MY198568A - Polycyclic carbamoylpyridone derivative - Google Patents

Polycyclic carbamoylpyridone derivative

Info

Publication number
MY198568A
MY198568A MYPI2020006045A MYPI2020006045A MY198568A MY 198568 A MY198568 A MY 198568A MY PI2020006045 A MYPI2020006045 A MY PI2020006045A MY PI2020006045 A MYPI2020006045 A MY PI2020006045A MY 198568 A MY198568 A MY 198568A
Authority
MY
Malaysia
Prior art keywords
polycyclic carbamoylpyridone
carbamoylpyridone derivative
ring
substituted
derivative
Prior art date
Application number
MYPI2020006045A
Other languages
English (en)
Inventor
Yoshiyuki Taoda
Yuto UNOH
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MY198568A publication Critical patent/MY198568A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53861,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MYPI2020006045A 2018-05-31 2019-05-30 Polycyclic carbamoylpyridone derivative MY198568A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018104156 2018-05-31
PCT/JP2019/021446 WO2019230858A1 (ja) 2018-05-31 2019-05-30 多環性カルバモイルピリドン誘導体

Publications (1)

Publication Number Publication Date
MY198568A true MY198568A (en) 2023-09-05

Family

ID=68698918

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2020006045A MY198568A (en) 2018-05-31 2019-05-30 Polycyclic carbamoylpyridone derivative

Country Status (37)

Country Link
US (3) US11649236B2 (https=)
EP (2) EP4257137A3 (https=)
JP (2) JP7328962B2 (https=)
KR (2) KR102741390B1 (https=)
CN (2) CN112513042B (https=)
AR (1) AR115455A1 (https=)
AU (2) AU2019277548B2 (https=)
BR (1) BR112020024077A2 (https=)
CA (1) CA3102063A1 (https=)
CL (1) CL2020003002A1 (https=)
CO (1) CO2020014294A2 (https=)
CR (2) CR20200644A (https=)
DK (1) DK3805220T3 (https=)
DO (1) DOP2020000221A (https=)
EA (1) EA202092921A1 (https=)
ES (1) ES2984245T3 (https=)
FI (1) FI3805220T3 (https=)
HR (1) HRP20241221T1 (https=)
HU (1) HUE068170T2 (https=)
IL (2) IL279051B2 (https=)
LT (1) LT3805220T (https=)
MA (1) MA52795B1 (https=)
MD (1) MD3805220T2 (https=)
MX (2) MX2020012176A (https=)
MY (1) MY198568A (https=)
NZ (1) NZ771017A (https=)
PE (2) PE20251594A1 (https=)
PH (1) PH12020552000A1 (https=)
PL (1) PL3805220T3 (https=)
PT (1) PT3805220T (https=)
RS (1) RS65891B1 (https=)
SG (1) SG11202011382PA (https=)
SI (1) SI3805220T1 (https=)
SM (1) SMT202400330T1 (https=)
UA (1) UA129229C2 (https=)
WO (1) WO2019230858A1 (https=)
ZA (1) ZA202007567B (https=)

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US20240018145A1 (en) * 2020-07-27 2024-01-18 Merck Sharp & Dohme Llc Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza
ES3064867T3 (en) 2020-09-30 2026-04-29 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds for a use in the treatment of hiv
US11613546B2 (en) 2021-01-19 2023-03-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
CN117751118A (zh) * 2021-07-30 2024-03-22 吉斯凯(苏州)制药有限公司 大环吡啶酮类化合物及其应用
TW202446773A (zh) 2022-04-06 2024-12-01 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
CN120379998A (zh) * 2022-09-20 2025-07-25 吉斯凯(苏州)制药有限公司 多环氮杂环酮类化合物及其应用

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JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
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EP3752144B1 (en) 2018-02-15 2022-12-28 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
KR20210005139A (ko) 2018-04-27 2021-01-13 머크 샤프 앤드 돔 코포레이션 Hiv 인테그라제 억제제로서 유용한 트리시클릭 헤테로사이클 화합물
CN110526930B (zh) 2018-05-23 2022-06-03 莫云芬 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用
MA52802A (fr) 2018-05-31 2021-04-14 Shionogi & Co Dérivé de pyridone polycyclique
EP3801543B1 (en) 2018-06-05 2024-09-11 Merck Sharp & Dohme LLC Tricyclic heterocycle compounds useful as hiv integrase inhibitors
CN108957755B (zh) 2018-07-27 2021-04-30 京东方科技集团股份有限公司 一种显示组件及其控制方法、平视显示器及汽车
MY201239A (en) 2019-03-22 2024-02-13 Gilead Sciences Inc Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use

Also Published As

Publication number Publication date
IL279051B2 (en) 2025-01-01
CL2020003002A1 (es) 2021-04-16
HUE068170T2 (hu) 2024-12-28
MA52795A (fr) 2021-04-14
IL279051A (en) 2021-01-31
SI3805220T1 (sl) 2024-10-30
US20210122751A1 (en) 2021-04-29
AU2019277548B2 (en) 2023-12-14
DOP2020000221A (es) 2021-03-15
PT3805220T (pt) 2024-08-16
CR20200644A (es) 2021-02-05
JP7328962B2 (ja) 2023-08-17
WO2019230858A1 (ja) 2019-12-05
PE20210477A1 (es) 2021-03-11
US20240352015A1 (en) 2024-10-24
MX2023010377A (es) 2023-09-12
FI3805220T3 (fi) 2024-08-30
IL279051B1 (en) 2024-09-01
PE20251594A1 (es) 2025-06-16
ZA202007567B (en) 2022-04-28
EP4257137A2 (en) 2023-10-11
JP7679427B2 (ja) 2025-05-19
JP2023145723A (ja) 2023-10-11
AU2024200783B2 (en) 2026-03-26
KR20250002769A (ko) 2025-01-07
UA129229C2 (uk) 2025-02-19
EP4257137A3 (en) 2023-11-01
AU2019277548A1 (en) 2021-01-14
AR115455A1 (es) 2021-01-20
EP3805220A4 (en) 2022-01-05
EP3805220A1 (en) 2021-04-14
MX2020012176A (es) 2021-01-29
CO2020014294A2 (es) 2020-12-21
BR112020024077A2 (pt) 2021-02-09
JPWO2019230858A1 (ja) 2021-06-24
DK3805220T3 (da) 2024-08-26
PL3805220T3 (pl) 2024-11-04
CN112513042A (zh) 2021-03-16
US11649236B2 (en) 2023-05-16
IL313474A (en) 2024-08-01
KR102741390B1 (ko) 2024-12-10
LT3805220T (lt) 2024-08-26
PH12020552000A1 (en) 2021-09-27
CA3102063A1 (en) 2019-12-05
HRP20241221T1 (hr) 2024-12-06
US20230227454A1 (en) 2023-07-20
CR20230571A (es) 2024-01-22
KR20210015922A (ko) 2021-02-10
NZ771017A (en) 2026-01-30
EP3805220B1 (en) 2024-07-31
US12139489B2 (en) 2024-11-12
MD3805220T2 (ro) 2024-10-31
AU2024200783A1 (en) 2024-02-29
ES2984245T3 (es) 2024-10-29
CN112513042B (zh) 2023-09-29
EA202092921A1 (ru) 2021-04-07
MA52795B1 (fr) 2024-09-30
SMT202400330T1 (it) 2024-09-16
RS65891B1 (sr) 2024-09-30
SG11202011382PA (en) 2020-12-30
CN117327072A (zh) 2024-01-02

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