JP2023520925A5 - - Google Patents
Info
- Publication number
- JP2023520925A5 JP2023520925A5 JP2022561469A JP2022561469A JP2023520925A5 JP 2023520925 A5 JP2023520925 A5 JP 2023520925A5 JP 2022561469 A JP2022561469 A JP 2022561469A JP 2022561469 A JP2022561469 A JP 2022561469A JP 2023520925 A5 JP2023520925 A5 JP 2023520925A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- heteroaryl
- alkyl
- aryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063007327P | 2020-04-08 | 2020-04-08 | |
| US63/007,327 | 2020-04-08 | ||
| US202063043920P | 2020-06-25 | 2020-06-25 | |
| US63/043,920 | 2020-06-25 | ||
| US202063072873P | 2020-08-31 | 2020-08-31 | |
| US63/072,873 | 2020-08-31 | ||
| US202063126493P | 2020-12-16 | 2020-12-16 | |
| US63/126,493 | 2020-12-16 | ||
| PCT/US2021/026435 WO2021207530A1 (en) | 2020-04-08 | 2021-04-08 | Compounds and methods for modulating splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023520925A JP2023520925A (ja) | 2023-05-22 |
| JP2023520925A5 true JP2023520925A5 (https=) | 2024-04-18 |
Family
ID=75747105
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561469A Pending JP2023520925A (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
| JP2022561468A Active JP7797407B2 (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561468A Active JP7797407B2 (ja) | 2020-04-08 | 2021-04-08 | スプライシングを調節するための化合物及び方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20240287097A1 (https=) |
| EP (2) | EP4132935A1 (https=) |
| JP (2) | JP2023520925A (https=) |
| KR (2) | KR20230005210A (https=) |
| CN (2) | CN116134036A (https=) |
| AU (2) | AU2021253571A1 (https=) |
| BR (2) | BR112022020337A2 (https=) |
| CA (2) | CA3175205A1 (https=) |
| CL (1) | CL2022002779A1 (https=) |
| CO (1) | CO2022015926A2 (https=) |
| CR (1) | CR20220567A (https=) |
| IL (1) | IL297149A (https=) |
| MX (2) | MX2022012676A (https=) |
| WO (2) | WO2021207550A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN114126613A (zh) | 2019-02-05 | 2022-03-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| CN113661162A (zh) | 2019-02-06 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| BR112022023025A2 (pt) | 2020-05-13 | 2023-03-28 | Chdi Foundation Inc | Moduladores de htt para tratar doença de huntington |
| WO2022194802A1 (en) * | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thiadiazolopyrimidone derivatives |
| BR112023018466A2 (pt) * | 2021-03-17 | 2023-10-10 | Hoffmann La Roche | Derivados de tiazolopirimidinona |
| CN116997555A (zh) * | 2021-03-17 | 2023-11-03 | 豪夫迈·罗氏有限公司 | 新颖噻吩并嘧啶酮衍生物 |
| WO2023064879A1 (en) * | 2021-10-13 | 2023-04-20 | Remix Therapeutics Inc. | Compounds and methods for modulating nucleic acid splicing |
| US12281116B2 (en) | 2021-11-17 | 2025-04-22 | Chdi Foundation, Inc. | HTT modulators for treating Huntington's disease |
| AU2022398247A1 (en) * | 2021-11-24 | 2024-06-13 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| CN115112899B (zh) * | 2022-06-15 | 2024-08-16 | 四川大学华西医院 | 检测羧肽酶a4的试剂和/或系统在制备恶性胸腔积液筛查产品中的用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB242502A (en) * | 1925-03-10 | 1925-11-12 | Hoe & Co R | Improvements in stapling and folding mechanism |
| JPS57142989A (en) * | 1981-02-27 | 1982-09-03 | Dai Ichi Seiyaku Co Ltd | Thiazolopyrimidine derivative |
| JPS58177997A (ja) * | 1982-04-12 | 1983-10-18 | Dai Ichi Seiyaku Co Ltd | チアジアゾロピリミジノン誘導体 |
| DE3763282D1 (de) * | 1986-03-19 | 1990-07-26 | Kumiai Chemical Industry Co | Fungizide zur verwendung in der landwirtschaft und im gartenbau. |
| TW449600B (en) * | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| US6153614A (en) * | 1998-07-16 | 2000-11-28 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
| AR038118A1 (es) * | 2002-01-14 | 2004-12-29 | Upjohn Co | Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales |
| US20060194871A1 (en) * | 2003-04-11 | 2006-08-31 | Barvian Kevin K | Heterocyclic mchr1 antagoists |
| US20050176738A1 (en) * | 2003-11-07 | 2005-08-11 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
| US7745447B2 (en) * | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
| AR056155A1 (es) * | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
| KR100846988B1 (ko) * | 2006-03-06 | 2008-07-16 | 제일약품주식회사 | 신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물 |
| WO2008057601A2 (en) * | 2006-11-08 | 2008-05-15 | The Rockefeller University | Organic compounds |
| CA2805724A1 (en) * | 2010-07-16 | 2012-01-19 | Rockefeller University | Oxadiazolo[3,2-a]pyrimidines and thiadiazolo[3,2-a]pyrimidines |
| EP2721036B1 (en) * | 2011-06-15 | 2015-07-22 | Takeda GmbH | Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds |
| US20130102601A1 (en) * | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| EP2804610B1 (en) * | 2012-01-16 | 2018-10-31 | The Rockefeller University | Organic compounds |
| DK2812004T3 (en) | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| CA2946702C (en) * | 2014-04-23 | 2022-06-28 | Mitsubishi Tanabe Pharma Corporation | Bicyclic or tricyclic heterocyclic compound |
| SI3143025T1 (sl) * | 2014-05-15 | 2020-01-31 | F. Hoffmann-La Roche Ag | Spojine za zdravljenje spinalne mišične atrofije |
| US10294243B2 (en) * | 2014-06-05 | 2019-05-21 | Bayer Cropscience Aktiengesellschaft | Bicyclic compounds as pesticides |
| WO2016128343A1 (en) | 2015-02-09 | 2016-08-18 | F. Hoffmann-La Roche Ag | Compounds for the treatment of cancer |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| JP6791717B2 (ja) * | 2015-10-22 | 2020-11-25 | 田辺三菱製薬株式会社 | 医薬組成物 |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| IL294124B2 (en) | 2015-12-10 | 2024-02-01 | Ptc Therapeutics Inc | Methods for treating huntington's disease |
| CA3037642A1 (en) * | 2016-09-23 | 2018-03-29 | Bayer Aktiengesellschaft | N 3 -cyclically substituted thienouraciles and use thereof |
| EA201991309A1 (ru) | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| KR20200017476A (ko) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | Rna 스플라이싱의 변경 방법 |
| EA201992780A1 (ru) * | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| KR20200057071A (ko) | 2017-09-25 | 2020-05-25 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱 조절제의 스크리닝 및 확인을 위한 방법 및 조성물 |
| CA3094988A1 (en) * | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| CN112272666A (zh) | 2018-04-10 | 2021-01-26 | 斯基霍克疗法公司 | 用于治疗癌症的化合物 |
| BR112020026637A2 (pt) * | 2018-06-27 | 2021-03-30 | Reborna Biosciences, Inc. | Agente profilático ou terapêutico para atrofia muscular espinhal |
| BR112023018466A2 (pt) * | 2021-03-17 | 2023-10-10 | Hoffmann La Roche | Derivados de tiazolopirimidinona |
| WO2022194802A1 (en) * | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thiadiazolopyrimidone derivatives |
-
2021
- 2021-04-08 KR KR1020227039044A patent/KR20230005210A/ko active Pending
- 2021-04-08 MX MX2022012676A patent/MX2022012676A/es unknown
- 2021-04-08 AU AU2021253571A patent/AU2021253571A1/en active Pending
- 2021-04-08 WO PCT/US2021/026477 patent/WO2021207550A1/en not_active Ceased
- 2021-04-08 JP JP2022561469A patent/JP2023520925A/ja active Pending
- 2021-04-08 JP JP2022561468A patent/JP7797407B2/ja active Active
- 2021-04-08 CN CN202180040768.XA patent/CN116134036A/zh active Pending
- 2021-04-08 US US17/917,868 patent/US20240287097A1/en active Pending
- 2021-04-08 US US17/917,842 patent/US20240279239A1/en active Pending
- 2021-04-08 EP EP21722687.7A patent/EP4132935A1/en active Pending
- 2021-04-08 CA CA3175205A patent/CA3175205A1/en active Pending
- 2021-04-08 BR BR112022020337A patent/BR112022020337A2/pt unknown
- 2021-04-08 IL IL297149A patent/IL297149A/en unknown
- 2021-04-08 WO PCT/US2021/026435 patent/WO2021207530A1/en not_active Ceased
- 2021-04-08 CA CA3175193A patent/CA3175193A1/en active Pending
- 2021-04-08 KR KR1020227039049A patent/KR20230004575A/ko active Pending
- 2021-04-08 CR CR20220567A patent/CR20220567A/es unknown
- 2021-04-08 BR BR112022020418A patent/BR112022020418A2/pt active Search and Examination
- 2021-04-08 MX MX2022012677A patent/MX2022012677A/es unknown
- 2021-04-08 EP EP21722693.5A patent/EP4132936A1/en active Pending
- 2021-04-08 AU AU2021251220A patent/AU2021251220A1/en active Pending
- 2021-04-08 CN CN202180040958.1A patent/CN116096725A/zh active Pending
-
2022
- 2022-10-07 CL CL2022002779A patent/CL2022002779A1/es unknown
- 2022-11-04 CO CONC2022/0015926A patent/CO2022015926A2/es unknown
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