JPWO2019230858A5 - - Google Patents
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- JPWO2019230858A5 JPWO2019230858A5 JP2020522577A JP2020522577A JPWO2019230858A5 JP WO2019230858 A5 JPWO2019230858 A5 JP WO2019230858A5 JP 2020522577 A JP2020522577 A JP 2020522577A JP 2020522577 A JP2020522577 A JP 2020522577A JP WO2019230858 A5 JPWO2019230858 A5 JP WO2019230858A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- ring
- alkyl
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023127333A JP7679427B2 (ja) | 2018-05-31 | 2023-08-03 | 多環性カルバモイルピリドン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018104156 | 2018-05-31 | ||
| JP2018104156 | 2018-05-31 | ||
| PCT/JP2019/021446 WO2019230858A1 (ja) | 2018-05-31 | 2019-05-30 | 多環性カルバモイルピリドン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127333A Division JP7679427B2 (ja) | 2018-05-31 | 2023-08-03 | 多環性カルバモイルピリドン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019230858A1 JPWO2019230858A1 (ja) | 2021-06-24 |
| JPWO2019230858A5 true JPWO2019230858A5 (https=) | 2022-02-09 |
| JP7328962B2 JP7328962B2 (ja) | 2023-08-17 |
Family
ID=68698918
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020522577A Active JP7328962B2 (ja) | 2018-05-31 | 2019-05-30 | 多環性カルバモイルピリドン誘導体 |
| JP2023127333A Active JP7679427B2 (ja) | 2018-05-31 | 2023-08-03 | 多環性カルバモイルピリドン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023127333A Active JP7679427B2 (ja) | 2018-05-31 | 2023-08-03 | 多環性カルバモイルピリドン誘導体 |
Country Status (37)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY201239A (en) | 2019-03-22 | 2024-02-13 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| WO2021107065A1 (ja) * | 2019-11-28 | 2021-06-03 | 塩野義製薬株式会社 | 多環性ピリドピラジン誘導体 |
| EP4066839A4 (en) * | 2019-11-28 | 2023-12-27 | Shionogi & Co., Ltd | PROPHYLACTIC AND THERAPEUTIC MEDICINAL PRODUCT FOR HIV INFECTIOUS DISEASES, CHARACTERIZED BY CONTAINING THE COMBINATION OF INTEGRAS INHIBITORS AND ANTI-HIV AGENTS |
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| JP7407976B2 (ja) * | 2020-05-21 | 2024-01-04 | シーセン ファーマシューティカル カンパニー リミテッド | 縮合環誘導体及びその薬学的用途 |
| US20240018145A1 (en) * | 2020-07-27 | 2024-01-18 | Merck Sharp & Dohme Llc | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
| ES3064867T3 (en) | 2020-09-30 | 2026-04-29 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv |
| US11613546B2 (en) | 2021-01-19 | 2023-03-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| CN117751118A (zh) * | 2021-07-30 | 2024-03-22 | 吉斯凯(苏州)制药有限公司 | 大环吡啶酮类化合物及其应用 |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN120379998A (zh) * | 2022-09-20 | 2025-07-25 | 吉斯凯(苏州)制药有限公司 | 多环氮杂环酮类化合物及其应用 |
Family Cites Families (41)
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| CA2498111A1 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| NZ540729A (en) | 2002-12-27 | 2008-03-28 | Angeletti P Ist Richerche Bio | Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| ATE516026T1 (de) | 2005-02-21 | 2011-07-15 | Shionogi & Co | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
| KR101363875B1 (ko) | 2005-04-28 | 2014-02-21 | 시오노기세야쿠 가부시키가이샤 | Ｈｉｖ 통합효소 억제 활성을 가지는 다환식카르바모일피리돈 유도체 |
| MX2008005137A (es) * | 2005-10-27 | 2008-09-29 | Shionogi & Co | Derivado de carbamoilpiridona policiclica que tiene actividad inhibidora en vih integrasa. |
| CN101346376A (zh) * | 2005-10-27 | 2009-01-14 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的多环性氨基甲酰基吡啶酮衍生物 |
| CA2789457A1 (en) | 2010-02-26 | 2011-09-01 | Susumu Miyazaki | 1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| RU2014113230A (ru) | 2011-10-12 | 2015-11-20 | Шионоги Энд Ко., Лтд. | Полициклическое производное пиридона, обладающее ингибирующей активностью в отношении интегразы |
| EP2931730B1 (en) * | 2012-12-17 | 2019-08-07 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| EA030003B1 (ru) | 2012-12-21 | 2018-06-29 | Джилид Сайэнс, Инк. | Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции |
| PE20151063A1 (es) | 2012-12-27 | 2015-08-03 | Japan Tobacco Inc | DERIVADO SUSTITUIDO DE ESPIROPIRIDO[1,2-a]PIRAZINA Y USO MEDICO DEL MISMO COMO INHIBIDOR DE LA INTEGRASA DEL VIH |
| RS56701B1 (sr) | 2013-05-17 | 2018-03-30 | Merck Sharp & Dohme | Fuzionisana triciklična heterociklična jedinjenja kao inhibitori hiv integraze |
| EP3008044B1 (en) | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| ES2859102T3 (es) | 2013-07-12 | 2021-10-01 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH |
| NO2865735T3 (https=) | 2013-07-12 | 2018-07-21 | ||
| WO2015039348A1 (en) | 2013-09-23 | 2015-03-26 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
| UA117499C2 (uk) | 2013-09-27 | 2018-08-10 | Мерк Шарп Енд Доум Корп. | Заміщені похідні хінолізину, які можна використовувати як інгібітори інтегрази віл |
| WO2015089847A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2015199167A1 (ja) | 2014-06-25 | 2015-12-30 | 日本たばこ産業株式会社 | 置換されたスピロピリド［１，２－ａ］ピラジン誘導体の製造方法および中間体 |
| JPWO2016027879A1 (ja) | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| WO2016090545A1 (en) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrate inhibitors |
| US10150780B2 (en) | 2014-12-09 | 2018-12-11 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as HIV integrase inhibitors |
| TWI695003B (zh) * | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| WO2016154527A1 (en) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors |
| KR20190057158A (ko) | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| US10624912B2 (en) | 2015-11-17 | 2020-04-21 | Merck Sharp & Dohme Corp. | Spirocyclic Pyridotriazine Derivatives useful as HIV integrase inhibitors |
| US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| CA3042314A1 (en) | 2016-12-02 | 2018-06-07 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| EP3752144B1 (en) | 2018-02-15 | 2022-12-28 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| KR20210005139A (ko) | 2018-04-27 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | Hiv 인테그라제 억제제로서 유용한 트리시클릭 헤테로사이클 화합물 |
| CN110526930B (zh) | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
| MA52802A (fr) | 2018-05-31 | 2021-04-14 | Shionogi & Co | Dérivé de pyridone polycyclique |
| EP3801543B1 (en) | 2018-06-05 | 2024-09-11 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| CN108957755B (zh) | 2018-07-27 | 2021-04-30 | 京东方科技集团股份有限公司 | 一种显示组件及其控制方法、平视显示器及汽车 |
| MY201239A (en) | 2019-03-22 | 2024-02-13 | Gilead Sciences Inc | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
-
2019
- 2019-05-30 EP EP23192706.2A patent/EP4257137A3/en active Pending
- 2019-05-30 MD MDE20210334T patent/MD3805220T2/ro unknown
- 2019-05-30 SI SI201930798T patent/SI3805220T1/sl unknown
- 2019-05-30 RS RS20240971A patent/RS65891B1/sr unknown
- 2019-05-30 PL PL19810498.6T patent/PL3805220T3/pl unknown
- 2019-05-30 CN CN201980050399.5A patent/CN112513042B/zh active Active
- 2019-05-30 AU AU2019277548A patent/AU2019277548B2/en active Active
- 2019-05-30 SG SG11202011382PA patent/SG11202011382PA/en unknown
- 2019-05-30 MX MX2020012176A patent/MX2020012176A/es unknown
- 2019-05-30 UA UAA202008303A patent/UA129229C2/uk unknown
- 2019-05-30 PE PE2025000789A patent/PE20251594A1/es unknown
- 2019-05-30 FI FIEP19810498.6T patent/FI3805220T3/fi active
- 2019-05-30 KR KR1020207037580A patent/KR102741390B1/ko active Active
- 2019-05-30 EA EA202092921A patent/EA202092921A1/ru unknown
- 2019-05-30 BR BR112020024077-0A patent/BR112020024077A2/pt active IP Right Grant
- 2019-05-30 AR ARP190101467A patent/AR115455A1/es unknown
- 2019-05-30 ES ES19810498T patent/ES2984245T3/es active Active
- 2019-05-30 EP EP19810498.6A patent/EP3805220B1/en active Active
- 2019-05-30 JP JP2020522577A patent/JP7328962B2/ja active Active
- 2019-05-30 CA CA3102063A patent/CA3102063A1/en active Pending
- 2019-05-30 CN CN202311258763.1A patent/CN117327072A/zh active Pending
- 2019-05-30 CR CR20200644A patent/CR20200644A/es unknown
- 2019-05-30 MA MA52795A patent/MA52795B1/fr unknown
- 2019-05-30 CR CR20230571A patent/CR20230571A/es unknown
- 2019-05-30 KR KR1020247040377A patent/KR20250002769A/ko active Pending
- 2019-05-30 PE PE2020001863A patent/PE20210477A1/es unknown
- 2019-05-30 MY MYPI2020006045A patent/MY198568A/en unknown
- 2019-05-30 NZ NZ771017A patent/NZ771017A/en unknown
- 2019-05-30 LT LTEPPCT/JP2019/021446T patent/LT3805220T/lt unknown
- 2019-05-30 WO PCT/JP2019/021446 patent/WO2019230858A1/ja not_active Ceased
- 2019-05-30 HR HRP20241221TT patent/HRP20241221T1/hr unknown
- 2019-05-30 SM SM20240330T patent/SMT202400330T1/it unknown
- 2019-05-30 US US17/058,251 patent/US11649236B2/en active Active
- 2019-05-30 IL IL279051A patent/IL279051B2/en unknown
- 2019-05-30 HU HUE19810498A patent/HUE068170T2/hu unknown
- 2019-05-30 PT PT198104986T patent/PT3805220T/pt unknown
- 2019-05-30 DK DK19810498.6T patent/DK3805220T3/da active
- 2019-05-30 IL IL313474A patent/IL313474A/en unknown
-
2020
- 2020-11-13 MX MX2023010377A patent/MX2023010377A/es unknown
- 2020-11-18 CL CL2020003002A patent/CL2020003002A1/es unknown
- 2020-11-18 CO CONC2020/0014294A patent/CO2020014294A2/es unknown
- 2020-11-20 PH PH12020552000A patent/PH12020552000A1/en unknown
- 2020-11-27 DO DO2020000221A patent/DOP2020000221A/es unknown
- 2020-12-04 ZA ZA2020/07567A patent/ZA202007567B/en unknown
-
2023
- 2023-03-22 US US18/124,827 patent/US12139489B2/en active Active
- 2023-08-03 JP JP2023127333A patent/JP7679427B2/ja active Active
-
2024
- 2024-02-08 AU AU2024200783A patent/AU2024200783B2/en active Active
- 2024-06-26 US US18/755,191 patent/US20240352015A1/en active Pending
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