885B2 (ja) | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| WO2016123665A1 (en) | 2015-02-02 | 2016-08-11 | Vaxxas Pty Limited | Microprojection array applicator and method |
| KR101667216B1 (ko) * | 2015-06-18 | 2016-10-18 | 방철환 | 약물 주입 장치 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| JP2017051312A (ja) * | 2015-09-08 | 2017-03-16 | 富士フイルム株式会社 | マイクロニードルアレイ |
| WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| KR101610598B1 (ko) * | 2015-09-21 | 2016-04-07 | 비엔엘바이오테크 주식회사 | 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법 |
| CA2999538A1 (en) | 2015-09-28 | 2017-04-06 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| JP7020399B2 (ja) * | 2016-03-25 | 2022-02-16 | 凸版印刷株式会社 | 経皮投与デバイス |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| US10596321B2 (en) | 2016-04-08 | 2020-03-24 | Allergan, Inc. | Aspiration and injection device |
| WO2017208962A1 (ja) * | 2016-05-31 | 2017-12-07 | Ｎｉｓｓｈａ株式会社 | マイクロニードルアレイ及びその製造方法 |
| US20180056053A1 (en) * | 2016-08-26 | 2018-03-01 | Juvic Inc. | Protruding microstructure for transdermal delivery |
| CN106474620A (zh) * | 2016-09-22 | 2017-03-08 | 北京化工大学 | 一种药物可控释放的聚合物微针、制备方法及微针贴片 |
| AU2018222745B2 (en) * | 2017-02-17 | 2021-02-18 | Allergan, Inc. | Microneedle array with active ingredient |
| ES2960937T3 (es) | 2017-03-31 | 2024-03-07 | Vaxxas Pty Ltd | Dispositivo y método para recubrir superficies |
| WO2018220926A1 (ja) * | 2017-05-30 | 2018-12-06 | Ｎｉｓｓｈａ株式会社 | マイクロニードルパッチとその梱包体 |
| US11175128B2 (en) | 2017-06-13 | 2021-11-16 | Vaxxas Pty Limited | Quality control of substrate coatings |
| EP4473998A3 (en) | 2017-08-04 | 2025-02-26 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map) |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| JP7305311B2 (ja) * | 2018-05-30 | 2023-07-10 | ロレアル | マイクロニードルシート |
| JP2020018327A (ja) * | 2018-07-17 | 2020-02-06 | ロレアル | マイクロニードルシート |
| EP3880112A4 (en) * | 2018-10-18 | 2022-07-06 | 3M Innovative Properties Company | DENTAL DEVICE WITH STRUCTURED SURFACE |
| CN109498804B (zh) * | 2018-12-04 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种温度响应型狂犬疫苗递送系统 |
| JP7666887B2 (ja) * | 2018-12-21 | 2025-04-22 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
| JP6778296B2 (ja) * | 2019-04-11 | 2020-10-28 | 富士フイルム株式会社 | マイクロニードルアレイ |
| KR20250056504A (ko) | 2023-10-19 | 2025-04-28 | 연세대학교 산학협력단 | 분리 수율이 높은 마이크로니들 구조체, 이를 포함하는 장치 및 이의 제조 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| CA2253549C (en) | 1996-06-18 | 2005-10-25 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| PT1187629E (pt) * | 1999-04-19 | 2005-02-28 | Glaxosmithkline Biolog Sa | Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| EP1345646A2 (en) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| ES2817249T3 (es) * | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| JP5584202B2 (ja) * | 2008-05-21 | 2014-09-03 | セラジェクト， インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
| EP2429627B1 (en) | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| RU2414255C1 (ru) * | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
| BR112012028263B1 (pt) | 2010-05-04 | 2020-06-02 | Corium, Inc. | Aplicador e dispositivo para matriz de microprojeção |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| AU2012225609B2 (en) * | 2011-03-07 | 2015-10-01 | Kindeva Drug Delivery L.P. | Microneedle devices and methods |
-
2014
- 2014-03-07 CN CN201480015948.2A patent/CN105188569B/zh active Active
- 2014-03-07 MX MX2015012433A patent/MX2015012433A/es unknown
- 2014-03-07 RU RU2015143551A patent/RU2662432C2/ru active
- 2014-03-07 ES ES14713727T patent/ES2921174T3/es active Active
- 2014-03-07 WO PCT/US2014/022087 patent/WO2014150069A1/en not_active Ceased
- 2014-03-07 JP JP2016500904A patent/JP2016518868A/ja active Pending
- 2014-03-07 EP EP14713727.7A patent/EP2967597B1/en active Active
- 2014-03-07 BR BR112015022432-6A patent/BR112015022432B1/pt not_active IP Right Cessation
- 2014-03-07 US US14/201,709 patent/US20140276378A1/en not_active Abandoned
- 2014-03-07 AU AU2014237499A patent/AU2014237499B2/en not_active Ceased
- 2014-03-07 CA CA2904335A patent/CA2904335C/en active Active
- 2014-03-07 EP EP22156402.4A patent/EP4059450A1/en not_active Withdrawn
- 2014-03-07 KR KR1020157026947A patent/KR102316739B1/ko active Active
-
2015
- 2015-09-02 IL IL241064A patent/IL241064A0/en unknown
- 2015-09-17 ZA ZA2015/06916A patent/ZA201506916B/en unknown
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