BR112018012112A2 - heteroaril-hidroxipirimidinonas como agonistas do receptor apj - Google Patents
heteroaril-hidroxipirimidinonas como agonistas do receptor apjInfo
- Publication number
- BR112018012112A2 BR112018012112A2 BR112018012112-6A BR112018012112A BR112018012112A2 BR 112018012112 A2 BR112018012112 A2 BR 112018012112A2 BR 112018012112 A BR112018012112 A BR 112018012112A BR 112018012112 A2 BR112018012112 A2 BR 112018012112A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxypyrimidinones
- heteroaryl
- receptor agonists
- apj receptor
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Abstract
a presente invenção refere-se a compostos de fórmula (i): (i) em que todas as variáveis são conforme definidas no relatório descritivo, e as composições compreendendo qualquer um dos referidos compostos novos. esses compostos são agonistas de apj que podem ser usados como medicamentos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562267997P | 2015-12-16 | 2015-12-16 | |
US62/267,997 | 2015-12-16 | ||
PCT/US2016/066750 WO2017106396A1 (en) | 2015-12-16 | 2016-12-15 | Heteroarylhydroxypyrimidinones as agonists of the apj receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018012112A2 true BR112018012112A2 (pt) | 2018-12-04 |
Family
ID=57708840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018012112-6A BR112018012112A2 (pt) | 2015-12-16 | 2016-12-15 | heteroaril-hidroxipirimidinonas como agonistas do receptor apj |
Country Status (21)
Country | Link |
---|---|
US (1) | US10669261B2 (pt) |
EP (1) | EP3390400B1 (pt) |
JP (1) | JP6948322B2 (pt) |
KR (1) | KR20180095577A (pt) |
CN (1) | CN108602813B (pt) |
AR (1) | AR107061A1 (pt) |
AU (1) | AU2016372048B2 (pt) |
BR (1) | BR112018012112A2 (pt) |
CA (1) | CA3008630A1 (pt) |
CL (1) | CL2018001621A1 (pt) |
CO (1) | CO2018007221A2 (pt) |
EA (1) | EA036736B1 (pt) |
ES (1) | ES2854733T3 (pt) |
HK (1) | HK1255163A1 (pt) |
IL (1) | IL259947B (pt) |
MX (1) | MX2018007155A (pt) |
PE (1) | PE20181487A1 (pt) |
SG (1) | SG11201804674UA (pt) |
TW (1) | TW201725203A (pt) |
UY (1) | UY37026A (pt) |
WO (1) | WO2017106396A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2017014956A (es) | 2015-06-03 | 2018-04-13 | Squibb Bristol Myers Co | Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril) piridin-2-ona como para uso en el tratamiento de trastornos cardiovasculares. |
JP6837482B2 (ja) | 2015-10-14 | 2021-03-03 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Apjアゴニストとしての2,4−ジヒドロキシ−ニコチンアミド |
EA037257B1 (ru) | 2015-12-04 | 2021-02-26 | Бристол-Маерс Сквибб Компани | Новые агонисты рецептора апелина и способы применения |
UA127863C2 (uk) | 2015-12-16 | 2024-01-31 | Локсо Онколоджі, Інк. | Сполуки, які можна застосовувати як інгібітори кінази |
EP3433247B1 (en) | 2016-03-24 | 2021-09-08 | Bristol-Myers Squibb Company | 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists |
US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
JP6993357B2 (ja) * | 2016-06-14 | 2022-01-13 | ブリストル-マイヤーズ スクイブ カンパニー | Apjアゴニストとしての6-ヒドロキシ-5-(フェニル/ヘテロアリールスルホニル)ピリミジン-4(1h)-オン |
CN109641843B (zh) | 2016-06-14 | 2022-07-19 | 百时美施贵宝公司 | 作为apj激动剂的4-羟基-3-磺酰基吡啶-2(1h)-酮 |
WO2018071622A1 (en) | 2016-10-14 | 2018-04-19 | Bristol-Myers Squibb Company | 3-sulfonyl-5-aminopyridine-2,4-diol apj agonists |
EP3541805B1 (en) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
WO2018097944A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
WO2018093580A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
EP3541804A1 (en) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
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JP6837482B2 (ja) | 2015-10-14 | 2021-03-03 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Apjアゴニストとしての2,4−ジヒドロキシ−ニコチンアミド |
EA037257B1 (ru) | 2015-12-04 | 2021-02-26 | Бристол-Маерс Сквибб Компани | Новые агонисты рецептора апелина и способы применения |
EP3433247B1 (en) | 2016-03-24 | 2021-09-08 | Bristol-Myers Squibb Company | 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists |
CN109641843B (zh) | 2016-06-14 | 2022-07-19 | 百时美施贵宝公司 | 作为apj激动剂的4-羟基-3-磺酰基吡啶-2(1h)-酮 |
JP6993357B2 (ja) | 2016-06-14 | 2022-01-13 | ブリストル-マイヤーズ スクイブ カンパニー | Apjアゴニストとしての6-ヒドロキシ-5-(フェニル/ヘテロアリールスルホニル)ピリミジン-4(1h)-オン |
WO2018071622A1 (en) | 2016-10-14 | 2018-04-19 | Bristol-Myers Squibb Company | 3-sulfonyl-5-aminopyridine-2,4-diol apj agonists |
-
2016
- 2016-12-15 ES ES16820507T patent/ES2854733T3/es active Active
- 2016-12-15 SG SG11201804674UA patent/SG11201804674UA/en unknown
- 2016-12-15 UY UY0001037026A patent/UY37026A/es unknown
- 2016-12-15 TW TW105141572A patent/TW201725203A/zh unknown
- 2016-12-15 BR BR112018012112-6A patent/BR112018012112A2/pt not_active Application Discontinuation
- 2016-12-15 AU AU2016372048A patent/AU2016372048B2/en not_active Ceased
- 2016-12-15 EA EA201891336A patent/EA036736B1/ru not_active IP Right Cessation
- 2016-12-15 JP JP2018531333A patent/JP6948322B2/ja active Active
- 2016-12-15 MX MX2018007155A patent/MX2018007155A/es unknown
- 2016-12-15 CA CA3008630A patent/CA3008630A1/en not_active Abandoned
- 2016-12-15 PE PE2018001129A patent/PE20181487A1/es unknown
- 2016-12-15 KR KR1020187019799A patent/KR20180095577A/ko not_active Application Discontinuation
- 2016-12-15 CN CN201680081704.3A patent/CN108602813B/zh active Active
- 2016-12-15 US US16/061,365 patent/US10669261B2/en active Active
- 2016-12-15 WO PCT/US2016/066750 patent/WO2017106396A1/en active Application Filing
- 2016-12-15 AR ARP160103867A patent/AR107061A1/es unknown
- 2016-12-15 EP EP16820507.8A patent/EP3390400B1/en active Active
-
2018
- 2018-06-11 IL IL259947A patent/IL259947B/en active IP Right Grant
- 2018-06-15 CL CL2018001621A patent/CL2018001621A1/es unknown
- 2018-07-11 CO CONC2018/0007221A patent/CO2018007221A2/es unknown
- 2018-11-08 HK HK18114280.0A patent/HK1255163A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN108602813B (zh) | 2021-10-29 |
US10669261B2 (en) | 2020-06-02 |
TW201725203A (zh) | 2017-07-16 |
WO2017106396A1 (en) | 2017-06-22 |
JP6948322B2 (ja) | 2021-10-13 |
HK1255163A1 (zh) | 2019-08-09 |
AU2016372048A1 (en) | 2018-08-02 |
EA036736B1 (ru) | 2020-12-14 |
AU2016372048B2 (en) | 2021-02-04 |
CA3008630A1 (en) | 2017-06-22 |
EP3390400A1 (en) | 2018-10-24 |
PE20181487A1 (es) | 2018-09-18 |
EP3390400B1 (en) | 2021-01-20 |
UY37026A (es) | 2017-06-30 |
CN108602813A (zh) | 2018-09-28 |
AR107061A1 (es) | 2018-03-14 |
JP2018538304A (ja) | 2018-12-27 |
ES2854733T3 (es) | 2021-09-22 |
CO2018007221A2 (es) | 2018-07-19 |
KR20180095577A (ko) | 2018-08-27 |
IL259947B (en) | 2020-10-29 |
US20180362508A1 (en) | 2018-12-20 |
EA201891336A1 (ru) | 2019-01-31 |
SG11201804674UA (en) | 2018-06-28 |
CL2018001621A1 (es) | 2018-08-03 |
MX2018007155A (es) | 2018-08-15 |
IL259947A (en) | 2018-07-31 |
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