CO2023012574A2 - Nuevos derivados de tiazolopirimidinona - Google Patents

Nuevos derivados de tiazolopirimidinona

Info

Publication number
CO2023012574A2
CO2023012574A2 CONC2023/0012574A CO2023012574A CO2023012574A2 CO 2023012574 A2 CO2023012574 A2 CO 2023012574A2 CO 2023012574 A CO2023012574 A CO 2023012574A CO 2023012574 A2 CO2023012574 A2 CO 2023012574A2
Authority
CO
Colombia
Prior art keywords
new
thiazolopyrimidinone
derivatives
thiazolopyrimidinone derivatives
compound
Prior art date
Application number
CONC2023/0012574A
Other languages
English (en)
Inventor
Hasane Ratni
Cosimo Dolente
Michael Reutlinger
Virginie Brom
Delphine Gaufreteau
Nadine Grether
Fionn Susannah O'hara
Matilde Piras
Walter Vifian
Claudio Zambaldo
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO2023012574A2 publication Critical patent/CO2023012574A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a un compuesto de fórmula (I), en el que R1-R4 y A1-A3 son como se definen en la descripción y en las reivindicaciones. El compuesto de fórmula (I) se puede usar como un medicamento.
CONC2023/0012574A 2021-03-17 2023-09-22 Nuevos derivados de tiazolopirimidinona CO2023012574A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21163259 2021-03-17
PCT/EP2022/056586 WO2022194801A1 (en) 2021-03-17 2022-03-15 New thiazolopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
CO2023012574A2 true CO2023012574A2 (es) 2023-09-29

Family

ID=74947249

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0012574A CO2023012574A2 (es) 2021-03-17 2023-09-22 Nuevos derivados de tiazolopirimidinona

Country Status (15)

Country Link
US (1) US20240018163A1 (es)
EP (1) EP4308576A1 (es)
JP (1) JP2024514421A (es)
KR (1) KR20230157367A (es)
CN (1) CN116981674A (es)
AU (1) AU2022240935A1 (es)
BR (1) BR112023018466A2 (es)
CA (1) CA3212341A1 (es)
CL (1) CL2023002705A1 (es)
CO (1) CO2023012574A2 (es)
CR (1) CR20230437A (es)
IL (1) IL305203A (es)
MX (1) MX2023010719A (es)
TW (1) TW202302604A (es)
WO (1) WO2022194801A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023064879A1 (en) * 2021-10-13 2023-04-20 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201609188WA (en) 2012-02-10 2016-12-29 Ptc Therapeutics Inc Compounds for treating spinal muscular atrophy
EP3663296B1 (en) 2014-05-15 2023-05-17 F. Hoffmann-La Roche AG Process for the preparation of compounds useful for treating spinal muscular atrophy
SG11201911615WA (en) * 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
US11382918B2 (en) * 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
KR20200058468A (ko) 2017-09-22 2020-05-27 에프. 호프만-라 로슈 아게 7-(4,7-다이아자스피로[2.5]옥탄-7-일)-2-(2,8-다이메틸이미다조[1,2-b]피리다진-6-일)피리도[1,2-a]피리미딘-4-온 유도체의 제조 방법
EP3814345A1 (en) * 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
WO2020005882A1 (en) * 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
MX2022012677A (es) * 2020-04-08 2023-01-11 Remix Therapeutics Inc Compuestos y metodos para modular el empalme.

Also Published As

Publication number Publication date
EP4308576A1 (en) 2024-01-24
CR20230437A (es) 2023-10-16
MX2023010719A (es) 2023-09-20
AU2022240935A1 (en) 2023-08-24
CL2023002705A1 (es) 2024-03-15
IL305203A (en) 2023-10-01
US20240018163A1 (en) 2024-01-18
CA3212341A1 (en) 2022-09-22
TW202302604A (zh) 2023-01-16
BR112023018466A2 (pt) 2023-10-10
WO2022194801A1 (en) 2022-09-22
KR20230157367A (ko) 2023-11-16
JP2024514421A (ja) 2024-04-02
CN116981674A (zh) 2023-10-31

Similar Documents

Publication Publication Date Title
CO2019003178A2 (es) Compuestos de dinucleótidos cíclicos
CL2021001330A1 (es) Nuevos compuestos heterocíclicos
CO2023012574A2 (es) Nuevos derivados de tiazolopirimidinona
CL2023000594A1 (es) Compuestos heterocíclicos
BR112015022804A2 (pt) novos derivados de octahidro-pirrol [3,4-c]-pirrol e seus análogos como inibidores de autotaxina
CR20160459A (es) Nuevos derivados de piridina
CL2020003331A1 (es) Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2
CO2023014721A2 (es) Compuestos heterocíclicos
CO2017003004A2 (es) Nuevas triazolo[4,5-d]pirimidinas
CR20160448A (es) Nuevos derivados de piridina
CO2018011231A2 (es) Derivados de [1,2,3]triazolo[4,5-d]pirimidina con afinidad por los receptores canabinoides tipo-2
CO2018004573A2 (es) Derivados de fenilo como agonistas del receptor 2 de cannabinoides
BR112022012130A2 (pt) Compostos antelmínticos compreendendo uma estrutura azaindólica
PA8574701A1 (es) Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen
CL2020003248A1 (es) Derivados de tetrahidrotienopiridina n-sustituidos y sus usos
CL2022002255A1 (es) Compuestos heterocíclicos de heteroarilo y usos de los mismos
DOP2016000293A (es) Derivados de diheterociclo enlazado a cicloalquilo
CO2021004553A2 (es) Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
CO2018007756A2 (es) Nuevos derivados pirrolidina
CO2022007621A2 (es) Nuevos inhibidores de braf como rompedores de la paradoja
CO2023008475A2 (es) Inhibidores de enzimas
AR126383A1 (es) Combinaciones insecticidas que comprenden un compuesto de antranilamida y tau-fluvalinato
BR112013028368A2 (pt) novos compostos de hexahidrociclopentapirrolona, hexahidropirrolopirrolona, octahidropirrolopiridinona e octahidropiridinona
UY38943A (es) Nuevas heteroaril piperidiniletanonas sustituidas de 6 miembros
CR20150073A (es) Nuevos derivados de piridina