BR112023018466A2 - Derivados de tiazolopirimidinona - Google Patents

Derivados de tiazolopirimidinona

Info

Publication number
BR112023018466A2
BR112023018466A2 BR112023018466A BR112023018466A BR112023018466A2 BR 112023018466 A2 BR112023018466 A2 BR 112023018466A2 BR 112023018466 A BR112023018466 A BR 112023018466A BR 112023018466 A BR112023018466 A BR 112023018466A BR 112023018466 A2 BR112023018466 A2 BR 112023018466A2
Authority
BR
Brazil
Prior art keywords
derivatives
thiazolopirimidinone
compound
formula
medicine
Prior art date
Application number
BR112023018466A
Other languages
English (en)
Inventor
Claudio Zambaldo
Cosimo Dolente
Delphine Gaufreteau
Susannah O'hara Fionn
Hasane Ratni
Matilde Piras
Michael Reutlinger
Nadine Grether
Virginie Brom
Walter Vifian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112023018466A2 publication Critical patent/BR112023018466A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

derivados de tiazolopirimidinona. a presente invenção refere-se a um composto de fórmula (i) (i) em que r1-r4 e a1-a3 são conforme definidos na descrição e nas reivindicações. o composto de fórmula (i) pode ser usado como um medicamento.
BR112023018466A 2021-03-17 2022-03-15 Derivados de tiazolopirimidinona BR112023018466A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21163259 2021-03-17
PCT/EP2022/056586 WO2022194801A1 (en) 2021-03-17 2022-03-15 New thiazolopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
BR112023018466A2 true BR112023018466A2 (pt) 2023-10-10

Family

ID=74947249

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023018466A BR112023018466A2 (pt) 2021-03-17 2022-03-15 Derivados de tiazolopirimidinona

Country Status (15)

Country Link
US (1) US20240018163A1 (pt)
EP (1) EP4308576A1 (pt)
JP (1) JP2024514421A (pt)
KR (1) KR20230157367A (pt)
CN (1) CN116981674A (pt)
AU (1) AU2022240935A1 (pt)
BR (1) BR112023018466A2 (pt)
CA (1) CA3212341A1 (pt)
CL (1) CL2023002705A1 (pt)
CO (1) CO2023012574A2 (pt)
CR (1) CR20230437A (pt)
IL (1) IL305203A (pt)
MX (1) MX2023010719A (pt)
TW (1) TW202302604A (pt)
WO (1) WO2022194801A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021251220A1 (en) * 2020-04-08 2022-11-03 Remix Therapeutics Inc. Compounds and methods for modulating splicing
WO2023064879A1 (en) * 2021-10-13 2023-04-20 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6092897B2 (ja) 2012-02-10 2017-03-08 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
CR20160518A (es) 2014-05-15 2017-02-21 Hoffmann La Roche Compuestos para tratar atrofia muscular espinal
EP3634953B1 (en) * 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
US11382918B2 (en) * 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
EP3684766A1 (en) 2017-09-22 2020-07-29 H. Hoffnabb-La Roche Ag Process for the prepration of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives
EP3814360B8 (en) * 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
AU2019294482B2 (en) * 2018-06-27 2022-09-01 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
AU2021251220A1 (en) * 2020-04-08 2022-11-03 Remix Therapeutics Inc. Compounds and methods for modulating splicing

Also Published As

Publication number Publication date
WO2022194801A1 (en) 2022-09-22
CN116981674A (zh) 2023-10-31
CA3212341A1 (en) 2022-09-22
JP2024514421A (ja) 2024-04-02
MX2023010719A (es) 2023-09-20
KR20230157367A (ko) 2023-11-16
TW202302604A (zh) 2023-01-16
US20240018163A1 (en) 2024-01-18
CR20230437A (es) 2023-10-16
CO2023012574A2 (es) 2023-09-29
AU2022240935A1 (en) 2023-08-24
IL305203A (en) 2023-10-01
EP4308576A1 (en) 2024-01-24
CL2023002705A1 (es) 2024-03-15

Similar Documents

Publication Publication Date Title
BR112023018466A2 (pt) Derivados de tiazolopirimidinona
BR112015020795A2 (pt) derivados de pirazol novos
BR112013031463A2 (pt) piridina-2-amidas úteis como agonistas de cb2
BR112018075939A2 (pt) compostos heterocíclicos como antibacterianos
BR112018076169A2 (pt) derivados azabenzimidazol como inibidores de pi3k beta
BR112015012919A2 (pt) novos derivados de piridina
CO2023017082A2 (es) Compuestos de tiadiazolilo unidos a un átomo de oxígeno como inhibidores de dna polimerasa θ
BR112018012112A2 (pt) heteroaril-hidroxipirimidinonas como agonistas do receptor apj
BR112015024272A2 (pt) novos derivados de piridina
BR112022023271A2 (pt) Compostos
BR112016017261A8 (pt) composto, composição farmacêutica, uso de um composto e processo para a fabricação de um composto
BR112015009603A2 (pt) novos derivados de pirazina
BR112018068341A2 (pt) 6-hidróxi-4-oxo-1,4-di-hidropirimidina-5-carboxamidas como agonistas de apj
BR112018075433A2 (pt) derivados de piperidinila, processo para sua preparação e composições farmacêuticas contendo-os
BR112017027831A2 (pt) derivados de hidroxiácido, um processo para sua preparação e composições farmacêuticas contendo-os
BR112018011562A2 (pt) novos derivados de fenil
BR112015032346A2 (pt) compostos de isotiazolina para o combate de pragas de invertebrados
BR112018077075A2 (pt) heterociclos de biarilmetila
BR112015027396A8 (pt) derivados de purina como agonistas do receptor de cb2
BR112022010633A2 (pt) Composto de fórmula, composição farmacêutica, uso de um composto, método para o tratamento ou profilaxia de câncer de tireoide e invenção
BR112014010047A8 (pt) novos derivados de pirazina
BR112022020798A2 (pt) Compostos tricíclicos como inibidores de nlrp3
BR112022001330A2 (pt) Derivados de 3,6-diamino-piridazin-3-ila, composições farmacêuticas contendo-os e seus usos como agentes pró-apoptóticos
BR112023003580A2 (pt) Compostos heterocíclicos
BR112018007068A2 (pt) derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta