RU2662432C2 - Массив микроструктур для доставки действующих агентов - Google Patents

Массив микроструктур для доставки действующих агентов Download PDF

Info

Publication number
RU2662432C2
RU2662432C2 RU2015143551A RU2015143551A RU2662432C2 RU 2662432 C2 RU2662432 C2 RU 2662432C2 RU 2015143551 A RU2015143551 A RU 2015143551A RU 2015143551 A RU2015143551 A RU 2015143551A RU 2662432 C2 RU2662432 C2 RU 2662432C2
Authority
RU
Russia
Prior art keywords
microstructures
array
active agent
polysaccharide
biocompatible
Prior art date
Application number
RU2015143551A
Other languages
English (en)
Russian (ru)
Other versions
RU2015143551A (ru
Inventor
Гохуа ЧЭНЬ
Чжунли ДИН
Еси ГХАРТИ-ТАГО
Парминдер СИНГХ
Original Assignee
Кориум Интернэшнл, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кориум Интернэшнл, Инк. filed Critical Кориум Интернэшнл, Инк.
Publication of RU2015143551A publication Critical patent/RU2015143551A/ru
Application granted granted Critical
Publication of RU2662432C2 publication Critical patent/RU2662432C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/042Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU2015143551A 2013-03-15 2014-03-07 Массив микроструктур для доставки действующих агентов RU2662432C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361800543P 2013-03-15 2013-03-15
US61/800,543 2013-03-15
PCT/US2014/022087 WO2014150069A1 (en) 2013-03-15 2014-03-07 Microstructure array for delivery of active agents

Publications (2)

Publication Number Publication Date
RU2015143551A RU2015143551A (ru) 2017-04-20
RU2662432C2 true RU2662432C2 (ru) 2018-07-26

Family

ID=50390285

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015143551A RU2662432C2 (ru) 2013-03-15 2014-03-07 Массив микроструктур для доставки действующих агентов

Country Status (14)

Country Link
US (1) US20140276378A1 (https=)
EP (2) EP2967597B1 (https=)
JP (1) JP2016518868A (https=)
KR (1) KR102316739B1 (https=)
CN (1) CN105188569B (https=)
AU (1) AU2014237499B2 (https=)
BR (1) BR112015022432B1 (https=)
CA (1) CA2904335C (https=)
ES (1) ES2921174T3 (https=)
IL (1) IL241064A0 (https=)
MX (1) MX2015012433A (https=)
RU (1) RU2662432C2 (https=)
WO (1) WO2014150069A1 (https=)
ZA (1) ZA201506916B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
ES2817249T3 (es) 2007-04-16 2021-04-06 Corium Inc Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
EP4094799A1 (en) 2013-03-12 2022-11-30 Corium, Inc. Microprojection applicators
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968119B1 (en) 2013-03-15 2019-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20160310412A1 (en) * 2013-12-16 2016-10-27 Takeda Pharmaceutical Company Limited Microneedle
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
AU2015307284B2 (en) * 2014-08-27 2018-11-01 Neuronano Ab Method of implantation of a medical device into neural tissue
CA2959506C (en) * 2014-08-29 2022-10-18 Corium International, Inc. Microstructure array for delivery of active agents
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
KR101667216B1 (ko) * 2015-06-18 2016-10-18 방철환 약물 주입 장치
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2017051312A (ja) * 2015-09-08 2017-03-16 富士フイルム株式会社 マイクロニードルアレイ
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
KR101610598B1 (ko) * 2015-09-21 2016-04-07 비엔엘바이오테크 주식회사 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
JP7020399B2 (ja) * 2016-03-25 2022-02-16 凸版印刷株式会社 経皮投与デバイス
KR101719319B1 (ko) * 2016-04-05 2017-03-23 주식회사 엘지생활건강 효율적인 피부 천공을 위한 마이크로니들 구조
US10596321B2 (en) 2016-04-08 2020-03-24 Allergan, Inc. Aspiration and injection device
WO2017208962A1 (ja) * 2016-05-31 2017-12-07 Nissha株式会社 マイクロニードルアレイ及びその製造方法
US20180056053A1 (en) * 2016-08-26 2018-03-01 Juvic Inc. Protruding microstructure for transdermal delivery
CN106474620A (zh) * 2016-09-22 2017-03-08 北京化工大学 一种药物可控释放的聚合物微针、制备方法及微针贴片
AU2018222745B2 (en) * 2017-02-17 2021-02-18 Allergan, Inc. Microneedle array with active ingredient
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
WO2018220926A1 (ja) * 2017-05-30 2018-12-06 Nissha株式会社 マイクロニードルパッチとその梱包体
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP4473998A3 (en) 2017-08-04 2025-02-26 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP6671616B2 (ja) * 2017-11-02 2020-03-25 コスメディ製薬株式会社 歯科用局所麻酔マイクロニードルアレイ
JP7305311B2 (ja) * 2018-05-30 2023-07-10 ロレアル マイクロニードルシート
JP2020018327A (ja) * 2018-07-17 2020-02-06 ロレアル マイクロニードルシート
EP3880112A4 (en) * 2018-10-18 2022-07-06 3M Innovative Properties Company DENTAL DEVICE WITH STRUCTURED SURFACE
CN109498804B (zh) * 2018-12-04 2022-07-26 中国人民解放军军事科学院军事医学研究院 一种温度响应型狂犬疫苗递送系统
JP7666887B2 (ja) * 2018-12-21 2025-04-22 ロレアル マイクロニードルシートを使用するキット及び美容方法
JP6778296B2 (ja) * 2019-04-11 2020-10-28 富士フイルム株式会社 マイクロニードルアレイ
KR20250056504A (ko) 2023-10-19 2025-04-28 연세대학교 산학협력단 분리 수율이 높은 마이크로니들 구조체, 이를 포함하는 장치 및 이의 제조 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080269685A1 (en) * 2007-04-16 2008-10-30 Parminder Singh Solvent-cast microneedle arrays containing active
RU2414255C1 (ru) * 2009-07-01 2011-03-20 Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления
WO2012122163A1 (en) * 2011-03-07 2012-09-13 3M Innovative Properties Company Microneedle devices and methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
PT1187629E (pt) * 1999-04-19 2005-02-28 Glaxosmithkline Biolog Sa Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5584202B2 (ja) * 2008-05-21 2014-09-03 セラジェクト, インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
EP2429627B1 (en) 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
BR112012028263B1 (pt) 2010-05-04 2020-06-02 Corium, Inc. Aplicador e dispositivo para matriz de microprojeção
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080269685A1 (en) * 2007-04-16 2008-10-30 Parminder Singh Solvent-cast microneedle arrays containing active
RU2414255C1 (ru) * 2009-07-01 2011-03-20 Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления
WO2012122163A1 (en) * 2011-03-07 2012-09-13 3M Innovative Properties Company Microneedle devices and methods

Also Published As

Publication number Publication date
BR112015022432A2 (pt) 2017-07-18
EP4059450A1 (en) 2022-09-21
ZA201506916B (en) 2016-12-21
KR20150126883A (ko) 2015-11-13
CA2904335C (en) 2022-03-29
CA2904335A1 (en) 2014-09-25
JP2016518868A (ja) 2016-06-30
EP2967597A1 (en) 2016-01-20
EP2967597B1 (en) 2022-05-04
CN105188569A (zh) 2015-12-23
AU2014237499B2 (en) 2018-11-15
BR112015022432B1 (pt) 2022-02-15
ES2921174T3 (es) 2022-08-19
WO2014150069A1 (en) 2014-09-25
MX2015012433A (es) 2016-02-03
KR102316739B1 (ko) 2021-10-26
AU2014237499A1 (en) 2015-09-17
CN105188569B (zh) 2020-11-20
BR112015022432A8 (pt) 2019-11-26
IL241064A0 (en) 2015-11-30
US20140276378A1 (en) 2014-09-18
RU2015143551A (ru) 2017-04-20

Similar Documents

Publication Publication Date Title
RU2662432C2 (ru) Массив микроструктур для доставки действующих агентов
US20260083948A1 (en) Microstructure array for delivery of active agents
US9498524B2 (en) Method of vaccine delivery via microneedle arrays
US20150112250A1 (en) Soluble microneedle arrays for buccal delivery of vaccines
JP2019076752A (ja) 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
JP2016512754A5 (https=)
CN101657188A (zh) 固体药物和疫苗剂
JP2018502927A (ja) マイクロニードルワクチンパッチ用ミョウバン含有コーティング製剤
KR20160030793A (ko) 흡수 속도를 개선한 마이크로니들 시스템