JP7281659B2 - 温度耐性型糖応答性ゲル - Google Patents

温度耐性型糖応答性ゲル Download PDF

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Publication number
JP7281659B2
JP7281659B2 JP2020522634A JP2020522634A JP7281659B2 JP 7281659 B2 JP7281659 B2 JP 7281659B2 JP 2020522634 A JP2020522634 A JP 2020522634A JP 2020522634 A JP2020522634 A JP 2020522634A JP 7281659 B2 JP7281659 B2 JP 7281659B2
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mol
gel
sugar
insulin
temperature
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JP2020522634A
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Japanese (ja)
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JPWO2019230961A5 (https=
JPWO2019230961A1 (ja
Inventor
孝祥 菅波
都 田中
亮 松元
裕子 松本
由桂 諸岡
裕二 宮原
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Tokyo Medical and Dental University NUC
Tokai National Higher Education and Research System NUC
Kanagawa Institute of Industrial Science and Technology
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Tokyo Medical and Dental University NUC
Tokai National Higher Education and Research System NUC
Kanagawa Institute of Industrial Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020522634A 2018-06-01 2019-05-31 温度耐性型糖応答性ゲル Active JP7281659B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018105788 2018-06-01
JP2018105788 2018-06-01
PCT/JP2019/021766 WO2019230961A1 (ja) 2018-06-01 2019-05-31 温度耐性型糖応答性ゲル

Publications (3)

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JPWO2019230961A1 JPWO2019230961A1 (ja) 2021-06-10
JPWO2019230961A5 JPWO2019230961A5 (https=) 2022-11-29
JP7281659B2 true JP7281659B2 (ja) 2023-05-26

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US (1) US11819570B2 (https=)
EP (1) EP3804762A4 (https=)
JP (1) JP7281659B2 (https=)
CN (1) CN112236170B (https=)
CA (1) CA3101963A1 (https=)
WO (1) WO2019230961A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113603816B (zh) * 2021-07-21 2022-08-19 上海应用技术大学 一种卡波姆衍生物及其制备方法与应用
CN115715756A (zh) * 2022-10-11 2023-02-28 浙江大学 一种丙烯酰基甘氨酰胺-含氟苯硼酸基糖敏微针及其制备方法
CN115746196A (zh) * 2022-11-15 2023-03-07 电子科技大学长三角研究院(湖州) 一种异丙基甲基丙烯酰胺-氟基苯硼酸共聚葡萄糖响应微凝胶的制备方法及其应用
JP2024106274A (ja) * 2023-01-26 2024-08-07 地方独立行政法人神奈川県立産業技術総合研究所 糖応答性ゲル

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011140537A (ja) 2010-01-05 2011-07-21 Univ Of Tokyo フェニルボロン酸系単量体及びフェニルボロン酸系重合体
JP2011246431A (ja) 2010-05-26 2011-12-08 Univ Of Tokyo 糖応答性ゲル及び薬剤投与デバイス

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5249808A (en) 1975-10-17 1977-04-21 Matsushita Electric Ind Co Ltd Rotary head type magnetic picture recording and playback device
JP3427447B2 (ja) 1993-11-05 2003-07-14 日本油脂株式会社 フッ素化フェニルボロン酸基含有重合体
CN102068700B (zh) * 2009-12-28 2012-11-21 中国人民解放军总医院 苯硼酸聚乙二醇凝胶及其作为葡萄糖敏感材料的用途
JP2015151427A (ja) 2014-02-12 2015-08-24 セイコーエプソン株式会社 刺激応答性ゲル材料および刺激応答性ゲル材料の製造方法
JP6784352B2 (ja) 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 インスリン送達用デバイス
US11141486B2 (en) 2015-10-23 2021-10-12 National University Corporation Tokyo Medical And Dental University Drug delivery device
JP6332653B1 (ja) 2016-12-27 2018-05-30 石油資源開発株式会社 地殻応力測定方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011140537A (ja) 2010-01-05 2011-07-21 Univ Of Tokyo フェニルボロン酸系単量体及びフェニルボロン酸系重合体
JP2011246431A (ja) 2010-05-26 2011-12-08 Univ Of Tokyo 糖応答性ゲル及び薬剤投与デバイス

Also Published As

Publication number Publication date
CA3101963A1 (en) 2019-12-05
US20210121400A1 (en) 2021-04-29
JPWO2019230961A1 (ja) 2021-06-10
CN112236170B (zh) 2024-04-26
EP3804762A4 (en) 2022-03-23
US11819570B2 (en) 2023-11-21
WO2019230961A1 (ja) 2019-12-05
EP3804762A1 (en) 2021-04-14
CN112236170A (zh) 2021-01-15

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