AR123648A1 - Compuestos de carbamoilpiridona tricíclicos puenteados y sus usos - Google Patents
Compuestos de carbamoilpiridona tricíclicos puenteados y sus usosInfo
- Publication number
- AR123648A1 AR123648A1 ARP210102713A ARP210102713A AR123648A1 AR 123648 A1 AR123648 A1 AR 123648A1 AR P210102713 A ARP210102713 A AR P210102713A AR P210102713 A ARP210102713 A AR P210102713A AR 123648 A1 AR123648 A1 AR 123648A1
- Authority
- AR
- Argentina
- Prior art keywords
- 4alkyl
- alkyl
- halo
- haloc1
- haloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen compuestos para uso en el tratamiento o prevención de infección con el virus de la inmunodeficiencia humana (VIH). Los compuestos tienen la siguiente fórmula (1), incluyendo sus estereoisómeros y sus sales farmacéuticamente aceptables. También se describen métodos asociados con la preparación y uso de los compuestos descriptos, así como composiciones farmacéuticas que comprenden dichos compuestos. Reivindicación 1: Un compuesto de la fórmula (1) o una sal aceptable farmacéuticamente de este, en donde R¹ es arilo C₆₋₁₀ o heteroarilo de 5 a 10 miembros, en donde el arilo C₆₋₁₀ o heteroarilo de 5 a 10 miembros se sustituye opcionalmente con uno a cuatro RA¹, en donde cada RA¹ es independientemente halo, alquilo C₁₋₆, haloalquilo C₁₋₄, ciano, -O-alquilo C₁₋₄, o alquilo C₁₋₄-O-alquilo C₁₋₄; R² es H, alquilo C₁₋₆, o haloalquilo C₁₋₄; R³ es halo o -OR³ᵃ, en donde R³ᵃ es H, -alquilo C₁₋₆, -haloalquilo C₁₋₄, o -cicloalquilo C₃₋₆; o R³ᵃ y uno cualquiera de R², R⁵ᵃ, y R⁶ᵃ junto con los carbonos a los que están unidos forman un anillo heterocíclico de 4 a 6 miembros que contiene uno o dos heteroátomos seleccionados independientemente de N, O, y S; R³ᵇ es H, -alquilo C₁₋₆, -haloalquilo C₁₋₄, o -alquileno C₁₋₄-O-alquilo C₁₋₄; R⁴ᵃ es -alquilo C₁₋₆ o -haloalquilo C₁₋₄; R⁴ᵇ es H, halo, -alquilo C₁₋₆, o -haloalquilo C₁₋₄; W¹ es un enlace o -CR⁵ᵃR⁵ᵇ-; R⁵ᵃ y R⁵ᵇ son independientemente H, alquilo C₁₋₆, haloalquilo C₁₋₄, o halo; o R⁵ᵃ y R³ᵃ junto con los carbonos a los que están unidos forman un anillo heterocíclico de 4 a 6 miembros que contiene uno o dos heteroátomos seleccionados independientemente de N, O, y S; y R⁵ᵇ es H, alquilo C₁₋₆, haloalquilo C₁₋₄, o halo; W² es -CR⁶ᵃR⁶ᵇ- o -CR⁷ᵃ=CR⁷ᵇ-; R⁶ᵃ y R⁶ᵇ son independientemente H, alquilo C₁₋₆, haloalquilo C₁₋₄, halo, hidroxilo, ciano, -O-alquilo C₁₋₄, o alquileno C₁₋₄-O-alquilo C₁₋₄; o R⁶ᵃ y R³ᵃ junto con los carbonos a los que están unidos forman un anillo heterocíclico de 4 a 6 miembros que contiene uno o dos heteroátomos seleccionados independientemente de N, O, y S; y R⁶ᵇ es H, alquilo C₁₋₆, haloalquilo C₁₋₄, halo, hidroxilo, ciano, -O-alquilo C₁₋₄, o -alquileno C₁₋₄-O-alquilo C₁₋₄; R⁷ᵃ y R⁷ᵇ son independientemente H, halo, haloalquilo C₁₋₄, o alquilo C₁₋₆; o R⁷ᵃ y R⁷ᵇ junto con los carbonos a los que están unidos forman un arilo C₅₋₁₀ sustituido opcionalmente con uno a cuatro RA², en donde cada RA² es independientemente halo, ciano, o alquilo C₁₋₄.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063085704P | 2020-09-30 | 2020-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123648A1 true AR123648A1 (es) | 2022-12-28 |
Family
ID=78463926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102713A AR123648A1 (es) | 2020-09-30 | 2021-09-30 | Compuestos de carbamoilpiridona tricíclicos puenteados y sus usos |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20220135565A1 (es) |
| EP (1) | EP4222152A1 (es) |
| JP (1) | JP2023543059A (es) |
| KR (1) | KR20230079137A (es) |
| CN (1) | CN116390924A (es) |
| AR (1) | AR123648A1 (es) |
| AU (1) | AU2021351491B2 (es) |
| CA (1) | CA3192145A1 (es) |
| TW (1) | TW202222798A (es) |
| WO (1) | WO2022072520A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4122537A1 (en) * | 2019-03-22 | 2023-01-25 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| CR20230315A (es) | 2021-01-19 | 2023-09-01 | Gilead Sciences Inc | Compuestos de piridotriazina sustituidos y usos de estos |
| TWI843506B (zh) | 2022-04-06 | 2024-05-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
| UA88313C2 (ru) | 2004-07-27 | 2009-10-12 | Гилиад Сайенсиз, Инк. | Фосфонатные аналоги соединений ингибиторов вич |
| EP2220046B1 (en) | 2007-11-16 | 2014-06-18 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| EA021377B9 (ru) | 2008-12-09 | 2015-09-30 | Джилид Сайэнс, Инк. | Модуляторы толл-подобных рецепторов |
| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| EP2488521B1 (en) * | 2009-10-13 | 2013-12-18 | Elanco Animal Health Ireland Limited | Macrocyclic integrase inhibitors |
| WO2011139637A1 (en) | 2010-05-03 | 2011-11-10 | Philadelphia Health & Education Corporation | Small-molecule modulators of hiv-1 capsid stability and methods thereof |
| BR112013000043A2 (pt) | 2010-07-02 | 2019-09-24 | Gilead Sciences Inc | derivados de ácido naft-2-ilacético para tratar aids |
| NZ604716A (en) | 2010-07-02 | 2014-12-24 | Gilead Sciences Inc | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| SG194512A1 (en) | 2011-04-21 | 2013-12-30 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| JP6205354B2 (ja) | 2011-07-06 | 2017-09-27 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖの処置のための化合物 |
| CN102863512B (zh) | 2011-07-07 | 2016-04-20 | 上海泓博智源医药技术有限公司 | 抗病毒化合物 |
| US9399645B2 (en) | 2011-12-20 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Inhibitors of HIV replication |
| ES2571479T3 (es) | 2012-04-20 | 2016-05-25 | Gilead Sciences Inc | Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH |
| ES2926068T3 (es) | 2012-12-21 | 2022-10-21 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policíclicos y su uso farmacéutico |
| US20140221378A1 (en) | 2012-12-27 | 2014-08-07 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR |
| PT3252058T (pt) * | 2013-07-12 | 2021-03-09 | Gilead Sciences Inc | Compostos policíclicos-carbamoílpiridona e seu uso para o tratamento de infecções por hiv |
| NO2865735T3 (es) * | 2013-07-12 | 2018-07-21 | ||
| ES2837383T3 (es) * | 2015-04-02 | 2021-06-30 | Gilead Sciences Inc | Compuestos de carbamoilpiridonas policíclicos y su utilización farmacéutica |
| EP4122537A1 (en) * | 2019-03-22 | 2023-01-25 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| CN113795491B (zh) * | 2019-04-30 | 2024-09-03 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
-
2021
- 2021-09-29 KR KR1020237014237A patent/KR20230079137A/ko active Search and Examination
- 2021-09-29 AU AU2021351491A patent/AU2021351491B2/en active Active
- 2021-09-29 US US17/489,406 patent/US20220135565A1/en active Pending
- 2021-09-29 WO PCT/US2021/052683 patent/WO2022072520A1/en active Application Filing
- 2021-09-29 JP JP2023519489A patent/JP2023543059A/ja active Pending
- 2021-09-29 CN CN202180067050.XA patent/CN116390924A/zh active Pending
- 2021-09-29 EP EP21801304.3A patent/EP4222152A1/en active Pending
- 2021-09-29 CA CA3192145A patent/CA3192145A1/en active Pending
- 2021-09-29 TW TW110136191A patent/TW202222798A/zh unknown
- 2021-09-30 AR ARP210102713A patent/AR123648A1/es unknown
-
2023
- 2023-12-04 US US18/527,967 patent/US20240246975A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240246975A1 (en) | 2024-07-25 |
| WO2022072520A1 (en) | 2022-04-07 |
| EP4222152A1 (en) | 2023-08-09 |
| KR20230079137A (ko) | 2023-06-05 |
| US20220135565A1 (en) | 2022-05-05 |
| JP2023543059A (ja) | 2023-10-12 |
| CA3192145A1 (en) | 2022-04-07 |
| TW202222798A (zh) | 2022-06-16 |
| AU2021351491A1 (en) | 2023-05-04 |
| AU2021351491B2 (en) | 2024-09-05 |
| CN116390924A (zh) | 2023-07-04 |
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