CR20230437A - Nuevos derivados de tiazolopirimidinona - Google Patents

Nuevos derivados de tiazolopirimidinona

Info

Publication number
CR20230437A
CR20230437A CR20230437A CR20230437A CR20230437A CR 20230437 A CR20230437 A CR 20230437A CR 20230437 A CR20230437 A CR 20230437A CR 20230437 A CR20230437 A CR 20230437A CR 20230437 A CR20230437 A CR 20230437A
Authority
CR
Costa Rica
Prior art keywords
new
thiazolopyrimidinone
derivatives
sup
sub
Prior art date
Application number
CR20230437A
Other languages
English (en)
Inventor
Fionn Susannah O´Hara
Delphine Gaufreteau
Nadine Grether
Hasane Ratni
Virginie Brom
Matilde Piras
Claudio Zambaldo
Cosimo Dolente
Michael Reutlinger
Walter Vifian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20230437A publication Critical patent/CR20230437A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un compuesto de fórmula (I), en el que R<sup>1</sup>-R<sup>4</sup> y A<sub>1</sub>-A<sub>3</sub> son como se definen en la descripción y en las reivindicaciones. El compuesto de fórmula (I) se puede usar como un medicamento.
CR20230437A 2021-03-17 2022-03-15 Nuevos derivados de tiazolopirimidinona CR20230437A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21163259 2021-03-17
PCT/EP2022/056586 WO2022194801A1 (en) 2021-03-17 2022-03-15 New thiazolopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
CR20230437A true CR20230437A (es) 2023-10-16

Family

ID=74947249

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230437A CR20230437A (es) 2021-03-17 2022-03-15 Nuevos derivados de tiazolopirimidinona

Country Status (15)

Country Link
US (1) US20240018163A1 (es)
EP (1) EP4308576A1 (es)
JP (1) JP2024514421A (es)
KR (1) KR20230157367A (es)
CN (1) CN116981674A (es)
AU (1) AU2022240935A1 (es)
BR (1) BR112023018466A2 (es)
CA (1) CA3212341A1 (es)
CL (1) CL2023002705A1 (es)
CO (1) CO2023012574A2 (es)
CR (1) CR20230437A (es)
IL (1) IL305203A (es)
MX (1) MX2023010719A (es)
TW (1) TW202302604A (es)
WO (1) WO2022194801A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021251220A1 (en) * 2020-04-08 2022-11-03 Remix Therapeutics Inc. Compounds and methods for modulating splicing
WO2023064879A1 (en) * 2021-10-13 2023-04-20 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6092897B2 (ja) 2012-02-10 2017-03-08 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
CR20160518A (es) 2014-05-15 2017-02-21 Hoffmann La Roche Compuestos para tratar atrofia muscular espinal
EP3634953B1 (en) * 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
US11382918B2 (en) * 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
EP3684766A1 (en) 2017-09-22 2020-07-29 H. Hoffnabb-La Roche Ag Process for the prepration of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives
EP3814360B8 (en) * 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
AU2019294482B2 (en) * 2018-06-27 2022-09-01 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
AU2021251220A1 (en) * 2020-04-08 2022-11-03 Remix Therapeutics Inc. Compounds and methods for modulating splicing

Also Published As

Publication number Publication date
WO2022194801A1 (en) 2022-09-22
CN116981674A (zh) 2023-10-31
CA3212341A1 (en) 2022-09-22
BR112023018466A2 (pt) 2023-10-10
JP2024514421A (ja) 2024-04-02
MX2023010719A (es) 2023-09-20
KR20230157367A (ko) 2023-11-16
TW202302604A (zh) 2023-01-16
US20240018163A1 (en) 2024-01-18
CO2023012574A2 (es) 2023-09-29
AU2022240935A1 (en) 2023-08-24
IL305203A (en) 2023-10-01
EP4308576A1 (en) 2024-01-24
CL2023002705A1 (es) 2024-03-15

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