DOP2017000239A - Sistema de suministro de insulina sensible a la glucosa usando nanocompuestos sensibles a la hipoxia - Google Patents
Sistema de suministro de insulina sensible a la glucosa usando nanocompuestos sensibles a la hipoxiaInfo
- Publication number
- DOP2017000239A DOP2017000239A DO2017000239A DO2017000239A DOP2017000239A DO P2017000239 A DOP2017000239 A DO P2017000239A DO 2017000239 A DO2017000239 A DO 2017000239A DO 2017000239 A DO2017000239 A DO 2017000239A DO P2017000239 A DOP2017000239 A DO P2017000239A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- sensitive
- insulin
- hypoxia
- vesicles
- glucose
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03004—Glucose oxidase (1.1.3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Abstract
Se describe un sistema de suministro de insulina de bucle cerrado. De forma más particular, el sistema de suministro de insulina que ahora se desvela pude comprender vesículas sensibles a glucosa que liberan insulina en respuesta a la hipoxia desencadenada por la reducción enzimática de glucosa. Además o como alternativa a la insulina, el sistema de suministro puede liberar otros agentes de tratamiento de la diabetes, tales como agentes de tratamiento de la diabetes no basados en insulina. Las vesículas pueden prepararse a partir de un polímero sensible a la hipoxia, tal como un ácido hialurónico sensible a la hipoxia (AH-SH). El AH-SH puede comprender grupos hidrofóbicos que pueden reducirse en entornos hipóxicos para formar grupos hidrófilos. Las vesículas pueden cargarse en microagujas y parches de matriz de microagujas para su uso en el tratamiento de la diabetes o para regular de otro modo los niveles de glucosa en sangre en sujetos que necesiten tal tratamiento. (fig. 1a)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150622P | 2015-04-21 | 2015-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2017000239A true DOP2017000239A (es) | 2018-01-15 |
Family
ID=57144247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2017000239A DOP2017000239A (es) | 2015-04-21 | 2017-10-17 | Sistema de suministro de insulina sensible a la glucosa usando nanocompuestos sensibles a la hipoxia |
Country Status (23)
Country | Link |
---|---|
US (2) | US11191815B2 (es) |
EP (2) | EP3285750B1 (es) |
JP (1) | JP6856546B2 (es) |
KR (1) | KR102624501B1 (es) |
CN (2) | CN107530296B (es) |
AU (2) | AU2016252738B2 (es) |
BR (1) | BR112017022535A2 (es) |
CA (1) | CA2983289C (es) |
CL (1) | CL2017002652A1 (es) |
CO (1) | CO2017011422A2 (es) |
DO (1) | DOP2017000239A (es) |
EC (1) | ECSP17073558A (es) |
HK (1) | HK1245105A1 (es) |
IL (1) | IL255155A0 (es) |
MA (1) | MA54623A (es) |
MX (1) | MX2017013337A (es) |
NZ (1) | NZ736578A (es) |
PE (1) | PE20180325A1 (es) |
PH (1) | PH12017501910A1 (es) |
RU (1) | RU2719584C2 (es) |
SG (1) | SG11201708509YA (es) |
TN (1) | TN2017000439A1 (es) |
WO (1) | WO2016172320A1 (es) |
Families Citing this family (26)
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SG11201708509YA (en) | 2015-04-21 | 2017-11-29 | Univ North Carolina State | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites |
CN108778248A (zh) | 2016-02-19 | 2018-11-09 | 北卡罗来纳州立大学 | 与生理响应性微针递送系统有关的方法和组合物 |
WO2018085809A1 (en) * | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
WO2018106697A1 (en) * | 2016-12-05 | 2018-06-14 | North Carolina State University | H 2o 2-responsive nanoparticles and uses thereof |
CN110167624B (zh) * | 2016-12-05 | 2021-11-19 | 北卡罗来纳州立大学 | 核-壳微针装置及其用途 |
US11850285B2 (en) | 2017-03-07 | 2023-12-26 | North Carolina State University | Insulin-responsive glucagon delivery patch |
US11096893B2 (en) | 2017-06-02 | 2021-08-24 | North Carolina State University | Glucose sensitive compositions for drug delivery |
JP6482604B2 (ja) * | 2017-06-22 | 2019-03-13 | 教裕 南郷 | 外皮内溶解型ニードル及びニードル装置 |
US11389405B2 (en) | 2017-09-18 | 2022-07-19 | North Carolina State University | Artificial beta cells and methods of use thereof |
EP3694539A4 (en) | 2017-10-10 | 2021-07-14 | North Carolina State University | GLUCOSE CARRIER INHIBITOR MODIFIED INSULIN FOR THE DELIVERY OF GLUCOSE SENSITIVE INSULIN |
EP3713594A4 (en) | 2017-11-21 | 2021-11-03 | North Carolina State University | LOAD CHANGE POLYMER DEPOSIT FOR DELIVERY OF GLUCOSE-TRIGGERED INSULIN WITH ULTRA-RAPID RESPONSE |
CN108484848A (zh) * | 2018-02-27 | 2018-09-04 | 同济大学 | 一种缺氧响应的聚合物纳米胶束及其制备方法 |
CN108440684A (zh) * | 2018-03-22 | 2018-08-24 | 华侨大学 | 一种NI-Cys-Alg自组装纳米载体及其制备方法和应用 |
CN108395489A (zh) * | 2018-03-22 | 2018-08-14 | 华侨大学 | 一种2-硝基咪唑-半胱氨酸-海藻酸盐材料及其制备方法 |
KR20210003799A (ko) * | 2018-04-13 | 2021-01-12 | 노쓰 캐롤라이나 스테이트 유니버시티 | 모발 성장 촉진을 위한 마이크로니들 패치의 사용 |
WO2019200081A1 (en) * | 2018-04-13 | 2019-10-17 | North Carolina State University | Ros-responsive microneedle patch for acne vulgaris treatment |
CN109464657A (zh) * | 2018-11-26 | 2019-03-15 | 常州工程职业技术学院 | 一种嵌段共聚物载胰岛素控制释放的方法 |
CN109568567A (zh) * | 2019-01-15 | 2019-04-05 | 武汉德丽福生物科技有限公司 | 一种微针减肥贴片及其制备方法 |
CN109771659A (zh) * | 2019-02-25 | 2019-05-21 | 天津大学 | 一种乏氧响应性纳米药物载体及其制备方法和应用 |
CN110652494B (zh) * | 2019-10-21 | 2021-09-28 | 南通大学 | 一种低氧响应聚氨基酸-peg立构载药胶束及其制备方法 |
CN110841065A (zh) * | 2019-12-05 | 2020-02-28 | 福州大学 | 一种pH/低氧双响应释药协同光动力治疗的纳米复合物及其制备方法 |
CN115317437B (zh) * | 2021-05-11 | 2023-09-08 | 中国科学院上海硅酸盐研究所 | 一种基于胆红素纳米材料的胰岛素递送微针及其制备方法 |
CN114376569B (zh) * | 2022-01-19 | 2023-10-13 | 浙江大学 | 用于救治低血糖的载胰高血糖素可穿戴设备 |
CN114432243B (zh) * | 2022-01-20 | 2023-08-29 | 华南师范大学 | 一种响应pH和葡萄糖的纳米载体及其应用 |
CN115120552A (zh) * | 2022-06-22 | 2022-09-30 | 华中科技大学 | 一种微环境响应释药的多肽载药微针贴片、制备及应用 |
CN115531309B (zh) * | 2022-09-29 | 2023-08-22 | 中国药科大学 | 一种肝靶向聚合物胶束递药系统及其制备方法和应用 |
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CA2902762A1 (en) * | 2012-02-17 | 2013-08-22 | Massachusetts Institute Of Technology | Glucose-responsive microgels for closed loop insulin delivery |
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SG11201708509YA (en) | 2015-04-21 | 2017-11-29 | Univ North Carolina State | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites |
US11141486B2 (en) | 2015-10-23 | 2021-10-12 | National University Corporation Tokyo Medical And Dental University | Drug delivery device |
CN108778248A (zh) | 2016-02-19 | 2018-11-09 | 北卡罗来纳州立大学 | 与生理响应性微针递送系统有关的方法和组合物 |
WO2018085809A1 (en) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
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2016
- 2016-04-21 SG SG11201708509YA patent/SG11201708509YA/en unknown
- 2016-04-21 MA MA054623A patent/MA54623A/fr unknown
- 2016-04-21 JP JP2017555709A patent/JP6856546B2/ja active Active
- 2016-04-21 TN TNP/2017/000439A patent/TN2017000439A1/en unknown
- 2016-04-21 AU AU2016252738A patent/AU2016252738B2/en active Active
- 2016-04-21 EP EP16783841.6A patent/EP3285750B1/en active Active
- 2016-04-21 EP EP20202740.5A patent/EP3795143A1/en not_active Withdrawn
- 2016-04-21 US US15/567,532 patent/US11191815B2/en active Active
- 2016-04-21 PE PE2017002202A patent/PE20180325A1/es not_active Application Discontinuation
- 2016-04-21 CN CN201680023377.6A patent/CN107530296B/zh active Active
- 2016-04-21 BR BR112017022535A patent/BR112017022535A2/pt not_active IP Right Cessation
- 2016-04-21 CA CA2983289A patent/CA2983289C/en active Active
- 2016-04-21 MX MX2017013337A patent/MX2017013337A/es unknown
- 2016-04-21 KR KR1020177033592A patent/KR102624501B1/ko active IP Right Grant
- 2016-04-21 RU RU2017139931A patent/RU2719584C2/ru active
- 2016-04-21 NZ NZ736578A patent/NZ736578A/en unknown
- 2016-04-21 CN CN202110614275.4A patent/CN113350489A/zh active Pending
- 2016-04-21 WO PCT/US2016/028605 patent/WO2016172320A1/en active Application Filing
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2017
- 2017-10-17 DO DO2017000239A patent/DOP2017000239A/es unknown
- 2017-10-19 IL IL255155A patent/IL255155A0/en unknown
- 2017-10-19 PH PH12017501910A patent/PH12017501910A1/en unknown
- 2017-10-19 CL CL2017002652A patent/CL2017002652A1/es unknown
- 2017-11-06 EC ECIEPI201773558A patent/ECSP17073558A/es unknown
- 2017-11-07 CO CONC2017/0011422A patent/CO2017011422A2/es unknown
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2018
- 2018-04-09 HK HK18104568.4A patent/HK1245105A1/zh unknown
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2021
- 2021-06-17 AU AU2021204048A patent/AU2021204048A1/en not_active Abandoned
- 2021-12-03 US US17/542,021 patent/US20220160841A1/en not_active Abandoned
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