BR112015022432A8 - arranjo de microestrutura e método de fabricação de um arranjo de microestrutura - Google Patents
arranjo de microestrutura e método de fabricação de um arranjo de microestrutura Download PDFInfo
- Publication number
- BR112015022432A8 BR112015022432A8 BR112015022432A BR112015022432A BR112015022432A8 BR 112015022432 A8 BR112015022432 A8 BR 112015022432A8 BR 112015022432 A BR112015022432 A BR 112015022432A BR 112015022432 A BR112015022432 A BR 112015022432A BR 112015022432 A8 BR112015022432 A8 BR 112015022432A8
- Authority
- BR
- Brazil
- Prior art keywords
- microstructure
- matrix
- water
- active agent
- microstructures
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Materials For Medical Uses (AREA)
Abstract
resumo microestrutura de matriz para a entrega de agentes ativos aqui proporcionada é uma microestrutura de matriz compreendendo uma multiplicidade de microestruturas, tais como dissolução de microprojeções fixadas a uma base. a pluralidade de microestruturas compreendem um agente ativo numa matriz biocompatível e solúvel em água, em que a matriz solúvel em água compreende de preferência um polímero de polissacárido e um álcool de açúcar, e a base compreende tipicamente uma matriz não solúvel em água. a pluralidade de microestruturas, à penetração da pele do sujeito, sofrer dissolução para entregar o agente ativo. além disso, desde que estejam relacionadas com formulações de microestrutura, na forma seca e líquidos, os métodos para a preparação de matrizes de microestrutura acima descrito, e métodos para a administração de um agente ativo através da aplicação de uma matriz de microestrutura tal como aqui proporcionada para a pele de um sujeito, entre outras funcionalidades.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361800543P | 2013-03-15 | 2013-03-15 | |
US61/800,543 | 2013-03-15 | ||
PCT/US2014/022087 WO2014150069A1 (en) | 2013-03-15 | 2014-03-07 | Microstructure array for delivery of active agents |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015022432A2 BR112015022432A2 (pt) | 2017-07-18 |
BR112015022432A8 true BR112015022432A8 (pt) | 2019-11-26 |
BR112015022432B1 BR112015022432B1 (pt) | 2022-02-15 |
Family
ID=50390285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015022432-6A BR112015022432B1 (pt) | 2013-03-15 | 2014-03-07 | Arranjo de microestrutura, método para fabricação do mesmo e formulação líquida para formar microestruturas de dissolução |
Country Status (14)
Country | Link |
---|---|
US (1) | US20140276378A1 (pt) |
EP (2) | EP4059450A1 (pt) |
JP (1) | JP2016518868A (pt) |
KR (1) | KR102316739B1 (pt) |
CN (1) | CN105188569B (pt) |
AU (1) | AU2014237499B2 (pt) |
BR (1) | BR112015022432B1 (pt) |
CA (1) | CA2904335C (pt) |
ES (1) | ES2921174T3 (pt) |
IL (1) | IL241064A0 (pt) |
MX (1) | MX2015012433A (pt) |
RU (1) | RU2662432C2 (pt) |
WO (1) | WO2014150069A1 (pt) |
ZA (1) | ZA201506916B (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
CA2686093C (en) | 2007-04-16 | 2018-05-08 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
EP2429627B1 (en) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
AU2012323782B2 (en) | 2011-10-12 | 2017-04-06 | Vaxxas Pty Limited | Delivery device |
AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
RU2674083C2 (ru) | 2013-03-12 | 2018-12-04 | Кориум Интернэшнл, Инк. | Аппликаторы с микровыступами |
WO2014150293A1 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
ES2761580T3 (es) | 2013-03-15 | 2020-05-20 | Corium Inc | Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
JP6556632B2 (ja) * | 2013-12-16 | 2019-08-07 | 武田薬品工業株式会社 | マイクロニードル |
US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
US20170251976A1 (en) * | 2014-08-27 | 2017-09-07 | Neuronano Ab | Method of implantation of a medical device into neural tissue |
JP7109188B2 (ja) * | 2014-08-29 | 2022-07-29 | コリウム, インコーポレイテッド | 活性剤の送達のための微細構造アレイ |
EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
JP6906885B2 (ja) * | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
US11147954B2 (en) | 2015-02-02 | 2021-10-19 | Vaxxas Pty Limited | Microprojection array applicator and method |
KR101667216B1 (ko) * | 2015-06-18 | 2016-10-18 | 방철환 | 약물 주입 장치 |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
JP2017051312A (ja) * | 2015-09-08 | 2017-03-16 | 富士フイルム株式会社 | マイクロニードルアレイ |
WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
KR101610598B1 (ko) * | 2015-09-21 | 2016-04-07 | 비엔엘바이오테크 주식회사 | 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법 |
CN108883262B (zh) * | 2016-03-25 | 2021-05-28 | 凸版印刷株式会社 | 经皮给药装置 |
KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
RU2725968C2 (ru) | 2016-04-08 | 2020-07-07 | Аллерган, Инк. | Аспирационно-инъекционное устройство |
EP3459584B1 (en) * | 2016-05-31 | 2021-03-31 | Nissha Co., Ltd. | Microneedle array and method of manufacturing same |
US20180056053A1 (en) * | 2016-08-26 | 2018-03-01 | Juvic Inc. | Protruding microstructure for transdermal delivery |
CN106474620A (zh) * | 2016-09-22 | 2017-03-08 | 北京化工大学 | 一种药物可控释放的聚合物微针、制备方法及微针贴片 |
WO2018151832A1 (en) * | 2017-02-17 | 2018-08-23 | Allergan, Inc. | Microneedle array with active ingredient |
WO2018176102A1 (en) | 2017-03-31 | 2018-10-04 | Vaxxas Pty Limited | Device and method for coating surfaces |
JP6968805B2 (ja) * | 2017-05-30 | 2021-11-17 | Nissha株式会社 | マイクロニードルパッチとその梱包体 |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
AU2018309562A1 (en) | 2017-08-04 | 2020-02-20 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
JP7305311B2 (ja) * | 2018-05-30 | 2023-07-10 | ロレアル | マイクロニードルシート |
JP2020018327A (ja) * | 2018-07-17 | 2020-02-06 | ロレアル | マイクロニードルシート |
CN112867462A (zh) * | 2018-10-18 | 2021-05-28 | 3M创新有限公司 | 具有结构化表面的牙科矫治器 |
CN109498804B (zh) * | 2018-12-04 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种温度响应型狂犬疫苗递送系统 |
JP2020099513A (ja) * | 2018-12-21 | 2020-07-02 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
JP6778296B2 (ja) * | 2019-04-11 | 2020-10-28 | 富士フイルム株式会社 | マイクロニードルアレイ |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
EP0914178B1 (en) | 1996-06-18 | 2003-03-12 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
DK1187629T3 (da) * | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
CA2686093C (en) * | 2007-04-16 | 2018-05-08 | Corium International, Inc. | Solvent-cast microneedle arrays containing active |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US9381680B2 (en) * | 2008-05-21 | 2016-07-05 | Theraject, Inc. | Method of manufacturing solid solution perforator patches and uses thereof |
EP2429627B1 (en) | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
RU2414255C1 (ru) * | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
CA2801247C (en) | 2010-05-04 | 2018-09-04 | Corium International, Inc. | Applicators for microneedles |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
JP5941072B2 (ja) * | 2011-03-07 | 2016-06-29 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルデバイス及び方法 |
-
2014
- 2014-03-07 WO PCT/US2014/022087 patent/WO2014150069A1/en active Application Filing
- 2014-03-07 EP EP22156402.4A patent/EP4059450A1/en active Pending
- 2014-03-07 KR KR1020157026947A patent/KR102316739B1/ko active IP Right Grant
- 2014-03-07 AU AU2014237499A patent/AU2014237499B2/en active Active
- 2014-03-07 ES ES14713727T patent/ES2921174T3/es active Active
- 2014-03-07 US US14/201,709 patent/US20140276378A1/en not_active Abandoned
- 2014-03-07 BR BR112015022432-6A patent/BR112015022432B1/pt active IP Right Grant
- 2014-03-07 EP EP14713727.7A patent/EP2967597B1/en active Active
- 2014-03-07 JP JP2016500904A patent/JP2016518868A/ja active Pending
- 2014-03-07 MX MX2015012433A patent/MX2015012433A/es unknown
- 2014-03-07 CN CN201480015948.2A patent/CN105188569B/zh active Active
- 2014-03-07 RU RU2015143551A patent/RU2662432C2/ru active
- 2014-03-07 CA CA2904335A patent/CA2904335C/en active Active
-
2015
- 2015-09-02 IL IL241064A patent/IL241064A0/en unknown
- 2015-09-17 ZA ZA2015/06916A patent/ZA201506916B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112015022432B1 (pt) | 2022-02-15 |
IL241064A0 (en) | 2015-11-30 |
KR102316739B1 (ko) | 2021-10-26 |
EP2967597B1 (en) | 2022-05-04 |
CA2904335C (en) | 2022-03-29 |
MX2015012433A (es) | 2016-02-03 |
EP2967597A1 (en) | 2016-01-20 |
AU2014237499A1 (en) | 2015-09-17 |
CA2904335A1 (en) | 2014-09-25 |
WO2014150069A1 (en) | 2014-09-25 |
CN105188569A (zh) | 2015-12-23 |
ZA201506916B (en) | 2016-12-21 |
US20140276378A1 (en) | 2014-09-18 |
RU2662432C2 (ru) | 2018-07-26 |
RU2015143551A (ru) | 2017-04-20 |
AU2014237499B2 (en) | 2018-11-15 |
JP2016518868A (ja) | 2016-06-30 |
BR112015022432A2 (pt) | 2017-07-18 |
KR20150126883A (ko) | 2015-11-13 |
CN105188569B (zh) | 2020-11-20 |
ES2921174T3 (es) | 2022-08-19 |
EP4059450A1 (en) | 2022-09-21 |
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