JP2021020924A5 - - Google Patents
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- Publication number
- JP2021020924A5 JP2021020924A5 JP2020173954A JP2020173954A JP2021020924A5 JP 2021020924 A5 JP2021020924 A5 JP 2021020924A5 JP 2020173954 A JP2020173954 A JP 2020173954A JP 2020173954 A JP2020173954 A JP 2020173954A JP 2021020924 A5 JP2021020924 A5 JP 2021020924A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxamide
- pyridin
- thiazole
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151274P | 2015-04-22 | 2015-04-22 | |
| US62/151,274 | 2015-04-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Division JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021020924A JP2021020924A (ja) | 2021-02-18 |
| JP2021020924A5 true JP2021020924A5 (https=) | 2021-04-22 |
| JP7050879B2 JP7050879B2 (ja) | 2022-04-08 |
Family
ID=55858915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Active JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
| JP2020173954A Active JP7050879B2 (ja) | 2015-04-22 | 2020-10-15 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Active JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US9982000B2 (https=) |
| EP (1) | EP3286181B1 (https=) |
| JP (2) | JP6835739B2 (https=) |
| KR (1) | KR102677905B1 (https=) |
| CN (2) | CN107438603B (https=) |
| AU (1) | AU2016252869B2 (https=) |
| BR (1) | BR112017022349B1 (https=) |
| CA (1) | CA2980800C (https=) |
| CL (1) | CL2017002640A1 (https=) |
| CO (1) | CO2017010583A2 (https=) |
| CY (1) | CY1124422T1 (https=) |
| DK (1) | DK3286181T3 (https=) |
| EA (1) | EA039043B1 (https=) |
| ES (1) | ES2861351T3 (https=) |
| HR (1) | HRP20210433T1 (https=) |
| HU (1) | HUE054042T2 (https=) |
| IL (1) | IL254615B (https=) |
| LT (1) | LT3286181T (https=) |
| MX (1) | MX380940B (https=) |
| MY (1) | MY189941A (https=) |
| PE (1) | PE20180118A1 (https=) |
| PH (1) | PH12017501925A1 (https=) |
| PL (1) | PL3286181T3 (https=) |
| PT (1) | PT3286181T (https=) |
| RS (1) | RS61636B1 (https=) |
| SG (2) | SG10201912656SA (https=) |
| SI (1) | SI3286181T1 (https=) |
| SM (1) | SMT202100186T1 (https=) |
| WO (1) | WO2016172560A1 (https=) |
| ZA (1) | ZA201706545B (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| LT3286181T (lt) * | 2015-04-22 | 2021-04-26 | Rigel Pharmaceuticals, Inc. | Pirazolo junginiai ir junginių gamybos bei naudojimo būdas |
| ES2946001T3 (es) | 2016-10-26 | 2023-07-11 | Rigel Pharmaceuticals Inc | Compuestos de pirazol amida como inhibidores de IRAK |
| JP7170634B2 (ja) | 2016-10-26 | 2022-11-14 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法 |
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CA3068305A1 (en) * | 2017-06-29 | 2019-01-03 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and methods for making and using |
| WO2019060742A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc | AGENTS FOR DEGRADING PROTEINS AND USES THEREOF |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| CN107987063A (zh) * | 2017-12-31 | 2018-05-04 | 窦玉玲 | 一种hsp90抑制剂及其在抗肿瘤药物的应用 |
| CN107857758B (zh) * | 2017-12-31 | 2018-08-24 | 广东莱恩医药研究院有限公司 | 一种酰胺类化合物及其作为hsp90抑制剂和抗肿瘤药物的应用 |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2019195810A2 (en) * | 2018-04-06 | 2019-10-10 | Praxis Biotech LLC | Atf6 inhibitors and uses thereof |
| WO2020010177A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Tricyclic crbn ligands and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| CN117285467A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| CN110862375B (zh) * | 2018-08-27 | 2022-10-25 | 深圳铂立健医药有限公司 | 吡唑化合物及其药物组合物和应用 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2021011868A1 (en) | 2019-07-17 | 2021-01-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| MX2022001596A (es) * | 2019-08-08 | 2022-03-11 | Rigel Pharmaceuticals Inc | Compuestos y metodos para tratar sindrome de liberacion de citocinas. |
| PE20220970A1 (es) * | 2019-08-30 | 2022-06-10 | Rigel Pharmaceuticals Inc | Compuestos de pirazol, formulaciones de los mismos y un metodo para usar los compuestos y/o formulaciones |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| CN116867758A (zh) | 2020-12-30 | 2023-10-10 | 凯麦拉医疗公司 | Irak降解剂和其用途 |
| US12171768B2 (en) | 2021-02-15 | 2024-12-24 | Kymera Therapeutics, Inc. | IRAK4 degraders and uses thereof |
| US12357623B2 (en) | 2021-03-03 | 2025-07-15 | Rigel Pharmaceuticals, Inc. | Method for treating a disease or condition using a pyrazole compound or formulation thereof |
| US20240174679A1 (en) * | 2021-03-17 | 2024-05-30 | Merck Sharp & Dohme Llc | Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| JP2024522988A (ja) * | 2021-06-01 | 2024-06-25 | レアルタ ライフ サイエンシズ インコーポレイテッド | ペプチドおよび使用方法 |
| US20240382470A1 (en) * | 2021-09-08 | 2024-11-21 | Rigel Pharmaceuticals, Inc. | Irak Inhibitor for Treating Cytokine Release-Related Conditions Associated With Infection by a Respiratory Virus |
| CA3236265A1 (en) | 2021-10-29 | 2023-05-04 | William Leong | Irak4 degraders and synthesis thereof |
| CA3243560A1 (en) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Iraqi Degradation Agents and Their Uses |
| IL315677A (en) | 2022-03-23 | 2024-11-01 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
| WO2024011116A2 (en) * | 2022-07-07 | 2024-01-11 | Dana-Farber Cancer Institute, Inc. | Potent and selective irreversible inhibitors of irak1 |
| CN117209489B (zh) * | 2023-05-30 | 2024-07-26 | 杭州邦顺制药有限公司 | Irak激酶抑制剂 |
| WO2025111251A1 (en) * | 2023-11-20 | 2025-05-30 | Exelixis, Inc. | Compounds that inhibit polo-like kinase 4 |
| CN121270516A (zh) * | 2024-07-03 | 2026-01-06 | 科辉智药(深圳)新药研究中心有限公司 | 一种irak抑制剂化合物的晶型及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003287965A1 (en) * | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| WO2006070202A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives having kinase modulating activity |
| WO2006070198A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| EP2206707B1 (en) * | 2007-10-24 | 2014-07-23 | Astellas Pharma Inc. | Azolecarboxamide compound or salt thereof |
| EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| WO2010121243A1 (en) | 2009-04-17 | 2010-10-21 | University Of Arizona | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles |
| EP2243481A1 (en) | 2009-04-24 | 2010-10-27 | PamGene B.V. | Irak kinase family as novel drug target for Alzheimer |
| WO2011043771A1 (en) | 2009-10-07 | 2011-04-14 | Nitto Denko Corporation | Narrow band excitation light source for fluorescence sensing system |
| JP2012254939A (ja) | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| JP6161537B2 (ja) | 2010-04-07 | 2017-07-12 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物及び使用の方法 |
| RU2632900C2 (ru) | 2010-11-19 | 2017-10-11 | Лиганд Фармасьютикалс Инкорпорейтед | Гетероциклические амины и их применение |
| EP2561102A1 (en) | 2010-12-02 | 2013-02-27 | Katholieke Universiteit Leuven K.U. Leuven R&D | Irak-related interventions and diagnosis |
| BR112013015460B1 (pt) | 2010-12-20 | 2022-01-25 | Merck Serono S.A. | Derivados de indazolil triazol, kit, e composição farmacêutica |
| WO2012097013A1 (en) | 2011-01-10 | 2012-07-19 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| BR112013020282A2 (pt) * | 2011-02-09 | 2017-07-18 | Nissan Chemical Ind Ltd | derivado pirazol e agente de controle |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| JP6126131B2 (ja) | 2012-01-10 | 2017-05-10 | ニンバス アイリス， インコーポレイテッド | Ｉｒａｋ阻害剤およびその使用 |
| AU2013322736A1 (en) * | 2012-09-26 | 2015-02-26 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP2903613B1 (en) * | 2012-10-08 | 2017-11-22 | Merck Sharp & Dohme Corp. | Pyrazole derivatives useful as inhibitors of irak4 activity |
| HUE032863T2 (en) | 2013-02-07 | 2017-11-28 | Merck Patent Gmbh | Piridazinonamid derivatives |
| HRP20171302T1 (hr) | 2013-02-07 | 2017-10-20 | Merck Patent Gmbh | Makrociklički derivati piridazinona |
| EP3092225B1 (en) | 2014-01-09 | 2019-02-27 | Merck Patent GmbH | Pyrimidine pyrazolyl derivatives and their use as irak inhibitors |
| JP6787892B2 (ja) | 2014-11-20 | 2020-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
| LT3286181T (lt) * | 2015-04-22 | 2021-04-26 | Rigel Pharmaceuticals, Inc. | Pirazolo junginiai ir junginių gamybos bei naudojimo būdas |
| DK3331879T3 (da) * | 2015-08-04 | 2020-08-10 | Rigel Pharmaceuticals Inc | Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne |
-
2016
- 2016-04-22 LT LTEP16719191.5T patent/LT3286181T/lt unknown
- 2016-04-22 HR HRP20210433TT patent/HRP20210433T1/hr unknown
- 2016-04-22 CN CN201680021522.7A patent/CN107438603B/zh active Active
- 2016-04-22 SM SM20210186T patent/SMT202100186T1/it unknown
- 2016-04-22 US US15/136,508 patent/US9982000B2/en active Active
- 2016-04-22 SG SG10201912656SA patent/SG10201912656SA/en unknown
- 2016-04-22 BR BR112017022349-0A patent/BR112017022349B1/pt active IP Right Grant
- 2016-04-22 WO PCT/US2016/028957 patent/WO2016172560A1/en not_active Ceased
- 2016-04-22 AU AU2016252869A patent/AU2016252869B2/en active Active
- 2016-04-22 SI SI201631128T patent/SI3286181T1/sl unknown
- 2016-04-22 JP JP2017555270A patent/JP6835739B2/ja active Active
- 2016-04-22 SG SG11201707752SA patent/SG11201707752SA/en unknown
- 2016-04-22 CN CN202110865696.4A patent/CN113750094A/zh active Pending
- 2016-04-22 RS RS20210394A patent/RS61636B1/sr unknown
- 2016-04-22 EP EP16719191.5A patent/EP3286181B1/en active Active
- 2016-04-22 KR KR1020177031696A patent/KR102677905B1/ko active Active
- 2016-04-22 CA CA2980800A patent/CA2980800C/en active Active
- 2016-04-22 PL PL16719191T patent/PL3286181T3/pl unknown
- 2016-04-22 PT PT167191915T patent/PT3286181T/pt unknown
- 2016-04-22 MY MYPI2017001562A patent/MY189941A/en unknown
- 2016-04-22 PE PE2017002190A patent/PE20180118A1/es unknown
- 2016-04-22 MX MX2017013413A patent/MX380940B/es unknown
- 2016-04-22 HU HUE16719191A patent/HUE054042T2/hu unknown
- 2016-04-22 EA EA201791927A patent/EA039043B1/ru unknown
- 2016-04-22 ES ES16719191T patent/ES2861351T3/es active Active
- 2016-04-22 DK DK16719191.5T patent/DK3286181T3/da active
-
2017
- 2017-09-24 IL IL254615A patent/IL254615B/en unknown
- 2017-09-28 ZA ZA2017/06545A patent/ZA201706545B/en unknown
- 2017-10-17 CO CONC2017/0010583A patent/CO2017010583A2/es unknown
- 2017-10-17 CL CL2017002640A patent/CL2017002640A1/es unknown
- 2017-10-20 PH PH12017501925A patent/PH12017501925A1/en unknown
-
2018
- 2018-03-22 US US15/928,335 patent/US10208074B2/en active Active
- 2018-03-23 US US15/934,692 patent/US10208075B2/en active Active
-
2019
- 2019-01-28 US US16/259,685 patent/US11370808B2/en active Active
-
2020
- 2020-10-15 JP JP2020173954A patent/JP7050879B2/ja active Active
-
2021
- 2021-04-07 CY CY20211100301T patent/CY1124422T1/el unknown
-
2022
- 2022-05-18 US US17/747,342 patent/US20220289776A1/en not_active Abandoned
-
2024
- 2024-11-27 US US18/963,039 patent/US20250326778A1/en active Pending
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