JP2023515617A5 - - Google Patents
Info
- Publication number
- JP2023515617A5 JP2023515617A5 JP2022552203A JP2022552203A JP2023515617A5 JP 2023515617 A5 JP2023515617 A5 JP 2023515617A5 JP 2022552203 A JP2022552203 A JP 2022552203A JP 2022552203 A JP2022552203 A JP 2022552203A JP 2023515617 A5 JP2023515617 A5 JP 2023515617A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- heteroaryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062983537P | 2020-02-28 | 2020-02-28 | |
| US62/983,537 | 2020-02-28 | ||
| US202063007134P | 2020-04-08 | 2020-04-08 | |
| US63/007,134 | 2020-04-08 | ||
| US202063040474P | 2020-06-17 | 2020-06-17 | |
| US63/040,474 | 2020-06-17 | ||
| US202063072781P | 2020-08-31 | 2020-08-31 | |
| US63/072,781 | 2020-08-31 | ||
| US202063126491P | 2020-12-16 | 2020-12-16 | |
| US63/126,491 | 2020-12-16 | ||
| PCT/US2021/020160 WO2021174170A1 (en) | 2020-02-28 | 2021-02-28 | Pyridazine dervatives for modulating nucleic acid splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023515617A JP2023515617A (ja) | 2023-04-13 |
| JP2023515617A5 true JP2023515617A5 (https=) | 2025-08-06 |
Family
ID=75278334
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022552203A Pending JP2023515617A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
| JP2022552206A Pending JP2023515618A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022552206A Pending JP2023515618A (ja) | 2020-02-28 | 2021-02-28 | 核酸スプライシングを調節するためのピリダジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20230365526A1 (https=) |
| EP (2) | EP4110774A1 (https=) |
| JP (2) | JP2023515617A (https=) |
| KR (2) | KR20220157407A (https=) |
| CN (2) | CN115551847A (https=) |
| AU (3) | AU2021228286A1 (https=) |
| BR (2) | BR112022017089A2 (https=) |
| CA (2) | CA3169667A1 (https=) |
| IL (2) | IL295953A (https=) |
| MX (2) | MX2022010634A (https=) |
| WO (2) | WO2021174176A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN114126613A (zh) | 2019-02-05 | 2022-03-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| EP3920915A4 (en) * | 2019-02-05 | 2022-10-05 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICE |
| CN113661162A (zh) | 2019-02-06 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| BR112022023025A2 (pt) | 2020-05-13 | 2023-03-28 | Chdi Foundation Inc | Moduladores de htt para tratar doença de huntington |
| US20240368163A1 (en) | 2021-08-30 | 2024-11-07 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2023034836A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US20250127789A1 (en) * | 2021-11-04 | 2025-04-24 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| US12281116B2 (en) | 2021-11-17 | 2025-04-22 | Chdi Foundation, Inc. | HTT modulators for treating Huntington's disease |
| US20250101006A1 (en) * | 2022-01-31 | 2025-03-27 | Novartis Ag | Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents |
| CA3242153A1 (en) * | 2022-04-01 | 2023-10-05 | Tyk Medicines, Inc. | COMPOUND SERVING AS A KINASE INHIBITOR AND ITS USE |
| EP4577543A1 (en) * | 2022-08-22 | 2025-07-02 | Redx Pharma Limited | Pyrido-pyrazoles as inhibitors of ddr's for the treatment of fibrotic disorders and cancer |
| WO2024182747A2 (en) * | 2023-03-01 | 2024-09-06 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2025211457A1 (ja) * | 2024-04-05 | 2025-10-09 | 日本新薬株式会社 | Ｃｕｇリピートｒｎａとｍｂｎｌタンパクとの結合阻害化合物および医薬 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7160876B2 (en) * | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| DK2812004T3 (en) | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| US9521848B2 (en) * | 2013-07-31 | 2016-12-20 | Sumitomo Chemical Company, Limited | Tetrazolinone compound and use therefor |
| MX381224B (es) * | 2014-10-31 | 2025-03-12 | Massachusetts Gen Hospital | Potentes moduladores de gamma-secretasa. |
| WO2016128343A1 (en) | 2015-02-09 | 2016-08-18 | F. Hoffmann-La Roche Ag | Compounds for the treatment of cancer |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| IL294124B2 (en) * | 2015-12-10 | 2024-02-01 | Ptc Therapeutics Inc | Methods for treating huntington's disease |
| EA201991309A1 (ru) | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| WO2018140578A1 (en) * | 2017-01-25 | 2018-08-02 | President And Fellows Of Harvard College | Non-fullerene solar panel acceptor compounds |
| KR20200017476A (ko) * | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | Rna 스플라이싱의 변경 방법 |
| WO2019028440A1 (en) * | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| KR20200057071A (ko) | 2017-09-25 | 2020-05-25 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱 조절제의 스크리닝 및 확인을 위한 방법 및 조성물 |
| IL273924B2 (en) * | 2017-10-20 | 2024-07-01 | Univ Vanderbilt | Antagonists of the muscarinic acetylcholine receptor m4 |
| IL276411B2 (en) * | 2018-02-02 | 2024-04-01 | Univ Vanderbilt | M4 muscarinic acetylcholine receptor antagonists |
| CN112272666A (zh) | 2018-04-10 | 2021-01-26 | 斯基霍克疗法公司 | 用于治疗癌症的化合物 |
| TWI823932B (zh) * | 2018-05-11 | 2023-12-01 | 中國大陸商迪哲（江蘇）醫藥有限公司 | 三唑并嘧啶化合物及其在治療癌症中之用途 |
-
2021
- 2021-02-28 MX MX2022010634A patent/MX2022010634A/es unknown
- 2021-02-28 BR BR112022017089A patent/BR112022017089A2/pt unknown
- 2021-02-28 CA CA3169667A patent/CA3169667A1/en active Pending
- 2021-02-28 KR KR1020227033652A patent/KR20220157407A/ko active Pending
- 2021-02-28 US US17/802,747 patent/US20230365526A1/en active Pending
- 2021-02-28 CN CN202180030690.3A patent/CN115551847A/zh active Pending
- 2021-02-28 BR BR112022017107A patent/BR112022017107A2/pt unknown
- 2021-02-28 CA CA3169643A patent/CA3169643A1/en active Pending
- 2021-02-28 IL IL295953A patent/IL295953A/en unknown
- 2021-02-28 KR KR1020227033654A patent/KR20220158236A/ko active Pending
- 2021-02-28 AU AU2021228286A patent/AU2021228286A1/en not_active Abandoned
- 2021-02-28 EP EP21715355.0A patent/EP4110774A1/en active Pending
- 2021-02-28 US US17/802,702 patent/US20230140983A1/en active Pending
- 2021-02-28 WO PCT/US2021/020173 patent/WO2021174176A1/en not_active Ceased
- 2021-02-28 AU AU2021228288A patent/AU2021228288A1/en active Pending
- 2021-02-28 CN CN202180031321.6A patent/CN115551843A/zh active Pending
- 2021-02-28 IL IL295954A patent/IL295954A/en unknown
- 2021-02-28 JP JP2022552203A patent/JP2023515617A/ja active Pending
- 2021-02-28 WO PCT/US2021/020160 patent/WO2021174170A1/en not_active Ceased
- 2021-02-28 JP JP2022552206A patent/JP2023515618A/ja active Pending
- 2021-02-28 MX MX2022010637A patent/MX2022010637A/es unknown
- 2021-02-28 EP EP21713826.2A patent/EP4110771A1/en active Pending
-
2024
- 2024-03-08 AU AU2024201568A patent/AU2024201568A1/en active Pending
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